FINANCIAL INSTRUMENTS - Schedule of Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024
Assets
Total cash and cash equivalents	$ 63,707	$ 55,370
Short-term restricted cash	20	690
Long-term restricted cash	1,532	1,532
Total assets measured at fair value	281,058	392,153
Liabilities
Contingent consideration - Apton acquisition	0	18,700
Total liabilities measured at fair value	0	18,700
Cash and money market funds
Assets
Total cash and cash equivalents	60,496	55,370
U.S. government & agency securities
Assets
Total cash and cash equivalents	3,211	0
Investments:
Assets
Total investments	215,799	334,561
Corporate debt securities
Assets
Total investments	23,250	46,905
U.S. government & agency securities
Assets
Total investments	192,549	287,656
Level 1
Assets
Total cash and cash equivalents	60,496	55,370
Short-term restricted cash	20	690
Long-term restricted cash	1,532	1,532
Total assets measured at fair value	62,048	57,592
Liabilities
Contingent consideration - Apton acquisition	0	0
Total liabilities measured at fair value	0	0
Level 1 \| Cash and money market funds
Assets
Total cash and cash equivalents	60,496	55,370
Level 1 \| U.S. government & agency securities
Assets
Total cash and cash equivalents	0	0
Level 1 \| Investments:
Assets
Total investments	0	0
Level 1 \| Corporate debt securities
Assets
Total investments	0	0
Level 1 \| U.S. government & agency securities
Assets
Total investments	0	0
Level 2
Assets
Total cash and cash equivalents	3,211	0
Short-term restricted cash	0	0
Long-term restricted cash	0	0
Total assets measured at fair value	219,010	334,561
Liabilities
Contingent consideration - Apton acquisition	0	0
Total liabilities measured at fair value	0	0
Level 2 \| Cash and money market funds
Assets
Total cash and cash equivalents	0	0
Level 2 \| U.S. government & agency securities
Assets
Total cash and cash equivalents	3,211	0
Level 2 \| Investments:
Assets
Total investments	215,799	334,561
Level 2 \| Corporate debt securities
Assets
Total investments	23,250	46,905
Level 2 \| U.S. government & agency securities
Assets
Total investments	192,549	287,656
Level 3
Assets
Total cash and cash equivalents	0	0
Short-term restricted cash	0	0
Long-term restricted cash	0	0
Total assets measured at fair value	0	0
Liabilities
Contingent consideration - Apton acquisition	0	18,700
Total liabilities measured at fair value	0	18,700
Level 3 \| Cash and money market funds
Assets
Total cash and cash equivalents	0	0
Level 3 \| U.S. government & agency securities
Assets
Total cash and cash equivalents	0	0
Level 3 \| Investments:
Assets
Total investments	0	0
Level 3 \| Corporate debt securities
Assets
Total investments	0	0
Level 3 \| U.S. government & agency securities
Assets
Total investments	$ 0	$ 0

PACIFIC BIOSCIENCES OF CALIFORNIA, INC. 10-K