UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, DC 20549

FORM 8-K

CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

Date of report (Date of earliest event reported): June 38, 2015

Bio-Reference Laboratories, Inc.
(Exact Name of Registrant as Specified in Charter)

New Jersey	0-15266	22-2405059
(State or Other Jurisdiction of Incorporation)	(Commission File Number)	(IRS Employer Identification No.)

481 Edward H. Ross Drive,
Elmwood Park, NJ 07407
(Address of Principal Executive Offices)

Registrant’s telephone number, including area code: (201) 791-2600

N/A
(Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):

~~[X]~~ ☒ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

~~[_]~~☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

~~[_]~~ ☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

~~[_]~~ ☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)

~~Section~~Item 8.01 1Other -Events. ~~Registrant’s Business and Operations~~

~~Item~~On June 8, 2015, Bio-Reference Laboratories, Inc. (the “Company”) and OPKO Health, Inc. issued a joint news release. A copy of the news release is attached as Exhibit 99.1.01 ~~Entry~~The Company will hold a joint conference call with OPKO Health, Inc. at 8:30 a.m. ET on Thursday, June 11, 2015, to discuss the previously announced entry into a ~~Material~~merger ~~Definitive~~agreement ~~Agreement~~for OPKO to acquire the Company and to discuss the Company’s second quarter financial results.

~~On June~~Important 3,Information ~~2015,~~For ~~Bio-Reference~~Investors ~~Laboratories,~~And Inc., a New Jersey corporation (the “Company”), OPKO Health, Inc., a Delaware corporation (“OPKO”) and Bamboo Acquisition, Inc., a New Jersey corporation and a direct wholly owned subsidiary of OPKO (“Sub”), entered into an agreement and plan of merger (the “Merger Agreement”). Pursuant to the Merger Agreement, Sub will be merged with and into the Company (the “Merger”) and the Company will be the surviving corporation and OPKO’s wholly owned subsidiary. The Merger is intended to qualify as a reorganization within the meaning of the Internal Revenue Code of 1986, as amended (the “Code”), so that none of OPKO, the Company nor any of the Company’s shareholders generally will recognize gain or loss for U.S. federal income tax purposes in the transaction.Shareholders

AtThis communication does not constitute an offer to buy or sell or the ~~effective~~solicitation ~~time~~of an offer to buy or sell any securities or a solicitation of ~~the~~any ~~Merger~~vote ~~(the~~or approval. This communication relates to a proposed business combination between Bio-Reference Laboratories, Inc. (“~~Effective~~Bio-Reference ~~Time~~Laboratories”) and OPKO Health, ~~each~~Inc. ~~issued~~(“OPKO”). ~~and~~In ~~outstanding~~connection ~~share~~with ofthis ~~the~~proposed ~~Company’s common~~business ~~stock~~combination, ~~par~~Bio-Reference ~~value~~Laboratories ~~$0.01~~and/or ~~per~~OPKO will ~~share~~file (relevant materials with the ~~“Company~~Securities ~~Common~~Exchange ~~Stock~~Commission (the “SEC”), ~~(other~~including ~~than~~an ~~any~~OPKO ~~shares~~registration ofstatement on ~~the~~Form ~~Company~~S-4 ~~Common Stock~~that ~~(including~~will ~~shares~~include ~~held~~a inproxy ~~treasury~~statement byof ~~the~~Bio-Reference ~~Company)~~Laboratories ~~held~~and byconstitute a prospectus of OPKO. orINVESTORS ~~any~~AND SECURITY HOLDERS OF BIO-REFERENCE LABORATORIES AND OPKO ~~subsidiary~~ARE orURGED ~~the~~TO ~~Company~~READ orTHE ~~any~~PROXY ~~Company~~STATEMENT/PROSPECTUS ~~subsidiary)~~AND OTHER DOCUMENTS THAT ~~will~~MAY ~~automatically~~BE beFILED ~~converted~~WITH ~~into~~THE ~~and~~SEC ~~exchanged~~CAREFULLY ~~for~~AND ~~the~~IN ~~right~~THEIR toENTIRETY ~~receive~~IF 2AND WHEN THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION.75 ~~shares~~Any definitive proxy statement (~~the~~if ~~“Exchange~~and ~~Ratio”~~when available) will be mailed to shareholders of Bio-Reference Laboratories. ~~OPKO’s~~Investors ~~common~~and ~~stock,~~security ~~par~~holders ~~value~~will ~~$0.01~~be ~~per~~able ~~share~~to obtain free copies of these documents (~~the~~if ~~“OPKO~~and ~~Common~~when ~~Stock”~~available). Noand ~~fractional~~other ~~shares~~documents filed ofwith the SEC by Bio-Reference Laboratories and/or OPKO ~~Common Stock~~through ~~will~~the bewebsite ~~issued~~maintained inby the ~~Merger,~~SEC ~~and~~at www.sec.gov. Copies of the ~~Company’s~~documents ~~shareholders~~filed with the SEC by Bio-Reference Laboratories will ~~receive~~be ~~one~~available ~~share~~free of ~~OPKO~~charge ~~Common~~on ~~Stock~~Bio-Reference inLaboratories’ website ~~lieu~~at ofhttp://www.bioreference.com or by contacting Bio-Reference Laboratories’ Investor Relations Department by email ~~any~~at ~~fractional~~tmackay@bioreference.com ~~shares,~~or ~~after~~by ~~taking~~phone ~~into~~at ~~account~~(201) ~~all~~791-2600. Copies of the ~~shares~~documents offiled with the ~~Company~~SEC ~~Common~~by ~~Stock~~OPKO ~~represented~~will bybe ~~certificates~~available free of charge on OPKO’s website at www.opko.com or by contacting OPKO’s Investor Relations Department by email at ~~book-entries,~~contact@opko.com ~~delivered~~or by ~~such~~phone ~~shareholder~~at (305) 575-4100.

