~~0001621221false00016212212025-11-172025-11-17iso4217:USDxbrli:sharesiso4217:USDxbrli:shares~~As filed with the Securities and Exchange Commission on March 20, 2026

As filed with the Securities and Exchange Commission on November 17, 2025

Registration No. 333-

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM S-1

REGISTRATION STATEMENT

UNDER THE SECURITIES ACT OF 1933

Artelo Biosciences, Inc.

(Exact name of registrant as specified in its charter)

Nevada	7389	33-1220924
(State or other jurisdiction ofincorporation or organization)	(Primary Standard IndustrialClassification Code Number)	(I.R.S. EmployerIdentification Number)
(State or other jurisdiction of incorporation or organization)	(Primary Standard Industrial Classification Code Number)	(I.R.S. Employer Identification Number)

505 Lomas Santa Fe, Suite 160

Solana Beach, CA USA

(858) 925-7049

(Address, including zip code, and telephone number, including area code, of registrant’s principal executive offices)

Gregory D. Gorgas

Chief Executive Officer and President

505 Lomas Santa Fe, Suite 160

Solana Beach, CA USA

(858) 925-7049

(Name, address, including zip code, and telephone number, including area code, of agent for service)

Copies to:

Martin J. Waters Robert L. Wernli, Jr., Wilson Sonsini Goodrich & Rosati, P.C. 12235 El Camino Real San Diego, CA 92130 (858) 350-2300

Louis A. Bevilacqua		Morris C. Zarif, Esq.
Bevilacqua PLLC		Zarif Law Group P.C.
1050 Connecticut Ave., NW		808 Springwood Avenue
Suite 500		Suite 110
Washington, DC 20036		Asbury Park, NJ 07711
(202)869-0888		(732) 755-0146

Approximate date of commencement of proposed sale to the public: As soon as practicable after this registration statement becomes effective.

If any of the securities being registered on this form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box. ☒

If this form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

If this form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

If this form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer

☐

Accelerated filer

☐

Non-accelerated filer

☒

Smaller reporting company

☒

Emerging growth company

☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period with any new or revised accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

The registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically states that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933, as amended, or until the registration statement shall become effective on such date as the Securities and Exchange Commission acting pursuant to such Section 8(a) may determine.

The information in this preliminary prospectus is not complete and may be changed. We may not sell these securities until the registration statement filed with the Securities and Exchange Commission is effective. This preliminary prospectus is not an offer to sell these securities, and we are not soliciting an offer to buy these securities in any state where the offer or sale is not permitted.

Subject to completion, dated November 17, 2025

PRELIMINARY PROSPECTUS

Subject to completion, dated March 20, 2026

Artelo Biosciences, Inc.

~~RESALE~~1,641,587 OFShares UPof TOCommon ~~899~~Stock or Pre-Funded Warrants to Purchase 1,~~972~~641,587 ~~SHARES~~Shares OFof ~~COMMON~~Common ~~STOCK~~Stock,

~~This~~Placement ~~prospectus~~Agent ~~relates~~Warrants to ~~the~~Purchase ~~offer and resale, from time to time, by the selling securityholders named in this prospectus (the “Selling Securityholders”) of~~ up to ~~an aggregate of 899~~131,~~972~~327 ~~shares~~Shares of ~~common stock, par value $0.001 per share (“~~Common Stock”), of Artelo Biosciences, Inc., consisting of (i) 215,292 shares of Common Stock issuable upon the conversion of convertible notes (the “Notes”), (ii) 246,498 shares of Common Stock issuable upon the exercise of warrants at an exercise price of $6.24 per share (the “$6.24 Warrants”), and (iii) 438,182 shares of Common Stock issuable upon the exercise of warrants at an exercise price of $3.40 per share (the “$3.40 Warrants”). The $6.24 Warrants and the $3.40 Warrants are collectively referred to herein as the “Warrants.” The shares of Common Stock issuable upon the conversion of the Notes and the Warrants are collectively referred to herein as the “Shares.”

The $6.24 Warrants were issued to the Selling Securityholders on October 28, 2025, upon the automatic conversion of a portion of the May 2025 Notes (as defined below) issued to the Selling Securityholders in a private placement that closed on May 1, 2025 (the “May 2025 Private Placement”), pursuant to a subscription agreement that we entered into with the Selling Securityholders, effective May 1, 2025 (the “May 2025 Subscription Agreement”). The Notes and the $3.40 Warrants were issued and sold to the Selling Securityholders in a private placement that closed on October 28, 2025 (the “October 2025 Private Placement”), pursuant to a subscription agreement among us and such selling stockholders effective October 28, 2025 (the “October 2025 Subscription Agreement,” and together with the May 2025 Subscription Agreement, the “Subscription Agreements”). We are filing the registration statement of which this prospectus is a part pursuant to the Subscription Agreements on behalf of the Selling Securityholders.

