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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-K

(Mark One)

☒	ANNUAL REPORT PURSUANT TO SECTION 13 OR 15( d ) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended December 31, 2021

☐	TRANSITION REPORT PURSUANT TO SECTION 13 OR 15( d ) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from ________________ to ________________

Commission File Number: 001-36030

Marrone Bio Innovations, Inc.

(Exact name of registrant as specified in its charter)

Delaware		20-5137161
(State or other jurisdiction of		(I.R.S. Employer
incorporation or organization)		Identification No.)

7780-420 Brier Creek Parkway, Raleigh, NC 27617

(Address of principal executive offices and zip code)

(530) 750-2800

(Registrant’s telephone number, including area code)

Securities registered pursuant to Section 12(b) of the Act:

Title of each class		Trading Symbol(s)		Name of each exchange on which registered
Common Stock, $0.00001 par value		MBII		Nasdaq Capital Market

Securities registered pursuant to Section 12(g) of the Act: None

Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes ☐ No ☒

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act. Yes ☐ No ☒

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☒ No ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer	☐	Accelerated filer	☐
Non-accelerated filer	☒	Smaller reporting company	☒
Emerging growth company	☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared or issued its audit report. Yes ☐ No ☒

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). Yes ☐ No ☒

As of June 30, 2021, the last day of the registrant’s most recently completed second quarter, the aggregate market value of the registrant’s voting and non-voting common stock held by non-affiliates was $105,751,347 based upon the closing price of the common stock as reported on the Nasdaq Capital Market. This calculation excludes the shares of common stock held by each officer, director and holder of 5% or more of the outstanding common stock as of June 30, 2021. This calculation does not reflect a determination that such persons are affiliates for any other purposes.

Indicate the number of shares outstanding of each of the issuer’s classes of common stock, as of the latest practicable date.

Class		Shares Outstanding at March 25, 2022
Common Stock, $0.00001 par value		182,274,641

DOCUMENTS INCORPORATED BY REFERENCE

Portions of Part III of this Annual Report on Form 10-K will be filed by amendment no later than 120 days after the end of the registrant’s fiscal year.

Auditor Firm Id: 688

Auditor Name: Marcum, LLP

Auditor Location: San Francisco, CA

TABLE OF CONTENTS

		Page
PART I.
Item 1.	Business	4
Item 1A.	Risk Factors	24
Item 1B.	Unresolved Staff Comments	42
Item 2.	Properties	42
Item 3.	Legal Proceedings	43
Item 4.	Mine Safety Disclosures	43
PART II.
Item 5.	Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities	43
Item 6.	Reserved	44
Item 7.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	44
Item 8.	Financial Statements and Supplementary Data	57
Item 9.	Changes in and Disagreements with Accountants on Accounting and Financial Disclosure	97
Item 9A.	Controls and Procedures	97
Item 9B.	Other Information	98
PART III.
Item 10.	Directors, Executive Officers and Corporate Governance	98
Item 11.	Executive Compensation	98
Item 12.	Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters	98
Item 13.	Certain Relationships and Related Transactions, and Director Independence	98
Item 14.	Principal Accounting Fees and Services	98
PART IV.
Item 15.	Exhibits, Financial Statement Schedules	99
Item 16.	Form 10-K Summary	99
SIGNATURES		104

Special Note Regarding Forward-Looking Statements and Trade Names

This Annual Report on Form 10-K includes a number of “forward-looking statements” within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements involve many risks and uncertainties, and may be identified by the use of the words “would”, “could”, “will”, “may”, “expect”, “believe”, “should”, “anticipate”, “outlook”, “if”, “future”, “intend”, “plan”, “estimate”, “predict”, “potential”, “targets”, “seek” or “continue” and similar words and phrases, including the negatives of these terms, or other variations of these terms, that denote future events. These forward-looking statements include: our beliefs with respect to the agricultural industry and related markets, including production levels, consolidation trends, and market opportunity; our plans and expectations regarding growth in our business, expansion to new markets, diversification of our product portfolio and strategic acquisitions and partnerships; our ability to effectively manage sales and marketing teams and distribution networks; our ability to integrate new products, technologies, and employee teams after any strategic acquisition; our expectations regarding revenues and sales, including potential growth in sales, changes to sales mix and expectations regarding seasonality and the impact of weather-related conditions; our expectations regarding discovering, developing, launching, commercializing and registering new products; our plans and expectations with regarding to manufacturing and production; our ability to protect our intellectual property in the United States and abroad; our ability to comply with ongoing and changing regulatory frameworks, including environmental, agricultural, and worker safety requirements, and to obtain product approvals; our ability to maintain a competitive position in our markets; our beliefs regarding our environmental, social, and governance leadership; our plans and expectations relating to our debt agreements; our ability to use carryforwards; our ability to influence customer perception of biological agricultural products; potential impact of the COVID-19 pandemic; our ability to maintain adequate cybersecurity measures to protect our information technology systems and infrastructure; our belief regarding our access to capital resources through equity offerings, debt financings, strategic collaborations or other means; our anticipated impact of certain accounting pronouncements; our expectations regarding market risk, including interest rate changes, foreign currency fluctuations and commodity price changes; statements regarding the potential completion of a merger transaction with Bioceres Crop Solutions; and our expectations with respect to our future expenditures, available cash and other financial and operating results. These statements reflect our current views with respect to future events and our potential financial performance and are subject to risks and uncertainties that could cause our actual results and financial position to differ materially and adversely from what is projected or implied in any forward-looking statements included in this Annual Report on Form 10-K. These factors include, but are not limited to, the risks described under Part I–Item 1A—”Risk Factors,” Part II–Item 7—”Management’s Discussion and Analysis of Financial Condition and Results of Operations,” elsewhere in this Annual Report on Form 10-K and those discussed in other documents we file with the U.S. Securities and Exchange Commission (SEC). We make these forward-looking statements based upon information available on the date of this Annual Report on Form 10-K, and we have no obligation (and expressly disclaim any such obligation) to update or alter any forward-looking statements, whether as a result of new information or otherwise except as otherwise required by securities regulations.

As used herein, “MBI”, the “Company”, “we”, “our” and similar terms refer to Marrone Bio Innovations, Inc., together with its subsidiaries, including Pro Farm Technologies OY (or “Pro Farm”), unless the context indicates otherwise.

Except as context otherwise requires, references in this Annual Report on Form 10-K to our product lines, such as Regalia, refer collectively to all formulations of the respective product line, such as Regalia Maxx, Regalia Rx or Regalia SC, and all trade names under which our distributors sell such product lines internationally, such as Sakalia^TM. Our logos, Grandevo®, Regalia®, Venerate®, Zequanox®, Haven®, Majestene®, Stargus®, Zelto®, Amplitude®, Jet-Ag®, Jet Oxide®, UBP-110®, Foramin® and other trade names, trademarks or service marks of MBI appearing herein are the property of MBI. We do not intend our use or display of other companies’ trade names, trademarks or service marks to imply relationships with, or endorsement or sponsorship of us by, these other companies.

PART I

ITEM 1. BUSINESS

We are a growth-oriented agricultural company that supports environmentally sustainable farming practices through the discovery, development and sale of innovative biological products for crop protection, crop health and crop nutrition. Our products are sold through distributors and other commercial partners to growers around the world for use in integrated pest management and crop protection systems that improve efficacy and increase yields and quality while protecting the environment. Our products are often used in conjunction with or as an alternative to other agricultural solutions to control pests and enhance plant nutrition and health.

Our research and development program uses proprietary technologies to isolate and screen naturally occurring microorganisms and plant extracts to create new, environmentally sound solutions in agriculture. Our research has resulted in novel biological products that help the grower:

	●	Protect crops from diseases, insects and weeds;
	●	Promote plant health and improve the soil microbiome; and
	●	Enhance a crop’s efficient use of nutrients.

Our products are supported by a robust portfolio of more than 400 issued and pending patents worldwide. Our products are approved by federal, state and foreign government agencies for use in organic and/or conventional farming systems. The majority of our legacy Marrone Bio products are produced or packaged at our dedicated, state-of-the-art manufacturing plant in Bangor, Michigan. We also have a minority ownership in a third-party manufacturing facility in Vyborg, Russia.

Industry Overview

Biological agricultural products, or biologicals, include bioprotection products, biofertilizers (bionutrition) and biostimulants, and occupy a unique space in agriculture as technologies that offer proven economic and environmental benefits to the consumer, the grower and the distributor.

For consumers, biologicals are part of the trend toward accessible, affordable, high-quality food produced in an environmentally sustainable manner. For growers and distributors, biologicals offer alternative solutions that not only enhance crop quality but also protect natural resources and reduce carbon footprint.

Farmers continually explore new options in crop production. Our portfolio of sustainable products give them innovative tools to increase yields and quality while protecting the safety of their operations and the health of their families, employees and land.

The global demand for alternative agricultural solutions drives the need for products that:

	●	Increase yield and crop quality;
	●	Improve soil health and nutrient utilization;
	●	Benefit the soil microbiome; and
	●	Provide greater convenience and flexibility in growing practices.

To meet these objectives, an increasing number of growers are implementing integrated pest management (IPM) programs. Growers use IPM to produce crops by the most economical means, and with the least possible hazard to people, property, and the environment. Biological agricultural products and crop cultivating techniques such as crop rotation and low-or-no tillage are among the most commonly used IPM practices.

The market for biological products is highly fragmented. There are approximately 300 known biopesticide active substances and organisms, and this high degree of fragmentation makes it difficult for the distribution channel and growers to differentiate between products and suppliers. Channel access favors those who can be long-term trusted partners consistently delivering products that provide the highest level of performance and return on investment.

Biologicals are developed and sold by two groups of agricultural companies. First, major, diversified agricultural suppliers who also sell seeds, fertilizers and chemical treatments for pest and weed control. Second, smaller companies dedicated primarily to research, development and commercialization of biologically based products.

Biologicals are delivering double-digit growth industrywide, as compared with low-single-digit growth for conventional crop protection products. We believe the market opportunity is significant: the market for agricultural biologicals, estimated to be more than $12.9 billion for 2022, still only represented approximately 10% of the total crop protection market for the same year, according to market research firms MarketandMarkets and Phillips McDougal, respectively.

Our Competitive Advantages

We are the leading pure-play, public company in the agricultural biologicals space, with a track record of revenue growth and gross margin expansion. To establish a leadership position in the biologicals space, we have spent significant time and resources advancing our product lines, expanding our portfolio through internal development and acquisitions, and building our infrastructure, plant capacity and global footprint. Our competitive advantages include:

Breadth and depth of experience –We have been a pioneer in the field of agricultural biological solutions, and have a track record of providing a wide range of products to specialty and row crop growers using conventional, organic and/or regenerative farming practices.

Unparalled product portfolio – We offer products across all three categories of biologicals: crop protection, crop health and crop nutrition. With 18 products to offer, we have size and scale that give us relevance within the agricultural distribution network and pull-through demand from growers.

Global commercial reach – We have partnerships with more than 56 distributors in over 30 countries that provide us outstanding channel access to our grower customers. We are reaping the benefits of the relationships we have built with partners in key growing regions outside the United States. We are becoming a less U.S.-centric company, with the potential to expand significantly in the large growing regions in Latin America and the European Union. We are rapidly diversifying our global mix, with a target to have our sales closer to an equal split between North America and the rest of the world.

Integration of strategic acquisitions – We made two strategic acquisitions in 2019: Pro Farm and the Jet-Ag and Jet-Oxide product families. Both were integrated into our operations and were immediate contributors to revenue growth and margin expansion. Pro Farm afforded us rapid entry into the key row crop markets of Europe and the Commonwealth of Independent States, and is central to our expansion in South America, including Brazil and Argentina. Aggressive field trial programs incorporating the Pro Farm crop nutrition products were conducted in 2020, often in combination with existing crop protection products in our historic portfolio. We anticipate the potential for further commercial synergies within distribution networks and product lines from this acquisition.

A robust, cost-efficient research and development pipeline – Our biological breakthrough research and development is based on a proprietary library of approximately 18,000 micro-organisms and 350 plant extracts. Our combined 10-year pipeline includes 16 potential product candidates. We are targeting approximately $50 million in incremental revenues from the launch of our pipeline products through 2026.

Speed to market – Discovery of new biologicals is cost effective: A new product can be brought to market at less than 5% of what it costs to develop a crop protection chemical, and in one-third of the time or less. We believe we have demonstrated our ability to develop and commercialize novel and effective products at commercially competitive rates and standards. We have continued to develop and refine these products, reducing manufacturing costs, producing new formulations, applying for expanded use labels and seeking new overseas markets, in each case at a cost of less than $11 million per product line.

Dedicated manufacturing capabilities – We operate out of two packaging and manufacturing facilities, one in Bangor, Michigan (Marrone Michigan Manufacturing, or MMM) which we own, and the other a third party manufacturer in Vyborg, Russia, in which we have a minority ownership interest. The MMM facility has made recent advances that have increased production yields and generally reduced cost of product revenues. This has been achieved through greater scale and improved utilization rates to increase volumes and yields while lowering overhead. During 2021, we invested more than $1 million in an upgrade of the facility with a projected two-year payback to allow us to bring additional production in-house, improve gross margins and reduce working capital.

Regulatory expertise and patent positions – As an early developer of biological agricultural products, we have in-depth experience seeking approvals and registrations for our unique products in countries around the world. Our commercial efforts are supported by more than 400 issued and pending patents worldwide.

Our Growth Strategy

We have built a full-service biologicals organization with scope and capabilities across the spectrum of biological products in the market today. Our strategic objective is to capitalize on that position and emerge as a leader in the biologicals space with the financial and operational wherewithal to accelerate our path to profitability.

Our success will be defined by:

The diversification of our portfolio, whether it be the products we sell, the crops we serve or the geographies we reach.

	●	In 2020, our sales were roughly one-third biofungicides, one-third bioinsecticides and bionematicides, and one-third seed-and-soil treatments. Over the next three years, as sales grow, we are targeting a shift in product mix to seed-and-soil treatments in the low to mid 30% and plant health products in the low to mid teens, while maintaining a strong position in crop protection products in the mid 50%.
	●	Specialty crops were the foundation of our historical sales, but we have made significant inroads into row crops, including soybeans and corn. We are targeting an increase in row crops to comprise up to half of our sales by 2023.
	●	We continue to target roughly equal sales between North America and the rest of the world in the long run, which would be a major change from our most recent sales trend with more than 75% of our product sales in North America.

Commercial launch of novel, efficacious agricultural biological products through investments in high-priority research and development projects that can accelerate the time to market and revenue contributions.

	●	We believe our pipeline uniquely positions us as a leader in the research, development and commercialization of products within this rapidly growing sector of agriculture. We are focused on a robust set of options across the entire sector, and especially in the seed-and-soil treatment market. In addition, we have significant opportunity to build on our leadership position in bioprotection products, while making further inroads into major row crops globally. Finally, we have made material advancements in our bioherbicide platform and remain excited about the opportunity to provide novel solutions aimed at combating weeds to our channel partners in the future.
	●	We continuously perform in-depth reviews of our research and development pipeline to ensure it delivers the maximum value for all key stakeholders – including our grower customers, our distribution channel partners, and our stockholders.
	●	We believe this revamped research and development program is highly responsive to customer needs, while making the most efficient use of available resources to provide the greatest returns on investment. By our estimates, our pipeline has the potential to add approximately $50 million in incremental revenues in the 2026 timeframe, and over $100 million in incremental revenues by 2030. Near-term, we have identified 3 pipeline products that have a high-probability of reaching the market within the next twelve months. All are well understood in our pipeline and commercial portfolio, with clear lines of sight into addressable markets, crops and customer value propositions.

Strategic, accretive acquisitions, as well as investments in partners with complementary technologies that would strengthen our pipeline or commercial offerings.

We have proactively identified the criteria for our acquisition strategy. Ideal candidates should generally have:

	●	A proven portfolio of efficacious products;
	●	A solid suite of intellectual property and protection;
	●	A track record of commercial success and growth;
	●	The potential for meaningful synergies and cost savings; and
	●	Accretion to earnings within 24 months.

Any partnerships, mergers or acquisitions should immediately broaden our portfolio, as well as have the opportunity to explore new combinations between respective technologies and pipelines that will expand our ability to bring novel products to market through our distribution channel partners.

An unrelenting focus on being brilliant at the basics — driving operational and financial excellence.

	●	We believe we have reached a turning point in our evolution as a commercial provider of sustainable, biological solutions. With more than five years of revenue growth and an annual gross profit margin in 2021 greater than 50%, we have established a commercial base from which we can accelerate our velocity and expand our leadership position in the space.
	●	We continue to be focused upon prudent management of our operating expenses relative to the growth of our revenues and gross profit. We continue to seek to maintain future operating expenses at a level that will support our continued strong growth and accelerate our path to profitability.

Our Markets

Our biological product portfolio provides growers with comprehensive solutions from planting to harvest; increasing plant vigor and health; controlling pests and diseases; reducing crop stress; increasing yields; and improving plant nutrient use efficiency, all of which provide growers a better return on investment for their farming operations.

Biologicals Product Categories

Our product categories include products often referred to as biopesticides, bioinsecticides, bionematicides, biofungicides, biostimulants and bionutrition, among others.

Crop Protection: Our historical commercial strength has been in the crop protection arena – biological products that protect crops against fungus, insects and nematodes. These are either sprayed on the leaves of plants and trees at various points in the growing season or used as seed- or soil-applied treatments at planting. This is the heart of our portfolio, and we continue to leverage this leading position in the biological control market, valued by market research firm DunhamTrimmer in their Global Biocontrol Report for 2021 at $5.2 billion globally. We have strengthened our competitive offerings through internal research that has resulted in next-generation advancements, as well as through the 2019 acquisition of the Jet-Ag and Jet-Oxide fungicides, bactericides and disinfectants.

Crop Health: For 2020, biostimulants were expected to represent a $2.1 billion market according to DunhamTrimmer. These products reduce plant stresses or enhance the crop’s tolerance to abiotic or external stresses, such as lack of water or excessive sunlight. This is a newer opportunity for us, and includes the 2021 launch of Pacesetter, a product for plant health that is used in combination with conventional products to boost yields and improve the grower’s return on investment.

Crop Nutrition: Our 2019 acquisition of Pro Farm allowed us to establish a global presence in the rapidly expanding biofertilizers market segment estimated at $2.3 billion for 2020 by MarketsandMarkets in their agricultural biologicals report. Crop nutrition products encourage better uptake of vital nutrients that allow the plant to withstand stresses and increase output. With the acquisition of Pro Farm, we added proprietary nutrient and biostimulant technology, as well as products for seed and foliar treatments. This portfolio of products uses a proprietary modes of action to stimulate plant growth and improve plant health, resulting in improved yields and crop quality.

Pro Farm’s proven technology is applied in seed, soil and foliar treatments in the major row and specialty crops of corn, cereals, sunflowers, oilseed rape (canola), sugar beets and vegetables, with other crops in development. Pro Farm has distribution agreements servicing most of the major global agricultural production areas, with particular strength in Europe and the Commonwealth of Independent States (CIS), and expansion under way in Latin America, North America, and Africa.

Product Applications

Foliar Applications: Foliar applications treat the plant by spraying the leaves to protect against pests, reduce stress or encourage plant health. Many of our products can be used as foliar treatments in specialty crops – such as tomatoes, leafy greens and melons – and in trees, nuts and vines – including almonds and grapes. Foliar applications also are commonly used in row crops and in greenhouse settings.

Seed and Soil Applications: The seed and soil treatment side of our business has created the most significant change in our product mix. A strategic collaboration established in 2016 with a major U.S. distributor created the first combination of our products in a seed treatment platform for row crops. Seed treatments provide insurance for growers, as they proactively respond to abiotic (external, environmental) and biotic (living organisms) stresses that are present at the time of planting, informed by grower experience and known growing conditions. Performance, usage rates, price and compatibility all factor into the buying decision. All else being equal, we believe distributors, seed companies and growers will continue to opt for biological treatments. We project that our seed and soil treatments account for about one third of our portfolio over the next three years.

BioUnite: The BioUnite strategy – which combines the power of biology with the performance of chemistry – remains a cornerstone of our ability to expand in new and existing markets. The BioUnite program provides growers with specific biological prescriptions for tank mixes of novel biological solutions with standard crop protection offerings. BioUnite is a powerful alternative in a grower’s integrated pest management program that eliminates guesswork, enhances performance and yields, and thus increases the grower’s return on investment. This proven approach has been tested over the past five years, in more than 200 trials for efficiency, safety, affordability and sustainability.

New partnerships will allow us to continue to expand our BioUnite offerings globally. We announced an agreement in 2020 with Vive Crop Protection, a leader in precision chemistry solutions and owner of the patented Allosperse® technology. We believe this partnership will provide a suite of ground-breaking products for U.S. growers by combining one of our leading biologicals with proven conventional chemistry using Vive’s Allosperse® Delivery System.

Our Products

The table below summarizes our current portfolio of commercially available product lines. On average, our bioprotection products progress through discovery, development, regulatory approvals, and market launch domestically and internationally within five years or less at a cost generally less than $11 million. We have continued to develop and refine these products, resulting in new formulations, expanded-use labels, and new markets.

All available formulations, with the exception of our Pro Farm product lines and Haven, are compliant with the U.S. Department of Agriculture’s National Organic Program and certified by the Organic Materials Research Institute (OMRI). All of our products have a low-risk profile as they are exempt from food tolerance requirements (that is, there are no pesticide residue concerns), and have an excellent safety profile for workers and consumers. For growers and others whose who work on farms, our products require minimal personal protective equipment (PPE) and allow workers to re-enter treated areas within four-hours of application, and with zero-day pre-harvest intervals. Our products also are low risk to pollinators, beneficial insects and other non-target organisms. In addition, our nutritional products create conditions that improve the soil microbiome and enhance the plant’s efficient use of water and nutrients.

NAME	MARKET	USE	DESCRIPTION	STATUS
Emergen	Row Crops Nutrition	Foliar Fertilizer	Nutrient complex for increasing crop health, yield and quality	Domestic Expansion Efforts Under Way, Available Internationally Under a Different Brand Name
Foramin	Crop protection	Foliar Fertilizer	Nutrient complex for increasing crop health, yield and quality	Commercially Available Internationally, Domestic Expansion Efforts Under Way
Foramin ST	Crop protection	Nutritional Seed Treatment	Nutrient complex for increasing crop health, yield and quality	Commercially Available Internationally, Domestic Expansion Efforts Under Way
Grandevo	Crop Protection, Home and Garden, Turf and Ornamentals, Seed Treatment	Insects and Mites	Controls a broad range of sucking and chewing insects through feeding	Commercially Available Domestically and Internationally
Haven	Crop Health, Home and Garden, Turf	Sun stress/Plant Crop Health, Quality	Reduces sun stress and dehydration, and increases yields and quality	Commercially Available Domestically and Internationally
Jet-Ag	Crop Protection	Plant Disease, Sanitation	Stops mold and bacteria on plants and other surfaces	Commercially Available Domestically
Jet-Oxide	Post Harvest	Sanitation	Disinfects hard surfaces	Commercially Available Domestically
Majestene	Crop Protection, Turf and Ornamentals, Seed Treatment	Plant Parasitic, Nematodes/Soil-Borne Insects	Controls soil-dwelling nematodes and certain soil borne insects.	Commercially Available Domestically, International Expansion Efforts Under Way
Optima	Crop Nutrition	Nutritional Seed Treatment	Nutrient complex for increasing crop health, yield and quality	Commercially Available Internationally, Domestic Expansion Efforts Under Way
Pacesetter	Row Crop Health	Crop Health	Improves yields and quality	Commercially Available Domestically, International Expansion Under Way
Regalia	Crop Protection, Home and Garden, Turf and Ornamentals, Seed Treatment	Plant Disease/Crop Health	Protects against fungal and bacterial diseases and enhances yields/quality	Commercially Available Domestically and Internationally
Stargus	Crop Protection, Home and Garden, Turf and Ornamentals, Seed Treatment	Plant Disease/Crop Health	Protects against fungal and bacterial diseases and enhances yields	Commercially Available Domestically and Internationally
Takla	Crop Nutrition	Nutritional Seed Treatment	Nutrient complex for increasing crop health, yield and quality	Commercially Available Internationally
UBP ST	Crop Nutrition	Nutritional Seed Treatment	Nutrient complex for increasing crop health, yield and quality	Commercially Available Internationally, Domestic Expansion Efforts Under Way
UBP	Crop Nutrition	Foliar Fertilizer	Nutrient complex for increasing crop health, yield and quality	Commercially Available Internationally, Domestic Expansion Efforts Under Way
Venerate	Crop Protection, Home and Garden, Turf and Ornamentals, Seed Treatment	Insects and Mites	Controls a broad range of sucking and chewing insects	Commercially Available Domestically and Internationally
Ympact	Crop Nutrition	Nutritional Seed Treatment	Nutrient complex for increasing crop health, yield and quality	Commercially Available Internationally, Domestic Expansion Efforts Under Way
Zelto	Seed Treatment, Turf	Plant Parasitic Nematodes/Soil-Borne Insects	Controls soil-dwelling nematodes and certain soil borne insects	Commercially Available Domestically

Emergen

	●	Foliar Fertilizer

	●	Row Crops

	●	Domestic Expansion Efforts Under Way, Available Internationally Under a Different Brand Name

Emergen is a foliar fertilizer that provides nutrients to the plant. It optimizes abiotic stress tolerance (e.g. drought, extreme heat), enhances conditions for higher yields, and provides an improved return on investment. It can be used in a mixture with traditional fungicides and with Pacesetter for improved and consistent yield.

Foramin

	●	Foliar Fertilizer

	●	Crops

	●	Available Internationally, Domestic Expansion Efforts Under Way

Foramin is a foliar fertilizer that enhances conditions for higher yields and improved return on investment. It delivers additional nutrients to the plant through the foliage and optimizes nutrient conditions for increased plant vigor.

Foramin’s nutrient composition and novel nutrient delivery mechanism are designed to have an overall positive effect on the plant physiology, by mitigating the adverse effects of abiotic stresses, Foramin improves both yield and quality, especially under less-than-favorable growing conditions.

Foramin ST

	●	Nutritional Seed Treatment

	●	Crops

	●	Available Internationally, Domestic Expansion Efforts Under Way

Foramin ST is a nutritional seed treatment that enhances conditions for increased yields and greater return on investment. It improves conditions for nutrient uptake and root growth. Foramin ST is easy to apply and use and is compatible with conventional seed treatments.

In the Foramin ST proprietary process, organic acids and biopolymers are combined with nutrients into a single organic molecular complex that allows plants to absorb up to 16 beneficial elements in a novel and more effective way (lower dose and lower cost).

Grandevo Bioinsecticide

	●	Bioinsecticide, Biomiticide and Bionematicide

	●	Crop Protection, Home and Garden, Turf and Ornamentals, Seed Treatment

	●	Available Domestically and Internationally

Grandevo Bioinsecticide is a water-dispersible granule based on a new species of microorganism (Chromobacterium subtsugae). It provides multiple modes of action to stop insect feeding and reproduction. Grandevo is particularly effective against certain chewing insects that destroy plant leaves (such as caterpillars), sucking insects that pierce plants and remove sap (such as Lygus and mealybugs), phytophagous mites and some flies whose larvae consume the plant’s fruit (such as the spotted wing Drosophila). The active ingredient in Grandevo has also shown efficacy on corn rootworm, a major pest of corn, and other yield-robbing soil pests when used as a seed treatment.

Haven Heat Stress Manager

	●	Crop Health

	●	Crops, Turf and Ornamentals

	●	Available Domestically and Internationally

Haven is a crop health product that is applied to the leaves of plants to reduce sun stress. Haven reflects light and heat from leaves, which lowers plant temperatures, resulting in less stress to the crops and higher yields and quality. Haven also increases the plant’s uptake of water and nutrients when it is under stress.

Haven is based on a technology of naturally derived, plant-based (coconut) compounds. Unlike competing products, Haven does not leave an undesirable deposit or residue on crops. Field trials over the last four years have demonstrated increased quality characteristics on citrus, watermelon, blackberries and grapes, and increased yields on walnuts, almonds, corn and wheat, often equal to or better than the conventional commercial standard.

