exhibit A

Agreement of Joint Filing

The undersigned hereby agree that a single Schedule 13D (or any amendment thereto) relating to the Common Stock of Aerovate Therapeutics, Inc. shall be filed on behalf of each of the undersigned and that this Agreement shall be filed as an exhibit to such Schedule 13D.

Date: February 3, 2023

	SOFINNOVA VENTURE PARTNERS X, L.P., a Delaware Limited Partnership

	By:	SOFINNOVA MANAGEMENT X, L.P., a Delaware Limited Partnership
	Its:	General Partner

	By:	SOFINNOVA MANAGEMENT X-A, L.L.C., a Delaware Limited Liability Company
	Its:	General Partner

	By:	/s/ Nathalie Auber
		Nathalie Auber
		Attorney-in-Fact

	SOFINNOVA MANAGEMENT X, L.P., a Delaware Limited Partnership

	By:	SOFINNOVA MANAGEMENT X-A, L.L.C., a Delaware Limited Liability Company
	Its:	General Partner

	By:	/s/ Nathalie Auber
		Nathalie Auber
		Attorney-in-Fact

	SOFINNOVA MANAGEMENT X-A, L.L.C., a Delaware Limited Liability Company

	By:	/s/ Nathalie Auber
		Nathalie Auber
		Attorney-in-Fact

	DR. JAMES I. HEALY
	DR. MAHA KATABI

	By:	/s/ Nathalie Auber
		Nathalie Auber
		Attorney-in-Fact

Jade Biosciences, Inc. SCHEDULE 13D/A