~~In addition,~~Participants ~~subject to certain limitations described~~ in the Merger Agreement, each option to purchase shares of the Company Common Stock will be converted into and become rights with respect to the OPKO Common Stock and OPKO will assume each such option, in accordance with the terms of the applicable option plan and/or stock option agreement. The number of shares of OPKO Common Stock subject to such options will be equal to the number of shares of Company Common Stock subject to such options multiplied by 2.75, rounded down to the nearest whole share. The per share exercise price under each option will be adjusted by dividing the per share exercise price of such option by 2.75 and rounding up to the nearest cent.Solicitation

~~The~~Bio-Reference ~~obligations~~Laboratories, ~~of the~~OPKO, ~~Company~~their respective directors and ~~OPKO~~certain toof ~~consummate~~their ~~the~~respective ~~Merger~~executive ~~are~~officers ~~subject~~may tobe ~~customary~~considered ~~conditions,~~participants ~~including,~~in ~~but~~the ~~not~~solicitation ~~limited~~of ~~to,~~proxies ~~(a)~~in ~~obtaining~~connection with the ~~required~~proposed ~~approvals~~transaction. ofInformation about the ~~Company’s~~directors ~~shareholders,~~and ~~(b)~~executive ~~termination~~officers of ~~the~~Bio-Reference ~~waiting~~Laboratories ~~period~~is ~~under~~set ~~the~~forth in ~~Hart~~its Annual Report on Form 10-~~Scott-Rodino~~K ~~Antitrust Improvements~~for ~~Act~~the ofyear ~~1976,~~ended asOctober ~~amended~~31, ~~(c)~~2014, ~~the~~which ~~absence~~was offiled ~~any~~with ~~injunction~~the orSEC ~~similar~~on ~~restraint~~January ~~prohibiting~~13, or2015, ~~making~~its ~~illegal consummation~~Quarterly ofReport on Form 10-Q for the ~~Merger~~quarter orended ~~any~~January of31, ~~the~~2015 ~~other~~which ~~transactions~~was ~~contemplated~~filed bywith the ~~Merger~~SEC ~~Agreement,~~on ~~(d)~~March ~~the~~9, ~~effectiveness~~2015 ofand ~~the~~its ~~registration~~Current Reports ~~statement~~on inForm ~~connection~~8-K, which were filed with the ~~issuance~~SEC ofon ~~OPKO~~March ~~Common~~5, ~~Stock~~2015, inand ~~the~~April ~~Merger~~29, ~~(e)~~2015. ~~the~~Information ~~approval~~about by the ~~New~~directors ~~York~~and ~~Stock Exchange with~~executive ~~respect~~officers toof ~~the~~OPKO ~~listing~~is ofset ~~the~~forth ~~shares~~in ofits ~~OPKO~~amended ~~Common~~Annual ~~Stock~~Report toon beForm ~~issued~~10-K infor the ~~Merger,~~year ~~(f)~~ended ~~subject~~December to31, ~~certain~~2014, ~~materiality~~which ~~exceptions,~~was filed with the ~~accuracy~~SEC ofon ~~the~~February ~~representations~~27, 2015 and ~~warranties~~April of30, ~~each party~~2015, ~~(g)~~its ~~the~~proxy ~~performance~~statement infor ~~all~~its ~~material~~2015 ~~respects~~annual bymeeting ~~each~~of ~~party~~stockholders, ~~of its~~which ~~obligations~~was ~~under~~filed with the ~~Merger~~SEC ~~Agreement~~on ~~(h)~~May ~~receipt~~7, by2015, ~~each~~its ~~party~~Quarterly ofReport anon ~~opinion~~Form of10-Q ~~counsel~~for to the ~~effect~~quarter ~~that~~ended ~~the~~March ~~Merger~~31, ~~will qualify~~2015 aswhich awas ~~“reorganization”~~filed ~~within~~with the ~~meaning~~SEC on ofMay ~~the~~11, ~~Code~~2015 and ~~(i)~~its ~~receipt~~Current ofReport ~~certain~~on ~~specified~~Form ~~third~~8-K, ~~party~~which ~~consents~~was filed with the SEC on March 19, 2015.