Jet-Ag

	●	Fungicide, Bactericide, and Sanitizer

	●	Crops, Turf, Structures, Hard Surfaces, and Pipes

	●	Available Domestically

Jet-Ag and Jet-Oxide are broad-spectrum peroxyacetic acid (PAA) sanitizers that prevent, suppress, eliminate and control algae, fungi and bacterial diseases in agriculture and horticultural industries.

Jet-Ag can be used to treat crops to kill or control the growth of disease organisms on plants. It is also an effective soil treatment prior to planting and an inoculant of beneficial microorganisms. Jet-Ag can be used in conjunction with our other products: for example, research has shown that using Jet-Ag and Regalia in a program can increase control of fire blight and using Jet-Ag and Grandevo in a program can decrease the population of spotted wing drosophila on berries.

Jet-Oxide

	●	Sanitizer and Disinfectant

	●	Hard Surfaces, Fruit and Vegetable Water Treatment and Post-Harvest Treatment

	●	Available Domestically

Jet-Oxide is a fast-acting, easy-to-use post-harvest peroxyacetic acid (PAA) sanitizer and industrial disinfectant that is used in post-harvest packing house sanitation, field equipment sanitation, industrial use, fruits and vegetables processing, and food and beverage sanitation. Jet-Oxide 15% has shown efficacy against E. coli, salmonella, listeria and Human Coronavirus Strain 229E and the active ingredient PAA is on the list of U.S. Environmental Protection Agency-approved COVID disinfectants.

Majestene Bionematicide

	●	Bionematicide and Bioinsecticide

	●	Crop Protection, Turf and Ornamentals, Seed Treatment

	●	Available Domestically, International Expansion Efforts Under Way

Majestene Bionematicide, also a soil insecticide, has been developed based on the microorganism Burkholderia rinojensis. This nematicide is active against a broad range of nematodes, wireworms, white grubs and other important soil-dwelling insects that damage crops such as soybean, corn, cotton, strawberries, turf, tomatoes, potatoes and sweet potatoes.

Our next-generation Majestene product (MBI-306) – is currently in development. In 2019 - 2020, this version demonstrated high performance at substantially lower rates per acre than our current product for in-furrow applications on corn and potatoes and as a seed treatment on corn, wheat, cotton and soybeans.

One of our distribution partners, Albaugh, commercialized BIOst a nematicidal seed treatment product that incorporates our Majestene technology, which was used to replace a chemical nematicide that presented both worker safety and ecotoxicity concerns. This seed treatment use has seen significant growth in the U.S. corn, cotton and soy markets and efforts are underway to add seed treatment options for additional row and specialty crops in the future.

In 2021, we signed an agreement with Argentina-based company, Rizobacter to introduce a nematicidal and insecticidal seed treatment, based upon the Majestene formulation, into the Brazilian row crop market. The regulatory dossier for that product, Rizonema, was completed in 2021 and submitted to Brazilian regulatory agencies in September 2021. In March 2022, we received confirmation from Brazilian regulators that the product had been granted fast-track review status, with a favorable ANVISA (human health protection ministry) review already completed. Rizonema has now been forwarded to IBAMA (environmental protection ministry) and MAPA (agriculture ministry) review.

Optima

	●	Nutritional Seed Treatment

	●	Crops

	●	Available Internationally, Domestic Expansion Efforts Under Way

Optima is a second-generation nutritional seed treatment product, optimized for hybrid crops. It is based on the same underlying technology as UBP. Optima boosts the conditions for improved germination and plant development, supports the development of a strong root system, and enhances the conditions for nutrient uptake and increased yield potential

Pacesetter

	●	Crop Health

	●	Row crops

	●	Available Domestically, International Expansion Efforts Under Way

Pacesetter, launched during 2021, is a bio-based plant health product for row crops such as corn, soybeans, cotton, peanuts, tobacco and cereal grains. When used alone or with conventional fungicides, Pacesetter improves root growth and chlorophyll production to deliver yield increases beyond what synthetic fungicides alone can generate.

Large demonstration trials in 2020 showed an average return on investment above six to one and numerous plant health benefits. For corn, longer and wider ear leaf size, longer and healthier corn kernels and less tip loss were observed. Soybeans had healthier plants and more pods per plant and/or more seeds per pod on average.

Regalia Biofungicide

	●	Biofungicide

	●	Crop Protection, Home and Garden, Ornamentals, Seed Treatment

	●	Available Domestically and Internationally

Regalia Biofungicide is the master brand name for our product line of biofungicides and plant growth regulators that improve plant health and crop quality while preventing disease. Regalia’s active ingredient is an extract of Reynoutria sachalinensis (giant knotweed plant).

Regalia acts by turning on a plant’s immune system, a process called induced systemic resistance or systematically acquired resistance. It improves overall biotic stress tolerance and enhances the efficacy of conventional fungicides. It is an excellent tank mix or rotation solution for both organic and conventional IPM programs. Target diseases include powdery mildew on many crops and fire blight on apples. The active incredient in Regalia also is effective when applied as a seed treatment for use in soybeans, corn and cotton, with efforts underway to develop a specific formulation for that market segment.

Stargus Biofungicide

	●	Biofungicide

	●	Crop Protection, Home and Garden, Turf and Ornamentals, Seed Treatment

	●	Available Domestically and Internationally

Stargus Biofungicide is based on microbial fermentations of a newly identified Bacillus nakamurai strain, F727, isolated using our proprietary screening platform. We have identified different compounds, some of which are novel, produced by the microorganism in Stargus that control a broad range of plant diseases, such as downy mildews, Botrytis and white molds. Application of Stargus to corn and wheat seeds has resulted in enhanced yields.

Takla

	●	Nutritional Seed Treatment

	●	Crops

	●	Available Internationally

Takla is a nutritional seed treatment product initially developed for specific severe conditions in the European market. Takla enhances seed health and plant emergence, boosts plant vigor, and improves crop establishment.

UBP

	●	Foliar Fertilizer

	●	Crops

	●	Available Internationally, Domestic Expansion Efforts Under Way

UBP is a foliar biological fertilizer that enhances conditions for increased yield and crop quality. It delivers nutrients through the foliage and optimizes tolerance to abiotic stress. UBP is also easy to apply and use, and compatible with common agrochemicals.

Field trials demonstrate that UBP consistently outperforms standard organic and synthetic fertilizers and nutrient products in terms of both crop yield and quality. By promoting plant vigor and health, trials also have demonstrated that crops treated with UBP recover more quickly from herbicide damage.

UBP ST

	●	Nutritional Seed Treatment

	●	Crops

	●	Available Internationally, Domestic Expansion Efforts Under Way

UBP ST is based on the same underlying technology as UBP. It uses renewable forestry industry byproducts to produce a molecular level complex that contains macro- and micro-nutrients that are more effectively and efficiently delivered to plants.

As a nutritional seed treatment, UBP ST to aids in nutrient uptake and root growth, while increased yields and crop quality. It is easy to apply and use, and compatible with conventional seed treatments.

Venerate Bioinsecticide

	●	Bioinsecticide and Biomiticide

	●	Crop Protection, Home and Garden, Turf and Ornamentals, Seed Treatment

	●	Available Domestically and Internationally

Venerate Bioinsecticide, a liquid formulation, is based on a microbial fermentation of a new bacterial species, Burkholderia rinojensis. Compounds produced by the microorganism control a broad range of chewing and sucking insects and mites, as well as certain species of flies. Our next-generation Venerate product – is currently in development and is currently one of our largest products for seed treatments. In 2019 and 2020, this version demonstrated high performance at substantially lower rates per acre than our current product for foliar application to control key pests in fruit, vegetable and nut crops.

Ympact

	●	Nutritional Seed Treatment

	●	Crops

	●	Available Internationally, Domestic Expansion Efforts Under Way

Ympact is a unique nutritional seed treatment product specifically designed for cereals. It is based on the same underlying technology as UBP. Ympact improves conditions for increased vigor and greater biomass, enhances conditions for increased yields and improved crop quality, and optimizes conditions for nutrient uptake and root growth.

Zelto Bionematicide and Bioinsecticide

	●	Bionematicide and Bioinsecticide

	●	Turf

	●	Available Domestically

Zelto Bionematicide and Bioinsecticide protects turf, such as golf course fairways and greens, and promotes turf health by improving plant and root health.

Zelto Bionematicide is used for the control of plant parasitic nematodes and soil dwelling pests. It works by reducing the nematode population while encouraging rapid plant regeneration. This results in increased turf density and overall improved plant and root health.

Product Pipeline

Our product pipeline is a significant contributor to our growth strategy. We have expanded the focus of our research and development pipeline based on the strengths of our proprietary product lines of crop protection, plant health and biological fertilizers; our research and development infrastructure and manufacturing capabilities; and our market access and global footprint. Our pipeline consists of products in three categories: bioprotection, seed and soil health, and plant health. These products are further categorized in terms of their time to market launch: near-term (2022), mid-term (2023/2024) and long-term (2025 and beyond). We have implemented a pipeline prioritization strategy that establishes commercial target goals as each pipeline product advances through product development, regulatory reviews, market research assessments and risk adjusted financial projections.

Bioprotection:

	●	Bioinsecticides: MBI-306 and Grandevo XC
	●	Biofungicides: MBI-110 G2
	●	Bioherbicide: MBI-015
	●	Bioherbicide: MBI-011
	●	Bioherbicide: MBI-007

The bioprotection product category is comprised of a wide spectrum of products – including insecticides, fungicides and herbicides – targeted for mid- to long-term market launches. These products advance our current commercial products and build on our unique understanding of and experience with agricultural biologicals from both a scientific and commercial perspective. These products address some of the most significant and challenging unmet market needs, including weed control, pest resistance management, and integrated pest management practices.

Greater penetration in existing markets and expansion to new markets – such as row crops – and uses – such as seed treatments – are the key commercial objectives for these products:

	●	MBI-306 is our next generation insecticide/nematicide. Our 2020 and 2021 field research established targeted reduction of product usage from the current foliar applications of 64-128 fl. oz./acre to a significantly lower 15-20 fl. oz./acre. MBI-306 was submitted to the U.S. Environmental Protection Agency in September 2021 and, currently, has a projected 2023 approval date. We are also developing dossiers, including field trial data, to submit to Brazil and Canada, with projected submission date in 2023.
	●	Grandevo XC is an experimental liquid version of the existing dry Grandevo product with better customer acceptance and improved field efficacy.
	●	MBI-015 is a post-emergent herbicide (sprayed on the weeds after they emerge) for use against a range of weeds, including Palmer amaranth and water hemp, have developed resistance to leading conventional chemical herbicides. MBI-015 is based upon the MBI-014 technical grade active ingredient of the Burkholderia rinojensis microbe is targeted for use in conventional row crops.
	●	MBI-011 is a post-emergent burndown product based on Sarmentine, an extract from Chinese Long Pepper. It targets annual broadleaves and as well as annual grasses. MBI-011 has been developed to be sprayed against weeds that affect yields on row crops such as soybeans, corn, canola, cotton and rice.
	●	MBI-007 has shown pre- and post-emergent efficacy on a wide spectrum of annual broadleaves, grasses and sedges, and mixes well with most chemical crop protection products and fertilizers. It provides an improvement in efficacy at lower rates than MBI-005. MBI-005 is our former herbicidal Streptomyces acidiscabies strain developed and registered with the U.S. Environmental Protection Agency (EPA) and Canada’s Pest Management Regulatory Agency.

Seed and Soil:

	●	Seed: MBI-306 ST, MBI-307, MBI-5P16
	●	Soil: MBI-306, MBI-306 Premix, MBI-601,

This is the highest growth category in our pipeline and builds on our strengths in biological crop protection and fertilizers. The majority of these products are targeted for use worldwide in row crops, such as corn, soybeans, rice and cereals, and in such high-value crops as tree nuts, grapes and leafy vegetables.

A key product for crop protection is MBI-306 and its variants (MBI-306 Premix and MBI-307). MBI-306 is an enhanced version of our current seed, and soil, applied product, and significantly improves the level of efficacy against target pests. Based on our 2020-2021 field research, we are targeting a nine-fold reduction in the amount of seed treatment required in application, which is a competitive rate when compared with conventional treatments for targeting corn rootworm, lesion, reniform and soybean cyst nematodes. For soil uses, such as in-furrow applications in corn, our 2020-2021 field research supports a reduction in rate of application, while providing control of corn rootworms, wireworms, lesion nematodes and seed corn maggots comparable to industry standards. The ability to provide additional insect control, coupled with nematode control, gives us greater access to the corn, soybean and cotton soil-applied in-furrow markets and potentially additional crops. MBI-306 was submitted for registration to EPA in September 2021.

Our in pipeline of novel seed-applied plant nutrition products designed for industrial seed treatments, can also be used in downstream applications. These include: new breakthrough formulations with UBP-technology, out of which MBI-5P16 is the first to be introduced to the market for row crops in the United States and European Union. Most of these products are also in compliance with the new harmonized EU biostimulant regulation scheduled for 2022 (European parliament, Regulation (EC) No. 2019/1009), which will allow for pan-European market access for our plant health products.

Plant Health

	●	Foliar (Zn Foliar) and Reyzox,

	●	Row crops and specialty crops

	●	North America, European Union and Latin America

	●	Zn Foliar is a foliar-applied product targeted for the Latin American row crop market to address zinc deficiency. Positive field trial results in 2020 were expanded upon during 2021.
	●	We have partnered with Vive Crop Protection to combine extract of Reynoutria sachalinensis (the active ingredient in Regalia) with proven conventional chemistry (azoxystrobin) using Vive’s unique Allosperse Delivery System. The combination product Reyzox will be targeted to the fruit and vegetables markets in specific geographies.

We are continually investigating new research and development pipeline projects, whether through internal product development, in collaboration with other companies, or as a new product concept. We have established a stage gate process to evaluate and further advance our research and development pipeline. Overall, we estimate the current pipeline will add incremental revenue growth of approximately $50 million in the long-term timeframe and approximately $100 million by 2030. Our microorganism collection has candidates that help reduce fertilizer rates by enhancing the uptake of nutrients such as phosphorous and sulfur or can fix nitrogen.

Sales, Marketing and Distribution

We sell our products in the United States through our internal sales force, is focused on managing distributor relationships and creating grower demand for our products. We have a dedicated team of employees who provide technical service support to both our customers and sales representatives on the use of our products in IPM and crop production programs, both for conventional and organic growers. Our sales force covers all major regions in the United States, including California and the Pacific Northwest, the Southeast, the Northeast, the Mid-Atlantic and the Great Lakes regions, with an emphasis on high-value specialty crops (fruits, nuts and vegetables). We currently sell our crop protection product lines through leading agricultural distributors, such as Albaugh, Aligned Ag, Helena Chemical, Nutrien Ag, Simplot and Wilbur Ellis. These are the same distribution partners that most major agrichemical companies use for delivering solutions to growers across the country.

We sell our UBP and UBP- based products through selected partners and distributors in Europe and Latin America. On top of our existing significant distribution relationships, such as the distribution agreement we have with Corteva for seed treatment for hybrid crops in Europe, in 2020 and 2021, Pro Farm entered into a distribution agreement with companies such as Rizobacter in South America and PGG Wrightson Seed in Uruguay related to Pro Farm foliar and seed treatment product sales in the region. Pro Farm is also working with numerous companies to improve its biological offerings. With Pro Farm, we expect to continue expanding our global distribution network and have hired sales managers in key territories to help achieve our growth goals and provide support to our seed and distribution customers.

We have exclusive legacy international agreements with major distributors such as our previously mentioned distribution partnership with Corteva in Europe (seed treatment for hybrid crops), FMC (for certain markets in Latin America) and Syngenta (for specialty crop markets in Europe). Our current strategy is to work with regional distributors and distributors in key countries who have brand recognition and established customer bases, and who can effectively conduct field trials and grower demonstrations with biopesticides and lead or assist in regulatory processes and market development. As such, we have signed a number of distribution agreements with: Agristar, Nufarm, UPL, Jocanima/Great Havest, Elephant Vert and Kenya Biologics, Hoptri, Lidorr, AMC/Agrimatco, Disagro and Kyung Nong Corporation.

We believe we can leverage our existing sales, marketing and distribution network, to bring in additional revenues, while enhancing our commercialized product portfolio.

We derived approximately 77% and 85% of our total revenues from Regalia, Grandevo, Venerate and UBP ST product families for the years ended December 31, 2021 and 2020, respectively. We currently rely, and expect to continue to rely, on a limited number of distributors for a significant portion of our revenues since we sell through highly concentrated, traditional distribution channels. For the year ended December 31, 2021, our top three distributors accounted for 48% of our total revenues, and 78% of our business was from the U.S. markets. In 2022, however, we expect our product mix to shift significantly because of sales generated through our Pro Farm subsidiary and continued progress on registrations of our collective product lines in new countries.

While the biopesticide industry has been growing, customers in the crop production sectors often require on-farm demonstrations of pest management or plant health products, based on their novel modes of action require additional education on their use. We are implementing the following strategies to accelerate adoption rates and promote sales of our biological pest management and plant health products:

Maintain a focused and effective sales and marketing team that shares our values. We believe after several years of investment that we have been able to build an improved sales and marketing team. In addition, we are now more effectively organizing the data and educational material that we have amassed over years of operations on our bio-based products, as well as organic and sustainable agricultural practices in order to train and equip our sales staff to communicate with and educate distributors and growers. We believe that hiring and training sales and marketing staff with a high level of technical expertise and knowledge regarding the capabilities of our bio-based products, and unwavering belief in the potential and value of biologicals for crop production, is essential to expanding adoption of our products by growers and sales to distributors. In addition, we have invested in our field development team to include more technical service activities to support sales. These concerted efforts to build and train our sales and marketing teams are yielding positive results, including growth in sales.

Develop an extensive demonstration program. We believe that for growers to be convinced that a biological pest management, plant nutrition or plant health product works, they often must see it for themselves. Growers risk their crop each time they try a new product, and often produce only one crop per year on any given plot of land. Further, bio-based pesticide and plant health products are often applied differently and at different times than conventional chemical products, and so therefore may be used incorrectly by an inexperienced grower or advisor, decreasing efficacy. We typically conduct on-farm demonstrations with growers in the first year of association. A grower will then in the second year try one of our products on smaller plots of land and on one crop to ensure successful application then progress to increased use of our products in future years across more acres, more crops and more products. In addition, we work with distributors to determine which crops and which areas to emphasize in a given year to maximize the effectiveness of our demonstration program.

Target early adopters of new pest management technologies. For our biological pest management, plant nutrition and plant health products, we target both distributors and growers, who generally set industry standards through more widespread adoption of new pest management technologies after they initially test them on smaller portions of their crops. We also target organic growers, who are more willing trial new products, give fewer alternatives and greater demand for increased yields. We plan to continue to recruit these growers and their consultants to participate in demonstrations and field trials, enabling them to become familiar with our biological pest management and plant health products. By experiencing their benefits firsthand, they can promote the use of our products with other growers in their regions.

Educate growers about the benefits of our biological pest management products. Education is critical to the use of biologicals, which often have different modes of action than chemical products. We will continue to perform on-farm demonstrations and provide field data packages to support and validate our product claims. We also will continue to participate in trade shows and conferences to educate growers and their licensed pest control advisors about the benefits of our biological pest management, plant nutrition and plant health products. In addition we have provided a wide range of instructional videos, blog posts, webinars, podcasts, teach-ins, by-lined articles and online courses on biological pest management products, the latter of which can be taken by growers for continuing education credit to maintain crop protection product applicator licenses.

Develop and leverage relationships with key industry influencers. We will continue to develop relationships early in the product development process with target market influencers, including large, innovative growers, technical experts at leading agricultural universities, licensed pest control advisors, wineries, food processors, produce packers, and retailers. We believe that educating industry influencers about the benefits of biologicals and our products increases the likelihood that they will recommend our products to distributors and end users. In addition, food companies and retailers are driven by consumers to require greater sustainability and transparency from their grower-suppliers. This consumer trend is driving awareness with both the grower and food channel of the benefits of biologicals to soil health, the new movements in regenerative agriculture, and sustainable crop production programs in general.

Leverage the synergies of our sales teams and businesses domestically and internationally. Because of the concentration of large growers in the United States, we can access these customers through our own sales force. For our specialty crop products and seed treatments we have distribution agreements with national and regional distributors in North America, Europe, Uruguay and Latin America. We believe we can leverage these existing relationships to expand sales of our Foramin and UBP product lines through our U.S.-based sales team and distributors and likewise expand sales of our legacy Marrone products through existing Pro Farm product distributors. For future products, distribution agreements will be developed with regional and national distributors or large multinationals on a case-by-case basis, depending on their expertise in the regions. For the fast-growing medicinal plant and hemp market, we have set up several specialty distributors who can benefit from our products.

Manufacturing

Our manufacturing processes for our crop protection products are developed in-house at our Davis, California, research and development facilities and transferred to our Bangor, Michigan, facility, or to our manufacturing partners. Biopesticide formulation, microbial fermentation and product packaging are among the facility’s core competencies. We believe in-house manufacturing enhances control and flexibility in production, ensuring quality, strengthening intellectual property security and lowering manufacturing costs over time. During 2021, we invested over $1 million to increase in-house manufacturing of our products Venerate and Majestene, expand manufacturing capacity.

We currently ferment our Grandevo product in our manufacturing facility but continue to use a third-party contractor for formulating it into spray-dried powder. The facility also accommodates full-scale production of Regalia. While we have the ability to produce the majority of our products using our own manufacturing capacity, we currently use third parties to manufacture Venerate and Majestene/Zelto as a result of regulatory requirements for the microorganism that underlies the technologies. In 2020, we secured the necessary federal and state approvals to begin Burkholderia rinojenis production at our Michigan facility. Stargus/Amplitude is also made at a third-party vendor because the Bacillus bacteria produce spores that are hard to contain and could pose contamination risks in the manufacturing of our other products. We intend to have fermentation of Bacillus at our own facility, but it will require a separate facility from our other products. Haven has previously been produced using a third party, however our Michigan facility has taken over all production of the product. We anticipate ramping up production volumes as we expand the facility in the future. We expect to continue to utilize third-party manufacturing in North America and the EU for supplemental production capacity to meet excess seasonal demand and mitigate any supply disruptions. As needed, we will also use our own facility or third parties to package and label products.

The active ingredient in our Regalia product line is derived from the giant knotweed plant, which is a food and medicinal plant native to China and Japan. We have scaled production of Regalia using a reliable, single supplier that acquires raw knotweed from numerous regional sources and performs an extraction process on this plant, following our specification. The resulting dried extract is shipped to our manufacturing plant for formulation, production and packaging. We do not maintain a long-term supply contract with this supplier, but we have worked with them for 10 years. While there can be no assurance that we will continue to be able to obtain dried giant knotweed plant extract from our supplier in China, at a competitive price point, we estimate that our current supply of the ingredient will be sufficient to manufacture product to meet the next 6- to -12 months’ demand. Should we elect or be required to do so, we have identified and received quality knotweed from a number of possible alternative suppliers, including one from outside China in the event additional inventory or diversified sourcing is necessary.

A majority of the production of our Pro Farm product lines, as well as associated raw materials, is conducted at a third-party manufacturing facility in Russia, in which we have a 12% ownership stake. A large-scale paper and pulp manufacturing site in close proximity to this plant is the main supplier of the wood waste by-product material we use in production. For our Pro Farm products, we source custom, made, bespoke micronutrient formulations from a European third-party supplier and have multiple third-party post-production and formulation facilities in Europe. Our Jet-Ag products are manufactured by a third party located in the United States.

Research and Development

We have leveraged an innovative and market-focused discovery process to generate a robust product line and pipeline. This has included isolating approximately 18,000 microorganisms, testing more than 16,000 of them against multiple pest targets and testing a subset of them for plant health and nutrient uptake enhancement. We have then developed more than one product line based on the same active technology. Developing multiple products based on the same microbe allows for a more efficient use of research, development and manufacturing resources, and enables us to leverage capital invested in existing technologies.

At this time, we are prioritizing our research and development to support our existing products and focus on our pipeline projects as discussed above. These pipeline products combine our legacy and acquired collective technologies and are targeted for broader categories or bioprotection, plant health and seed and soil health.

As of December 31, 2021, we had 51 full-time equivalent employees dedicated to research and development and patent related activities, 7 of whom hold doctorates, plus 9 field development personnel who focus on technical support and demonstration and research field trials. Our research and development team has technical expertise in microbiology, molecular biology, bioinformatics, natural product, formulation and analytical chemistry, biochemistry, fermentation, entomology, nematology, weed science, plant physiology and plant pathology. Our research and development activities include discovery, product development, product support, regulatory, patent and field trial activities, which are principally conducted at our Davis, California, facility or onsite by our field development specialists in their respective regions. We have made, and will continue to make, substantial investments in research and development, such as increasing the number and locations of field trials and adding toxicology and regulatory consultants for new products and international expansion. Our Davis research and development headcount has remained relatively flat for several years. Our research and development expenses, including patent, regulatory and field trial expenses, were $12.1 million and $11.3 million for the years ended December 31, 2021 and 2020, respectively.

We advanced three novel bioherbicides in our research and development pipeline. These microbe or nature-derived herbicides are a key component of the company’s strategic growth plan, and provide entry into the $27 billion weed control market. These herbicides are expected to provide options to our customers that will enhance performance and profitability, and provide a more environmentally responsible option for both conventional and organic farmers. Our bioherbicides can control the most economically significant and resistant weeds, including annual broadleaves, grasses and sedges in major row crops as well as vegetable and turf markets. The products can be used at various points in the growing season to give farmers maximum flexibility to control weeds before, during and after planting.

Among our portfolio of three herbicides, the first two, MBI-005 (pre and post emergent herbicide) and MBI-011 (burn-down, contact herbicide), have prior regulatory approval from the U.S. Environmental Protection Agency, and now are undergoing further production and formulation refinement. MBI-005 program will continue as MBI-007 as we inked a licensing deal for improved production strains from Novozymes. The third program, MBI-014/015 (broadleaf herbicide), has progressed to advanced stages of development. Current results indicate that MBI-014/015 has herbicidal properties estimated to be 50 to100 times more active than leading chemical alternatives.

Intellectual Property Rights

We rely on patents and other proprietary right protections, including trade secrets and proprietary know-how, to preserve our competitive position. As of December 31, 2021, we had a total of 428 issued patents worldwide, of which 66 were issued in the U.S. and 362 were issued foreign patents. For pending patent applications, we had a total of 97 pending applications worldwide, of which 18 were pending U.S. provisional and non-provisional patent applications, and 79 were pending foreign patent applications relating to microorganisms and natural product compounds, uses and related technologies. As of December 31, 2021, we had 8 copyright registrations. As of December 31, 2021, we had 290 trademark registrations and applications globally, out of which 27 were U.S. trademark applications, and 28 were U.S. trademark registrations, 195 were registered trademarks worldwide, and 40 were trademark applications pending in various other countries.

When we find a microbial product in our screen that kills or inhibits one or more pests or pathogens in at least three replicated tests, and we can identify the microorganism and its associated chemistry, we file a patent application claiming any one or more of the following:

	●	the microorganism, its DNA products, as well as mutations and other derivatives;

	●	the use of the microorganism for pest management;

	●	novel natural product compounds, their analogs and unique mixtures of compounds produced by the microorganism;

	●	the new use of known natural product compounds for pest management;

	●	formulations of the microorganism or compounds; and

	●	synergistic mixtures of the microorganism or compounds with conventional chemical or other pesticides.

One of our commercially available products and certain of our lead product candidates are based on microbes we had identified using our proprietary discovery process, including Venerate, Majestene/Zelto and MBI-015, which are based on a Burkholderia bacterium, for which we had 60 issued patents and 20 pending patent applications (both U.S. and foreign) and MBI-110, is based on a Bacillus strain, for which we had 30 issued patents and 2 pending patent applications (both U.S. and foreign). Foramin and UBP products are based on technology developed by Pro Farm scientists for producing organic molecular complexes that facilitate nutrient absorption, and are protected by 4 issued U.S. patents, one issued Canadian patent, one Russian patent and 15 pending patent applications (both U.S. and foreign) comprising issued method of use patents and pending applications for method of manufacture.

