Insider Trading Arrangements	3 Months Ended
Insider Trading Arrangements	Sep. 30, 2025 shares
Trading Arrangements, by Individual
Material Terms of Trading Arrangement	The following directors and officers adopted into or terminated a Rule 10b5-1 trading arrangement during the second quarter of 2025: • Andrew Callos – Mr. Callos terminated an existing 10b5-1 trading arrangement, which had been adopted on December 12, 2024, on September 2, 2025. Mr. Callos adopted a new Rule 10b5-1 trading arrangement on September 5, 2025 that was intended to satisfy the affirmative defense provided for under Rule 10b5-1(c) (the “Callos Plan”). The Callos Plan provides for the sale of up to 219,833 shares of our common stock at pre-specified dates during the term of the plan. The Callos Plan will terminate on the earlier of (x) December 1, 2026 and (y) the sale of all securities that are subject to the plan. • John T. Henderson – Dr. Henderson adopted a Rule 10b5-1 trading arrangement on September 2, 2025 that was intended to satisfy the affirmative defense provided for under Rule 10b5-1(c) (the “Henderson Plan”). The Henderson Plan provides for the sale of up to 28,750 shares of our common stock. The Henderson Plan will terminate on the earlier of (x) May 18, 2026 and (y) the sale of all securities that are subject to the plan. • B. Lynne Parshall – Ms. Parshall adopted a Rule 10b5-1 trading arrangement on August 20, 2025 that was intended to satisfy the affirmative defense provided for under Rule 10b5-1(c) (the “Parshall Plan”). The Parshall Plan provides for the sale of up to 20,000 shares of our common stock. The Parshall Plan will terminate on the earlier of (x) September 3, 2026 and (y) the sale of all securities that are subject to the plan. Certain of our officers have made elections to participate in, and are participating in, our employee stock purchase plan, which may be designed to satisfy the affirmative defense conditions of Rule 10b5-1 under the Exchange Act or may constitute non-Rule 10b5–1 trading arrangements. In addition, certain of our directors have made elections to participate in, and are participating in, our director equity in lieu of cash retainer option program (as described in the “Director Compensation” section of our Proxy Statement for our 2024 Annual Meeting), which may be designed to satisfy the affirmative defense conditions of Rule 10b5-1 under the Exchange Act or may constitute non-Rule 10b5–1 trading arrangements.
Andrew Callos [Member]
Trading Arrangements, by Individual
Name	Andrew Callos
Rule 10b5-1 Arrangement Adopted	true
Adoption Date	September 5, 2025
Rule 10b5-1 Arrangement Terminated	false
Expiration Date	December 1, 2026
Arrangement Duration	456 days
Aggregate Available	219,833
John T. Henderson [Member]
Trading Arrangements, by Individual
Name	John T. Henderson
Rule 10b5-1 Arrangement Adopted	true
Adoption Date	September 2, 2025
Rule 10b5-1 Arrangement Terminated	false
Expiration Date	May 18, 2026
Arrangement Duration	207 days
Aggregate Available	28,750
B. Lynne Parshall [Member]
Trading Arrangements, by Individual
Name	B. Lynne Parshall
Rule 10b5-1 Arrangement Adopted	true
Adoption Date	August 20, 2025
Rule 10b5-1 Arrangement Terminated	false
Expiration Date	September 3, 2026
Arrangement Duration	380 days
Aggregate Available	20,000

CYTOKINETICS INC 10-Q