UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934


Date of Report (Date of Earliest Event Reported):		September 3, 2009

Altus Pharmaceuticals Inc.
__________________________________________
(Exact name of registrant as specified in its charter)


Delaware	0-51711	04-3573277
_____________________ (State or other jurisdiction	_____________ (Commission	______________ (I.R.S. Employer
of incorporation)	File Number)	Identification No.)

610 Lincoln Street, Waltham, Massachusetts		02451
_________________________________ (Address of principal executive offices)		___________ (Zip Code)


Registrant’s telephone number, including area code:		781-373-6000

Not Applicable
______________________________________________
Former name or former address, if changed since last report

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

[  ]  Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
[  ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
[  ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
[  ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

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Item 2.05 Costs Associated with Exit or Disposal Activities.

On September 3, Altus Pharmaceuticals Inc. (the "Company") announced a reduction in headcount of approximately 30% of its employees. The reduction in headcount is due to financial constraints. The Company has been seeking, but has been unable to date to secure, funds to finance the ongoing operations of the Company and is considering various strategic alternatives.

Employees directly affected by the restructuring plan have received notification and will be provided with severance payments.

The Company expects to record a restructuring charge of approximately $0.5 million in the third quarter of 2009, primarily representing cash payments for severance and related expenses. Severance expenses will be paid in a lump sum.

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.


	Altus Pharmaceuticals Inc.

September 9, 2009	By:	Thomas J. Phair, Jr.

		Name: Thomas J. Phair, Jr.
		Title: Vice President, Finance and Treasurer

Altus Pharmaceuticals Inc. 8-K