~~Subject~~These todocuments can be obtained free of charge from the ~~satisfaction~~sources orindicated ~~waiver~~above. ofAdditional information regarding the ~~foregoing~~participants ~~conditions~~in the proxy solicitations and ~~the~~a ~~other~~description ~~terms~~of their direct and ~~conditions~~indirect interests, by security holdings or otherwise, will be contained in the ~~Merger~~proxy ~~Agreement,~~statement/prospectus ~~the~~and ~~transaction~~other isrelevant ~~expected~~materials to ~~close~~be infiled with the ~~second~~SEC ~~half~~when ofthey ~~2015~~become available.

~~The~~Cautionary ~~Merger~~Statement ~~Agreement contains~~Regarding ~~certain~~Forward-Looking termination rights for both the Company and OPKO in certain circumstances, including: (a) by mutual written agreement of the parties; (b) by either party if the Merger is not consummated on or before December 2, 2015, provided that such date will be extended by an additional 90 days under certain circumstances, and provided further that such failure is not principally caused by any breach of the Merger Agreement by the party proposing to terminate; (c) by either party upon a final and nonappealable injunction or similar restraint permanently restraining, enjoining or otherwise prohibiting consummation of the transactions contemplated by the Merger Agreement; (d) by either party if the Company’s shareholders fail to approve the transactions contemplated by the MergerStatements

~~Agreement;~~Certain ~~(e)~~statements byin ~~OPKO,~~this ifcommunication ~~(i)~~regarding the ~~Company~~proposed ~~breaches~~acquisition ~~or fails to perform its representations and warranties or covenants in the Merger Agreement and such breach (A) is not capable~~ of ~~being~~Bio-Reference ~~cured~~Laboratories ~~or is not cured within 90 days following receipt~~ by ~~the Company of~~ OPKO’s, ~~written~~including ~~notice~~any ~~and~~statements ~~(B)~~regarding ~~would result in~~ the ~~failure~~expected oftimetable afor ~~condition~~completing tothe proposed ~~closing~~transaction, ~~being satisfied~~synergies, ~~(ii)~~benefits ~~the~~and ~~Board~~opportunities of ~~Directors of~~ the ~~Company~~proposed ~~fails to recommend that the Company’s shareholders approve the Merger Agreement~~transaction, ~~(iii)~~future ~~there~~opportunities isfor ~~a Change in Recommendation (as defined in~~ the combined ~~Merger~~company ~~Agreement)~~and orproducts, afuture ~~Company~~financial ~~Intervening~~performance ~~Event~~and ~~Change~~any inother ~~Recommendation~~statements ~~(as~~regarding ~~defined~~OPKO’s inand ~~the~~Bio-Reference ~~Merger~~Laboratories’ future ~~Agreement)~~expectations, ~~(iv)~~beliefs, ~~there~~plans, isobjectives, ~~a publicly~~financial ~~announced~~conditions, ~~Acquisition~~assumptions ~~Proposal~~or ~~(as~~future ~~defined~~events inor ~~the~~performance ~~Merger Agreement)~~ that isare not historical ~~with~~facts ~~respect~~are to“forward-looking” astatements ~~tender~~made ~~offer~~within ~~or exchange offer and~~ the ~~Board~~meaning of ~~Directors~~Section of27A ~~the Company fails to publicly reaffirm its recommendation~~ of the ~~Merger~~Securities ~~Agreement~~Act ~~within five~~of ~~business days after OPKO so requests in writing~~1933, ~~(v) the Company enters into a written agreement with respect to a Company Acquisition Agreement (~~as ~~defined in the Merger Agreement)~~amended, orand ~~(vi)~~Section ~~the~~21E ~~Company or its Board~~ of ~~Directors publicly announce~~ the ~~Company’s intention~~Securities toExchange doAct ~~any~~ of ~~the~~1934, ~~foregoing;~~as oramended. ~~(f)~~The bywords ~~the~~“anticipate,” ~~Company~~“believe,” “ensure,” “expect,” “if,” ~~(i)~~“intend,” ~~OPKO~~“estimate,” ~~breaches or fails to perform its representations and warranties~~“probable,” or“project,” ~~covenants~~“forecasts,” in“predict,” ~~the~~“outlook,” ~~Merger~~“aim,” ~~Agreement and such breach (A) is not capable of being cured or is not cured within 90 days following~~“will,” ~~receipt~~“could,” by“should,” ~~OPKO of the Company’s written notice and (B)~~ “would,” ~~result~~“potential,” in“may,” ~~the failure of a condition to closing being satisfied~~“might,” ~~(ii)~~“anticipate,” ~~there~~“likely” is“plan,” a“positioned,” ~~Change~~“strategy,” inand ~~Recommendation~~similar expressions, ~~(but~~and ~~not an Intervening Event Change in Recommendation) or (iii)~~ the ~~Company~~negative ~~enters~~thereof, ~~into a~~are ~~written~~intended ~~agreement with respect~~ to aidentify ~~Superior~~forward-looking ~~Proposal (as defined in the Merger Agreement)~~statements.