WeUp ~~will~~to ~~not receive any proceeds from the sale of the Shares by the Selling Securityholders. We will~~1, ~~however~~772,914 ~~receive~~Shares ~~the net proceeds~~ of ~~any~~Common ~~Warrants~~Stock ~~exercised~~Underlying ~~for cash. Our registration of~~ the ~~Shares~~Pre-Funded ~~covered~~Warrants byand ~~this~~Placement ~~prospectus~~Agent ~~does not mean that the Selling Securityholders will offer or sell any of the Shares.~~Warrants

We ~~will~~are ~~bear~~offering ~~all~~on ~~costs,~~a ~~expenses~~best ~~and~~efforts ~~fees~~basis inup ~~connection~~to ~~with~~1,641,587 ~~the~~shares ~~registration~~ of ~~the~~our ~~Shares.~~common ~~The~~stock, ~~Selling~~par ~~Securityholders~~value ~~will~~$0.001 ~~bear~~per ~~all commissions and discounts~~share, ifat ~~any,~~an ~~attributable~~assumed topublic ~~their~~offering ~~sales~~price of ~~the Shares~~$7.31, ~~The~~which ~~Selling~~was ~~Securityholders and any of their permitted transferees may offer and sell~~ the ~~shares~~last ~~covered~~reported bysale ~~this~~price ~~prospectus in a number~~ of ~~different~~our ~~ways~~common ~~and~~stock aton ~~varying prices.~~ The ~~Securities~~Nasdaq ~~and~~Capital ~~Exchange~~Market ~~Commission~~tier ~~may take a position that each~~ of the ~~Selling~~Nasdaq ~~Securityholders~~Stock isMarket anLLC ~~“underwriter” within the meaning of Section 2~~(~~a)(11) of the Securities Act of 1933, as amended (the~~ “~~Securities Act~~Nasdaq”). ~~Additional information~~ on ~~the~~March ~~Selling Securityholders~~18, and the times and manner in which they may offer and sell shares of our Common Stock under this prospectus, is provided under “Selling Securityholders” and “Plan of Distribution” in this prospectus2026.

~~Our~~We ~~Common~~are ~~Stock~~also isoffering ~~traded~~to onthose purchasers, if any, whose purchase of shares of our common stock in this offering would otherwise result in such purchaser, together with its affiliates and certain related parties, beneficially owning more than 4.99% (or, at the ~~Nasdaq~~election ~~Capital~~of ~~Market~~the ~~under~~purchaser, 9.99%) of our outstanding shares of common stock immediately following the ~~symbol~~consummation ~~“ARTL~~of this offering, the opportunity to purchase, if any such purchaser so chooses, pre-funded warrants to purchase shares of common stock in lieu of shares of common stock that would otherwise result in such purchaser’s beneficial ownership exceeding 4.”99% ~~The~~(or, ~~last~~at ~~reported~~the ~~sales~~election ~~price~~of the purchaser, 9.99%) of our outstanding shares of ~~Common~~common ~~Stock~~stock. onThe ~~November~~purchase 14price of each pre-funded warrant will be equal to the price per share of common stock being sold to the public in this offering, ~~2025~~minus ~~was~~$0.001, and the exercise price of each pre-funded warrant will be $10.85001 per share. The pre-funded warrants will be immediately exercisable and may be exercised at any time until all of the pre-funded warrants are exercised in full. For each pre-funded warrant we sell, the number of shares of common stock we are offering will be decreased on a one-for-one basis. The shares of common stock issuable from time to time upon exercise of the pre-funded warrants are also being offered by this prospectus.

Our common stock is listed on Nasdaq under the symbol “ARTL.” The last reported sales price of our shares of common stock on March 18, 2026 was $7.31 per share. The actual public offering price per share or per pre-funded warrant, as the case may be, will be determined between us, the placement agent and the investors in the offering, and may be at a discount to the current market price of our common stock. Therefore, the assumed public offering price used throughout this prospectus may not be indicative of the final offering price. There is no established public trading market for the pre-funded warrants, and we do not expect such a market to develop. In addition, we do not intend to apply for a listing of the pre-funded warrants on any national securities exchange or other nationally recognized trading system.