We have also entered into in-license and research and development agreements with respect to the use and commercialization of Grandevo and Haven, as well as certain products under development. Under the licensing arrangements for our commercially available products, we are obligated to pay royalty fees in the mid-single digits of net sales of these products. The exclusivity and royalty provisions of these agreements are generally tied to the expiration of underlying patents. In addition, the in-licensed U.S. patent for Grandevo is expected to expire in or around 2024, but we have issued U.S. patents and pending U.S. patent applications relating to Grandevo that would expire later than 2024. We also have filed separate patent applications for Grandevo, of which 13 have been issued in the U.S. on a novel compound and insecticidal uses for nematodes, corn rootworm and a variety of insects, as well as new formulations and other uses. Additionally, we have filed separate patent applications with respect to Regalia and have been issued 6 U.S. patents.

While third parties thereafter may develop products using the technology under the expired patents, we do not believe that they can produce competitive products without infringing other aspects of our proprietary technology. We therefore do not expect the expiration of the patents or the related exclusivity obligations to have a significant adverse financial or operational impact on our business.

Regulatory Considerations

Our activities are subject to extensive federal, state, local and foreign governmental regulations. These regulations may prevent us or our collaborators from developing or commercializing products in a timely manner or under technically or commercially feasible conditions and may impose expenses, delays and other impediments to our product development and registration efforts. In the United States, the EPA regulates our bio-based pest management products under the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA), the Federal Food, Drug and Cosmetics Act (FFDCA) and the Food Quality Protection Act (FQPA). In addition, some of our plant health products are regulated as fertilizers, auxiliary plant substances, soil amendments and/or beneficial substances in each of the 50 states.

In 2004, the U.S. Congress passed the Pesticide Registration Improvement Renewal Act, which has been reauthorized in regular four-year cycles. This act is a result of efforts from an industry coalition of pesticide companies and environmental groups to codify pesticide approval times in return for user fees. Generally, EPA approvals, or registrations, for new pesticide active ingredients take on average 19 months. Registration processes for state and foreign governments vary amongst jurisdictions and can take 2-to-24 months for state governments - with states such as California and New York taking the longest and up to 36 months or more for foreign governments. In some instances, California and Canada will conduct joint reviews with the EPA, which allows some pesticides to receive concurrent approvals in California, Canada and the United States. However, in most instances, most foreign government submissions will not occur until after a U.S. registration has been secured. To register a crop protection product with the EPA, companies must demonstrate the product is “safe”, when used as directed, to mammals, non-target organisms, endangered species and the environment. To demonstrate the biological pest management product’s safety, required studies must be conducted that evaluate mammalian toxicology, toxicological effects to non-target organisms in the environment (ecotoxicological exposures) and physical and chemical properties of the product. The registration dossier is subject to both scientific and administrative reviews by EPA scientists and management before registration approval. The scientific review involves thorough evaluation of submitted data and completion of risk assessments for human dietary and ecotoxicological exposures. Upon completion of this process, the registration package, including the proposed label, is sent to the Office of General Council for legal review. The final step in the registration process is administrative sign-off by the EPA director of the Biopesticides and Pollution Prevention Division.

In addition to EPA approval, we are required to obtain regulatory approval from the appropriate state regulatory authority in individual states and foreign regulatory authorities before we can market or sell any pest management product in those jurisdictions. Foreign governments typically require up to two seasons of locally generated field efficacy data on crop-pest combinations before a product dossier can be submitted for review. California and some foreign jurisdictions also require us to submit product efficacy data, data which the EPA historically has not required for agricultural uses, but may request in the future.

We also generally pursue organic certification for our product portfolio, including USDA National Organic Program, Organic Materials Review Institute (OMRI), EcoCert and Control Union. These certifications often entail a two to four-month review process and, in many instances, require annual or semi-annual audits.

While these regulations substantially increase the time and cost associated with bringing our products to market, we believe that our management team’s significant experience in bringing our and other companies’ technologies through EPA, state and international regulatory approval; our efficient development process; and our ability to leverage our strategic collaborations to assist with registrations, particularly in Europe and Latin America, have and will continue to enable us to overcome these challenges.

Around the globe, the regulatory process for biostimulants and bionutrients (biofertilizers) is significantly accelerated compared to that for biopesticides. In the United States, if plant health products are not used to control pests or do not act as plant (growth) regulators, they currently fall outside the legal scope of FIFRA, FFDCA and FQPA and, therefore, we do not need to submit applications for EPA registrations for such products. However, we must still submit state registrations for our plant health products, including Haven and our Pro Farm products. Products containing microbes of foreign origin may also need to be “deregulated” (or determined not to be a plant pest) under the Plant Protection Act by the USDA Animal and Plant Health Inspection Service prior to use in field trials or for large scale release. Europe and the United States have industry coalitions that have developed more formal definitions of “biostimulant” and made recommendations for possible streamlined regulatory frameworks for these products. The 2018 Farm Bill for the first time proposed a federal definition of biostimulants. As mandated by U. S. Congress in the 2018 Farm Bill, in December 2019, the Secretary of Agriculture submitted a study to Congress recommending options for the official definition and regulation of biostimulants in the United States. Joint federal, state and industry discussions are now underway to review those options and to recommend a suitable path forward and policy framework for the regulation of biostimulants in the United States.

All of our biopesticide product lines are EPA-approved. However, as with any pesticide, our pest management products will continue to be subject to review by the EPA and state regulatory agencies. The EPA has the authority to revoke the registration or impose limitations on the use of any of our pest management products if we do not comply with the regulatory requirements; if unexpected problems occur with a product; or if the EPA receives other newly discovered adverse information. (See Part I-Item 1A-“Risk Factors—Risks Relating to Our Business and Strategy—Our inability to obtain regulatory approvals, or to comply with ongoing and changing regulatory requirements, could delay or prevent sales of the products we are developing and commercializing.”) Our research and development activities also are subject to federal, state and local worker safety, air pollution, water pollution and solid and hazardous waste regulatory programs and periodic inspection. We believe that our facilities are in substantial compliance with all applicable environmental regulatory requirements.

Competition

For agricultural products, performance and value are critical competitive factors. To compete against manufacturers of conventional chemical pesticides, chemical fertilizers and genetically modified crops, we need to demonstrate the advantages of our products over these more established products. Many large agrichemical companies are developing, and have introduced, new conventional chemical pesticides and genetically modified products that they believe are safer and more environmentally friendly than older conventional chemical products.

The pest management market is highly competitive and dominated by multinational chemical and life sciences companies such as Syngenta Crop Protection, Bayer Crop Science, BASF, Corteva Agriscience, UPL, FMC and Sumitomo Corporation. Additionally, universities, research institutes and government agencies may also conduct research, seek patent protection and, through collaborations, develop competitive pest management products. Other companies, including bio-specialized biopesticide businesses such as Certis Biologicals (owned by Mitsui & Co), Novozymes and Valent Biosciences (subsidiary of Sumitomo Chemical) may prove to be significant competitors in the biological pest management and plant health market. Because of the lower regulatory barriers as compared with crop protection products, the market for bionutrition and biostimulant products is very fragmented and includes larger players like Valagro (recently acquired by Syngenta Crop Protection), UPL and Acadian Seaplants and startups such as Sound Ag, Bioconsortia, New Leaf Symbiotics and Pivot Bio.

In many instances, agrichemical companies have substantially greater financial, technical, development, distribution and sales and marketing resources than we do. Moreover, these companies may have greater brand recognition and may offer greater discounts as a competitive tactic. There can be no assurance that our competitors will not succeed in developing pest management products that are more effective or less expensive than our products or that would render our products obsolete or less competitive. Our success will depend in large part on our ability to maintain a competitive position with our technologies and products.

Environmental Social and Governance

In our actions and engagement with stakeholders, we are committed to being a responsible corporate citizen. We aim to be a leader in the movement toward a more sustainable world through the discovery, development and promotion of biological solutions for pest management and plant health. We operate our business with a consistent focus on protecting the environment, safeguarding the health and safety of our employees, supporting our local communities, and operating with ethics and integrity. As reflected in our values, we are committed to aligning with environmental, social and governance (ESG) best practices and standards:

	●	We believe in sustainable business practices that are economically viable, socially equitable and environmentally responsible.
	●	We strive to conduct all business dealings with integrity, treating all stakeholders, collaborators and trade partners with respect, fairness and honesty at all times
	●	We promote a culture of accountability, continuous learning and diversity to bring about better decision-making.

We believe the environmental benefits of our products and our promotion of environmental stewardship, social responsibility and good governance through our leadership in the sustainable agriculture movement puts us in a strong market position as customers, strategic partners, investors and other stakeholders continue to assess ESG factors in their decision making.

In March 2021, we confirmed our commitment to a more sustainable economy and world and became a signatory to the United Nations Global Compact. Membership in the Global Compact obligates us to make progress on the UN’s ten key principles for a fairer, safer and more sustainable work environment. Our first “communication on progress” can be found at the UN Global Compact website.

Environmental

Our business revolves around producing environmentally responsible products for pest management, plant nutrition and plant health. All of our product families for crop protection are EPA-registered as biopesticides and our biological products enable customers to mitigate environmental concerns associated with conventional chemical pesticide products.

In general, our products are:

	●	Fermented microbes or extracted from plants (knotweed and coconuts) and use agricultural or other biological raw materials in these fermentation or plant extraction processes, resulting in lower fossil fuel usage.
	●	Assessed by the EPA, and other regulators, as having the lowest pesticide residue risk levels for pesticidal products, known legally as being “exempt from the requirement of a food tolerance.”
	●	Lower risk to pollinators and other non-target organisms.
	●	Biodegradable, breaking down quickly into carbon, hydrogen and oxygen.
	●	Designed to increase soil health by supporting or increasing microbial diversity in the soil.

We are also proud of the results of a study we conducted in cooperation with the UC-Davis Graduate School of Management showing that switching from conventional chemical pesticide products to our Regalia, Grandevo, Venerate and Majestene product lines could, potentially, result in average net reductions of greenhouse gas emissions of 69% to 91% (or 39 to 46 kilograms of CO₂ equivalents per acre per year). Recently completed life cycle analyses by Boundless Impact Research & Analytics of two products, our Venerate XC insecticide and Albaugh’s BIOst nematocidal seed treatment, which incorporates our technology, demonstrate that our bio-based approach to product development creates pest management tools that perform better than our chemical and biological competitors on a broad spectrum of human safety and environmental metrics, including greenhouse gas emissions, soil health, air and water quality, pollinator safety and worker safety.

Social

Ensuring the safety, health and well-being of our employees, growers and farm workers and the public at large is central to our vision for our business. Within our workplace, safety is both an individual and shared responsibility including periodic internal safety audits and safety trainings. In the wake of COVID-19, we have implemented the Centers for Disease Control and Prevention guidelines including masks and social distancing at both our corporate headquarters and our manufacturing plant; restricting commercial travel by employees; requiring daily temperature checks; scaling down our operations, including at our manufacturing plant; and frequent communications of our safety plans in light of COVID-19. Even as masks mandates have been lifted, our masks mandate at our manufacturing plant continues to be in place. We take a holistic approach to employee health and well-being by offering wellness programs that promote and incentivize healthy habits, such as physical fitness, smoking cessation and weight loss.

We support employees at all levels who are interested in making a difference in their local communities through nonprofit board service, donations and volunteer time. Our recent and current partnerships and projects include:

	●	Partnering with the fire department, high school science department and various community nonprofits in Bangor, Michigan, where our manufacturing facility is located;
	●	Supporting local programs in Yolo County, California, where our headquarters is located, including adopting families in need for Christmas through the Short Term Emergency Aid Committee; serving on the board of Empower Yolo; supporting the Center for Land-based Learning, an institution that trains beginning farmers, with a focus on veterans and under-represented populations; and donating fresh produce from our research farm to the local food bank; and
	●	Being actively involved in the national chapter and Sacramento Valley chapters of the Association for Women in Science, as well as supporting several STEM education initiatives in the region.

Our high-performing, biological solutions are safe to manufacture and generally safer for our customers and their workers to handle and use than conventional chemicals-based products, and inherently safer for consumers as well from the perspective of product residue. We launched our cultivated garden (CG) versions of three of our products to enable access to our products to the general public at competitive prices.

Governance and Ethics

Our board of directors has direct oversight of our ESG strategy, which is implemented internally by our cross-functional ESG steering committee led by our Chief Sustainability Officer, who also serves as our Senior Vice President of Regulatory and Government Affairs. Four of our eight directors possess directly relevant sustainability experience, including two directors with large-farm experience. For example, Dr. Pam Marrone, a member of our Board of Directors and our founder, received the Steward of Sustainable Agriculture Award by the Ecological Farming Association in January 2019 in recognition of her long-term, significant contributions to the well-being of agriculture and the planet.

Our Code of Business Conduct and Ethics promotes honest and ethical conduct; full, fair, accurate, timely and understandable disclosures; compliance with applicable governmental laws, rules and regulations; protection of Company assets; fair dealing practices; prompt reporting of Code violations to the appropriate person; and accountability for adherence to the Code. All employees are required to acknowledge our Code of Business Conduct and Ethics, which we make publicly available on our company website along with our Whistleblower Policy and Board of Directors Committee Charters. Finally, we adhere to the governance requirements established by federal and state law, the Securities and Exchange Commission and Nasdaq.

Human Capital

Our support of our employees extends to ensuring they are compensated fairly for their work. We believe we provide employees with a competitive and comprehensive pay and benefits package including but not limited to both cash and non-cash compensation, health benefits and paid time off. Our commitment to pay equity is shared by Company leaders. For example, the compensation of our Chief Executive Officer and other senior managers is generally less than 15 times that of our lowest paid full time employee.

We believe our human capital is one of our many great assets, and we strive for a workplace that realizes the potential of our people:

	●	We believe entrepreneurial attitudes, agility, and out-of-the-box thinking and creativity are the lifeblood of innovation.
	●	We demand open and honest communication and respect for the views of others and seek to minimize internal politics and value the input of all employees in our strategy, goal setting and decision-making.
	●	We believe that a diverse workforce, with diverse opinions, working together in teams leads to better decision-making. We actively try to enhance diversity in our workforce.
	●	We promote a culture of accountability, continuous learning, coaching and mentoring for personal and professional growth.

As of December 31, 2021, we had 153 full-time equivalent employees, of whom 14 hold Ph.D. degrees or doctorates. Approximately 51 employees are engaged in research and development and patent related activities, 30 in sales and marketing (including 9 sales and field development personnel who focus on technical support and demonstration and research field trials), 47 in operations, including manufacturing, supply chain and quality assurance, and 25 in management, accounting/finance and administration.

We take pride in the diversity of our workforce and being an equal opportunity provider. As a growing company focused on innovation, we strive to foster diversity and inclusion, with women representing approximately 48% of all employees (and 22% of senior management and 62% of our research and development team) and racial or ethnic minorities representing approximately 35% of employees (and 33% of senior management).

Our corporate policies provide employees opportunities to grow by offering tuition reimbursements, company-sponsored third-party web-based learnings, and time for community involvement.

None of our employees are represented by a labor union.

Bioceres Crop Solutions Merger Agreement

On March 16, 2022, we entered into an Agreement and Plan of Merger (as it may be amended or supplemented from time to time, the “Merger Agreement”) with BCS Merger Sub, Inc. (“Merger Sub”), which is a wholly owned subsidiary of Bioceres Crop Solutions Corp., a Cayman Islands exempted company (“Bioceres”), and Bioceres. The Merger Agreement provides that, upon the terms and subject to the conditions set forth therein, the Merger Sub will merge with and into the Company (the “Merger”), with the Company surviving the Merger as a wholly owned subsidiary of Bioceres. At the effective time of the Merger, as set forth in the Merger Agreement, each share of our common stock issued and outstanding immediately prior to the effective time, other than shares owned by Bioceres or held by us, will be cancelled and extinguished and automatically converted into the right to receive 0.088 validly issued, fully paid and nonassesable ordinary shares of Bioceres, and our shares would cease to be publicly held.

The consummation of the Merger is subject to certain closing conditions, including (i) the approval of the Company’s stockholders, (ii) the expiration or termination of all waiting periods under the Hart-Scott Rodino Antitrust Improvements Act of 1976 and receipt of any other specified merger control consents or clearances, (ii) the effectiveness of the registration statement to be filed by Bioceres with the SEC pursuant to the Merger Agreement, (iii) the approval for listing on Nasdaq of Bioceres’ ordinary shares to be issued as Merger Consideration in connection with the Merger, subject to official notice of issuance, (iv) the absence of any judgment or law issued by any governmental entity enjoining or otherwise prohibiting the consummation of the Merger, and (vii) other customary conditions specified in the Merger Agreement. See Note 16 to our consolidated financial statements for additional information regarding the Merger.

Corporate Information

We were originally incorporated in the State of Delaware in June 2006 as Marrone Organic Innovations, Inc. Our principal executive offices are located at 7780-420 Brier Creek Parkway, Raleigh, NC 27617. Our telephone number is (530) 750-2800. Our website address is www.marronebioinnovations.com.

ITEM 1A. RISK FACTORS

Our operations and financial results are subject to various risks and uncertainties, including those described below, which could adversely affect our business, financial condition, results of operations, cash flows, growth prospects and the trading price of our common stock.

Summary Risk Factors

Our business is subject to a number of risks, including risks that may prevent us from achieving our business objectives or may adversely affect our business, financial conditions, results of operations, cash flows and prospects that you should consider before making a decision to invest in our Common Stock. These risks are discussed more fully in the section titled “Risk Factors” beginning on page 24 of this Annual Report, and include the following:

Risks Relating to our Financial Position

	●	We have a history of operating losses and expect to incur additional losses in the future;

	●	there is uncertainty about our ability to continue as a going concern; and

	●	we expect to require additional financing in the future to maintain and expand our business, and to service our debt.

Risks Relating to the Acquisition of the Company by Bioceres

	●	Uncertainty about the Merger may adversely affect relationships with our distributors, suppliers, business partners, and employees, whether or not the Merger is completed;

	●	if the Merger does not occur, it could have a material adverse effect on our business, results of operations, financial condition and stock price; and

	●	Our combination with Bioceres may be more difficult, costly or time consuming than expected and we may fail to realize the anticipated benefits of the Merger.

Risks Relating to Our Business and Strategy

	●	We currently have limited sales and marketing experience and capabilities, and will need to continue expanding our sales and marketing infrastructure;

	●	if we are unable to maintain and further establish successful relations with the third-party distributors that are our principal customers, or they do not focus adequate resources on selling our products or are unsuccessful in selling them to end users, sales of our products will be adversely affected;

	●	we currently rely on a limited number of distributors;

	●	the high level of competition in the market for biological agricultural products may result in pricing pressure, reduced margins or the inability of our products to achieve market acceptance;

	●	the product candidates we select for development and commercialization may fail to generate significant revenues;

	●	our product sales are subject to weather conditions and other factors beyond our control, which may cause our operating results to fluctuate significantly quarterly and annually;

	●	biological crop protection and plant health products are not well understood, which necessitates investment in customer education and makes effectively marketing and selling our products difficult;

	●	if we or our third-party manufacturers are unable to produce our products at a satisfactory quality, in a timely manner, in sufficient quantities or at an acceptable cost, our business could be negatively impacted;

	●	failure to achieve expected manufacturing yields and pesticidal activity or contamination of our production runs could negatively impact our operating results;

	●	we currently rely on a single supplier based in China for a key ingredient of Regalia;

	●	any decline in U.S. agricultural production could have a material adverse effect on the market for pesticides and on our results of operations and financial position;

	●	we are subject to risks associated with our international sales and operations;

	●	a variety of risks associated with our subsidiary, manufacturing facilities and operations in Russia and the recent Russian invasion of Ukraine could adversely affect our business;

	●	our intellectual property is integral to our business. If we are unable to protect our patents and proprietary rights in the United States and foreign countries, our business could be adversely affected;

	●	increases in costs, disruption of supply or shortage of raw materials, as well as reductions in manufacturer capacity, could harm our business;

	●	significant disruptions of information technology systems or breaches of data security could adversely affect our business;

	●	the COVID-19 pandemic, or any other pandemic, epidemic or outbreak of an infectious disease, may materially and adversely affect our business and operations;

	●	increases in costs, disruption of supply or shortage of raw materials, as well as reductions in manufacturer capacity, could harm our business; and

	●	we depend on our highly skilled employees to grow and operate our business and if we are unable to hire, retain, manage and motivate our employees, or if our new employees do not perform as anticipated, we may not be able to grow effectively and our business, financial condition and operating results could be materially adversely affected.

Risks Relating to Product Development and Regulatory Matters

	●	our inability to obtain regulatory approvals, or to comply with ongoing and changing regulatory requirements, could delay or prevent sales of the products we are developing and commercializing;

	●	we use hazardous materials in our business and are subject to potential liability under environmental laws;

	●	inability to comply with regulations applicable to our facilities and procedures could delay, limit or prevent our research and development or manufacturing activities;

	●	our business is subject to various governmental regulations, and compliance with these regulations may cause us to incur significant expenses; and we may experience disruptions to our business as a result of the relocation of our headquarters and general expansion of our operations.

Risks Related to Ownership of Our Common Stock

	●	our principal stockholders have significant voting power and may take actions that may not be in the best interest of other stockholders;

	●	our common stock may experience extreme price and volume fluctuations, and you may not be able to resell shares of our common stock at or above the price you paid;

	●	substantial future sales of our common stock, or the perception in the public markets that these sales may occur, may depress our stock price;

	●	we are a “smaller reporting company” and we cannot be certain if the reduced disclosure requirements applicable to smaller reporting companies will make our common stock less attractive to investors; and

	●	we have in the past identified material weaknesses, and if we fail to establish and maintain proper and effective internal controls, our ability to produce accurate financial statements on a timely basis could be impaired, which could adversely affect our consolidated operating results, our ability to operate our business, our stock price and investors’ views of us.

Risks Relating to Our Financial Position

We have incurred significant losses to date and anticipate continuing to incur losses in the future. Unless we significantly increase sales, we may not achieve or maintain profitability and our business may fail.

We have incurred operating losses since our inception in June 2006, we expect to continue to incur operating losses for the foreseeable future and we may never become profitable. As of December 31, 2021, we had an accumulated deficit of $357.4 million, and for the years ended December 31, 2021 and 2020, we had a net loss attributable to common stockholders of $16.6 million and $20.2 million, respectively. Our future success depends on our ability to market and sell in significantly larger volume our legacy Marrone products and our acquired products, and to successfully introduce new products like Pacesetter, Optima, Takla and Ympact.

While we have and plan to continue to invest considerable resources in the sale and launch of our products, various factors have impeded and continue to impede higher growth in sales of these products. For example, we believe adverse conditions globally, including low commodity prices in some regions and for some crops, may have reduced demand for our products. Delays in regulatory approvals of certain of our products in Europe, Latin America and other jurisdictions have and may continue to slow international growth, and any delay in a product launch that causes us to miss a growing season may require us to wait a year to enter that market. Extended drought in some markets such as California and excessive rain in other markets reduced demand for our products as fewer acres are planted, recent changes in weather patterns have resulted in a shortened bloom cycle in different markets in different years and resulted in fewer pesticide and plant health products being used, and certain of our strategic collaborations have not resulted in the significant increases in sales we expected both inside and outside of the Unites States.

Lower than expected sales growth as a result of these and other factors may adversely affect our financial results in several ways, including increases in write-offs and inventory obsolescence, higher proportional operating expense levels and increases in our cost of product revenues and decreases in product margins. Further, if we are unable to achieve our planned operating results and increase sales of our commercialized products, our available cash and ability to raise additional capital will decrease which could cause the market price of our common stock to decline, and our business may fail.

There is uncertainty about our ability to continue as a going concern.

Our historical operating results as of December 31, 2021 indicate substantial doubt exists related to our ability to continue as a going concern for the 12 months from the issuance of the accompanying financial statements. However, we believe that our existing cash and cash equivalents of $19.6 million at December 31, 2021, together with expected revenues, net proceeds from future debt or equity financings, and continued cost management will be sufficient to fund operations as currently planned for at least one year from the date of the issuance of the accompanying financial statements. However, we cannot predict, with certainty, the outcome of actions to grow revenues, obtain financing and/or manage or reduce costs. We have based this belief on assumptions and estimates that may prove to be wrong, and we could spend our available financial resources less or more rapidly than currently expected. We may continue to require additional sources of cash for general corporate purposes, which may include operating expenses, working capital to improve and promote our commercially available products, advance pipeline candidates, expand international presence and commercialization, general capital expenditures and satisfaction of debt obligations. Should we seek additional financing from outside sources, we may not be able to raise such financing on terms acceptable to us or at all. The actions discussed above cannot be considered probable of occurring and mitigating the substantial doubt raised by our historical operating results and satisfying our estimated liquidity needs for 12 months from the issuance of the accompanying financial statements. If we become unable to continue as a going concern, we may have to liquidate our assets, and stockholders may lose all or part of their investment in our common stock.

We expect to require additional financing in the future to maintain and expand our business, and to service our debt. Such capital raising may be costly, difficult or not possible to obtain and, if obtained, could significantly dilute current stockholders’ equity interests, and we may be unable to repay our secured indebtedness.

We expect to continue to incur significant losses until we are able to significantly increase our revenue. Accordingly, we expect to need significant additional financing to maintain and expand our business, including, for example, working capital associated with increased sales, costs associated with increased headcount, potential capital expenditures to grow capacity at our Bangor manufacturing facility, potential acquisitions of complementary technologies, businesses, and other strategic opportunities as well as to meet the financial covenants of and pay the principal and interest under our debt agreements.

We may also seek additional funds from public or private equity offerings, debt financings, and strategic collaborations involving up-front cash payments or other means. However, additional capital may not be available on terms acceptable to us, or at all. Any additional equity financing we do raise will be significantly dilutive to stockholders or, in some cases, require us to seek stockholder approval for the financing or result in antidilution adjustments to the prices of our outstanding warrants, reducing potential proceeds from their exercise. Any debt financing, if available, may include restrictive covenants and bear high rates of interest. In addition, our existing loan agreements contain certain restrictive covenants that either limit our ability to or require a mandatory prepayment if we incur additional indebtedness and liens and enter into various specified transactions. We therefore may not be able to engage in any of the foregoing transactions unless we obtain the consent of our lenders or prepay the outstanding amounts under the debt agreements, which could require us to pay additional prepayment penalties. In addition, we may incur substantial costs in pursuing future capital financing, including investment banking fees, legal fees, accounting fees and other costs. We also may be required to recognize non-cash expenses in connection with certain securities we issue, such as warrants, which may adversely impact our financial results.

Certain of our debt agreements also contain financial covenants, including maintaining minimum current, debt-to-worth and loan-to-value ratios and provisions providing for an event of default if there is a material adverse change in our financial condition or if we are in default under certain of our other agreements. We are not in compliance with certain of these covenants and have received waivers from our lenders, none whom have previously declared an event of default on our indebtedness. Breach of covenants included in our debt agreements, which could result in the lenders demanding payment of the unpaid principal and interest balances. If we fail to pay any principal or interest under our indebtedness when due, or are otherwise in violation of certain covenants under our debt agreements, this may result in the acceleration of our indebtedness, which would have a material adverse effect upon our business and would likely require us to seek to renegotiate these debt arrangements with the lenders, as we may not have sufficient funds to repay that indebtedness.

Further, the Merger Agreement restricts our ability, prior to the closing of the transactions contemplated by the Merger Agreement, to issue equity securities, incur indebtedness, or materially change our business operations without the consent of Bioceres. These restrictions may make it difficult for us to raise capital and adversely impact our business.

If we cannot raise more money when needed, or are unable to use our future working capital, borrowings or equity financing to repay or refinance the amounts outstanding under our debt agreements or to renegotiate our debt arrangements with lenders, we may have to reduce our capital expenditures, scale-back our development of new products, reduce our workforce or license to others products that we otherwise would seek to commercialize ourselves. Any of these eventualities would likely have a material adverse impact on our value and the value of our equity.

Our ability to use our net operating loss carryforwards to offset future taxable income may be subject to certain limitations.

As of December 31, 2021, we had net operating loss carryforwards of $113.4 million. The net operating loss carryforwards for federal and state purposes were reduced as a result of the effect of an ownership change as defined under Internal Revenue Code (IRC) Section 382, the change related to the February 5, 2018 previously disclosed financing transactions. The federal and state reductions were $176.4 million and $119.1 million, respectively. The federal net operating loss generated after 2017 in the amount of $74.4 million will not expire. In addition, as of December 31, 2021, we had federal research and development tax credit carryforwards of $0.6 million, which begin to expire in 2038, and state research and development tax credit carryforwards of $3.1 million, which have no expiration date. The federal research and development tax credit carryforwards were also reduced by the Section 382 ownership change of $2.3 million. It is possible that we will not generate taxable income to use these loss carryforwards in cases where they are subject to expiration or where they are able to be carried forward indefinitely. Additionally, while we believe that foreign loss carryforwards in connection with our acquisition of Pro Farm have been retained, there can no assurance the initial position will not be reversed in future periods by the foreign taxing authorities.