IfAll ~~the~~forward-looking ~~Merger~~information ~~Agreement~~are subject to numerous risks isand ~~terminated~~uncertainties, ~~under~~many ~~certain~~of ~~circumstances~~which ~~specified~~are inbeyond the ~~Merger~~control ~~Agreement~~of Bio-Reference Laboratories and OPKO, that could cause actual results to differ materially from the ~~Company~~results ~~will~~expressed beor ~~required~~implied toby ~~pay~~the ~~OPKO~~statements. aThese ~~termination fee~~risks ofand ~~$54~~uncertainties include,~~000,000~~ (but are not limited to: failure to obtain the ~~“Termination~~required ~~Fee”)~~vote of Bio-Reference Laboratories’ shareholders; ~~however,~~the iftiming to consummate the proposed ~~Merger~~transaction; ~~Agreement~~the isrisk ~~terminated~~that ~~due~~a condition to aclosing ~~Company~~of ~~Intervening~~the proposed transaction may not be satisfied or that the closing ~~Event~~of ~~Change~~the inproposed ~~Recommendation,~~transaction might otherwise not occur; the ~~Company~~risk ~~will~~that a regulatory approval that may be required for the proposed transaction is not obtained or is obtained subject to ~~pay~~conditions ~~OPKO~~that ~~$40,500,000~~are (not anticipated; the ~~“Company~~diversion ~~Intervening~~of ~~Event~~management ~~Termination~~time on ~~Fee”)~~transaction-related inissues; ~~lieu~~ability ofto successfully integrate the ~~Termination~~businesses; ~~Fee.~~risk ~~Additionally,~~that ifthe ~~OPKO~~transaction ~~terminates~~and ~~the~~its ~~Merger~~announcement ~~Agreement~~could have ~~and~~an ~~receives~~adverse aeffect ~~Company~~on ~~Intervening Event~~Bio-Reference ~~Termination~~Laboratories’ ~~Fee,~~ability ~~and~~to ~~within~~retain 12customers ~~months~~and ~~after~~retain ~~such~~and ~~termination,~~hire key personnel; the risk ~~Company~~that ~~enters~~any ~~into~~potential asynergies ~~Company~~from ~~Acquisition~~the ~~Agreement~~transaction may not be fully realized or may take longer to realize than expected; new ~~consummates~~information aarising ~~Company~~out ~~Acquisition~~of ~~Proposal~~clinical ~~(as~~trial ~~defined~~results; inand the ~~Merger~~risk ~~Agreement),~~that ~~then~~ the ~~Company~~safety and/or efficacy results of existing clinical trials will ~~pay~~not ~~OPKO~~support ~~$13~~continued clinical development,~~500,000~~ as well as risks inherent in funding, developing and obtaining regulatory approvals ~~addition~~of tonew, ~~the~~commercially-viable ~~Company~~and ~~Intervening~~competitive ~~Event~~products ~~Termination~~and ~~Fee~~treatments. In addition, ~~under~~forward-looking ~~certain~~statements ~~circumstances~~may also be adversely affected by general market factors, competitive product development, product availability, federal and state regulations and legislation, the ~~Company~~regulatory ~~would~~process for new products and indications, manufacturing issues that may arise, patent positions and litigation, among other factors. The forward-looking statements contained in this communication may become outdated over time. OPKO and Bio-Reference Laboratories do not assume any responsibility for updating any forward-looking statements. Additional information concerning these and other factors can be ~~obligated~~found in Bio-Reference Laboratories’ and OPKO’s respective filings with the SEC and available tothrough ~~reimburse~~the SEC’s Electronic Data Gathering and Analysis Retrieval system at www.sec.gov, including Bio-Reference Laboratories’ and OPKO’s ~~out~~most recent Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. The foregoing list of ~~pocket~~important ~~expenses~~factors ~~incurred~~is innot ~~connection~~exclusive. ~~with~~Bio-Reference ~~the~~Laboratories ~~Merger~~and ~~Agreement~~OPKO upassume no obligation to $3update or revise any forward-looking statements as a result of new information,~~000~~ future events or otherwise,~~000~~ except as may be required by law. Readers are cautioned not to place undue reliance on these forward-looking statements that speak only as of the date hereof.

