v3.26.1

CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)	Common Stock	Additional Paid-in Capital	Accumulated Deficit	Total
Beginning Balance at Dec. 31, 2023	$ 8,891	$ 450,329,515	$ (436,285,863)	$ 14,052,543
Beginning Balance (in shares) at Dec. 31, 2023	8,891,420
Shares purchased pursuant to ATM agreement	$ 8	36,894		36,902
Shares purchased pursuant to ATM agreement (in shares)	8,178
Issuance of common stock from exercise of stock options	$ 25	62,134		$ 62,159
Issuance of common stock from exercise of stock options (in shares)	25,602			25,602
Issuance of common stock, prefunded warrants and warrants for cash, net of offering costs	$ 1,784	14,890,469		$ 14,892,253
Issuance of common stock, prefunded warrants and warrants for cash, net of offering costs (in shares)	1,783,805
Stock-based compensation		245,864		245,864
Net loss			(10,731,315)	(10,731,315)
Ending Balance at Dec. 31, 2024	$ 10,708	465,564,876	(447,017,178)	18,558,406
Ending Balance (in shares) at Dec. 31, 2024	10,709,005
Shares purchased pursuant to ATM agreement	$ 5,359	9,858,524		9,863,883
Shares purchased pursuant to ATM agreement (in shares)	5,358,292
Issuance of common stock from exercise of prefunded warrants	$ 605			605
Issuance of common stock from exercise of prefunded warrants (in shares)	605,830
Stock-based compensation		537,540		537,540
Net loss			(12,163,620)	(12,163,620)
Ending Balance at Dec. 31, 2025	$ 16,672	$ 475,960,940	$ (459,180,798)	$ 16,796,814
Ending Balance (in shares) at Dec. 31, 2025	16,673,127

Number of new stock and warrants to purchase common stock issued during the reporting period.

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