Risks Relating to the Acquisition of the Company by Bioceres

Uncertainty about the Merger may adversely affect relationships with our distributors, suppliers, business partners, and employees, whether or not the Merger is completed.

On March 16, 2022, we entered into the Merger Agreement. Uncertainty about the Merger and our efforts to complete the Merger could create uncertainty surrounding and significantly disrupt our business. Uncertainty regarding our future could also adversely affect our relationships with existing and potential customers, distributors, suppliers, vendors, strategic partners, employees. For example, clients, distributors, and other counterparties may delay or defer decisions concerning entering into contracts or otherwise working with us, seek to change our existing business relationships or consider doing business with other companies rather than us. Competitors may also target our customers by highlighting potential uncertainties and other risks related to the Merger. The pendency of the Merger may also divert management’s attention and resources towards completing the Merger and preparing for integration activities and away from ongoing business and operations. Uncertainty as to whether the merger will be completed may also affect our ability to recruit prospective employees or to retain and motivate existing employees. Employee retention may be particularly challenging while the Merger is pending because employees may experience uncertainty about their roles following the Merger. These risks and the resulting adverse effects on business, financial condition and results of operations could be exacerbated by any delays in completion of the Merger or termination of the Merger Agreement.

Stockholder litigation could prevent or delay the closing of the Merger or otherwise negatively impact our business, operating results and financial condition.

We may incur additional costs in connection with any future stockholder litigation in connection with the Merger. Such litigation may adversely affect our ability to complete the Merger. We could incur significant costs in connection with any such litigation, including attorneys’ fees and costs associated with the indemnification obligations to our directors.

If the Merger does not occur, it could have a material adverse effect on our business, results of operations, financial condition and stock price.

Upon completion of the Merger, we will become a wholly owned subsidiary of Bioceres and will cease to be publicly owned and traded. There are, however, many contingencies which may cause the Merger not to occur.

Completion of the Merger is subject to the satisfaction of various conditions, including but not limited to, (i) the approval of the Company’s stockholders, (ii) the expiration or termination of all waiting periods under the Hart-Scott Rodino Antitrust Improvements Act of 1976 and receipt of any other specified merger control consents or clearances, (ii) the effectiveness of the registration statement to be filed by Bioceres with the SEC pursuant to the Merger Agreement, (iii) the approval for listing on Nasdaq of Bioceres’ ordinary shares to be issued as Merger Consideration in connection with the Merger, subject to official notice of issuance, (iv) the absence of any judgment or law issued by any governmental entity enjoining or otherwise prohibiting the consummation of the Merger, and (vii) other customary conditions specified in the Merger Agreement. Bioceres’ obligations to complete the Merger are also subject to our compliance with the covenants set forth in the agreement, including (i) covenants relating to conducting our business in the ordinary course consistent with past practice and refraining from taking certain types of actions without Bioceres’ consent, (ii) covenants relating to removing certain inventory from certain jurisdictions and (iii) certain restrictions on the Company’s ability to solicit alternative acquisition proposals from third parties, and/or to provide information to third parties and to engage in discussions with third parties, in each case, in connection with alternative acquisition proposals, subject to certain exceptions. There is no assurance that all of the various conditions will be satisfied, or that the Merger will be completed on the proposed terms, within the expected timeframe, or not at all:

The Merger gives rise to inherent risks that include:

	●	the price of our common stock will change if the Merger is not completed to the extent that the current market price of our stock reflects an assumption that the Merger will be completed;
	●	the exchange ratio under the Merger Agreement is fixed and will not be adjusted for changes in our business, assets, liabilities;
	●	prospects, outlook, financial condition or results of operations or in the event of any change in the market price of, analyst estimates of, or projections relating to, our common stock;
	●	legal or regulatory proceedings, including regulatory approvals from domestic and foreign governmental entities (including any conditions, limitations or restrictions placed on these approvals) and the risk that such governmental entities may delay or deny approval, or other matters that affect the timing or ability to complete the transaction as contemplated;
	●	potential stockholder litigation that could prevent or delay the Merger or otherwise negatively impact our business and operations;
	●	the possibility of disruption to our business, including increased costs and diversion of management time and resources;
	●	difficulties maintaining business and operational relationships, including relationships with customers, suppliers, and other business partners;
	●	the inability to attract and retain key personnel pending consummation of the Merger;
	●	the inability to pursue alternative business opportunities or make changes to our business pending the completion of the Merger;
	●	the requirement that we pay a termination fee of $9.7 million to Bioceres if the Merger Agreement is terminated under certain circumstances;
	●	developments beyond our control including, but not limited to, changes in domestic or global economic conditions, a pandemic, or war that may affect the timing or success of the Merger; and
	●	the risk that if the Merger is not completed, the market price of our common stock could decline, investor confidence could decline, shareholder litigation could be brought against us or our directors, relationships with customers, suppliers and other business partners may be adversely impacted, we may be unable to retain key personnel, and profitability may be adversely impacted due to costs incurred in connection with the proposed Merger.

Our combination with Bioceres may be more difficult, costly or time consuming than expected and we may fail to realize the anticipated benefits of the Merger.

The success of the Merger will depend, in part, on the ability to realize the anticipated synergies, operating efficiencies, and cost savings from combining our business with that of Bioceres. To realize the anticipated benefits and cost savings from the Merger, Bioceres must integrate and combine our business in a manner that permits these cost savings to be realized, without adversely affecting current revenues and future growth. If we and Bioceres are not able to successfully achieve these objectives, the anticipated benefits of the Merger may not be realized fully or at all or may take longer to realize than expected. In addition, the actual cost savings of the Merger could be less than anticipated, the costs associated with effecting the Merger may be more than anticipated, and integration may result in additional and unforeseen expenses.

An inability to realize the full extent of the anticipated benefits of the Merger and the other transactions contemplated by the Merger Agreement, as well as any delays encountered in the integration process, could have an adverse effect upon the revenues, levels of expenses and operating results and financial condition of the combined company, which may adversely affect the value of the common stock of Bioceres after the completion of the Merger.

We and Bioceres have operated and, until the completion of the Merger, must continue to operate, independently. It is possible that the integration process could result in the loss of key associates, the disruption of each company’s ongoing businesses or inconsistencies in standards, controls, procedures and policies that adversely affect each company’s ability to maintain relationships with clients, customers and other business parties or to achieve the anticipated benefits and cost savings of the Merger. Integration efforts between the two companies may also divert management attention and resources. These integration matters could have an adverse effect on us and/or Bioceres during this transition period and for an undetermined period after completion of the Merger on the combined company.

Risks Relating to Our Business and Strategy

We will need to continue expanding our sales and marketing infrastructure.

We currently have limited sales and marketing experience and capabilities. As of December 31, 2021, we employed 30 full-time equivalent sales and marketing personnel, 9 of whom focus on technical support and demonstration and conducting field trials and 4 of which focus on marketing. The majority of these sales personnel were hired after 2018 and thereafter. New personnel require significant training to attain a high level of technical expertise and knowledge regarding the capabilities of our biological products compared with conventional chemical pest management products and techniques in order to educate growers and independent distributors on the uses and benefits of our products. We will need to further develop our sales and marketing capabilities and find partners in order to successfully increase sales of our commercially available products and to commercialize other products we are developing, which may involve substantial costs. There can be no assurance that our field development specialists and other members of our sales and marketing team will successfully compete against the sales and marketing teams of our current and future competitors, many of which may have more established relationships with distributors and growers. Our inability to recruit, train and retain sales and marketing personnel, or their inability to effectively market and sell the products we are developing, could impair our ability to gain market acceptance of our products and cause our sales to suffer.

If we are unable to maintain and further establish successful relations with the third-party distributors that are our principal customers, or they do not focus adequate resources on selling our products or are unsuccessful in selling them to end users, sales of our products will be adversely affected.

In the United States, we rely on independent distributors of agrichemicals to distribute and assist us with the marketing and sale of our current product portfolio and other products we are developing. These distributors are our principal customers, and revenue growth will depend in large part on our success in establishing and maintaining this sales and distribution channel. However, there can be no assurance that our distributors will be successful in selling our products to end users, or will focus adequate resources on selling them, and they may not continue to purchase or market our products for a number of reasons.

For example, many distributors lack experience in marketing biological agricultural products, which generally must be used differently than conventional chemical products. In addition, many of our distributors are in the business of distributing and manufacturing other, possibly competing, biological agricultural products, including internally developed and commercialized biological products as well as biological products developed by larger agrichemical companies that negotiate to “bundle” such specialty products with other high demand products. For example, a portion of our sales of Venerate are tied to Albaugh’s promotion, sales and services related to products under its BIOST platform, in addition to the effectiveness of their proprietary blend, which while containing Venerate, is developed by Albaugh and not by us. To the extent our distributors are unsuccessful in selling our products to end users, or in marketing their own products that incorporate our products, they may purchase lower volumes from us, which could have a material adverse effect on our business. In addition, our distributors may earn higher margins by selling competing products or combinations of competing products. If we are unable to establish or maintain successful relationships with independent distributors, we need to further develop our own sales and demand creation capabilities, which would be expensive and time-consuming, the success of which would be uncertain.

We depend on a limited number of distributors.

Our current revenues are derived from a limited number of key customers, each of which serves as a third-party distributor to our products’ end users. For each year ended December 31, 2021 and 2020, our top three distributors accounted for 48% of our total revenues. We expect a limited number of distributors to continue to account for a significant portion of our total revenues for the foreseeable future. This customer concentration increases the risk of quarterly fluctuations in our revenues and operating results. The loss or reduction of business from one or a combination of our significant distributors could materially adversely affect our revenues, financial condition and results of operations.

The high level of competition in the market for biological agricultural products may result in pricing pressure, reduced margins or the inability of our products to achieve market acceptance.

The markets for biological agricultural products are intensely competitive, rapidly changing and undergoing consolidation. We may be unable to compete successfully against our current and future competitors, which may result in price reductions, reduced margins and the inability to achieve market acceptance for our products.

Many entities are engaged in developing biological agricultural products. Our competitors include major multinational agrichemical companies, some of which have developed biological products for our target markets, as well as specialized biological agricultural businesses such as Certis Biologicals (owned by Mitsui & Co), Novozymes and Valent Biosciences (subsidiary of Sumitomo Chemical). Many of these organizations have longer operating histories, significantly greater resources, greater brand recognition and a larger base of customers than we do. As a result, they may be able to devote greater resources to the manufacture, promotion or sale of their products, receive greater resources and support from independent distributors, initiate or withstand substantial price competition or more readily take advantage of acquisition or other opportunities. Further, many of the large agrichemical companies have a more diversified product offering, which may give these companies an advantage in meeting customers’ needs by enabling them to offer a broader range of crop protection, plant nutrition and plant health solutions. In addition, we could face competition in the future from new, well-financed start-up companies.

The product candidates we select for development and commercialization may fail to generate significant revenues.

Our internal development efforts are focused on a number of product candidates including in the near term Reyzox, Zn Foliar, MBI-306, MBI-011, MBI-015 and MBI-007. Simultaneously, we are seeking collaborations with third parties to develop and commercialize early-stage candidates on which we have elected not to expend significant internal resources.

Successful development of product candidates will require significant additional investment, including costs associated with research and development, completing field trials and obtaining regulatory approval, as well as the ability to manufacture our products in large quantities at acceptable costs while also preserving high product quality. Difficulties often encountered in scaling up production include problems involving production yields, quality control and assurance, shortage of qualified personnel, production costs and process controls. In addition, we are subject to inherent risks associated with new products and technologies. These risks include the possibility that any product candidate may:

	●	be found unsafe;
	●	be harmful to consumers, growers, farm workers, animals, beneficial insects or the environment;
	●	be harmful to crops when used in connection with conventional chemical pesticides;
	●	cause a major crop failure;
	●	be ineffective or less effective than anticipated;
	●	be displaced by new technologies;
	●	fail to receive or take longer to receive necessary regulatory approvals;
	●	be difficult to competitively price relative to alternative pest management solutions;
	●	be difficult or impossible to manufacture on an economically viable scale;
	●	be subject to supply chain constraints for raw materials;
	●	fail to be developed and accepted by the market prior to the successful marketing of similar products by competitors;
	●	be impossible to market because it infringes on the proprietary rights of third parties; or
	●	be too expensive for commercial use.

Our decisions regarding which product candidates to pursue may cause us to fail to capitalize on product candidates that could have given rise to viable commercial products and profitable market opportunities.

Our product sales are subject to weather conditions and other factors beyond our control, which may cause our operating results to fluctuate significantly quarterly and annually.

In recent years, we have increasingly had higher sales during the first half of the year than the second half, and expect this trend to continue. However, the level of seasonality in our business may change due to a number of factors, including our expansion into new geographical territories, the introduction of new products, the timing of introductions of new formulations and products, the addition or changes to distributors or distributor programs and the impact of weather and climate change. It is possible that our business may become more seasonal, or experience seasonality in different periods.

Notwithstanding any such seasonality, we expect substantial fluctuation in sales year over year and quarter over quarter as a result of a number of variables on which sales of our products are dependent. Weather conditions, natural disasters and other factors affect planting and growing seasons and incidence of pests and plant disease, and accordingly affect decisions by our distributors, direct customers and end users about the types and amounts of pest management and plant health products to purchase and the timing of use of such products. In addition, disruptions that cause delays by growers in harvesting or planting can result in the movement of orders to a future quarter, which would negatively affect the quarter and cause fluctuations in our operating results. Customers also may purchase large quantities of our products in a particular quarter to store and use over long periods of time or time their purchases to manage their inventories, which may cause significant fluctuations in our operating results for a particular quarter or year.

Our expense levels are based in part on our expectations regarding future sales. As a result, any shortfall in sales relative to our expectations could cause significant fluctuations in our operating results from quarter to quarter, which could result in uncertainty surrounding our level of earnings and possibly a decrease in our stock price.

Biological crop protection and plant health products are not well understood, which necessitates investment in customer education and makes effectively marketing and selling our products difficult.

The market for biological agricultural products is underdeveloped when compared to conventional products. Customers in the crop production sector are generally cautious in their adoption of new products and technologies. Growers often require on-farm demonstrations of a given crop protection or plant health product. Initial purchases of the product tend to be conservative, with the grower testing on a small portion of their overall crop. As the product is proven, growers incorporate the product into their rotational programs and deploy it on a greater percentage of their operations. As a result, large scale adoption generally takes several growing seasons.

Customers have historically perceived biological agricultural products as more expensive and less effective than conventional products. To succeed, we will need to continue to change that perception. To the extent that the market for biological agricultural products does not further develop or customers elect to continue to purchase and rely on conventional chemical products, our market opportunity will be limited.

If we or our third-party manufacturers are unable to produce our products at a satisfactory quality, in a timely manner, in sufficient quantities or at an acceptable cost, our business could be negatively impacted.

We have transitioned a significant amount of our manufacturing processes in-house to our facility in Bangor, Michigan. If severe weather, a fire or natural disaster occurs, a contaminant grows in our fermentations, or a mechanical or labor problem leads to a reduced capacity or shutdown of our fermenters or other equipment, we may not be successful in producing the amount and quality of product we anticipate in the facility and our results of operations may suffer as a result.

We also continue to rely on third parties to produce or in the process for manufacturing our products and from time to time, including the 12% minority interest in a Russian manufacturing facility and we expect to use third-party manufacturers for supplemental production capacity to meet excess seasonal demand and some packaging. Our reliance on third parties to manufacture our products presents significant risks to us, including the following:

	●	Pushed out or canceled delivery due to tariff restrictions or infectious disease quarantines including COVID-19;
	●	reduced control over delivery schedules, yields and product reliability;
	●	price increases;
	●	manufacturing deviations from internal and regulatory specifications, including contaminations;
	●	the failure of a key manufacturer to perform its obligations to us for technical, market or other reasons;
	●	challenges presented by introducing our fermentation processes to new manufacturers or deploying them in new facilities, including contaminations;
	●	difficulties in establishing additional manufacturers if we are presented with the need to transfer our manufacturing process technologies to them;
	●	supply chain disruptions and increased sanctions compliance requirements caused by Russia’s invasion of Ukraine (see the discussion under the heading “A variety of risks associated with our subsidiary, manufacturing facilities and operations in Russia and the recent Russian invasion of Ukraine could adversely affect our business” below);
	●	misappropriation of our intellectual property; and
	●	other risks in potentially meeting our product commercialization schedule or satisfying the requirements of our distributors, direct customers and end users.

We have not entered into any long-term manufacturing or supply agreements for any of our products, and we may need to enter into additional agreements for the commercial development, manufacturing and sale of our products. There can be no assurance that we can do so on favorable terms, if at all.

Our products have been produced in quantities, and on timelines, sufficient to meet commercial demand and for us to satisfy our delivery schedules. However, our dependence upon others for the production of a portion of our products, or for a portion of the manufacturing process, particularly for drying and for all our production of Venerate, may adversely affect our ability to satisfy demand, support agriculture retailers and distributors operating shifting to “just-in-time” inventory approach and meet delivery obligations, as well as to develop and commercialize new products, on a timely and competitive basis. If manufacturing capacity is reduced or eliminated at one or more of our third-party manufacturers’ facilities, we could have difficulties fulfilling our customer orders, which could adversely affect customer relationships, and our net revenues and results of operations could decline.

We must accurately forecast demand for our products to obtain adequate and cost-effective capacity from our third-party manufacturers and to purchase certain of the raw materials used in our products at cost-effective rates. Our third-party manufacturers are not required to supply us products until we place, and they accept, our purchase orders, which generally occurs approximately three months prior to the anticipated product delivery date to customers based on our own rolling forecasts. Our purchase orders may not be accepted and our third-party manufacturers may not be willing to provide us with additional products on a timely basis if they prioritize orders placed by other companies, many of whom are more established than us and order larger volumes of products. In addition, while raw material orders are generally placed one month in advance of suppliers’ orders, because certain of the raw materials used in our products are in short supply or are subject to capacity demands, we place some raw material orders approximately six months in advance to avoid paying higher prices. Accordingly, if we inaccurately forecast demand for our products, we may be unable to meet our customers’ delivery requirements, or we may accumulate excess inventories of products and raw materials.

Failure to achieve expected manufacturing yields and pesticidal activity or contamination of our production runs could negatively impact our operating results.

We do not know whether a yield problem exists until our products are manufactured. When a yield issue is identified, the product is analyzed and tested to determine the cause. As a result, yield deficiencies may not be identified until well into the production process. We may experience inability to ramp up yields in our own manufacturing facility or third-party manufacturers. In the event that we continue to rely on third-party manufacturers, resolution of yield problems requires cooperation among, and communication between, us and our manufacturers. Third-party manufacturers as well as our own plant in Michigan may contaminate the runs of our products while in process, causing a run failure and causing us to miss sales opportunities or a season. We will not succeed if we cannot maintain or decrease our production costs and effectively scale our technology and manufacturing processes with the desired yields and pesticidal activity and without contaminations.

We rely on a single supplier based in China for a key ingredient of Regalia.

The active ingredient in our Regalia product line is derived from the giant knotweed plant, which we obtain from China. Our single supplier acquires raw knotweed from numerous regional sources and performs an extraction process on this plant, following our specifications, thus creating a dried extract that is shipped to our manufacturing facility in Bangor, Michigan. Although we have identified additional sources of knotweed at competitive prices that appear to be reliable and of appropriate quality, there can be no assurance that we will continue to be able to obtain dried extract from China at a competitive price point, including due to impact of any deterioration in the trade relationship between the United States and China such as tariffs placed on Chinese goods exported to the United States, unusual and significant deterioration status of supplier resources due to the outbreak of COVID-19, changes in the exchange rate between the U.S. Dollar and the Renminbi and potential actions taken by regulators in China. We endeavor to keep at least 6 - 12 months of knotweed extract on hand at any given time.

Any decline in U.S. agricultural production could have a material adverse effect on the market for pesticides and on our results of operations and financial position.

Conditions in the U.S. agricultural industry significantly impact our operating results. The U.S. agricultural industry has contracted in recent periods, and can be affected by a number of factors, including weather patterns and field conditions, current and projected grain inventories and prices, domestic and international demand for U.S. agricultural products and U.S. and foreign policies regarding trade in agricultural products. State and federal governmental policies, including farm subsidies and commodity support programs, as well as the prices of fertilizer products and the prices at which produce may be sold, may also directly or indirectly influence the number of acres planted, the mix of crops planted and the use of pesticides for particular agricultural applications.

We have acquired, and may in the future acquire, other companies, employee teams, products or technologies, which could divert our management’s attention, result in additional dilution to our stockholders, and otherwise disrupt our operations and adversely affect our operating results.

We have acquired, and we may in the future acquire, other companies, employee teams, or technologies to further complement or expand our product portfolio, enhance our technical capabilities, obtain personnel, or otherwise offer growth opportunities. For example, in September 2019, we completed our acquisition of Pro Farm, which added proprietary nutrient and plant health technology and products for seed and foliar treatments to our product portfolio, and also in September 2019, we completed the purchase of substantially all rights and assets related to our Jet products. The pursuit of acquisitions may divert the attention of management and cause us to incur various expenses in identifying, investigating, and pursuing suitable acquisitions, whether or not they are consummated, and if an acquired business fails to meet our expectations, or the costs associated with the acquisition outweigh the benefits, our business, operating results, and financial position may suffer.

We may not be able effectively manage the integration of acquired personnel, operations, and technologies successfully, or effectively manage the combined operations following any acquisition, which may prevent us from achieving anticipated benefits from an acquisition. We also may not achieve the anticipated benefits from an acquisition, including the Pro Farm acquisition, due to a number of other factors, including:

●	acquisition related costs, liabilities, or tax impacts, some of which may be unanticipated;
●	ineffective or inadequate controls, procedures, or policies at the acquired company;
●	multiple product lines or service offerings, as a result of our acquisitions, that are offered, priced, and supported differently;
●	potential unknown liabilities or risks associated with the acquired businesses, including those arising from existing contractual obligations or litigation matters;
●	adverse effects on our existing business relationships with business partners and customers as a result of the acquisition;
●	potential write-offs of acquired assets and potential financial and credit risks associated with acquired customers;
●	inability to maintain relationships with key customers, suppliers, and partners of the acquired business;
●	difficulty in predicting and controlling the effect of integrating multiple acquisitions concurrently;
●	lack of experience in new markets, products, or technologies;
●	diversion of management’s attention from other business concerns;
●	use of resources that are needed in other parts of our business; and
●	use of substantial portions of our available cash to consummate the acquisition.

A significant portion of the purchase price of companies or technologies we acquire may be allocated to acquired goodwill and other intangible assets, which must be assessed for impairment at least annually. In the future, if our acquisitions do not yield expected returns, we may be required to take charges to our operating results based on this impairment assessment process, which could adversely affect our operating results. Further, even if integration of acquired businesses is successful, we may be required to expend additional legal, accounting and other administrative costs with respect to managing subsidiaries in multiple international jurisdictions, including compliance with local laws and filing applicable tax returns.

We are subject to risks associated with our international sales and operations.

We expect sales to our international customers to account for an increasing portion of our sales in future fiscal years, including as a result of the Pro Farm acquisition and its formation as a subsidiary of the Company, through which we now sell directly to certain of our customers in Europe and South America. As a result of having global operations, the sudden disruption of sales caused by events outside of our control could impact our results of operations.

Our international operations are subject to inherent risks, and our future results could be adversely affected by a variety of factors, many of which are outside of our control, including:

	●	greater difficulty in collecting accounts receivable and longer collection periods;
	●	difficulties of managing manufacturing, infrastructure and legal compliance costs associated with producing products internationally;
	●	political, social and economic instability, including wars, terrorism, political unrest, boycotts, public health emergencies, curtailment of trade and other business restrictions;
	●	tariff and trade barriers and other regulatory requirements or contractual limitations on our ability to sell or develop our products in certain foreign markets;
	●	less effective protection of intellectual property than is afforded to us in the United States or other developed countries;
	●	potentially adverse tax consequences;
	●	effects of changes in currency exchange rates, particularly relative increases in the exchange rate of the U.S. dollar versus other currencies that could negatively affect our financial results and cash flows; and
	●	changes in governmental trade policies can lead to the imposition of new duties, tariffs or quotas affecting agricultural commodities, fertilizer or industrial products. These can alter trade flows, access to supplies or demand, and regional balances for our products.

Because of the importance of international sales, sourcing and manufacturing to our business, our financial condition and results of operations could be significantly harmed if any of the risks described above were to occur or if we are otherwise unsuccessful in managing our increasingly global business.

A variety of risks associated with our subsidiary, manufacturing facilities and operations in Russia and the recent Russian invasion of Ukraine could adversely affect our business.

In February 2022, Russia escalated its conflict with Ukraine, resulting in wide-ranging sanctions and international protests. In addition to our U.S. operations, we maintain an indirectly wholly owned subsidiary in Russia, Pro Farm Russia, LLC, and own a 12% minority interest in a third-party manufacturing plant in Vyborg, Russia. While our revenues derived from sales to customers in Ukraine and Russia are currently immaterial, products for Pro Farm, our wholly owned subsidiary, are partially sourced by suppliers from the manufacturing plant in Russia, and we have agreed in the Merger Agreement with Bioceres to cause a targeted amount of certain related inventory to be located outside of specified conflict regions by April 30, 2022. We may face risks associated with maintaining our subsidiary in Russia and minority ownership of the manufacturing plant, or with any international operations in Russia, including risks associated with our compliance with evolving international sanctions and potential reputational harm as a result of our operations in Russia. Further, Russia’s president Vladimir Putin has declared that he will seek authorization for the government to seize assets owned by foreign businesses that leave Russia and has taken steps to invalidate intellectual property protections for U.S.-based companies operating in Russia. In addition, should the conflict escalate or be prolonged, supply chain, trade routes and agricultural markets could be adversely affected, which, in turn, could materially, adversely affect our business operations and financial performance. While we have policies and procedures in place designed to ensure compliance with applicable sanctions and trade restrictions, our employees, contractors, and agents may take actions in violation of such policies and applicable law and we could be held ultimately responsible. If we are held responsible for a violation of U.S. sanctions laws, we may be subject to various penalties, any of which could have a material adverse effect on our business, financial condition or results of operations.

Our intellectual property is integral to our business. If we are unable to protect our patents and proprietary rights in the United States and foreign countries, our business could be adversely affected.

Our success depends in part on our ability to obtain and maintain patent and other proprietary rights protection for our technologies and products in the United States and other countries. If we are unable to obtain or maintain these protections, we may not be able to prevent third parties from using our proprietary rights. It is also possible that we will fail to identify patentable aspects of our research and development output before it is too late to obtain patent protection. As of December 31, 2021, we had 66 issued U.S. patents and 428 issued foreign patents, 18 pending provisional and non-provisional U.S. patent applications and 97 pending foreign patent applications.

The patent position of biotechnology and biochemical companies generally is highly uncertain, involves complex legal and factual questions and has in recent years been the subject of much litigation. As a result, the issuance, scope, validity, enforceability and commercial value of our patent rights are highly uncertain. Our pending and future patent applications may not result in patents being issued which protect our technology or products, in whole or in part, or which effectively prevent others from commercializing competitive technologies and products. Changes in either the patent laws or interpretation of the patent laws in the United States and other countries may diminish the value of our patents or narrow the scope of our patent protection. For example, the U.S. Supreme Court has ruled on several patent cases in recent years, either narrowing the scope of patent protection available in certain circumstances or weakening the rights of patent owners in certain situations. In addition, recent changes to the patent laws of the United States provide additional procedures for third parties to challenge the validity of issued patents, some of which allow a lower evidentiary standard to hold a patent claim invalid. The laws of some foreign countries do not protect proprietary rights to the same extent as the laws of the United States, and we may encounter significant problems and costs in protecting our proprietary rights in these foreign countries.