The Company has made customary representations and warranties regarding, among other things: organization, standing and corporate power; authority; capitalization; SEC filings; governmental approvals; absence of undisclosed liabilities; absence of certain changes; tax matters; intellectual property; environmental matters; compliance with laws; labor relations; healthcare regulatory matters; employee benefit plans; accounts receivable; material contracts; legal proceedings; and insurance.

OPKO and Sub have made customary representations and warranties regarding, among other things: organization, standing and corporate power; authority; capitalization; SEC filings; absence of undisclosed liabilities; absence of certain changes or events; tax matters; environmental matters; intellectual property; regulatory matters; compliance with laws; and legal proceedings.

The Merger Agreement contains customary covenants of each of the Company, OPKO and Sub, including, among other things, that (i) the Company will cooperate with OPKO to prepare as promptly as reasonably practicable, a proxy statement relating to the special meeting of the Company’s shareholders (the “Proxy Statement” and when included with the Registration Statement (defined below) as a prospectus, the “Proxy Statement/Prospectus”), which the Company will file with the U.S. Securities and Exchange Commission (the “SEC”), (ii) OPKO will prepare with the Company, and OPKO will file with the SEC, a registration statement on Form S-4 (the “Registration Statement”), which will include the Proxy Statement/Prospectus, for the offering of the OPKO Common Stock in the Merger; and (iii) each party will cooperate with each other and use their respective reasonable best efforts to obtain all governmental consents, approvals and authorizations that are necessary to consummate the transactions contemplated by the Merger Agreement. Each party is also required to take all actions necessary to obtain antitrust regulatory approval (including agreeing to divestitures) unless the assets subject to such divestitures generated or were reasonably necessary to service more than 2.5% of consolidated revenues, in their

respective most recently completed fiscal years, of the Company, the Company’s subsidiaries, OPKO and OPKO’s subsidiaries.

Prior to the approval of the Merger Agreement by the Company’s shareholders, its Board of Directors may, upon receipt of a Superior Proposal and in certain other circumstances, change its recommendation that the Company’s shareholders approve the Merger Agreement, subject to complying with notice and other specified conditions, including giving OPKO the opportunity to propose changes to the Merger Agreement in response to such Superior Proposal or other circumstances.

Each of OPKO and the Company have additionally agreed, subject to certain exceptions, to conduct its business in the ordinary course consistent with past practice between the execution of the Merger Agreement and the Effective Time and not to take certain actions during such period.

This summary and the copy of the Merger Agreement attached hereto as Exhibit 2.1 are included solely to provide investors with information regarding the terms of the Merger Agreement. They are not intended to provide factual information about the parties or any of their respective subsidiaries or affiliates. Investors are cautioned that the representations, warranties and covenants included in the Merger Agreement were made by the Company, OPKO and Sub to each other. These representations, warranties and covenants were made as of specific dates and only for purposes of the Merger Agreement and are subject to important exceptions and limitations, including a contractual standard of materiality that may be different from that generally relevant to investors, and are qualified by information disclosed in the Company’s and OPKO’s public filings as well as in confidential disclosure schedules that the parties exchanged in connection with the execution of the Merger Agreement. In addition, the representations and warranties may have been included in the Merger Agreement for the purpose of allocating risk between the Company, OPKO and Sub rather than to establish matters as facts. The representations and warranties contained in the Merger Agreement are solely for the benefit of the parties to the Merger Agreement. Investors are not third-party beneficiaries under the Merger Agreement and in reviewing the representations, warranties and covenants contained in the Merger Agreement or any descriptions thereof in this summary, it is important to bear in mind that such representations, warranties and covenants or any descriptions were not intended by the parties to the Merger Agreement to be characterizations of the actual state of facts or condition of the Company, OPKO or any of their respective subsidiaries or affiliates. Moreover, information concerning the subject matter of the representations, warranties and covenants may change after the date of the Merger Agreement, which subsequent information may or may not be fully reflected in the Company’s or OPKO’s public disclosures. For the foregoing reasons, the representations, warranties and covenants or any descriptions of those provisions should not be read alone and should instead be read in conjunction with the other information contained in the reports, statements and filings that the Company and OPKO publicly file with the SEC. The Company acknowledges that, notwithstanding the inclusion of the foregoing cautionary statements, it is responsible for considering whether additional specific disclosures of material information regarding material contractual provisions are required to make the statements in this Form 8-K not misleading.

The foregoing description of the Merger Agreement and the transactions contemplated thereby does not purport to be complete and is qualified in its entirety by reference to the Merger Agreement, which is filed as Exhibit 2.1 to this Current Report on Form 8-K and incorporated by reference herein.

Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

Employment Agreement of Dr. Marc D. Grodman

On June 3, 2015, the Company entered into a new employment agreement (the “New CEO Contract”) with its Chief Executive Officer, Dr. Marc D. Grodman, and OPKO, which will become effective as of, and contingent upon, the closing of the Merger and replace Dr. Grodman’s existing employment agreement with the Company, dated as of December 31, 2010. If the closing of the Merger does not occur, the New CEO Contract will be null and void ab initio and Dr. Grodman’s existing

employment agreement terms will continue to apply.