OnThe ~~June~~shares ~~11,~~of ~~2025,~~common westock ~~filed~~and apre-funded ~~Certificate~~warrants ofwill ~~Change~~be ~~(the~~offered ~~“Certificate~~at ofa ~~Change”)~~fixed price and are expected to ~~our~~be ~~Amended~~issued ~~and~~in ~~Restated~~a ~~Articles~~single closing. There is no minimum number of ~~Incorporation~~securities ~~(as~~or ~~amended,~~minimum ~~the~~aggregate ~~“Articles~~amount of ~~Incorporation”)~~proceeds ~~with~~for this offering to close. However, notwithstanding the ~~Secretary~~foregoing, ofthe ~~State~~shares of ~~Nevada~~our tocommon ~~effect~~stock aunderlying 1any pre-~~for-6~~funded ~~reverse~~warrants ~~stock~~will ~~split~~be ofoffered on a continuous basis pursuant to Rule 415 under the ~~shares~~Securities Act of ~~our~~1933, ~~Common~~as ~~Stock~~amended. ~~either~~This ~~issued~~offering ~~and~~will ~~outstanding,~~be ~~held~~completed bynot uslater asthan ~~treasury~~[ ~~stock~~], 2026, and ~~authorized,~~we ~~effective~~will asdeliver ofall ~~2:01~~securities ~~a.m.~~to ~~(Eastern~~be ~~time)~~issued onin ~~June~~connection 13with this offering delivery versus payment or receipt versus payment, ~~2025~~as (the ~~“Reverse~~case ~~Stock~~may ~~Split”).~~be, ~~All~~upon ~~Common~~receipt ~~Stock~~of ~~share~~investor ~~and~~funds ~~per~~received ~~share~~by ~~amounts~~us. inAccordingly, ~~this~~neither ~~prospectus~~we nor the placement agent have ~~been~~made ~~adjusted~~any arrangements to ~~give~~place ~~effect~~investor tofunds in an escrow account or trust account since the ~~Reverse~~placement ~~Stock~~agent ~~Split~~will ~~unless~~not ~~otherwise~~receive ~~stated~~investor funds in connection with the sale of the securities offered hereunder.

~~You~~We ~~should~~have ~~read~~engaged Craft Capital Management LLC (the “placement agent” or “Craft Capital”) to act as our exclusive placement agent in connection with this offering. The placement agent has agreed to use its reasonable best efforts to solicit offers to purchase the securities offered by this prospectus. The placement agent is not purchasing or selling any of the securities we are offering, ~~together~~and ~~with~~the ~~additional~~placement ~~information~~agent ~~described~~is ~~under~~not required to arrange the ~~heading~~purchase ~~“Where~~or ~~You~~sale ~~Can~~of ~~Find~~any ~~More~~specific ~~Information”~~number ~~carefully~~or ~~before~~dollar ~~you~~amount ~~invest~~of securities. Because there is no minimum offering amount required as a condition to closing in this offering, the actual offering amount, placement agent’s fee and proceeds to us, if any, are not presently determinable and may be substantially less than the total maximum offering amounts described throughout this prospectus. We have agreed to pay the placement agent, the placement agent fees set forth in the table below and to provide certain other compensation to the placement agent. See “Plan of ~~our~~Distribution” ~~securities~~for more information regarding these arrangements.

We are a “smaller reporting company” as defined under the federal securities laws and, as such, we may continue to elect to comply with certain reduced public company reporting requirements in future reports.

Investing in our securities involves a high degree of risk. See “Risk Factors” beginning on page 811 of this prospectus ~~and~~, as well as the risk factors contained in our most recent Annual Report on Form 10-K for the ~~other~~year ~~documents~~ended ~~that~~December ~~are~~31, ~~incorporated~~2025, byany ~~reference~~subsequent ~~into~~Annual ~~this~~Reports ~~prospectus~~on ~~before~~Form ~~purchasing~~10-K, any ofsubsequent ~~the~~Quarterly ~~shares~~Reports ~~offered~~on Form 10-Q, which are incorporated by reference into this prospectus.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or determined if this prospectus is truthful or complete. Any representation to the contrary is a criminal offense.