Our patents, and those patents for which we have license rights, may be challenged, narrowed, invalidated or circumvented. In addition, our issued patents may not contain claims sufficiently broad to protect us against third parties with similar technologies or products or provide us with any competitive advantage. We are not certain that our pending patent applications will be issued. Moreover, our competitors could challenge or circumvent our patents or pending patent applications. It is also not possible to patent and protect all knowledge and know-how associated with our products, so there may be areas that are not protected such as certain formulations and manufacturing processes. Costly and time-consuming litigation could be necessary to enforce and determine the scope of our proprietary rights, and failure to obtain or maintain trade secret protection could adversely affect our competitive business position.

On March 6, 2022, Russia issued a decree permitting the use of certain patents without compensation or license for inventions, industrial designs, and utility models originating in unfriendly countries, which include the United States. Currently, we have eight patents issued by the Russian Federation, which following the March 6, 2022 decree may no longer be afforded any intellectual rights protections. If third party individuals, including the majority owners of the third-party manufacturing plant in Vyborg, Russia, utilize our patents and create versions of our products we would likely have limited to no recourse and would not receive any compensation for any unauthorized use.

For certain of our products, we hold co-exclusive licenses to certain of the intellectual property related to these products. Although our products that are derived from intellectual property licensed to us on a co-exclusive basis also include our own proprietary technology, the third parties with whom we share co-exclusive rights may develop products based on the same underlying intellectual property. This could adversely affect the sale of our products.

Significant disruptions of information technology systems or breaches of data security could adversely affect our business.

We are dependent on information technology systems and infrastructure, some which are hosted by third party vendors or suppliers, to operate our business. Despite our security measures, potential vulnerabilities can be exploited from inadvertent or intentional actions of our employees, third-party vendors, business partners, or by malicious third parties. Attacks of this nature are increasing in their frequency, levels of persistence, sophistication and intensity, and are being conducted by sophisticated and organized groups and individuals with a wide range of motives (including, but not limited to, industrial espionage) and expertise, including organized criminal groups, “hacktivists,” nation states and others. In addition to the extraction of sensitive information, such attacks could include the deployment of harmful malware, ransomware, denial-of-service attacks, phishing attacks social engineering and other means to affect service reliability. While we have incurred no material cyber-attacks or security breaches to date, any material cyber-related incident, including unauthorized access, disclosure or other loss of information, could result in legal claims or proceedings, investigations by law enforcement or regulatory bodies, liability under laws that protect the confidentiality of personal information, regulatory penalties, could disrupt our operations, could compromise our ability to protect our intellectual property rights, could damage our reputation, which could adversely affect our business, financial condition, and operating results, and could negatively impact our stock price.

Our business is subject to risks arising from the COVID-19 illness.

The outbreak of COVID-19 and the resulting public health crisis continues to have a widespread impact on our business, our customers, and our business environment, as well as the economic climate in the United States and globally. The initial wave and variants of the COVID-19 outbreak caused disruption to our business activities, as state and local authorities mandated shutdown, which led us to scale down our headquarters and manufacturing facilities. For the safety of our workforce, employees were encouraged to work from home if it was not absolutely essential to complete their responsibilities at the physical workspace. Since the initial shutdown orders, we continued to operate certain aspects of our business at a scaled down level and although generally many geographic locations have reopened with limitations, we cannot determine when our operations will revert to the productivity levels we had in early- and mid- March 2020. For example, while we cannot directly determine the value of the impact, we generally believe that scaling down our operations at our manufacturing plant for safety measures impacted our manufacturing levels and contributed to the higher idle capacity expense recognized for the year ended December 31, 2020 when compared to December 31, 2021. Additionally, the continued spread of COVID-19 and the mitigation measures taken by various governments of countries affected, could disrupt the supply chain for, the manufacture or shipment of, and the demand for our products and adversely impact our business, financial condition or results of operations. The COVID-19 outbreak and mitigation measures may also have an adverse impact on global economic conditions, which could have an adverse effect on our business and financial condition, including by limiting our ability to obtain financing or to rely on our existing financing facilities. Although we presently expect continued revenue growth in 2022 despite the impact of COVID-19, the extent to which the COVID-19 outbreak impacts our results will depend on future developments that are highly uncertain and cannot be predicted, including new information that may emerge concerning the severity of the virus and the actions to contain its impact. For example, our commercial efforts may include on-site farmer demonstrations and attendance at trade shows and conferences, some of which were either limited by travel restrictions we imposed on our employees or due to capacity restrictions imposed by governmental agencies, were deferred or cancelled altogether during 2021.

Increases in costs, disruption of supply or shortage of raw materials, as well as reductions in manufacturer capacity, could harm our business.

Due to a variety of factors, including the COVID-19 pandemic, we and the third-party manufacturers we rely on are currently, or may in the future, experience supply chain disruptions, increases in costs or shortages in various raw materials utilized in the manufacturing and delivery our products. These and other factors are also causing plant shutdowns, reductions in capacity, delays and increased costs with our third-party manufacturers. We believe that we have sufficient supplies of raw materials and that our recent investments in our manufacturing plant provide sufficient manufacturing capacity so that we can continue to manufacture our products. However, our operating results may be negatively impacted if there continues to be pressure on global supply chains of raw materials, decreased ability of third-party manufacturers to manufacture and deliver our products and increased manufacturing costs. Substantial increases in the prices of our raw materials or manufacturing costs will increase our operating costs, and could reduce our margins if we cannot recoup the increased costs through increased prices for our products. In addition, in order to recoup the increased costs, we have increased prices for our products, which may reduce customer demand and result in an overall loss of current or historical market share and negatively impact our operating results including anticipated revenues.

We depend on our highly skilled employees to grow and operate our business and if we are unable to hire, retain, manage and motivate our employees, or if our new employees do not perform as anticipated, we may not be able to grow effectively and our business, financial condition and operating results could be materially adversely affected.

Our future success will depend in part on the continued service of our senior management team, key technical employees and other highly skilled employees, and on our ability to continue to identify, hire, develop, motivate and retain talented employees. Our U.S.-based employees, including our senior management team, work for us on an at-will basis and there is no assurance that any such employee will remain with us. For example, Suping (Sue) Cheung, our Chief Financial Officer, resigned on March 9, 2022, and the Board approved the retention of LaDon Johnson as the Interim Chief Financial Officer under an agreement with CFO Systems, LLC, which is a provider of senior financial and accounting executive and support services. We have also had other turnover of our finance team members. Any other changes in our senior management team or our failure to engage in effective succession planning may be disruptive to our business.

We face intense competition for highly skilled employees. To attract and retain top talent, we have offered and we believe we will need to continue to offer competitive compensation and benefits packages. Our ability to offer competitive compensation and benefits packages may be limited by the restrictions on compensation included in the Merger Agreement, which may decrease our ability to attract and retain top talent. Our competitors may be successful in recruiting and hiring members of our management team or other key employees and it may be difficult for us to find suitable replacements on a timely basis, on competitive terms, or at all. If we are unable to attract and retain the necessary employees, particularly in critical areas of our business, we may not achieve our strategic goals. Current job market dynamics, where the number of workers who quit their job in a single month in 2021 has broken multiple all-time U.S. records - referred to as the “Great Resignation” - increases the challenge of employee retention.

Job candidates and existing employees often consider the value of the equity awards they receive in connection with their employment. If the perceived value of our equity awards declines, for example in connection with our anticipated merger with Bioceres, it may adversely affect our ability to attract and retain highly qualified employees. On the other hand, our employees may receive significant proceeds from sales of our equity which may reduce their motivation to continue to work for us. We may need to invest significant amounts of cash and equity to attract and retain new employees and expend significant time and resources to identify, recruit, train and integrate such employees and we may never realize returns on these investments. If we are unable to effectively manage our hiring needs or successfully integrate new hires, our efficiency, ability to meet forecasts and employee morale, productivity and engagement could suffer, which could adversely affect business, financial conditions and operating results.

Risks Relating to Product Development and Regulatory Matters

If our ongoing or future field trials are unsuccessful, we may be unable to obtain regulatory approval of, or commercialize, our products on a timely basis.

The successful completion of multiple field trials in domestic and foreign locations on various crops is critical to the success of our product development and marketing efforts. If our ongoing or future field trials are unsuccessful or produce inconsistent results or unanticipated adverse side effects on crops or on non-target organisms, or if we are unable to collect reliable data, regulatory approval of our products could be delayed, or we may be unable to commercialize our products. In addition, more than one growing or treatment season may be required to collect sufficient data and we may need to collect data from different geographies to prove performance for customer adoption. Although we have conducted successful field trials on a broad range of crops, we cannot be certain that additional field trials conducted on a greater number of acres, or on crops for which we have not yet conducted field trials, will be successful. Moreover, the results of our ongoing and future field trials are subject to a number of conditions beyond our control, including weather-related events such as drought or floods, severe heat or frost, hail, tornadoes and hurricanes, or low or no natural occurrence of the pests intended for testing. Generally, we pay third parties, such as growers, consultants and universities, to conduct field tests on our behalf. Incompatible crop treatment practices or misapplication of our products by these third parties or lack of sufficient occurrence of the identified pests in nature for a particular trial could impair the success of our field trials.

Our inability to obtain regulatory approvals, or to comply with ongoing and changing regulatory requirements, could delay or prevent sales of the products we are developing and commercializing.

The field testing, manufacture, sale and use of crop protection, plant health and plant nutrition products are extensively regulated by the EPA and other state, local and foreign governmental authorities. These regulations substantially increase the time and cost associated with bringing our products to market. If we do not receive the necessary governmental approvals to test, manufacture and market our products, or if regulatory authorities revoke our approvals, do not grant approvals in a timely manner or grant approvals subject to restrictions on their use, we may be unable to sell our products in the United States or other jurisdictions, which could result in a reduction in our future revenues.

As we introduce new formulations of and applications for our products, we may need to seek EPA approval prior to commercial sale. For any such approval, the EPA may require us to fulfill certain conditions within a specified period of time following initial approval. We are also required to obtain regulatory approval from other state and foreign regulatory authorities before we market our products in their jurisdictions, some of which have taken, and may take, longer than anticipated.

Some of these states and foreign countries may apply different criteria than the EPA in their approval processes. Although federal pesticide law preempts separate state and local pesticide registration requirements to some extent, state and local governments retain authority to control pesticide use within their borders.

There can be no assurance that we will be able to obtain regulatory approval for marketing our additional products or new product formulations and applications we are developing. Although the EPA has in place a registration procedure for biopesticides there can be no assurance that all of our products or product extensions will be eligible for this streamlined procedure or that additional requirements will not be mandated by the EPA that could make the procedure more time consuming and costly for our future products.

Additionally, for certain state registration and registration in jurisdictions outside of the United States, all products need to be proven efficacious for each proposed crop-pest combination, which can require costly field trial testing, and a favorable result is not assured. Because many of the products that may be sold by us must be registered with one or more government agencies, the registration process can be time consuming and expensive, and there is no guarantee that the product will obtain all required registrations. We have intentionally obtained registration in some jurisdictions and not in others. California is one of the largest and most important producers of agricultural products in the world. As such, we view California as one of the most natural and attractive markets for our products, but it is also very stringent in its regulations, generally requiring more time and effort, and lacking legally mandated deadlines for its reviews of reduced-risk biopesticides. Therefore, gaining concurrent approvals with the EPA, other states and other countries may not always be achievable. Even if we obtain all necessary regulatory approvals to market and sell our products, they will be subject to continuing review and extensive regulatory requirements, including periodic re-registrations. The EPA, as well as state and foreign regulatory authorities, could withdraw a previously approved product from the market upon receipt of newly discovered information, including an inability to comply with their regulatory requirements or the occurrence of unanticipated problems with our products, or for other reasons.

We use hazardous materials in our business and are subject to potential liability under environmental laws. Any claims relating to improper handling, storage or disposal of hazardous materials could be time consuming and costly to resolve.

We are subject to federal, state and local laws and regulations governing the use, manufacture, storage, handling, disposal and release of hazardous materials and certain waste products. Our research and development and manufacturing activities involve the controlled use of hazardous materials and/or biological waste. Some of these materials may be novel, including bacteria with novel properties and bacteria that produce biologically active compounds. We cannot eliminate the risk of accidental contamination or discharge and any injury resulting from these materials. In addition, although we have not currently identified any environmental liabilities, our manufacturing facility may have existing environmental liabilities associated with it that may also result in successor liabilities for us, and we will be subject to increased exposure to potential environmental liabilities as we manufacture our products on a larger scale. We may also be held liable for hazardous materials brought onto the premises of our manufacturing facility before we acquired title, without regard for fault for, or knowledge of, the presence of such substances, as well as for hazardous materials that may be discovered after we no longer own the property if we sell it in the future. In the event of an accident, or if any hazardous materials are found within our operations or on the premises of our manufacturing facility in violation of the law at any time, we may be liable for all cleanup costs, fines, penalties and other costs. This liability could exceed our resources, and, if significant losses arise from hazardous substance contamination, our financial viability may be substantially and adversely affected.

In addition, we may have to incur significant costs to comply with future environmental laws and regulations. We cannot predict the impact of new governmental regulations that might have an adverse effect on the research, development, production and marketing of our products. We may be required to incur significant costs to comply with current or future laws or regulations. Our business may be harmed by the cost of compliance.

Our collaborators may use hazardous materials in connection with our collaborative efforts. To our knowledge, their work is performed in accordance with applicable biosafety regulations. In the event of a lawsuit or investigation, however, we could be held responsible for any injury caused to persons or property by exposure to, or release of, hazardous materials used by these parties. Further, we may be required to indemnify our collaborators against all damages and other liabilities arising out of our development activities or products produced in connection with these collaborations.

Inability to comply with regulations applicable to our facilities and procedures could delay, limit or prevent our research and development or manufacturing activities.

Our research and development and manufacturing facilities and procedures are subject to continual review and periodic inspection. We must spend funds, time and effort in the areas of production, safety and quality control and assurance to ensure full technical compliance with the regulations applicable to these facilities and procedures. If the EPA or another regulatory body determines that we are not in compliance with these regulations, regulatory approval of our products could be delayed, or we may be required to limit or cease our research and development or manufacturing activities or pay a monetary fine. If we are required to limit or cease our research and development activities, our ability to develop new products would be impaired. In addition, if we are required to limit or cease our manufacturing activities, our ability to produce our products in commercial quantities would be impaired or prohibited, which would harm our business.

Our business is subject to various governmental regulations, and compliance with these regulations may cause us to incur significant expenses. If we fail to maintain compliance with applicable regulations, we may be forced to recall products and cease their manufacture and distribution, which could subject us to civil or criminal penalties.

The complex legal and regulatory environment exposes us to compliance and litigation costs and risks that could materially affect our operations and financial results. These laws and regulations may change, sometimes significantly, as a result of political or economic events. They include environmental laws and regulations, tax laws and regulations, import and export laws and regulations, government contracting laws and regulations, labor and employment laws and regulations, securities and exchange laws and regulations, economic sanctions laws and regulations, and other laws such as the Foreign Corrupt Practices Act. In addition, proposed laws and regulations in these and other areas could affect the cost of our business operations. We face the risk of changes in both domestic and foreign laws regarding trade, potential loss of proprietary information due to piracy, misappropriation or foreign laws that may be less protective of our intellectual property rights. Violations of any of these laws and regulations could subject us to criminal or civil enforcement actions, any of which could have a material adverse effect on our business, financial condition or results of operations.

We may experience disruptions to our business as a result of the relocation of our headquarters and general expansion of our operations.

In December 2021, we relocated our headquarters from Davis, California, to Raleigh, North Carolina and entered into a lease agreement for 2,291 square feet of office space to primarily house our executive team. In connection with the relocation, we could experience unexpected costs or business disruption and diversion of management attention, which could negatively impact our business operations and result in additional costs. Following the relocation, we may experience additional costs associated with operating two large facilities on different coasts. The relocation may have a significant adverse effect on our ability to motivate and retain current employees. Further significant managerial and operational challenges could arise, such as ineffective transfer of institutional knowledge from current employees to newly-hired employees and we could encounter more difficulty than expected in hiring qualified employees to help staff our Raleigh headquarters.

Risks Related to Ownership of Our Common Stock

Our principal stockholders have significant voting power and may take actions that may not be in the best interest of other stockholders.

As of December 31, 2021, our executive officers and directors and their affiliates, including Ospraie Ag Science LLC (“Ospraie”), beneficially owned or controlled (i.e., directly or indirectly and including exercisable warrants), an aggregate of approximately 70.8 million shares, or 38.9% of our common stock. In addition, affiliates of Ardsley Advisory Partners (“Ardsley”) beneficially owns 9.7% of our common stock. These principal stockholders collectively beneficially owned or controlled, directly or indirectly an aggregate of 88.6 million shares or 48.6% of our total common stock outstanding and if all of these security holders act together, or exercise their warrants, they will be able to exert significant control over our management and affairs, which could result in some corporate actions that our other stockholders do not view as beneficial such as failure to approve change of control transactions that could offer holders of our common stock a premium over the market value of our company. For example, Ospraie and Ardsley, who collectively hold voting power over approximately 48.6% of our outstanding common stock, entered into a Transaction Support Agreement, dated March 16, 2022, agreeing to, among other things, vote their shares in favor of the Merger, subject to applicable terms and conditions. As a result, the market price of our common stock could be adversely affected.

Our common stock may experience extreme price and volume fluctuations, and you may not be able to resell shares of our common stock at or above the price you paid.

We have had a history of losses, and our business, financial results and stock price have been adversely affected by operating results. Since shares of our common stock were sold in our initial public offering in August 2013 at a price of $12.00 per share, our stock price has ranged between $0.60 and $20.00 through December 31, 2021. The trading price of our common stock will likely continue to be highly volatile and could be subject to wide fluctuations in price in response to various factors, some of which are beyond our control. These factors include

	●	our public float relative to the total number of shares of common stock that are issued and outstanding;
	●	quarterly variations in our results of operations, those of our competitors or those of our customers;
	●	announcements of technological innovations, new products or services or new commercial relationships by us or our competitors;
	●	our ability to develop and market new products on a timely basis;
	●	disruption to our operations;
	●	media reports and publications about our financials or about pest management products;
	●	announcements concerning our competitors or the pest management industry in general;
	●	our entry into, modification of or termination of key license, research and development or collaborative agreements;
	●	new regulatory pronouncements and changes in regulatory guidelines or the status of our regulatory approvals;
	●	general and industry-specific economic conditions, such as the recent uncertainty in the global economy caused by the COVID-19 pandemic;
	●	any major change in our board of directors or management;
	●	the commencement of, or our involvement in, litigation;
	●	changes in financial estimates, including our ability to meet our future net revenues and operating profit or loss projections; and
	●	changes in earnings estimates or recommendations by securities analysts.

In addition, the price of our common stock may be adversely affected by the announcement of the Merger. The Merger Agreement provides that, if the Merger closes, each share of our common stock will be exchanged for 0.088 ordinary shares of Bioceres. Due to this, our stock price will be highly influenced by the trading prices of Bioceres and news affecting Bioceres ordinary shares, which will be affected by a variety of factors, including many of those applicable to our common stock described above. The closing price of Bioceres’ ordinary shares has also been volatile since they completed their merger with Union Acquisition Corp., which resulted in them being a publicly listed company, with the closing price for their ordinary shares ranging from a low of $4.10 on May 17, 2019 to a high of $16.00 on November 17, 2021.

Substantial future sales of our common stock, or the perception in the public markets that these sales may occur, may depress our stock price.

Sales of substantial amounts of our common stock in the public market, or the perception that such sales could occur, could adversely affect the market price of our common stock. As of December 31, 2021, we had approximately 182.2 million shares of common stock outstanding, 1.8 million which were held by our directors and officers. Although these shares are subject in some cases to volume and manner of sale restrictions of Rule 144 of the Securities Act, any determination by holders of a substantial number of such shares to sell our stock, or the perception that such sales may occur, could cause our stock price to decline.

In addition, as of December 31, 2021, we had 10.1 million shares of our common stock available to be awarded under our equity incentive plans, 4.0 million shares of our common stock issuable upon the settlement of outstanding restricted stock units, 12.7 million shares of our common stock issuable upon the exercise of outstanding options with a weighted average exercise price of $2.35 per share and 0.2 million shares of our common stock issuable upon the exercise of outstanding warrants with a weighted average exercise price of $3.45 per share. These shares may be sold in the public market upon issuance.

We are a “smaller reporting company” and we cannot be certain if the reduced disclosure requirements applicable to smaller reporting companies will make our common stock less attractive to investors.

We are a “smaller reporting company” as defined by the Securities and Exchange Commission. For as long as we continue to be a smaller reporting company, we may choose to take advantage of certain scaled disclosures from various reporting requirements applicable to other public companies but not to smaller reporting companies, which include, among other things:

	●	reduced disclosure obligations related to Management’s Discussion and Analysis of Financial Conditions and Results of Operations;
	●	reduced disclosure obligations regarding executive compensation in our periodic reports and proxy statements;
	●	reduced income statement, cash flow, and changes in stockholders’ equity statements from three years to two years.

We cannot predict if investors will find our common stock less attractive if we rely on these exemptions. If some investors find our common stock less attractive as a result, there may be a less active trading market for our common stock and our stock price may be more volatile.

We have in the past identified material weaknesses, and if we fail to establish and maintain proper and effective internal controls, our ability to produce accurate financial statements on a timely basis could be impaired, which could adversely affect our consolidated operating results, our ability to operate our business, our stock price and investors’ views of us.

Our management is responsible for establishing and maintaining adequate internal control over financial reporting to ensure that information regarding the reliability of our financial reporting and the preparation of financial statements for external purposes in accordance with GAAP, but in the past, we have identified material weaknesses in these controls. While we believe we have appropriately remediated previous material weaknesses in our internal control over financial reporting, we can provide no assurances that other material weaknesses in our internal control over financial reporting, will not be identified in the future. Remediation of any material weaknesses requires substantial management time and attention, and ensuring that we have adequate internal control over financial reporting and procedures in place to produce accurate financial statements on a timely basis will continue to be a costly and time-consuming effort.

Any failure to implement effective internal control over financial reporting or to complete and maintain the remediation of our identified control deficiencies may result in errors, material misstatements or delays in our financial reporting, failure to meet our financial reporting obligations or failure to avoid or detect fraud in our financial reporting. This in turn would have a material adverse effect on our business and results of operations and could have a substantial adverse impact on the trading price of our common stock and our relationships with customers and suppliers.

Our management does not expect that our internal control over financial reporting will prevent or detect all errors and all fraud. A control system, no matter how well designed and operated, can provide only reasonable, not absolute, assurance that the control system’s objectives will be met. Because of the inherent limitations in all control systems, no evaluation of controls can provide absolute assurance that misstatements due to error or fraud will not occur or that all control issues and instances of fraud, if any, within the Company will have been detected.

Unforeseen problems with the maintenance of our information systems, or failure to design and operate effective internal controls over information systems, could have an adverse effect on our operations and could result in ineffective internal control over our financial reporting.

As we add functionality and increase the use of our enterprise risk planning or other key information systems, we may incur additional costs and problems could arise that we have not foreseen, including interruptions in service, loss of data, or reduced functionality. Such problems could adversely impact our ability to run our business in an efficient and timely manner.

In addition, we do not have extensive experience with implementing controls over our current information systems. While we believe we have designed the appropriate controls around our information systems, if we have not designed controls within or around these systems that are effective at preventing and detecting unreliable data, or if we are unable to design or operate controls within or around these systems to provide effective control around program changes and access to the systems, we may be at risk for future material weaknesses. This in turn would have a material adverse effect on our business and results of operations and could have a substantial adverse impact on the trading price of our common stock and our relationships with customers and suppliers.

Provisions in our charter documents and under Delaware law could discourage a takeover that stockholders may consider favorable.

Provisions in our amended and restated certificate of incorporation and bylaws may have the effect of delaying or preventing a change of control or changes in our management. These provisions include the following:

	●	the right of our board of directors to elect directors to fill a vacancy created by the expansion of our board of directors or the resignation, death or removal of a director, which prevents stockholders from being able to fill vacancies on our board of directors;

	●	the establishment of a classified board of directors requiring that only a subset of the members of our board of directors be elected at each annual meeting of stockholders;

	●	the prohibition of cumulative voting in our election of directors, which would otherwise allow less than a majority of stockholders to elect director candidates;

	●	the requirement that stockholders provide advance notice to nominate individuals for election to our board of directors or to propose matters that can be acted upon at a stockholders’ meeting. These provisions may discourage or deter a potential acquirer from conducting a solicitation of proxies to elect the acquirer’s own slate of directors or otherwise attempting to obtain control of our company;

	●	the ability of our board of directors to issue, without stockholder approval, shares of undesignated preferred stock with terms set by the board of directors, which rights could be senior to those of our common stock. The ability to authorize undesignated preferred stock makes it possible for our board of directors to issue preferred stock with voting or other rights or preferences that could impede the success of any attempt to acquire us;

	●	the ability of our board of directors to alter our bylaws without obtaining stockholder approval;

	●	the inability of our stockholders to call a special meeting of stockholders and to take action by written consent in lieu of a meeting;

	●	the required approval of the holders of at least two-thirds of the shares entitled to vote at an election of directors to adopt, amend or repeal our bylaws;

	●	the required approval of the holders of at least two-thirds of the shares entitled to vote at an election of directors to repeal or adopt any provision of our certificate of incorporation regarding the election of directors;

	●	the required approval of the holders of at least 80% of such shares to amend or repeal the provisions of our bylaws regarding the election and classification of directors; and

	●	the required approval of the holders of at least two-thirds of the shares entitled to vote at an election of directors to remove directors without cause.

As a Delaware corporation, we are also subject to certain Delaware anti-takeover provisions. Under Delaware law, a corporation may not engage in a business combination with any holder of 15% or more of its common stock unless the holder has held the stock for three years or, among other things, the board of directors has approved the transaction. Our board of directors could rely on Delaware law to prevent or delay an acquisition of us.

Our stock price does not meet and may in the future fail to meet the continued listing requirements of the Nasdaq Capital Market. Our ability to publicly or privately sell equity securities and the liquidity of our common stock could be adversely affected if we are delisted from the Nasdaq Capital Market.

On November 5, 2021, we received a notification letter from the Listing Qualifications Department of the Nasdaq Capital Market indicating that as of November 5, 2021 we were not in compliance with the $1.00 minimum closing bid price requirement. We have been given a grace period of 180 days from the notification, or until May 4, 2022, to regain compliance, by having the closing bid price of our common stock exceed $1.00 for a minimum of ten (10) consecutive trading days during the grace period. If we do not regain compliance by May 4, 2022, we may be eligible for a second 180 day compliance period, provided that, on such date, we meet the continued listing requirement for market value of publicly held shares and all other applicable initial listing requirements for the Nasdaq Capital Market (other than the minimum closing bid price requirement) and we provide written notice to Nasdaq of our intention to cure the deficiency during the second compliance period, by effecting a reverse stock split, if necessary.

There is no assurance, however, that we will regain compliance during the grace period or be able to maintain compliance with Nasdaq’s listing requirements in the future. If we are not able to regain compliance during the grace period, or any extension of the grace period for which we may be eligible, Nasdaq will notify us that our common stock will be suspended and subject to delisting. If we are subject to delisting, we may appeal Nasdaq’s determination to delist to a hearings panel. During any appeal process, shares of our common stock would continue to trade on Nasdaq. If our common stock were delisted from Nasdaq, among other things, it would likely lead to a number of negative implications, including an adverse effect on the price of our common stock, reduced liquidity in our common stock, the loss of federal preemption of state securities laws with respect to shares issued in future offerings, greater difficulty in obtaining financing, potential loss of confidence by employees, loss of institutional investor interest and fewer business development opportunities. In the event of a delisting, we would take actions to restore our compliance with Nasdaq’s listing requirements, but we can provide no assurance that any such action taken by us would allow our common stock to become listed again, stabilize the market price or improve the liquidity of our common stock, prevent our common stock from dropping below the Nasdaq minimum bid price requirement or prevent future non-compliance with Nasdaq’s listing requirements.

ITEM 1B. UNRESOLVED STAFF COMMENTS

Not applicable.

ITEM 2. PROPERTIES

In December 2021 we entered into a lease and relocated our headquarters to 7780-420 Brier Creek Parkway in Raleigh, North Carolina. The office space consists of approximately 2,291 square feet and primarily house our executive team. The initial term of the lease is for a period of 48 months with two optional lease periods of 36 months, as discussed in Note 3 of our consolidated financial statements.