Dr. Grodman agreed to replace his existing employment agreement with the New CEO Contract as part of an agreement to waive his “single trigger” severance rights under his existing employment agreement. Under his existing employment agreement, he would have had the right to resign from his position within 30 days following the closing of the Merger and receive a lump sum cash severance payment equal to 2.99 times the average of his annual taxable compensation for the previous five years.

Under the New CEO Contract, Dr. Grodman will continue to serve as the Company’s President and CEO for a term of five years from the closing of the Merger.

The New CEO Contract provides Dr. Grodman with his current annual base salary of $1,050,676. Dr. Grodman is also eligible to participate in the Company’s management incentive bonus plan and receive discretionary bonus payments as determined by OPKO. Dr. Grodman is entitled to substantially similar automobile and aircraft benefits as provided for in his existing employment agreement. Dr. Grodman is also eligible to participate in any fringe benefit and bonus plans otherwise available to the Company’s employees.

On or as soon as practicable after the effective date of the Merger, Dr. Grodman is entitled to receive a grant of stock options under OPKO’s 2007 Equity Incentive Plan (the “OPKO Plan”) to purchase shares of OPKO’s common stock at Fair Market Value (as such term is defined in the OPKO Plan), subject to the terms of the OPKO Plan and the applicable award agreement. Upon a change in control or certain termination events, any then unvested stock options held by Dr. Grodman will become fully vested and exercisable.

The Company may terminate Dr. Grodman’s employment with or without “Cause” and Dr. Grodman has the right to terminate his employment with or without “Good Reason” (as such terms are defined in the New CEO Contract). Upon a termination of employment by the Company without Cause or by Dr. Grodman for Good Reason, Dr. Grodman is eligible to receive: (i) a lump sum payment equal to three times the sum of Dr. Grodman’s then current base salary, target bonus and annual COBRA premium at the time of termination and (ii) a pro-rata bonus based on actual performance for the year of termination that is payable when it otherwise would have been paid for such year. Dr. Grodman is also entitled to receive the foregoing payments and benefits upon terminating his employment with the Company within 30 days following the effective time of a change in control of the Company or OPKO (other than the Merger) (a “Change in Control”). Dr. Grodman’s receipt of the foregoing payments and benefits is conditioned upon his execution of a release.

Dr. Grodman is entitled to receive substantially similar payments and benefits upon a termination of employment due to his death or disability as provided for in his existing employment agreement.

Payments and benefits under the New CEO Contract in connection with a Change in Control are subject to a contingent cutback to the extent it results in a greater after-tax amount to Dr. Grodman as compared to having such payments and benefits be subject to excise tax under Sections 280G and 4999 of the Code.

The New CEO Contract also contains perpetual confidentiality and non-disclosure obligations. The New CEO Contract also contains a non-competition covenant, non-hire covenant and non-solicitation covenant.

The foregoing description of the New CEO Contract is not complete and is qualified in its entirety by reference to a copy of the New CEO Contract that is filed as Exhibit 10.1 to this Form 8-K, the contents

of which are incorporated herein by reference.

Employment Agreement of Nicholas Papazicos

On June 3, 2015, the Company executed an employment agreement (the “CFO Contract”) with Nicholas Papazicos, the Company’s Senior Vice President and Chief Financial Officer, which amends and restates his prior employment agreement with the Company dated March 4, 2008 (the “Prior CFO Contract”). The term of the CFO Contract has an initial term ending on October 31, 2018 and is automatically extended each year for one additional year unless the Company provides written notice of non-extension to Mr. Papazicos at least ten days prior to October 31 of any year during the term of the CFO Contract. The CFO Contract was entered into in connection with the Merger and will become effective only upon the closing of the Merger. Upon effectiveness, the CFO Contract will replace and supersede the Prior CFO Contract. If the closing of the Merger does not occur, the CFO Contract will be null and void ab initio and Mr. Papazico’s existing employment agreement terms will continue to apply.

Mr. Papazicos agreed to replace the Prior CFO Contract with the CFO Contract as part of an agreement to waive his “single trigger” severance rights under the Prior CFO Contract. Under the Prior CFO Contract, he would have had the right to resign from his position within 30 days following the closing of the Merger and receive a lump sum cash severance payment equal to 2.99 times the average of his annual taxable compensation for the previous five years.

