UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 6-K

REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934

For the month of May 2025.

____________________________________

Commission File Number: 001-40627

SOPHiA GENETICS SA

(Exact name of registrant as specified in its charter)

La Pièce 12

CH-1180 Rolle

Switzerland

(Address of principal executive office)

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F:

Form 20-F

Form 40-F

SIGNATURE

SOPHiA GENETICS SA (the “Company”) ~~provided~~today topublished its ~~shareholders~~Environmental, anSocial ~~invitation~~and toGovernance ~~the~~Impact ~~Company’s~~Summary ~~annual~~as ~~general~~per ~~meeting~~December of31, ~~shareholders.~~2024 ~~The~~(“2024 ~~annual~~ESG ~~general~~Impact ~~meeting~~Summary”). ofThe ~~shareholders~~2024 isESG ~~expected~~Impact toSummary ~~take~~is ~~place~~available on ~~June 18, 2025 at 8:00 a~~www.msophiagenetics.com, ~~EDT~~in ~~/ 2:00 p.m. CEST at~~ the ~~Company’s~~Investor ~~office~~Relations ~~at La Pièce 12, 1180 Rolle/VD, Switzerland~~section.

		SOPHiA GENETICS SA
Date:	May 816, 2025
		By:	/s/ Daan van Well
		Name:	Daan van Well
		Title:	Chief Legal and Regulatory Officer

EXHIBIT INDEX

Exhibit No.			Description
99.1			~~Invitation~~2024 toESG ~~the~~Impact ~~Annual General Meeting 2025~~Summary
99.2			Shareholder Annual General Meeting Notice 2025
99.3			Annual General Meeting Proxy Card (Broker) 2025
99.4			Annual General Meeting Proxy Card (Common Shareholder) 2025

Filing Compare · SOPHiA GENETICS SA