We also maintain a facility at 1540 Drew Avenue in Davis, California, consisting of approximately 27,300 square feet of office, laboratory and greenhouse space under a lease entered into in September 2013. This facility accommodates our research, development, sales, marketing, operations, finance and administrative activities. The facility includes a new, state-of-the-art fermentation lab and pilot plant, an expanded formulation lab and pilot with spray drying and granulation capabilities, an insectary, a plant pathology and nematology lab and a plant and weed sciences lab, among others. The initial term of the lease was for a period of 60 months and in November 2018, we exercised the first lease extension option, extending the lease term for an additional 60 months.

We own an 11,400 square-foot manufacturing facility in Bangor, Michigan for the manufacturing of our products.

In March 2021, we entered into an office lease in Helsinki, Finland for use by our Finland subsidiary as their headquarters. The office space consists of approximately 4,500 square feet and includes laboratory space. The initial lease term is for a period of 24 months and requires six-month notice prior to termination, as discussed in Note 3 of our consolidated financial statements.

We believe that our leased facilities and our manufacturing facility are adequate to meet our needs.

ITEM 3. LEGAL PROCEEDINGS

Not applicable.

ITEM 4. MINE SAFETY DISCLOSURES

Not applicable.

PART II

ITEM 5. MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES

Market Information for Common Stock

Our common stock has been listed on the NASDAQ Global Market under the symbol “MBII” from August 2, 2013 through September 5, 2016. Since September 6, 2016, our common stock has been listed on the Nasdaq Capital Market.

Holders of Record

As of December 31, 2021, there were 69 stockholders of record of our common stock, and the closing price of our common stock was $0.72 per share as reported on the Nasdaq Capital Market. Because some of our shares of common stock are held by brokers and other institutions on behalf of stockholders, we are unable to estimate the total number of stockholders represented by these record holders.

Dividend Policy

We have never declared or paid any cash dividend on our common stock. We intend to retain any future earnings and do not expect to pay dividends in the foreseeable future.

Equity Compensation Plan Information

Information regarding equity compensation plans approved and not approved by stockholders is summarized in the following table as of December 31, 2021:

PLAN CATEGORY	NUMBER OF SECURITIES TO BE ISSUED UPON CONVERSION OF RESTRICTED STOCK UNITS AND EXERCISE OF OUTSTANDING OPTIONS, WARRANTS AND RIGHTS		WEIGHTED-AVERAGE EXERCISE PRICE OF OUTSTANDING OPTIONS, WARRANTS AND RIGHTS		NUMBER OF SECURITIES REMAINING AVAILABLE FOR FUTURE ISSUANCE UNDER EQUITY COMPENSATION PLANS (EXCLUDING SECURITIES REFLECTED IN COLUMN (a)⁽¹⁾
		(a)		(b)
Equity compensation plans approved by stockholders		16,657,738	$	2.07		10,052,819
Equity compensation plans not approved by stockholders		—		—		—
Total		16,657,738	$	2.07		10,052,819

⁽¹⁾	Consists of shares available for issuance under our 2013 Stock Incentive Plan.

ITEM 6. RESERVED

ITEM 7. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

You should read the following discussion of our financial condition and results of operations in connection with our consolidated financial statements and the related notes included in Part II-Item 8- “Financial Statements and Supplementary Data” in this Annual Report on Form 10-K. Additional information regarding the Company is also available in our other reports filed with the Securities and Exchange Commission, which are also available on our investor relations website, investors.marronebio.com, which we also use, together with our corporate Twitter account, @Marronebio, as a means of disclosing material non-public information and for complying with our disclosure obligations under Regulation FD. We encourage our investors to monitor and review the information we make public in these locations. The information contained in the foregoing locations are not incorporated by reference into this filing, and the Company’s references to website URLs are intended to be inactive textual references only. In addition to our historical consolidated financial information, the following discussion contains forward-looking statements that reflect our plans, estimates and beliefs. Our actual results could differ materially from those discussed in the forward-looking statements. Factors that could cause or contribute to these differences include those discussed below and elsewhere in this Annual Report on Form 10-K, particularly in Part I-Item 1A-”Risk Factors.”

We are a growth-oriented agricultural company that supports environmentally sustainable farming practices through the discovery, development and sale of innovative biological products for crop protection, crop health and crop nutrition. Our products are sold through distributors and other commercial partners to growers around the world for use in integrated pest management systems that improve efficacy and increase yields while protecting the environment. Our products are often used in conjunction with or as an alternative to other agricultural solutions to control pests and enhance plant nutrition and health.

Our portfolio of 18 products helps customers operate more sustainably while increasing their return on investment. Our products are used globally, and can be applied as foliar treatments or as seed-and-soil treatments, either on their own or in combination with other agricultural products. We target the major markets that use conventional chemical pesticides and fertilizers where our biological products are used as alternatives or mixed with, conventional chemical products. We also target new markets for which there are no available conventional chemical products, the use of conventional chemical products may not be desirable (including for organically certified crops) or permissible either because of health and environmental concerns or because the development of pest resistance has reduced the efficacy of conventional chemical pesticides. We sell our products through distributors and other commercial partners to growers who use our bioprotection products to manage pests and plant diseases, our plant health products to reduce crop stress and both our plant health and bionutrition products to increase yields and quality.

2021 Highlights

The following are the more significant financial results for the fiscal year ending December 31, 2021:

●	Revenues grew to $44.3 million in 2021, a 15.5% increase compared with $38.4 million in 2020, as sales of our portfolio of products expanded with current and new customers, across new crops and geographies.
●	Gross margins expanded to 61.5% in 2021, compared with 59.6% in 2020, reflecting a favorable mix effect from higher sales of the Regalia, UBP ST, and Venerate product families.
●	Full-year operating expenses were $42.7 million in 2021, compared to $40.1 million in operating expenses in 2020, which included a $1.4 million decrease as a result of a fully forgiven Payment Protection Program Loan.
●	Net loss decreased by $3.7 million to a loss of $16.6 million, or ($0.09) per share.
●	Obtained $9.7 million in connection with exercises of warrants.
●	Increased our inventory line of credit by $1.5 million

The following are the more significant business highlights for the fiscal year ending December 31, 2021:

●	We joined the United Nations Global Compact and Launched our Environmental, Social, and Governance Initiative.
●	Our Venerate XC Bioinsecticide achieved climate impact score of 8.6 out of 10 in an independent study conducted by Boundless Impact Research & Analytics.
●	We launched three new seed treatments, Optima, Takla and Ympact in Europe.
●	We increased our finished goods inventory advance with LSQ by $1.5M.
●	We acquired exclusive rights to high-performing strains of Streptomyces acidiscabies, allowing for the accelerated commercialization of a new, second-generation bioherbicide, MBI-006.
●	We executed distribution agreements with Corteva to distribute our Pro Farm foliar products.
●	We entered into strategic alliances with Novozymes to bring next-generation crop protection solutions to growers.

Business Strategy and Key Trends

Biologicals are delivering double-digit growth industrywide, as compared with low-single-digit growth for conventional crop protection products. We believe the market opportunity is significant, and we have built a full-service biologicals organization with scope and capabilities across the spectrum of biological products in the market today. Our strategic objective is to capitalize on that position and emerge as the clear leader in the biologicals space with the financial and operational wherewithal to accelerate our path to profitability.

Our sales are increasing as a result as a result of our global expansion. In part as a result of our 2019 acquisition of Pro Farm, we have been moving away from sales concentrated in the United States to sales that are split roughly equally between North America and the rest of the world. Our margins have also seen improvement as we bring manufacturing in house, and we expect to see continued long-term improvement. However, Russia’s invasion of Ukraine has posed uncertainty around Pro Farm’s operations due to the increased sanctions and potential supply chain disruptions, which creates uncertainty regarding our ability to increase our global sales.

As we look forward, our goal is to leverage our base business, while accelerating our expansion plans and broadening our global reach. We are committed to launching the brand extensions and pipeline products that offer the greatest return on investment for our channel partners and grower customers. We believe recent acquisitions or partnerships by major agricultural enterprises of biologicals companies signal a trend toward further consolidation, underscoring the value of the sector in the broader agricultural industry landscape. Accordingly, we anticipate that synergistic, value-creating acquisitions and partnerships will be part of our strategy. We believe we can continue to tuck in additional product lines as we build a larger commercial presence with a scalable platform.

Our strategy for the current long-term period includes the diversification of our portfolio which includes expanding our reach globally moving away from having sales concentrated in the United States continued research and development efforts to accelerate the time to market and revenue contributions of our pipeline products, and a focus on operations to continue our revenue growth and path to profitability, and stockholder value creation.

Bioceres Merger Agreement

On March 16, 2022, we entered into the Merger Agreement with Bioceres. At the effective time of the Merger, as set forth in the Merger Agreement, each share of our common stock issued and outstanding immediately prior to the effective time, other than shares owned by Bioceres or held by us, will be cancelled and extinguished and automatically converted into the right to receive 0.088 validly issued, fully paid and nonassesable ordinary shares of Bioceres, and our shares would cease to be publicly held.

Financial Overview

Our total revenues were $44.3 million and $38.4 million for the years ended December 31, 2021 and 2020, respectively, and have risen as growers have adopted our products and have used our products on an expanded number of crops. We generate our revenues primarily from product sales, which are principally attributable to sales of our Grandevo, Regalia, UBP ST and Venerate product lines for the year ended December 31, 2021 and 2020, but also sales of our other products. For the year ended December 31, 2021, 78% of our business has been primarily driven by the U.S. market, which has been our historical trends for geographic revenue mix. In 2022, we expect a larger portion of our business to be driven by international markets, through our Pro Farm products and our continued focus on commercialization progress of our products in new countries. We continue to believe our revenues will largely be impacted by weather, trade tariffs, natural disasters, infectious diseases, and other factors affecting planting and growing seasons and incidence of pests and plant disease, and, accordingly, the decisions by our distributors, direct customers and end users about the types and amounts of crop protection and plant health products to purchase and the timing of use of such products.

We currently rely, and expect to continue to rely, on a limited number of distributors for a significant portion of our revenues since we sell through highly concentrated, traditional distribution channels. Distributors to which 10% or more of our total revenues are attributable for any one of the periods presented consist of the following:

	CUSTOMER
	A			B			C
Twelve months ended December 31,
2021		20	%		14	%		14	%
2020		22	%		13	%		13	%

While we expect product sales to a limited number of distributors to continue to be our primary source of revenues, as we continue to develop our pipeline and introduce new products to the marketplace, we anticipate that our revenue stream will be diversified over a broader product portfolio and customer base, including as a result of our Pro Farm products and customers.

Since 2011, we have also recognized revenues from our strategic collaboration and distribution agreements, which amounted to $0.5 million for each of the years ended December 31, 2021 and 2020.

Our cost of product revenues was $17.1 million and $15.5 million for the years ended December 31, 2021 and 2020, respectively. Cost of product revenues consists principally of the cost of inventory, which includes the cost of raw materials, and third-party services and allocation of operating expenses of our manufacturing plant related to procuring, processing, formulating, packaging and shipping our products. Cost of product revenues also include charges recorded for write-downs of inventory and idle capacity at our manufacturing plant. We expect our cost of product revenues related to the cost of inventory to increase and cost of product revenues relating to write-downs of inventory and idle capacity of our manufacturing plant to decrease as we expand sales and increase production of our existing commercial products. We expect to see a gradual increase in gross margin over the life cycle of each of our products as we improve production processes, gain efficiencies and increase product yields. These increases may be offset by additional charges for inventory write-downs and idle capacity at our manufacturing plant until overall volume in the plant increases significantly, however we are expecting these charges to decrease over time.

Our research, development and patent expenses have historically comprised a significant portion of our operating expenses, amounting to $12.1 million and $11.3 million for the years ended December 31, 2021 and 2020, respectively. For the year ended December 31, 2020, our expenses for research, development and patent expenses were reduced by $0.7 million in connection with receipt of Paycheck Protection Program (PPP) funds. We are seeking collaborations with third parties to develop and commercialize more early stage candidates, on which we have elected not to expend significant resources given our efforts on cost containment.

Selling, general and administrative expenses incurred to establish and build our market presence and business infrastructure have generally comprised the remainder of our operating expenses, amounting to $30.6 million and $28.7 million for the years ended December 31, 2021 and 2020, respectively. For the year ended December 31, 2020, our selling, general and administrative expenses were reduced by $0.7 million in connection with receipt of PPP funds. We have been building a sales and marketing organization that provides for increased training and a better ability to educate and support customers and for our product development staff to undertake responsibility for technical sales support, field trials and demonstrations to promote sales growth.

Historically, we have funded our operations from the issuance of shares of common stock, preferred stock, warrants and convertible notes, the issuance of debt and entry into financing arrangements, product sales, payments under strategic collaboration and distribution agreements and government grants, but we have experienced significant losses as we invested heavily in our acquisition strategy and research and development. We expect to incur additional losses related to our investment in these endeavors including continued development, expansion and marketing of our product portfolio.

In August 2019, April 2020 and December 2020, we executed various agreements with warrant holders to provide greater predictability around cash flow from warrant exercises and to reduce warrant overhang substantially by the end of 2021. As a result, we have raised an aggregate of $25.8 million from the exercise of 33,278,391 shares subject to warrants issued in connection with such transactions. As of December 31, 2021, we have remaining outstanding warrants to purchase 26,786 shares at $8.40 per share, expiring in 2023 and warrants to purchase 124,500 shares at $2.38 per share, expiring in 2026 which together have an intrinsic value of $0 (see Note 9 to our consolidated financial statements).

Key Components of Our Results of Operations

Product Revenues

Product revenues consist of revenues generated primarily from sales to distributors, net of rebates and cash discounts. Product revenues constituted 99%, of our total revenues for each of the years ended December 31, 2021 and 2020, respectively. Product revenues in the United States constituted 78% and 77% of our total revenues for the years ended December 31, 2021 and 2020, respectively.

We account for all revenues under Accounting Standards Codification (ASC) 606, Revenue from contracts with Customers (“ASC 606”) in which revenue recognition criteria for distributor sales are satisfied at the time title and risk of loss passes to the distributor.

License Revenues

License revenues generally consist of revenues recognized under our strategic collaboration and distribution agreements for exclusive distribution rights, either for Regalia, for other commercial products, or for our broader pipeline of products, for certain geographic markets or for market segments that we are not addressing directly through our internal sales force. Our strategic collaboration and distribution agreements generally outline overall business plans and include payments we receive at signing and for the achievement of certain testing validation, regulatory progress and commercialization events. As these activities and payments are associated with exclusive rights that we provide over the term of the strategic collaboration and distribution agreements, revenues related to the payments received are deferred and recognized as revenues over the term of the exclusive period of the respective agreements, which we estimate to be between 5 and 17 years based on the terms of the contract and the covered products and regions. For each of the years ended December 31, 2021 and 2020, license revenues constituted 1% of total revenues, respectively. As of December 31, 2021, we have received an aggregate of $4.1 million in payments under our strategic collaboration and distribution agreements. In addition, there is $0.8 million in payments under these agreements that we could potentially receive if certain testing validation, regulatory progress and commercialization events occur.

Cost of Product Revenues and Gross Profit

Cost of product revenues consists principally of the cost of raw materials, including inventory costs and third-party services related to procuring, processing, formulating, packaging and shipping our products. As we have used our Bangor, Michigan manufacturing plant to produce certain of our products, cost of product revenues includes an allocation of operating costs including direct and indirect labor, production supplies, repairs and maintenance, depreciation, utilities and property taxes. The amount of indirect labor and overhead allocated to finished goods is determined on a basis presuming normal capacity utilization. Operating costs incurred in excess of production allocations, considered idle capacity, are expensed to cost of product revenues in the period incurred rather than added to the cost of the finished goods produced. Cost of product revenues may also include charges due to inventory adjustments and reserves. In addition, costs associated with license revenues have been included in cost of product revenues as they have not been significant. Gross profit is the difference between total revenues and cost of product revenues. Gross margin is gross profit expressed as a percentage of total revenues.

We have entered into in-license technology agreements with respect to the use and commercialization of two of our commercially available product lines, Grandevo and Haven and certain products under development. Under these licensing arrangements, we typically make royalty payments based on net product revenues, with royalty rates varying by product in the mid-single digit of net sales. These royalty payments are included in cost of product revenues, but they have historically not been significant. The exclusivity and royalty provisions of these agreements are generally tied to the expiration of underlying patents. The in-licensed U.S. patent for Grandevo is expected to expire in 2024. There are pending in-licensed patent applications relating to Grandevo, which could expire later than 2024 if issued. The licensed patents for Haven began expiring in November 2019. After the termination of these provisions, we may continue to produce and sell these products. While third parties thereafter may develop products using the technology under expired patents, we do not believe that they can produce competitive products without infringing other aspects of our proprietary technology, including pending patent applications related to Grandevo and Haven and we therefore do not expect the expiration of the patents or the related exclusivity obligations to have a significant adverse financial or operational impact on our business.

We expect to see increases in gross profit over the life cycle of each of our products as gross margins are expected to increase over time as production processes improve and as we gain efficiencies and increase product yields. While we expect margins to improve on a product-by-product basis, our overall gross margins may vary as we introduce new products, or as we experience changes in the sales mix of these products. In particular, we may experience downward pressure on overall gross margins as we rollout Haven, Stargus and expand sales of Grandevo. Gross margin has been and will continue to be affected by a variety of factors, including plant utilization, product manufacturing yields, changes in production processes, new product introductions, product sales mix and average selling prices.

We began full-scale manufacturing in our facility in 2014. We continue to utilize third-party manufacturers for Venerate, Majestene, Haven, Stargus, and for spray-dried powder formulations of Grandevo. We expect gross margins to improve as we move more production to our manufacturing facility and as sales volumes increase.

Research, Development and Patent Expenses

Research, development and patent expenses include personnel costs, including salaries, wages, benefits and share-based compensation, related to our research, development and patent staff in support of product discovery and development activities. Research, development and patent expenses also include costs incurred for laboratory supplies, field trials and toxicology tests, quality control assessment, consultants and facility and related overhead costs.

Selling, General and Administrative Expenses

Selling, general and administrative expenses consist primarily of personnel costs, including salaries, wages, benefits and share-based compensation, related to our executive, sales, marketing, finance and human resources personnel, as well as professional fees, including legal and accounting fees, acquisition costs, public company expenses and other selling costs incurred related to business development and to acquire or build product and brand awareness. We create brand awareness through programs such as speaking at industry events, trade show displays and hosting local-level grower and distributor meetings. In addition, we dedicate significant resources to technical marketing literature, targeted advertising in print and online media, webinars and radio advertising. Costs related to these activities, including travel, are included in selling expenses.

In order to drive our strategy and revenue growth, we expect selling, general, and administrative expenses of sales and marketing to increase in the future as we increase our marketing communications campaigns and put more “boots on the ground”, which should increase grower demand, or pull-through, and develop new customers, as well as expand business with existing customers.

Interest Expense

We recognize interest expense on notes payable and other debt obligations.

In March 2017, we entered into an invoice purchase agreement with LSQ Funding Group, L.C. (“LSQ”), which was subsequently amended in January 2020, and allows us to receive advances of up to $20.0 million against receivables sold to LSQ.

In addition to the January 2020 amendment, we simultaneously entered into an Amended Inventory Financing Addendum (the “Addendum”) with LSQ. The Addendum us to request an advance of up to the lesser of (i) 100% of the Company’s unpaid finished goods inventory; (ii) 65% of the appraised value of the Company’s inventory performed on or on behalf of LSQ; or (iii) $3,000,000. Funds advance under the Addendum are subject to a monthly inventory management fee of 0.5% on the average monthly inventory funds available and a daily interest rate of 0.025%. In December 2021, the Addendum was amended to increase the maximum funds advance to $4,500,000.

As of December 31, 2021, we had an outstanding balance of $14.8 million in secured borrowings.

Income Tax Provision

Since our inception, we have been subject to income taxes principally in the United States. Due to the acquisition of Pro Farm and as we further expand our sales into foreign countries, we have become subject to taxation based on foreign statutory rates and our effective tax rate could fluctuate accordingly.

Income taxes are computed using the asset and liability method, under which deferred tax assets and liabilities are determined based on the difference between the consolidated financial statement and tax bases of assets and liabilities using enacted tax rates in effect during the year in which the differences are expected to affect taxable income. Valuation allowances are established when necessary to reduce deferred tax assets to the amount expected to be realized. As of December 31, 2021, based on the available information, it is more likely than not that our deferred tax assets will not be realized, and accordingly we have taken a full valuation allowance against all of our U.S. deferred tax assets and certain foreign deferred tax assets.

As of December 31, 2021, we had net operating loss carryforwards of $113.4 million. The federal net operating loss generated after 2017 in the amount of $74.4 million will not expire. In addition, as of December 31, 2021, we had federal research and development tax credit carryforwards of $0.6 million, which will begin to expire in 2038, and state research and development tax credit carryforwards of $3.1 million, which have no expiration date.

Our ability to use our federal and state net operating loss carryforwards and federal and state tax credit carryforwards to reduce future taxable income and future taxes, respectively, may be subject to restrictions attributable to equity transactions that may have resulted in a change of ownership as defined by IRC Section 382. In the event we have had such a change in ownership, utilization of these carryforwards could be severely restricted and could result in significant amounts of these carryforwards expiring prior to benefitting us.

Results of Operations

The following table sets forth certain statements of operations data as a percentage of total revenues:

	DECEMBER 31,			DECEMBER 31,
	2021			2020
Revenues:
Product		99	%		99	%
License		1			1
Total revenues		100			100
Cost of product revenues		39			40
Gross profit		61			60
Operating Expenses:
Research, development and patent		27			30
Selling, general and administrative		69			75
Total operating expenses		96			105
Loss from operations		(35	)		(45	)
Other income (expense):
Interest expense		(3	)		(4	)
Loss on modification of warrants		-			(0	)
Loss on issuance of new warrants		-			(4	)
Change in fair value of contingent consideration		1			(1	)
Other income (expense), net		(0	)		1
Total other expense, net		(2	)		(8	)
Net loss before income taxes		(37	)		(53	)
Income tax expense		(0	)		(0	)
Net loss		(37	)%		(53	)%

Comparison of the Years Ended December 31, 2021 and 2020

Product Revenues

	DECEMBER 31,			DECEMBER 31,
	2021			2020
	(Dollars in thousands)
Product revenues	$	43,812		$	37,915
% of total revenues		99	%		99	%

Product revenues increased by $5.9 million, or 15.6%, in 2021 compared to 2020 due to an increase in overall sales across all of our product offerings, driven most significantly by increased sales of the Grandevo, Regalia, UBP ST, and Venerate product families.

License Revenues

	DECEMBER 31,			DECEMBER 31,
	2021			2020
	(Dollars in thousands)
License revenues	$	498		$	459
% of total revenues		1	%		1	%

License revenues related to certain strategic collaboration and distribution agreements remained relatively flat compared to 2020 as expected. License revenues do not comprise a significant portion of our total revenues.

Cost of Product Revenues

	DECEMBER 31,			DECEMBER 31,
	2021			2020
	(Dollars in thousands)
Cost of product revenues	$	17,064		$	15,505
% of total revenues		39	%		40	%
Gross profit		27,246			22,869
		61.5	%		59.6	%

Cost of product revenues increased by $1.6 million, or 10.1%, in 2021 compared to 2020. Our gross margins increased to 61.5% in 2021 from 59.6% in 2020. Cost of products decreased as a percentage of revenues, and gross margins increased in 2021 compared to 2020, primarily due to a favorable mix of higher margin product offerings including Venerate and UBP ST product families and continued improved in-house manufacturing and third-party manufacturing efficiencies.

Research, Development and Patent Expenses

	DECEMBER 31,			DECEMBER 31,
	2021			2020
	(Dollars in thousands)
Research, development and patent	$	12,077		$	11,330
% of total revenues		27	%		30	%

Research, development and patent expenses increased by $0.7 million, or 6.6%, in 2021 compared to 2020 included increases of approximately $0.3 million related to wages and benefits, $0.5 million in direct licensing fees, $0.2 million in consulting and other outside services and $0.1 million each in regulatory trials and lab supplies. These increases were offset by decreases of $0.6 million in field studies, $0.4 million in toxicology and $0.2 million in patent and registration fees. While the majority of the increase was based on management’s strategy, we believe that the global impact of COVID-19, also impacted the timing of certain of our third-party expenses that would have been incurred in earlier or future periods, but are not yet readily quantifiable. Additionally, in connection with COVID-19 and our receipt of PPP funds, for the year ended December 31, 2020, our operating expenses for research, development and patent expenses were reduced by $0.7 million.

Selling, General and Administrative Expenses

	DECEMBER 31,			DECEMBER 31,
	2021			2020
	(Dollars in thousands)
Selling, general administrative expenses	$	30,573		$	28,734
% of total revenues		69	%		75	%

Selling, general, and administrative expenses increased $1.8 million, or 6.4%, in 2021 compared to 2020. The majority of the increase was attributable increases in personnel related expense of $1.0 million in wages, benefits, and payroll taxes and $0.2 in bonus expense offset by $0.6 million in severance payments and retention of temporary help and $0.2 million in stock-based compensation, increases of $0.4 million related to business operation expenses such as insurance and rent, and $1.0 million in consulting and other outside services, were offset by $0.6 million in legal costs, which were primarily related to activity associated with the recently announced entry into the Merger Agreement with Bioceres and $0.4 million in audit costs and taxes. Due to the lifting of COVID-19 restrictions in 2021, expenses related to travel and marketing increased by $0.1 million each. During December 31, 2020, we also benefited from a reduction of $0.7 million in connection with our receipt of PPP funds.

Other Income (Expense), Net

	DECEMBER 31,			DECEMBER 31,
	2021			2020
	(Dollars in thousands)
Interest expense		(1,570	)		(1,443	)
Loss on modification of warrants		-			(72	)
Loss on issuance of new warrants		-			(1,391	)
Change in fair value of contingent consideration		639			(445	)
Other income (expense) net		(174	)		407
	$	(1,105	)	$	(2,944	)

Other income (expense) decreased $1.8 million for the year ended December 31, 2021 compared to 2020. The decrease included $1.5 million related to our loss on modification of certain warrants and offset by $1.1 million in relation to the change in fair value of contingent consideration for the year ended December 31, 2021 and 2020, respectively. Refer to Notes 7 and 9 of our consolidated financial statements.

Seasonality

In recent years, we have increasingly had higher sales during the first half of the year than the second half. However, the level of seasonality in our business may change due to a number of factors, such as our expansion into new geographical territories, the introduction of new products, the timing of introductions of new products, and the impact of weather and climate change. It is possible that our business may become more seasonal, or experience seasonality in different periods, than anticipated, particularly if we expand into new geographical territories, add or change distributors or distributor programs or introduce new products with different applicable growing seasons. Notwithstanding any such seasonality, we expect substantial fluctuation in sales year over year and quarter over quarter as a result of the number of variables on which sales of our products are dependent. Weather conditions, new trade tariffs, natural disasters, outbreaks of infectious diseases and other factors affect planting and growing seasons and incidence of pests and plant disease, may, accordingly affect decisions by our distributors, direct customers and end users about the types and amounts of pest management and plant health products to purchase and the timing of use of such products. In addition, disruptions that cause delays by growers in harvesting or planting can result in the movement of orders to a future quarter, which would negatively affect the quarter and cause fluctuations in our operating results. Customers also may purchase large quantities of our products in a particular quarter to store and use over long periods of time or time their purchases to manage their inventories, which may cause significant fluctuations in our operating results for a particular quarter or year, and low commodity prices may discourage growers from purchasing our products in an effort to reduce their costs and increase their margins for a growing season.

Liquidity and Capital Resources

Since our inception, our operations have been financed primarily by net proceeds from public offerings of common stock and private placements of convertible preferred stock, convertible notes and promissory notes, exercise of warrants, and term loans, as well as proceeds from the sale of our products and payments under strategic collaboration and distribution agreements and government grants. As of December 31, 2021, our cash and cash equivalents totaled $19.6 million, and we had an additional $1.6 million of restricted cash that we are contractually obligated to maintain in accordance with a debt agreement with Five Star Bank.