The CFO Contract provides Mr. Papazicos with a minimum annual base salary of $450,000, subject to annual percentage increases based on the Consumer Price Index as well as other increases from time to time. This minimum annual base salary represents a slight increase from Mr. Papazicos’ current annual base salary of $403,265. Under the CFO Contract, the Company agreed to lease and insure an automobile for his benefit on the same terms as provided for in the Prior CFO Contract. Mr. Papazicos is also eligible to participate in any fringe benefit and bonus plans otherwise available to the Company’s employees. In the event the Merger is consummated, Mr. Papazicos will receive a one-time payment of $200,000 for his services in connection with the Merger and as reasonable compensation for the services he will render to the Company following the Merger.

On or as soon as practicable after the effective date of the Merger, Mr. Papazicos is entitled to receive a grant of stock options under OPKO Plan to purchase shares of OPKO’s common stock at Fair Market Value (as such term is defined in the OPKO Plan), subject to the terms of the OPKO Plan and the applicable award agreement. Upon certain termination events, any then unvested stock options held by Mr. Papazicos will become fully vested and exercisable.

Under the CFO Contract, upon a termination without Cause or his resignation for Good Reason, Mr. Papazicos is entitled to receive a lump sum payment equal to three times his base salary or, if such a termination were to occur within 12 months of the Merger, an amount not less than $1,147,493. Subject to applicable law, Mr. Papazicos would also be entitled to receive either (i) health care benefits for three years following his termination of employment or (ii) a lump sum amount equal to, on an after-tax basis, the costs of the premiums that would have otherwise been paid to provide Mr. Papazicos with health care benefits during the three year period following the termination of employment.

Payments and benefits under the CFO Contract are subject to a contingent cutback to the extent it results in a greater after-tax amount to Mr. Papazicos as compared to having such payments and benefits be subject to excise tax under Sections 280G and 4999 of the Code.

The CFO Contract also provides Mr. Papazico with certain salary continuation and other benefits if he dies or becomes totally or partially disabled.

The CFO Contract contains perpetual confidentiality and non-disclosure obligations. The CFO Contract also contains a non-competition covenant and a non-solicitation covenant.

The foregoing description of the CFO Contract is not complete and is qualified in its entirety by reference to a copy of the CFO Contract that is filed as Exhibit 10.2 to this Form 8-K, the contents of which are incorporated herein by reference.

Item 8.01 Other Events.

On June 4, 2015, Bio-Reference Laboratories, Inc. and OPKO Health, Inc. issued a joint news release. A copy of the news release is attached as Exhibit 99.1.

Important Information For Investors And Shareholders

This communication does not constitute an offer to buy or sell or the solicitation of an offer to buy or sell any securities or a solicitation of any vote or approval. This communication relates to a proposed business combination between Bio-Reference Laboratories, Inc. (“Bio-Reference Laboratories”) and OPKO Health, Inc. (“OPKO”). In connection with this proposed business combination, Bio-Reference Laboratories and/or OPKO will file relevant materials with the Securities Exchange Commission (the “SEC”), including an OPKO registration statement on Form S-4 that will include a proxy statement of Bio-Reference Laboratories and constitute a prospectus of OPKO. INVESTORS AND SECURITY HOLDERS OF BIO-REFERENCE LABORATORIES AND OPKO ARE URGED TO READ THE PROXY STATEMENT/PROSPECTUS AND OTHER DOCUMENTS THAT MAY BE FILED WITH THE SEC CAREFULLY AND IN THEIR ENTIRETY IF AND WHEN THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION. Any definitive proxy statement (if and when available) will be mailed to shareholders of Bio-Reference Laboratories. Investors and security holders will be able to obtain free copies of these documents (if and when available) and other documents filed with the SEC by Bio-Reference Laboratories and/or OPKO through the website maintained by the SEC at www.sec.gov. Copies of the documents filed with the SEC by Bio-Reference Laboratories will be available free of charge on Bio-Reference Laboratories’ website at http://www.bioreference.com or by contacting Bio-Reference Laboratories’ Investor Relations Department by email at tmackay@bioreference.com or by phone at (201) 791-2600. Copies of the documents filed with the SEC by OPKO will be available free of charge on OPKO’s website at www.opko.com or by contacting OPKO’s Investor Relations Department by email at contact@opko.com or by phone at (305) 575-4100.

Participants in Solicitation

Bio-Reference Laboratories, OPKO, their respective directors and certain of their respective executive officers may be considered participants in the solicitation of proxies in connection with the proposed transaction. Information about the directors and executive officers of Bio-Reference Laboratories is set forth in its Annual Report on Form 10-K for the year ended October 31, 2014, which was filed with the SEC on January 13, 2015, its Quarterly Report on Form 10-Q for the quarter ended January 31, 2015 which was filed with the SEC on March 9, 2015 and its Current Reports on Form 8-K, which were filed with the SEC on March 5, 2015, and April 29, 2015. Information about the directors and executive officers of OPKO is set forth in its amended Annual Report on Form 10-K for the year ended December 31, 2014, which was filed with the SEC on February 27, 2015 and April 30, 2015, its proxy statement for its 2015 annual meeting of stockholders, which was filed with the SEC on May 7, 2015, its Quarterly Report on Form 10-Q for the quarter ended March 31, 2015 which was filed with the SEC on May 11, 2015 and its Current Report on Form 8-K, which was filed with the SEC on March 19, 2015.