In March 2017, we entered into an invoice purchase agreement with LSQ, pursuant to which LSQ may elect to purchase up to $7.0 million of eligible customer invoices from us. Our obligations under the LSQ financing are secured by a lien on substantially all of the Company’s personal property; such lien is first priority with respect to the Company’s accounts receivable, inventory, and related property. In January 2020, we entered into a second amendment to the invoice purchase agreement, the terms of which included among other terms an increase to $20.0 million of eligible customer invoices to be purchased and simultaneously entered into an addendum to allow the Company to request that LSQ advance a maximum of $3.0 million of the Company’s finished goods inventory. In December 2021 we amended the addendum increasing the LSQ advance maximum from $3.0 million to $4.5 million. As of December 31, 2021, we had an outstanding balance of $14.8 million in secured borrowings.

In February 2018 we completed certain financing transactions which resulted in the issuance of an aggregate of 70.5 million shares of common stock and warrants to purchase an aggregate of 48.9 million shares of common stock, the deleveraging of our balance sheet by reducing principal payments that were outstanding by $49 million, and the deferral of payment on $7.5 million of remaining outstanding debt until December 31, 2022.

On February 8, 2021, we issued a shelf registration statement on Form S-3 with the SEC, which was declared effective by the SEC on March 26, 2021. Under the shelf registration statement, if and upon becoming effective, we may offer and sell, from time to time over a three-year period, various securities in an amount of up to $90 million.

As of December 31, 2021 debt outstanding includes $25.9 million in principal and accrued interest with a maturity date of December 31, 2022. To the extent that debt is not restructured, extended, converted or otherwise amended, we will be required to repay these debts along with our general operating expenses in that period.

As of December 31, 2021, we were out of compliance with certain covenant requirements under our June 2014 Secured Promissory Note. However, the lender, Five Star Bank, has waived its right to deem recurring losses, liquidity, going concern, and financial condition as material adverse changes through March 31, 2023. Thereafter, unless the lender further extends its waiver a material adverse change clause could be triggered and the entire unpaid principal and interest balances would be due and payable upon demand as well as trigger certain covenants under each of our other debt agreements (refer to Note 8 of the consolidated financial statements).

Since our inception, we have incurred significant net losses, and we expect to incur additional losses related to the continued development and expansion of our business. We believe that our existing cash and cash equivalents of $19.6 million as of December 31, 2021, expected revenues, cost management and cost reductions will be sufficient to fund operations as currently planned. However, our operation plans may not be achieved and therefore would not alleviate substantial doubts related to our ability to continue as a going concern for one year from the date of the issuance of our accompanying consolidated financial statements. Changes in our current plans, or slower than expected adoption of our products may require that we secure additional sources through equity and/or debt financings, or through other sources of financing, which we cannot predict, with certainty, will be based on terms acceptable to us or at all. We may also require additional sources of cash for general corporate purposes, which may include operating expenses, working capital to improve and promote our commercially available products, advance product candidates, expand international presence and commercialization, general capital expenditures and satisfaction of debt obligations which are not currently planned.

Additional information regarding risks related to our capital and liquidity is described in this Annual Report filed on Form 10-K in Part I— Item 1A— “Risk Factors”, and further discussion of our going concern assessment can be found in Note 1 to the accompanying consolidated financial statements, both of which should be read in connection with this disclosure.

We had the following debt arrangements in place as of December 31, 2021, in each case as discussed below (dollars in thousands):

				PRINCIPAL
	STATED ANNUAL			BALANCE (INCLUDING
DESCRIPTION	INTEREST RATE			ACCRUED INTEREST)		PAYMENT/MATURITY
Promissory Notes ⁽¹⁾		8.00	%	$	3,229	Due December 31, 2022
Promissory Note ⁽²⁾		5.25	%		7,942	Monthly/June 2036
Promissory Notes ⁽³⁾		8.00	%		6,900	Due December 31, 2022
Secured Borrowing ⁽⁴⁾		12.78	%		14,881	Varies⁽⁵⁾/November 2021
Loan Facility		1.00	%		309	Proportionately each September 2022, 2023, 2024, 2025

Refer to Note 8 of our consolidated financial statements for each of the following debt arrangements:

(1)	“—October 2012 and April 2013 Secured Promissory Notes.”
(2)	“—June 2014 Secured Promissory Note.”
(3)	“—August 2015 Senior Secured Promissory Notes.”
(4)	“—LSQ Financing.”
(5)	Payable through the lender’s direct collection of certain accounts receivable through March 2022.

Our debt arrangements contain certain representations and warranties by and between us and each of the debtors, certain indemnification provisions in favor of the lenders and customary restrictive covenants (including limitations on other debt, liens, acquisitions, investments and dividends), and events of default (including payment defaults, breaches of covenants, a material impairment in the lender’s security interest or in the collateral, and events relating to bankruptcy or insolvency). Refer to Note 8 of our consolidated financial statements. As of December 31, 2021, we were in compliance with these covenants or have obtained the appropriate waivers for non-compliance with such covenants.

The following table sets forth a summary of our cash flows for the periods indicated:

	DECEMBER 31,			DECEMBER 31,
	2021			2020

Net cash used in operating activities	$	(9,961	)	$	(15,959	)
Net cash used in investing activities		(1,843	)		(1,797	)
Net cash provided in financing activities		15,586			27,345
Net increase in cash, cash equivalents, and restricted cash		3,782			9,589

Cash Flows from Operating Activities

Net cash used in operating activities of $10.0 million during the twelve months ended December 31, 2021 primarily resulted from our net loss of $16.6 million, which included $3.5 million of depreciation and amortization expense, $3.4 million of share-based compensation expense, $0.2 million of non-cash interest expense, and $0.6 million of change in the fair value of the contingent consideration in connection with the acquisition of Pro Farm. In addition, net cash used in operating activities resulted from an increase of $3.1 million in accounts receivables, $2.0 million in inventory, and $1.1 million in lease liabilities offset by increases of $4.7 in accrued and other liabilities, and a decrease of $0.7 in prepaid and other assets.

Net cash used in operating activities of $16.0 million during the twelve months ended December 31, 2020 primarily resulted from our net loss of $20.2 million, which included $3.6 million of depreciation and amortization expense, $3.6 million of share-based compensation expense, $0.2 million of non-cash interest expense, $0.4 million of change in the fair value of the contingent consideration in connection with the acquisition of Pro Farm, and $1.5 million on loss on modification and issuance of warrants and $0.8 million in amortization of right of use assets. In addition, net cash used in operating activities resulted from a decrease of $1.4 million in accounts payables, $0.8 million decrease related to lease liabilities and $1.7 related to inventory, and a $0.6 million decrease in deferred revenue, off-set by an increase of $4.2 million in accounts receivables due to overall revenue growth, and $0.2 million in prepaids and $0.2 million increase in accrued liabilities.

Cash Flows from Investing Activities

Net cash used in investing activities was $1.8 million each during the years ended December 31, 2021 and 2020. For December 31, 2021, cash flow from investing activities included $0.8 million related to deferred acquisition payments in connection with the acquisition of our Jet-Ag product lines with the remainder resulting from purchases of property, plant and equipment to support our operations including our investment in our manufacturing plant in Michigan to increase manufacturing capacity.

For the year ended December 30, 2020, cash flow from investing activities included $1.2 million related to deferred acquisition payments in connection with the acquisition of our Jet-Ag product lines with the remainder resulting from purchases of property, plant and equipment to support our operations.

Cash Flows from Financing Activities

Net cash provided in financing activities of $15.6 million during the twelve months ended December 31, 2021 consisted primarily of $9.7 million in proceeds from the exercise of warrants, $43.3 million in proceeds from the issuance of debt, $0.3 million in proceeds from employee stock purchases, and $0.1 million in proceeds from exercises of options, offset by reductions and repayment of debt of $37.5 million.

Net cash provided in financing activities of $27.3 million during the twelve months ended December 31, 2020 consisted primarily of $22.1 million in proceeds from the exercise of warrants, $40.3 million in proceeds from the issuance of debt, $0.2 million in proceeds from employee stock purchases, and $0.1 million in proceeds from exercises of options, offset by reductions and repayment of debt of $35.3 million.

Recently Issued Accounting Pronouncements

Refer to Note 2 of our consolidated financial statements.

Critical Accounting Policies and Estimates

Our consolidated financial statements and the related notes included elsewhere in this Annual Report on Form 10-K are prepared in accordance with GAAP. The preparation of these consolidated financial statements requires us to make estimates and assumptions that affect the reported amounts of assets, liabilities, net revenue, costs and expenses, and any related disclosures. We base our estimates on historical experience and on various other assumptions that we believe to be reasonable under the circumstances. Changes in accounting estimates are reasonably likely to occur from period to period. Accordingly, actual results could differ significantly from the estimates made by our management. We evaluate our estimates and assumptions on an ongoing basis. To the extent that there are material differences between these estimates and our actual results, our future financial statement presentation, financial condition, results of operations and cash flows will be affected. Refer to Note 2 of our consolidated financial statements for additional information regarding our significant accounting policies.

Inventories

Inventories are stated at the lower of cost or market value (net realizable value or replacement cost) and include the cost of material and external and internal labor and manufacturing costs. Cost is determined on the first-in, first-out basis. We provide for inventory reserves when conditions indicate that the selling price may be less than cost due to physical deterioration, obsolescence, changes in price levels or other factors. Additionally, we provide reserves for excess and slow-moving inventory on hand that is not expected to be sold to reduce the carrying amount of excess and slow-moving inventory to its estimated net realizable value. The reserves are based upon estimates about future demand from our customers and distributors and market conditions. While we believe the assumptions used to estimate future sales are reasonable, there can be no assurance that the forecasted sales will be realized. As a result, additional reserves against inventories which would have been recognized in earlier periods may not be recognized until later periods if actual sales and net realizable values deviate unfavorably from forecasted sales estimates.

Goodwill

Goodwill represents the excess of purchase price over the underlying net assets of businesses acquired. Goodwill is reviewed for impairment on an annual basis as of the first day of the fourth quarter or our fiscal year, or more frequently if events or changes in circumstances indicate that the carrying amount of goodwill may be impaired. We assess goodwill in accordance with Accounting Standards Codification 350, Intangibles – Goodwill and other (“ASC 330”), by first assessing through a qualitative analysis whether events and circumstances lead to the conclusion that a quantitative analysis is required. For the quantitative test, the review for impairment of goodwill is based on a combination of income-based and market-based approaches.

Under the income-based approach, we determine fair value using a discounted cash flow approach that requires significant judgment with respect to revenue and profitability growth rates, based upon annual budgets and longer-range strategic plans, and the selection of an appropriate discount rates. Under the market-based approach, we determine fair value by comparing reporting units to similar businesses or guideline companies whose securities are actively traded in public markets.

Fair value estimates employed in our annual impairment review of goodwill were determined using models involving several assumptions. Changes in assumptions could materially impact fair value estimates. Assumptions critical to our fair value estimates were: (i) discount rates; (ii) projected future revenues and profitability used in the reporting unit; and (iii) projected long-term growth rates used in the derivation of terminal year values. These and other assumptions are impacted by economic conditions and expectations of management and may change in the future based on period-specific facts and circumstances. While we believe the assumptions used to estimate future cash flows are reasonable, there can be no assurance that the expected future cash flows will be realized. As a result, impairment charges that possibly would have been recognized in earlier periods may not be recognized until later periods if actual results deviate unfavorably from earlier estimates. The use of different assumptions would increase or decrease discounted cash flows or earnings projections and, therefore, could change impairment determinations.

Fair Value of Financial Instruments

Fair value is defined as an exit price that would be received from the sale of an asset or paid to transfer a liability in an orderly transaction between market participants on the measurement date. A three-tier fair value hierarchy has been established, which prioritizes the inputs used in measuring fair value as follows: Level 1, observable inputs such as quoted prices in active markets; Level 2, inputs other than the quoted prices in active markets that are observable either directly or indirectly; and Level 3, unobservable inputs in which there is little or no market data, which requires that we develop our own assumptions. This hierarchy requires the use of observable data, when available, and minimizes the use of unobservable inputs when determining fair value.

Estimates employed in our valuation of contingent consideration involving several assumptions. Changes in assumptions could materially impact fair value estimates. Assumptions critical to our fair value estimates were: (i) discount rates; (ii) projected future revenues and profitability used in the reporting unit; and (iii) projected long-term growth rates used in the derivation of terminal year values. These and other assumptions are impacted by economic conditions and expectations of management and may change in the future based on period-specific facts and circumstances. While we believe the assumptions used to estimate future cash flows are reasonable, there can be no assurance that the expected future cash flows will be realized. As a result, changes in the contingent consideration liability that possibly would have been recognized in earlier periods may not be recognized until later periods if actual results deviate significantly from earlier estimates.

Revenue Recognition

Under ASC 606, we recognize revenue for product sales at a point in time following the transfer of control of such products to the customers, which typically occurs upon shipment or delivery depending on the terms of the underlying contracts. We may enter into contracts in which the standalone selling prices (SSP) is different from the amount we are entitled to bill the customer. Product revenues consist of revenues generated from sales of our products to distributors and direct customers, net of rebates and cash discounts.

Estimates employed in our revenue recognition include variable considerations were determined involving several assumptions. Assumptions critical to our variable consideration estimates includes projected future revenues volumes. These assumptions are impacted by economic conditions and expectations of management and may change in the future based on period-specific facts and circumstances. While we believe the assumptions used to estimate future revenue volumes, there can be no assurance that the expected future sales volume will be realized. As a result, revenue reductions which possibly would have been recognized in earlier periods may not be recognized until later periods if actual results deviate unfavorably from earlier estimates. The use of different assumptions would increase or decrease variable consideration amount and, therefore, could change the total amounts recognized in prior or future periods.

Income Taxes

We use the asset and liability method of accounting for income taxes. Deferred tax assets and liabilities are recognized for the estimated future tax consequences attributable to the differences between the consolidated financial statement carrying amounts of existing assets and liabilities and their respective tax bases. Deferred tax assets and liabilities are measured using enacted tax rates expected to apply to taxable income in the years in which those temporary differences are expected to be recovered or settled. To the extent that deferred tax assets cannot be recognized under the preceding criteria, we establish valuation allowances, as necessary, to reduce deferred tax assets to the amounts expected to be realized.

ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

	Page
Report of Independent Registered Public Accounting Firm (PCAOB ID No. 688)	58
Consolidated Balance Sheets as of December 31, 2021 and 2020	59
Consolidated Statements of Operations for the years ended December 31, 2021 and 2020	60
Consolidated Statements of Stockholders’ Equity for the years ended December 31, 2021 and 2020	61
Consolidated Statements of Cash Flows for the years ended December 31, 2021 and 2020	62
Notes to Consolidated Financial Statements	63

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

To the Shareholders and Board of Directors of

Marrone Bio Innovations, Inc.

Opinion on the Financial Statements

We have audited the accompanying consolidated balance sheets of Marrone Bio Innovations, Inc. (the “Company”) as of December 31, 2021 and 2020, the related consolidated statements of operations, stockholders’ equity and cash flows for each of the two years in the period ended December 31, 2021, and the related notes (collectively referred to as the “financial statements”). In our opinion, the financial statements present fairly, in all material respects, the financial position of the Company as of December 31, 2021 and 2020, and the results of its operations and its cash flows for each of the two years in the period ended December 31, 2021, in conformity with accounting principles generally accepted in the United States of America.

Explanatory Paragraph – Going Concern

The accompanying consolidated financial statements have been prepared assuming that the Company will continue as a going concern. As more fully described in Note 1, the Company has incurred significant losses and needs to raise additional funds to meet its obligations and sustain its operations. These conditions raise substantial doubt about the Company’s ability to continue as a going concern. Management’s plans in regard to these matters are also described in Note 1. The consolidated financial statements do not include any adjustments that might result from the outcome of this uncertainty.

Basis for Opinion

These financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on the Company’s financial statements based on our audits. We are a public accounting firm registered with the Public Company Accounting Oversight Board (United States) (“PCAOB”) and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB.

We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. As part of our audits we are required to obtain an understanding of internal control over financial reporting but not for the purpose of expressing an opinion on the effectiveness of the Company’s internal control over financial reporting. Accordingly, we express no such opinion.

Our audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe that our audits provide a reasonable basis for our opinion.

Critical Audit Matters

The critical audit matters communicated below are matters arising from the current period audit of the financial statements that were communicated or required to be communicated to the audit committee and that: (1) relate to accounts or disclosures that are material to the financial statements and (2) involved our especially challenging, subjective, or complex judgments. The communication of critical audit matters does not alter in any way our opinion on the financial statements, taken as a whole, and we are not, by communicating the critical audit matters below, providing separate opinions on the critical audit matters or on the accounts or disclosures to which they relate.

1. Valuation of Goodwill

Description of the Matter

As discussed in Note 2 to the consolidated financial statements, the Company tests goodwill for impairment annually (or under certain circumstances, more frequently) at the reporting unit level using either a qualitative or quantitative approach. Under the quantitative approach to test for goodwill impairment, the Company compares the fair value of a reporting unit to its carrying amount, including goodwill. Generally, the Company estimates the fair value of its reporting unit using a combination of a discounted cash flows analysis and market-based valuation methodologies.

Auditing the Company’s quantitative goodwill impairment tests involved subjective auditor judgment due to the significant estimation required in management’s determination of the fair value of the reporting unit. The significant estimation was primarily due to the sensitivity of the underlying assumptions including changes in the weighted average cost of capital, projected revenue growth rates and EBITDA margins. These assumptions relate to the expected future operating performance of the Company’s reporting unit, are forward-looking, and are sensitive to and affected by economic, industry and company-specific qualitative factors.

How We Addressed the Matter in Our Audit

To test the estimated fair value of the Company’s reporting unit, we performed audit procedures that included, among others, assessing the valuation methodologies used by the Company, involving our valuation specialists to assist in testing the significant assumptions discussed above, and testing the completeness and accuracy of the underlying data the Company used in its valuation analyses. For example, we compared the significant assumptions used by management to current industry, market and economic trends, the historical results of the reporting unit, and other relevant factors. We also assessed the historical accuracy of management’s estimates and performed sensitivity analyses of significant assumptions used in the annual impairment test to evaluate the change in the fair value of the reporting unit resulting from changes in the significant assumptions.

2. Fair Value of Contingent Consideration

Description of the Matter

As discussed in note 2 to the consolidated financial statements, the Company’s acquisition-related purchase price contingent consideration liability, which is estimated using Monte Carlo simulation of a geometric Brownian motion model based upon the Company’s estimated results of the Pro Farm subsidiary for the periods specified in the share purchase agreement of 2022 to 2023 and is remeasured to its estimated fair value at each reporting period, with changes in fair value recorded in the consolidated statements of operations.

Auditing the valuation of the acquisition-related contingent consideration liability was complex and highly judgmental due to the significant estimation required in determining the fair value. In particular, the fair value estimate was sensitive to significant assumptions such as the Company’s estimated results of the Pro Farm subsidiary for the periods specified in the share purchase agreement of 2022 to 2023, future industry, market or economic conditions, and are forward-looking and inherently uncertain.

How We Addressed the Matter in Our Audit

To evaluate the estimated fair value of the contingent consideration liability, we performed audit procedures that included, among others, assessing the terms of the arrangement, evaluating the methodology used, and testing the significant assumptions discussed above used by the Company in its analysis. We involved our valuation specialists to assist in the evaluation of the significant assumptions and methodology used by the Company. We also compared the significant assumptions to current industry, market and economic trends.

Marcum LLP

We have served as the Company’s auditor since 2018

San Francisco, CA
March 30, 2022

MARRONE BIO INNOVATIONS, INC.

Consolidated Balance Sheets

(In Thousands, Except Par Value)

	DECEMBER 31,			DECEMBER 31,
	2021			2020

Assets
Current assets:
Cash and cash equivalents	$	19,623		$	15,841
Accounts receivable		13,211			10,113
Inventories		8,633			6,618
Prepaid expenses and other current assets		1,211			1,688
Total current assets		42,678			34,260
Property, plant and equipment, net		12,676			12,565
Right of use assets, net		3,637			3,760
Intangible assets, net		19,011			21,383
Goodwill		6,740			6,740
Restricted cash		1,560			1,560
Other assets		754			929
Total assets	$	87,056		$	81,197

Liabilities and stockholders’ equity
Current liabilities:
Accounts payable	$	2,687		$	1,895
Accrued liabilities		14,851			11,650
Deferred revenue, current portion		360			374
Lease liability, current portion		1,381			1,008
Debt, current portion, net		25,909			9,301
Total current liabilities		45,188			24,228
Deferred revenue, less current portion		1,165			1,628
Lease liability, less current portion		2,511			3,050
Debt, less current portion, net		7,691			11,479
Debt due to related parties		-			7,300
Other liabilities		848			2,102
Total liabilities		57,403			49,787
Commitments and contingencies		-			-
Stockholders’ equity:
Preferred stock: $0.00001 par value; 20,000 shares authorized and no shares issued or outstanding at December 31, 2021 and 2020		—			—
Common stock: $0.00001 par value; 250,000 shares authorized, 182,224 and 167,478 shares issued and outstanding as of December 31, 2021 and 2020, respectively		1			1
Additional paid in capital		387,023			372,226
Accumulated deficit		(357,371	)		(340,817	)
Total stockholders’ equity		29,653			31,410
Total liabilities and stockholders’ equity	$	87,056		$	81,197

The accompanying notes are an integral part of these consolidated financial statements.

MARRONE BIO INNOVATIONS, INC.

Consolidated Statements of Operations

(In Thousands, Except Per Share Data)

	DECEMBER 31,			DECEMBER 31,
	2021			2020
Revenues:
Product	$	43,812		$	37,915
License		498			459
Total revenues		44,310			38,374
Cost of product revenues		17,064			15,505
Gross profit		27,246			22,869
Operating Expenses:
Research, development and patent		12,077			11,330
Selling, general and administrative		30,573			28,734
Total operating expenses		42,650			40,064
Loss from operations		(15,404	)		(17,195	)
Other income (expense):
Interest expense		(1,570	)		(1,443	)
Loss on modification of warrants		-			(72	)
Loss on issuance of new warrants		—			(1,391	)
Change in fair value of contingent consideration		639			(445	)
Other income, net		(174	)		407
Total other expense, net		(1,105	)		(2,944	)
Net loss before income taxes		(16,509	)		(20,139	)
Income tax expense		(45	)		(29	)
Net Loss	$	(16,554	)	$	(20,168	)
Basic and diluted net loss per common share:	$	(0.09	)	$	(0.14	)
Weighted-average shares outstanding used in computing basic and diluted net loss per common share:		174,832			148,892

The accompanying notes are an integral part of these consolidated financial statements.

MARRONE BIO INNOVATIONS, INC.

Consolidated Statements Stockholders’ Equity

(In Thousands)


	COMMON STOCK				ADDITIONAL PAID IN			ACCUMULATED			TOTAL STOCKHOLDERS’
	SHARES		AMOUNT		CAPITAL			DEFICIT			EQUITY
Balance at January 1, 2020		139,526	$	1	$	344,206		$	(320,649	)	$	23,558
Net loss		—		—		—			(20,168	)		(20,168	)
Net settlement of options		100		—		108			—			108
Share-based compensation		—		—		3,595			—			3,595
Employee stock purchase plan		268		—		254			—			254
Settlement of restricted stock units		657		—		—			—			—
Issuance of restricted stock units in lieu of bonus payments		—		—		632			—			632
Financing costs		—		—		(104	)		—			(104	)

, shares
Exercise of warrants		26,927		—		22,072			—			22,072
Modification of existing warrants		—		—		1,463			—			1,463
Balance at December 31, 2020		167,478	$	1	$	372,226		$	(340,817	)	$	31,410
Net loss		—		—		—			(16,554	)		(16,554	)
Net settlement of options		79		—		87			—			87
Share-based compensation		—		—		3,351			—			3,351
Employee stock purchase plan		312		—		287			—			287
Settlement of restricted stock units		1,195		—		—			—			-
Issuance and settlement of restricted stock units in lieu of bonus payments, net		188		—		348			—			348
Exercise of warrants		12,414		—		9,720			—			9,720
Issuance of common stock in settlement of contingent consideration		558		—		1,004			—			1,004
Balance at December 31, 2021		182,224	$	1	$	387,023		$	(357,371	)	$	29,653

The accompanying notes are an integral part of these consolidated financial statements.

MARRONE BIO INNOVATIONS, INC.

Consolidated Statements of Cash Flows

(In Thousands)

	DECEMBER 31,			DECEMBER 31,
	2021			2020
Cash flows from operating activities
Net loss	$	(16,554	)	$	(20,168	)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization		3,531			3,558
Gain on disposal of equipment		—			(9	)
Change in inventory reserves		(35	)		(139	)
Right of use assets amortization		1,036			807
Share-based compensation		3,351			3,595
Non-cash interest expense		179			226
Loss on modification of warrants		—			72
Loss on issuance of new warrants		—			1,391
Change in fair value of contingent consideration		(639	)		445
Net changes in operating assets and liabilities:
Accounts receivable		(3,098	)		(4,188	)
Inventories		(1,980	)		1,670
Prepaid Expenses and other assets		652			(219	)
Accounts payable		585			(1,409	)
Accrued and other liabilities		4,718			(148	)
Lease Liability		(1,079	)		(825	)
Deferred revenue		(628	)		(618	)
Net cash used in operating activities		(9,961	)		(15,959	)
Cash flows from investing activities
Payment of consideration in connection with previous asset purchase		(750	)		(1,240	)
Purchases of property, plant and equipment		(1,093	)		(559	)
Proceeds from sale of equipment		—			2
Net cash used in investing activities		(1,843	)		(1,797	)
Cash flows from financing activities
Proceeds from issuance of debt		-			202
Proceeds from secured borrowings		43,340			40,127
Repayment in secured borrowings		(37,476	)		(34,790	)
Repayment of debt		(372	)		(524	)
Exercise of stock options		—			108
Equity offering costs		—			(104	)
Net settlement of options		87			—
Proceeds from employee stock purchase plan		287			254
Exercise of warrants		9,720			22,072
Net cash provided by financing activities		15,586			27,345
Net increase in cash and cash equivalents and restricted cash		3,782			9,589
Cash and cash equivalents and restricted cash, beginning of period		17,401			7,812
Cash and cash equivalents and restricted cash, end of period	$	21,183		$	17,401

Supplemental disclosure of cash flow information
Cash paid for interest	$	1,383		$	1,166

Cash paid for income taxes	$	92		$	—
Supplemental disclosure of non-cash investing and financing activities
Property, plant and equipment included in accounts payable and accrued liabilities	$	207		$	44
Right of use assets (non-cash) acquired	$	913		$	—
Conversion of accrued liabilities into equity associated with the granting of restricted stock units	$	348		$	632
Contingent consideration milestone settled in common shares		1,004			—

The accompanying notes are an integral part of these consolidated financial statements.

MARRONE BIO INNOVATIONS, INC.

Notes to Consolidated Financial Statements

December 31, 2021

1. Summary of Business, Basis of Presentation

Marrone Bio Innovations, Inc. (the “Company”), formerly Marrone Organic Innovations, Inc., was incorporated under the laws of the State of Delaware on June 15, 2006, and is located in Davis, California. In July 2012, the Company formed a wholly-owned subsidiary, Marrone Michigan Manufacturing LLC (“MMM LLC”), which holds the assets of a manufacturing plant the Company purchased in July 2012. In September 2019, the Company closed its acquisition of Pro Farm Technologies OY, a Finnish limited company, which consisted of Pro Farm Technologies OY and its five subsidiaries Pro Farm International Oy (Finland), Pro Farm OU (Estonia), Pro Farm Technologies Comercio de Insumos Agricolas do Brasil ltda. (Brazil – 99% controlling interest), Pro Farm Inc. (Delaware), and Glinatur SA (Uruguay) (collectively “Pro Farm”). As a result of the acquisition, Pro Farm became a wholly-owned subsidiary of the Company. On December 31, 2019, Pro Farm Russia, LLC was formed as a subsidiary under Pro Farm Technologies OY. The consolidated financial statements include the accounts of the Company and its wholly-owned subsidiaries. All significant intercompany balances and transactions have been eliminated in consolidation.