These documents can be obtained free of charge from the sources indicated above. Additional information regarding the participants in the proxy solicitations and a description of their direct and indirect interests, by security holdings or otherwise, will be contained in the proxy statement/prospectus and other relevant materials to be filed with the SEC when they become available.

Cautionary Statement Regarding Forward-Looking Statements

Certain statements in this communication regarding the proposed acquisition of Bio-Reference Laboratories by OPKO, including any statements regarding the expected timetable for completing the proposed transaction, synergies, benefits and opportunities of the proposed transaction, future opportunities for the combined company and products, future financial performance and any other statements regarding OPKO’s and Bio-Reference Laboratories’ future expectations, beliefs, plans, objectives, financial conditions, assumptions or future events or performance that are not historical facts are “forward-looking” statements made within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. The words “anticipate,” “believe,” “ensure,” “expect,” “if,” “intend,” “estimate,” “probable,” “project,” “forecasts,” “predict,” “outlook,” “aim,” “will,” “could,” “should,” “would,” “potential,” “may,” “might,” “anticipate,” “likely” “plan,” “positioned,” “strategy,” and similar expressions, and the negative thereof, are intended to identify forward-looking statements.

All forward-looking information are subject to numerous risks and uncertainties, many of which are beyond the control of Bio-Reference Laboratories and OPKO, that could cause actual results to differ materially from the results expressed or implied by the statements. These risks and uncertainties include, but are not limited to: failure to obtain the required vote of Bio-Reference Laboratories’ shareholders; the timing to consummate the proposed transaction; the risk that a condition to closing of the proposed transaction may not be satisfied or that the closing of the proposed transaction might otherwise not occur; the risk that a regulatory approval that may be required for the proposed transaction is not obtained or is obtained subject to conditions that are not anticipated; the diversion of management time on transaction-related issues; ability to successfully integrate the businesses; risk that the transaction and its announcement could have an adverse effect on Bio-Reference Laboratories’ ability to retain customers and retain and hire key personnel; the risk that any potential synergies from the transaction may not be fully realized or may take longer to realize than expected; new information arising out of clinical trial results; and the risk that the safety and/or efficacy results of existing clinical trials will not support continued clinical development, as well as risks inherent in funding, developing and obtaining regulatory approvals of new, commercially-viable and competitive products and treatments. In addition, forward-looking statements may also be adversely affected by general market factors, competitive product development, product availability, federal and state regulations and legislation, the regulatory process for new products and indications, manufacturing issues that may arise, patent positions and litigation, among other factors. The forward-looking statements contained in this communication may become outdated over time. OPKO and Bio-Reference Laboratories do not assume any responsibility for updating any forward-looking statements. Additional information concerning these and other factors can be found in Bio-Reference Laboratories’ and OPKO’s respective filings with the SEC and available through the SEC’s Electronic Data Gathering and Analysis Retrieval system at www.sec.gov, including Bio-Reference Laboratories’ and OPKO’s most recent Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. The foregoing list of important factors is not exclusive. Bio-Reference Laboratories and OPKO assume no obligation to update or revise any forward-looking statements as a result of new information, future events or otherwise, except as may be required by law. Readers are cautioned not to place undue reliance on these forward-looking statements that speak only as of the date hereof.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits.

299.1 ~~Agreement~~Joint ~~and~~News ~~Plan~~Release of ~~Merger dated as of June 3, 2015 among~~ Bio-Reference Laboratories, Inc., and OPKO Health, Inc. ~~and~~dated ~~Bamboo~~June ~~Acquisition~~8, ~~Inc.(1)~~2015

10.1 Employment Agreement dated as of June 3, 2015 among Bio-Reference Laboratories, Inc., OPKO Health, Inc. and Marc D. Grodman

10.2 Employment Agreement dated as of June 3, 2015 between Bio-Reference Laboratories, Inc. and Nicholas Papazicos

99.1 Joint News Release of Bio-Reference Laboratories, Inc. and OPKO Health, Inc. dated June 3, 2015

(1) The exhibits to the Agreement and Plan of Merger have been omitted from this filing pursuant to Item 601(b)(2) of Regulation S-K. The Company will furnish copies of any such schedules and exhibits to the U.S. Securities and Exchange Commission upon request.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: June 4, 2015	Bio-Reference Laboratories, Inc.
Date: June 8, 2015	Bio-Reference Laboratories, Inc.
	By:	/s/ Marc D. Grodman
		Name: Marc D. GrodmanTitle: Chairman of the Board, President and Chief Executive Officer
		Name: Marc D. Grodman Title: Chairman of the Board, President and Chief Executive Officer

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