The accompanying consolidated financial statements and notes thereto have been prepared in accordance with the rules and regulations of the Securities and Exchange Commission (SEC) for Form 10-K and include all of the information and disclosures required by accounting principles generally accepted in the United States of America (GAAP) for financial reporting. Certain amounts in the prior periods’ financial statements and related footnote disclosures have been reclassified to conform to the current presentation with no impact on previously reported net income or stockholders’ equity.

The Company makes biological crop protection, plant health and nutrition products. The Company targets the major markets that use conventional chemical products, including certain agricultural markets where its biological products are used as alternatives for, or mixed with, conventional chemical products. The Company also targets new markets for which (i) there are no available conventional chemical products or (ii) the use of conventional chemical products may not be desirable or permissible either because of health and environmental concerns (including for organically certified crops) or because the development of pest resistance has reduced the efficacy of conventional chemical products. The Company delivers EPA-approved and registered biological crop protection products and other biological products that address the global demand for effective, safe and environmentally responsible products.

Going Concern, Liquidity, and Management Plans

The accompanying consolidated financial statements have been prepared under the assumption that the Company will continue to operate, although there is substantial doubt about its ability to continue as a going concern for 12 months after the issuance of these consolidated financial statements. This assessment contemplates the realization of assets and the settlement of liabilities in the normal course of business. The consolidated financial statements do not include any adjustments to reflect the possible future effects on the recoverability and classification of assets or the amounts of liabilities that may result from the Company’s substantial doubt about its ability to continue as a going concern.

The Company has a limited number of commercialized products and has incurred significant losses since inception, and expects to continue to incur losses for the foreseeable future. The Company’s historical operating results, including prior periods of negative use of operating cash flows and debt maturities due within the 12 months of the balance sheet date indicate that substantial doubt exists related to the Company’s ability to continue as a going concern for the next 12 months from the date of issuance of these consolidated financial statements. As of December 31, 2021, the Company had a working capital deficit of $2,510,000, including cash and cash equivalents of $19,623,000. In addition, as of December 31, 2021, the Company had consolidated short-term and long-term debt of $33,600,000, for which the underlying debt agreements contain various financial and non-financial covenants, and certain material adverse change clauses. As of December 31, 2021, the Company had a total of $1,560,000 of restricted cash relating to these debt agreements. (Refer to Notes 8 of these consolidated financial statements)

If the Company breaches covenants contained within the debt agreements or if the material adverse change clauses are triggered, the entire unpaid principal and interest balances would be due and payable upon demand. Without entering into a continuation of its current waiver, which expires March 31, 2023, entering into strategic agreements that include significant cash payments upfront, significantly increasing revenues from sales or raising additional capital through the issuance of equity, the Company expects it will exceed its current ratio and maximum debt-to-worth requirement under the June 2014 Secured Promissory Note with Five Star Bank. Further, a violation of a covenant in one debt agreement will cause the Company to be in violation of certain covenants under each of its other debt agreements. Breach of covenants included in the Company’s debt agreements, which could result in the lenders demanding payment of the unpaid principal and interest balances, will have a material adverse effect upon the Company and would likely require the Company to seek to renegotiate these debt arrangements with the lenders. If such negotiations are unsuccessful, the Company may be required to seek protection from creditors through bankruptcy proceedings. The Company’s inability to maintain compliance with its debt covenants could have a negative impact on the Company’s financial condition and ability to continue as a going concern.

The June 2014 Secured Promissory Note contains a material adverse change clause that could be invoked by the lender as a result of the uncertainty related to the Company’s ability to continue as a going concern. If the lender were to declare an event of default, the entire amount of borrowings related to all debt agreements at that time would have to be reclassified as current in the consolidated financial statements. The lender has waived its right to deem recurring losses, liquidity, going concern, and financial condition a material adverse change through March 31, 2023. As a result, the long-term portion of the June 2014 Secured Promissory Note has not been reclassified to current in these consolidated financial statements as of December 31, 2021.

The Company believes that its existing cash and cash equivalents of $8,793,000 at March 25, 2022, together with expected revenues, expected future extension of debt maturities, equity financings and cost management will be sufficient to fund operations as currently planned through one year from the date of the issuance of these consolidated financial statements. The Company anticipates securing additional sources of cash through equity and/or debt financings, or through other sources of financing, consistent with historic results. However, the Company cannot predict, with certainty, the outcome of its actions to grow revenues, to manage or reduce costs or to secure additional financing from outside sources on terms acceptable to the Company or at all. Further, the Company may continue to require additional sources of cash for general corporate purposes, which may include operating expenses, working capital to improve and promote its commercially available products, advance product candidates, expand international presence and commercialization, and general capital expenditures.

Although the Company recognizes that it will likely need to raise additional funds in the future, there can be no assurance that such efforts will be successful or that, in the event that they are successful, the terms and conditions of such financing will not be unfavorable. Any future equity financing may result in dilution to existing stockholders and any debt financing may include additional restrictive covenants. Any failure to obtain additional financing or to achieve the revenue growth necessary to fund the Company with cash flows from operations will have a material adverse effect upon the Company and will likely result in a substantial reduction in the scope of the Company’s operations and impact the Company’s ability to achieve its planned business objectives. The actions discussed above cannot be considered to mitigate the substantial doubt raised by its historical operating results and satisfying its estimated liquidity needs for 12 months from the issuance of these consolidated financial statements.

2. Significant Accounting Policies

Use of Estimates

The preparation of these consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent assets and liabilities as of the date of the consolidated financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates.

The Company believes that the assumptions and estimates associated with the Company’s forecast used in its going concern, goodwill and contingent consideration assessments, revenue recognition, including assumptions and estimates used in determining the timing and amount of revenue to recognize for those transactions with variable considerations and inventory valuation, have the greatest potential impact on the consolidated financial statements. Therefore, the Company considers these estimates to be its significant estimates.

Concentrations of Credit Risk

Financial instruments that potentially subject the Company to concentrations of credit risk consist principally of cash, cash equivalents, accounts receivable and debt. The Company deposits its cash and cash equivalents with high credit quality domestic financial institutions with locations in the U.S and globally. Such deposits may exceed federal deposit insurance or foreign deposit guarantee funds limits. The Company believes the financial risks associated with these financial instruments are minimal.

The Company’s customer base is dispersed across many different geographic areas, and currently most customers are pest management distributors in the U.S. Generally, receivables are due up to 120 days from the invoice date and are considered past due after this date, although the Company may offer extended terms from time to time.

During the years ended December 31, 2021 and 2020, 22% and 24%, respectively, of the Company’s revenues were generated from international customers. The Company’s international customers were concentrated in the European Union.

The Company’s principal sources of revenues were its Grandevo, Regalia, UBP ST, and Venerate product lines for the years ended December 31, 2021 and 2020, accounting for 77% and 85%, respectively, of the Company’s total revenues.

Customers to which 10% or more of the Company’s total revenues are attributable for any one of the periods presented consist of the following:

	CUSTOMER
	A			B			C
Twelve months ended December 31,
2021		20	%		14	%		14	%
2020		22	%		13	%		13	%

Customers to which 10% or more of the Company’s outstanding accounts receivable are attributable as of either December 31, 2021 or 2020, consist of the following:

	CUSTOMER
	A			B			C			D
December 31, 2021		39	%		13	%		10	%		1	%
December 31, 2020		49	%		4	%		-	%		14	%

Concentrations of Supplier Dependence

The active ingredient in the Company’s Regalia product line is derived from the giant knotweed plant, which the Company obtains from China. The Company currently relies on one supplier for this plant. Such single supplier acquires raw knotweed from numerous regional sources and performs an extraction process on this plant, creating a dried extract that is shipped to the Company’s manufacturing plant. While the Company does not have a long-term supply contract with this supplier, the Company does have a long-term business relationship with this supplier. The Company endeavors to keep 6 to 12 months of knotweed extract on hand at any given time, but an unexpected disruption in supply, including disruptions resulting from the COVID-19 pandemic, could have an effect on Regalia supply and revenues. Although the Company has identified additional sources of raw knotweed, there can be no assurance that the Company will continue to be able to obtain dried extract from China at a competitive price.

The Company continues to rely on third parties to formulate Grandevo into spray-dried powders, for the majority of its Venerate and Majestene/Zelto products and all of its production of Stargus and Haven, and from time to time, third-party manufacturers for supplemental production capacity to meet excess seasonal demand and for packaging. The Company’s products have been produced in quantities, and on timelines, sufficient to meet commercial demand and for the Company to satisfy its delivery schedules. However, the Company’s dependence upon others for the production of a portion of its products, or for a portion of the manufacturing process, may adversely affect its ability to satisfy demand and meet delivery obligations, as well as to develop and commercialize new products, on a timely and competitive basis. The Company has not entered into any long-term manufacturing or supply agreements for any of its products, and it may need to enter into additional agreements for the commercial development, manufacturing and sale of its products. There can be no assurance that it can do so on favorable terms, if at all.

Pro Farm products are currently partially sourced by suppliers from one manufacturing plant in Russia, in which the Company owns a 12% interest. The Company plans for enough inventory on hand to meets its revenue forecasts for 12 months at any given time, but an unexpected disruption in supply, including related to COVID-19, could have an adverse effect on the supply and revenues related to the subsidiary. Although the Company has identified additional manufacturers who are capable suppling the products, there can be no assurance that the Company will continue to be able to obtain products at a competitive price.

Cash and Cash Equivalents

The Company considers all highly liquid financial instruments purchased with a maturity of three months or less to be cash equivalents. Cash and cash equivalents consist of cash on deposit, money market funds and certificates of deposit accounts with U.S. and global financial institutions. The Company is exposed to credit risk in the event of default by financial institutions to the extent that cash and cash equivalents balances with financial institutions are in excess of amounts that are insured including for amounts held at U.S. by the Federal Deposit Insurance Corporation and in Finland by the Deposit Guarantee Fund. The Company has not experienced any losses on these deposits. The following table provides a reconciliation of cash, cash equivalents and restricted cash to amounts shown in the statement of cash flows (in thousands):

	DECEMBER 31,		DECEMBER 31,
	2021		2020
Cash and cash equivalents	$	19,623	$	15,841
Restricted cash, less current portion		1,560		1,560
Total cash, cash equivalents and restricted cash	$	21,183	$	17,401

Restricted Cash

The Company’s restricted cash consists of cash that the Company is contractually obligated to maintain in accordance with the terms of its June 2014 Secured Promissory Note (refer to Note 8 of the consolidated financial statements).

Accounts Receivable

The carrying value of the Company’s receivables represents their estimated net realizable values. The Company generally does not require collateral and estimates any required allowance for doubtful accounts based on historical collection trends, the age of outstanding receivables and existing economic conditions. If events or changes in circumstances indicate that specific receivable balances may be impaired, further consideration is given to the collectability of those balances and the allowance is recorded accordingly. Past-due receivable balances are written-off when the Company’s internal collection efforts have been unsuccessful in collecting the amount due. During the years ended December 31, 2021 and 2020, the Company did not have any material receivables balances written off. As of December 31, 2021 and 2020, the Company had $58,000 and no allowance for doubtful accounts, respectively.

Inventories

Inventories, net consist of the following (in thousands):

Schedule of Inventories, Net

	DECEMBER 31,		DECEMBER 31,
	2021		2020
Raw materials	$	3,311	$	2,487
Work in progress		671		987
Finished goods		4,651		3,144
Inventory	$	8,633	$	6,618

During the year ended December 31, 2021, the Company recorded, as a component of cost of product revenues, adjustments to inventory reserves of $422,000 due to quantities on hand that may not be used or sold prior to expiration, and an adjustment of $578,000 as a result of actual utilization of the Company’s manufacturing plant being less than what is considered normal capacity.

During the year ended December 31, 2020, the Company recorded, as a component of cost of product revenues, adjustments to inventory reserves of $387,000 due to quantities on hand that may not be used or sold prior to expiration, and an adjustment of $1,770,000 as a result of actual utilization of the Company’s manufacturing plant being less than what is considered normal capacity.

Right of Use Assets and Lease Liabilities

The Company determines if an arrangement includes a lease at the inception of the agreement and the right-of-use asset and lease liability is determined at the lease commencement date and is based on the present value of estimated lease payments. The Company’s lease agreements contain both fixed and variable lease payments, none of which are based on a rate or an index. Fixed lease payments are included in the determination of the right-of-use asset and lease liability. Variable lease payments that are not based on a rate or index are expensed when incurred. The present value of estimated lease payments is determined utilizing the rate implicit in the lease agreement if that rate can be determined. If the implicit rate cannot be determined, the present value of estimated lease payments is determined utilizing the Company’s incremental borrowing rate. The incremental borrowing rate is determined at the lease commencement date and is estimated utilizing similar or collateralized borrowing instruments adjusted for the terms of leasing arrangement as necessary. Some of the leases include an option to renew that can extend the lease term. For those leases which are reasonably certain to be renewed, the Company included the renewal period in the lease term. The Company’s lease agreements do not contain any material residual value guarantees or material restrictive covenants.

Impairment of Long-Lived Assets

Impairment losses related to long-lived assets are recognized in the event the net carrying value of such assets is not recoverable and exceeds fair value. The Company evaluates the recoverability of its long-lived assets whenever events or changes in circumstances indicate that the carrying value of an asset may not be recoverable. The carrying amount of a long-lived asset (asset group) is not recoverable if it exceeds the sum of the undiscounted cash flows expected to result from the use and eventual disposition of the asset (asset group). If the carrying amount of a long-lived asset (asset group) is considered not recoverable, the impairment loss is measured as the amount by which the carrying value of the asset or asset group exceeds its estimated fair value.

Property, Plant and Equipment

Property, plant and equipment are recorded at cost and are depreciated using the straight-line method over their estimated useful lives. The Company generally uses the following estimated useful lives for each asset category:

ASSET CATEGORY		ESTIMATED USEFUL LIFE
Building		30 years
Computer equipment		2-3 years
Machinery and equipment		3-20 years
Office equipment		3-5 years
Furniture		3-5 years
Leasehold improvements		Shorter of lease term or useful life
Software		3 years

Maintenance, repairs and minor renewals are expensed as incurred. Expenditures that substantially increase an asset’s useful life are capitalized. The Company did not recognize any amounts related to impairment for the years ended December 31, 2021 and 2020.

Intangible Assets

Intangible assets are acquired individually or as part of a group at fair value. Intangible assets with definitive lives are amortized over the useful life of the intangible asset, which is the period over which the asset is expected to contribute directly or indirectly to the entity’s future cash flows.

ASSET CATEGORY		ESTIMATED USEFUL LIFE
Customer Relationship		15 years
Developed Technology		10 years
Tradenames		10-15 years
Non-compete		6 years
In Process Research and Development		11 years

The Company evaluates intangible assets for impairment at least annually and more often whenever events or changes in circumstances indicate that the carrying value may not be recoverable. Whenever any such impairment exists, an impairment loss will be recognized for the amount by which the carrying value exceeds the fair value. The Company’s intangible assets include customer relationships, patents, trademarks, and in process research and development. The Company has not recorded impairment to intangible assets for the years ended December 31, 2021 and 2020.

Goodwill

Goodwill represents the excess of purchase price over the underlying net assets of businesses acquired. Goodwill is reviewed for impairment on an annual basis as of the first day of the Company’s fiscal fourth quarter or more frequently if events or changes in circumstances indicate that the carrying amount of goodwill may be impaired. The Company assesses goodwill in accordance with Accounting Standards Codification 350, Intangibles – Goodwill and other (“ASC 350”) by first assessing through a qualitative analysis whether events and circumstances lead to the conclusion that a quantitative analysis is required. For the quantitative test, the review for impairment of goodwill is based on a combination of income-based and market-based approaches.

Under the income-based approach, the Company determines fair value using a discounted cash flow approach that requires significant judgment with respect to revenue and profitability growth rates, based upon annual budgets and longer-range strategic plans, and the selection of an appropriate discount rates. Under the market-based approach, the Company determines fair value by comparing reporting units to similar businesses or guideline companies whose securities are actively traded in public markets.

Fair value estimates employed in our annual impairment review of goodwill were determined using models involving several assumptions. Changes in assumptions could materially impact fair value estimates. Assumptions critical to the Company’s fair value estimates were: (i) discount rates; (ii) projected future revenues and profitability used in the reporting unit; and (iii) projected long-term growth rates used in the derivation of terminal year values. These and other assumptions are impacted by economic conditions and expectations of management and may change in the future based on period specific facts and circumstances. While the Company believes the assumptions used to estimate future cash flows are reasonable, there can be no assurance that the expected future cash flows will be realized. As a result, impairment charges that possibly would have been recognized in earlier periods may not be recognized until later periods if actual results deviate unfavorably from earlier estimates. The use of different assumptions would increase or decrease discounted cash flows or earnings projections and, therefore, could change impairment determinations.

For the year ended December 31, 2021, the Company completed a quantitative assessment which did not result in an impairment charge.

Fair Value

Accounting Standards Codification 820, Fair Value Measurements (“ASC 820”), clarifies that fair value is an exit price, representing the amount that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants. As such, fair value is a market-based measurement that should be determined based on assumptions that market participants would use in pricing an asset or liability.

ASC 820 requires that the valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. ASC 820 establishes a three-tier value hierarchy, which prioritizes inputs that may be used to measure fair value as follows:

	●	Level 1—Quoted prices in active markets for identical assets or liabilities.

	●	Level 2—Observable inputs other than quoted prices in active markets for identical assets and liabilities, quoted prices for identical or similar assets or liabilities in inactive markets or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities.

	●	Level 3—Inputs that are generally unobservable and typically reflect management’s estimate of assumptions that market participants would use in pricing the asset or liability.

The change in fair value for the reporting period was driven by the result of the unobservable fair value model, a Monte Carlo simulation in a risk-neutral framework assuming Geometric Browning Motion. The most significant input to the model was the estimated results of the Pro Farm subsidiary for the periods specified in the share purchase agreement of 2022 – 2023. The following represents other inputs used in determining the fair value of the contingent consideration liability:

	DECEMBER 30,			DECEMBER 31,
	2021			2020
Discount Rate		14.9	%		15.5	%
Volatility		47.0	%		45.8	%
Credit spread		6.1	%		9.0	%
Risk-free rate		0.7	%		0.2	%

Discount Rate. Discount rate is based on an adjusted weighted cost of capital contribution considering an estimated operational leverage ratio and a risk-free rate, each determined by publicly traded peer group median except the risk-free rate.

Estimated Volatility Factor. Volatility factor is based on the adjusted weighted cost of capital, operating asset volatility, operating leverage ratio and risk-free interest rate, each determined by publicly traded peer group median except the risk-free rate.

Credit Spread. Credit spread cased on the Company’s financial ratio in comparison with those of publicly traded peer group.

Interest Rate. Interest rate based on U.S. Constant Maturity Treasury rates for the same period as the period of performance of 2022 to 2023.

The change in the fair value estimate is recognized in the Company’s consolidated statement of operations in Other Income (expense) under caption Change in fair value of contingent consideration. The contingent consideration will be determined at each reporting period and will be settled with the issuance of the Company’s common shares.

Deferred Revenue

Under ASC 606, when the Company receives consideration, or such consideration is unconditionally due, from a customer prior to transferring control of goods or services to the customer under the terms of a sales contract, the Company records deferred revenue, which represents a contract liability. The Company recognizes deferred revenue as net sales after the Company has transferred control of the goods or services to the customer and all revenue recognition criteria are met. The Company’s deferred revenue is broken out as follows:

Schedule of Deferred Revenue

	DECEMBER 31,			DECEMBER 31,
	2021			2020
Product revenues	$	87		$	189
Financing costs		477			581
License revenues		961			1,232
Total deferred revenues		1,525			2,002
Less current portion		(360	)		(374	)
Long term portion	$	1,165		$	1,628

Revenue Recognition

Under ASC 606, the Company recognizes revenue for product sales at a point in time following the transfer of control of such products to the customers, which typically occurs upon shipment or delivery depending on the terms of the underlying contracts. The Company may enter into contracts in which the SSP are different from the amount the Company is entitled to bill the customer. Product revenues consist of revenues generated from sales of the Company’s products to distributors and direct customers, net of rebates and cash discounts.

Product Sales. The Company recognizes revenue for product sales at a point in time following the transfer of control of such products to the customers, which typically occurs upon shipment or delivery depending on the terms of the underlying contracts. The Company may enter into contracts in which the SSP is different from the amount the Company is entitled to bill the customer. As of December 31, 2021 and 2020, the Company had deferred product revenue in the amount of $87,000 and $189,000, respectively, associated primarily with billings in excess of SSP.

Licenses Revenues. The Company recognizes license revenues pursuant to strategic collaboration and distribution agreements under which the Company receives payments for the achievement of certain testing validation, regulatory progress and commercialization events. As these activities and payments are associated with exclusive rights that the Company provides in connection with strategic collaboration and distribution agreements over the term of the agreements, revenues related to the payments received are deferred and recognized over the term of the exclusive distribution period of the respective agreement. Since inception through December 31, 2021, the Company has received an aggregate of $4,100,000 in payments under certain strategic collaboration and distribution agreements of which no amounts were received during December 31, 2021 and 2020. In addition to the amounts already received, an additional $800,000 in payments under these agreements could potentially receive if certain testing validation, regulatory progress and commercialization events occur.

Financing Component Revenues. The Company recognizes a financing component, if material, when the Company receives consideration from the customer, and when the Company expects control of the product or service to be transferred to the customer in a period of greater than one year from the date of receipt of the consideration. As such, the financing component is determined to be long-term and therefore recorded in the consolidated balance sheet as part of deferred revenues. For each year ended December 31, 2021 and 2020 the Company recognized $68,000 and $32,000, respectively of financing revenues.

Revenue recognition requires the Company to make a number of estimates that include variable consideration. For example, customers may receive sales or volume-based pricing incentives or receive incentives for providing the Company with marketing-related information. The Company makes estimates surrounding variable consideration and the net impact to revenues. In making such estimates, significant judgment is required to evaluate assumptions related to the amount of net contract revenues, including the impact of any performance incentives and the likelihood that customers will achieve them. In the event estimates related to variable consideration change, the cumulative effect of these changes is recognized as if the revised estimates had been used since revenue was initially recognized under the contract. Such revisions could occur in any reporting period, and the effects may be material.

From time to time, the Company offers certain product rebates to its distributors and growers, which are estimated and recorded as reductions to product revenues, and an accrued liability is recorded at the later of when the revenues are recorded, or the rebate is being offered.

Contract Assets. The Company does not have contract assets since revenue is recognized as control of goods are transferred or as services are performed or such contract assets are incurred or expensed within one year of the recognition of the revenue.

Contract Liabilities. The contract liabilities consist of deferred revenue. The Company classifies deferred revenue as current or noncurrent based on the timing of when the Company expects to recognize revenue. Generally, all contract liabilities, excluding deferred revenue, are expected to be recognized within one year and are included in accounts payable in the Company’s consolidated balance sheet.

Research, Development and Patent Expenses

Research and development expenses include payroll-related expenses, field trial costs, toxicology costs, regulatory costs, consulting costs and lab costs. Patent expenses include legal costs relating to the patents and patent filing costs. These costs are expensed to operations as incurred. During the years ended December 31, 2021 and 2020, research and development expenses totaled $11,114,000 and $10,316,000, respectively, and patent expenses totaled $963,000 and $1,014,000, respectively.

Shipping and Handling Costs

Amounts billed for shipping and handling are included as a component of product revenues. Related costs for shipping and handling have been included as a component of cost of product revenues. Shipping and handling costs for the year ended December 31, 2021 and 2020 were $2,081,000 and $1,473,000, respectively.

Advertising

The Company expenses advertising costs as incurred and has included these expenses as a component of Selling, General and Administrative costs. Advertising costs for the years ended December 31, 2021 and 2020 were $654,000 and $631,000, respectively.

Share-Based Compensation

The Company recognizes share-based compensation expense for all stock options and restricted stock units granted to employees and directors based on estimated fair values.

The Company estimates the fair value of restricted stock units based on the closing bid price of the Company’s common stock on the date of grant.

The Company estimates the fair value of stock options on the date of grant using an option-pricing model. The value of the portion of the stock options that is ultimately expected to vest is recognized as expense on a straight-line basis over the requisite service period. Forfeitures are estimated on the date of grant and revised, if necessary, in subsequent periods if actual forfeitures differ from those estimates.

The Company uses the Black-Scholes-Merton option-pricing model to calculate the estimated fair value of stock options on the measurement date (generally, the date of grant). The required inputs in the option-pricing model include the expected life of the stock options, estimated volatility factor, risk-free interest rate and expected dividend yield. These inputs are subjective and generally require significant judgment. During the years ended December 31, 2021 and 2020, the Company calculated the fair value of stock options granted based on the following assumptions:

Fair Value Assumptions of Stock Options

	DECEMBER 31,	DECEMBER 31,
	2021	2020
Expected life (years)	5.77-6.08	2.14-6.08
Estimated volatility factor	59.1%-63.8%	57.9%-59.9%
Risk-free interest rate	0.58%-1.33%	0.28%-0.96%
Expected dividend yield	—	—

Expected Life. Expected life represents the period that share-based payment awards are expected to be outstanding. The Company uses the “simplified method” in accordance with Staff Accounting Bulletin (“SAB”) No. 107, Share-Based Payment (“SAB No. 107”), and SAB No. 110, Simplified Method for Plain Vanilla Share Options (“SAB No. 110”), to calculate the expected term of stock options determined to be “plain vanilla.” Under this approach, the expected term is presumed to be the midpoint between the vesting date and the contractual end of the stock option grant. For stock options granted with an exercise price not equal to the determined fair value, the Company estimates the expected life based on historical data and management’s expectations about exercises and post-vesting termination behavior. The Company will use the simplified method until it has sufficient historical data necessary to provide a reasonable estimate of expected life in accordance with SAB No. 107 and SAB No. 110.

Estimated Volatility Factor. Estimated volatility factor is based on the Company’s trading history adjusted for certain periods of the Company’s trading history, not indicative of normal trading.

Risk-Free Interest Rate. The Company calculates the risk-free interest rate based on the implied yield currently available on U.S. Treasury constant-maturity securities with the same or substantially equivalent remaining term as the expected life of the stock options.

Expected Dividend Yield. The Company has not declared dividends, nor does it expect to in the foreseeable future. Therefore, a zero value was assumed for the expected dividend yield.

Estimated Forfeitures. The Company considers voluntary and involuntary termination behavior and actual stock option forfeitures when estimating forfeitures. If, in the future, the Company determines that other methods for calculating these assumptions are more reasonable, or if other methods are prescribed by authoritative guidance, the fair value calculated for the Company’s stock options could change significantly. Higher volatility factors and longer expected lives result in an increase to the share-based compensation expense determined at the date of grant. Share-based compensation expense is recorded in the Company’s research, development and patent expense and selling, general and administrative expense.

Warrants

The Company has a number of outstanding warrants. From time to time the terms of the warrants may be exchanged, amended or otherwise modified. Historically, the Company’s warrants have been deemed stand-alone equity instruments and as such changes to the original terms of the warranted have been accounted for a modification under Accounting Standards Codification (“ASC”) 718, Compensation – Stock Based Compensation.

On April 29, 2020, the Company entered into a warrant exchange agreement (“Warrant Exchange Agreement”) with certain holders of warrants under the August 2015 Senior Secured Promissory Notes, the Securities Purchase Agreement and the Warrant Reorganization Agreement. Pursuant to the Warrant Exchange Agreement, the Company agreed to exchange an aggregate of 45,977,809 warrants (“August 2015 Warrants”, “February 2018 Warrants 1 & 2”, and all “August 2019 Warrants” collectively, “the exchanged warrants”) for 29,881,855 warrants (“April 2020 Warrants”) (refer to Note 9 of the consolidated financial statements).

The fair value of the April 2020 Warrants was not greater than the fair values of the exchanged warrants immediately prior to the modification date and therefore had no impact on the Company’s year ended results. The fair value of each exchanged warrants immediately prior to the modification were estimated utilizing either a Black Scholes Merton or Monte Carlo option pricing model. The fair value of each April 2020 Warrants immediately after the modification were estimated utilizing a Black Scholes Merton option pricing model. The following table outlines the range of assumptions utilized in the option pricing models:

	EXCHANGED WARRANTS	APRIL 2020 WARRANTS
Contractual life (years)	0.68-3.31	0.38-1.63
Estimated volatility factor	43-52%	38-46%
Risk-free interest rate

MARRONE BIO INNOVATIONS INC 10-K