The date of this prospectus is November 17, 2025

Per Share

Per Pre-

Funded

Warrant

Total⁽²⁾

Public offering price

Placement agent fees⁽¹⁾

Proceeds, before expenses, to us

	(1)	The placement agent fees shall be 8.0% of the gross proceeds of the securities sold by us in this offering. In addition, we have agreed to issue to the placement agent, on the applicable closing date of this offering, warrants in an amount equal to 8.0% of the aggregate number of shares of common stock and pre-funded warrants sold by us in this offering (the “Placement Agent Warrants”). See “Plan of Distribution” for a description of compensation payable to the placement agent and “Description of Securities–Placement Agent Warrants” for additional information regarding the Placement Agent Warrants.

	(2)	Because there is no minimum number of securities or amount of proceeds required as a condition to closing in this offering, the actual public offering amount, placement agent fees, and proceeds to us, if any, are not presently determinable and may be substantially less than the total maximum offering amounts set forth above. For more information, see “Plan of Distribution.”

Delivery of the securities offered hereby is expected to be made on or about [ ], 2026, subject to satisfaction of certain customary closing conditions.

Craft Capital Management LLC

The date of this prospectus is [ ], 2026

TABLE OF CONTENTS

		Page
SUMMARY		1
SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS		8
RISK FACTORS		9
SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS		13
USE OF PROCEEDS		13
USE OF PROCEEDS		14
DIVIDEND POLICY		13
DIVIDEND POLICY		15
CAPITALIZATION		14
SELLING SECURITYHOLDERS		16
DILUTION		16
PLAN OF DISTRIBUTION		19
PRINCIPAL STOCKHOLDERS		17
PRINCIPAL STOCKHOLDERS		21
DESCRIPTION OF SECURITIES WE ARE OFFERING		19
DESCRIPTION OF CAPITAL STOCK		23
PLAN OF DISTRIBUTION		23
MATERIAL U.S. FEDERAL INCOME TAX CONSEQUENCES TO NON-U.S. HOLDERS		26
LEGAL MATTERS		27
LEGAL MATTERS		31
EXPERTS		27
EXPERTS		31
WHERE YOU CAN FIND MORE INFORMATION		27
WHERE YOU CAN FIND MORE INFORMATION		31
INCORPORATION OF CERTAIN INFORMATION BY REFERENCE		28
INCORPORATION OF CERTAIN INFORMATION BY REFERENCE		32

iii

Table of Contents

ABOUT THIS PROSPECTUS

AsUnless ~~used in this prospectus, unless~~ the context ~~otherwise~~clearly ~~requires or~~ indicates otherwise, references toin ~~“the~~this ~~Company,”~~prospectus to “we,” “our,” “~~ourselves~~ours,” “us,” the “Company” and “Artelo” refer to Artelo Biosciences, Inc.

This prospectus is part of a registration statement on Form S-1 that we filed with the Securities and Exchange Commission (the “SEC”), ~~under~~for ~~which~~ the ~~Selling~~offering ~~Securityholders~~by ~~may,~~us ~~from~~of ~~time~~our ~~to time, sell the~~ securities ~~described in this prospectus in one or more offerings or otherwise described under “Plan of Distribution~~.”

WeYou ~~may~~should ~~also~~not ~~file~~assume athat ~~prospectus supplement or post-effective amendment to~~ the ~~registration~~information ~~statement~~contained ofin ~~which~~ this prospectus ~~forms~~is aaccurate ~~part~~on ~~that~~any ~~may~~date ~~contain~~subsequent ~~material information relating~~ to ~~these~~the ~~offerings.~~date ~~Such~~set ~~prospectus~~forth ~~supplement~~on orthe ~~post-effective~~front ~~amendment~~cover ~~may~~of ~~also~~this ~~add~~prospectus, ~~update~~even orthough ~~change information contained in~~ this prospectus ~~with~~is ~~respect~~delivered toor ~~that~~our ~~offering.~~securities Ifregistered ~~there~~under isthe ~~any~~registration ~~inconsistency~~statement ~~between~~of ~~the~~which ~~information in~~ this prospectus ~~and~~forms ~~the~~a ~~applicable~~part ~~prospectus~~are ~~supplement~~sold or ~~post-effective~~otherwise ~~amendment,~~disposed ~~you~~of ~~should rely~~ on ~~the~~a ~~prospectus~~later ~~supplement~~date. orIt ~~post-effective~~is ~~amendment,~~important asfor ~~applicable.~~you ~~Before~~to ~~purchasing~~read ~~any~~and ~~securities,~~consider ~~you~~all ~~should~~information ~~carefully~~contained ~~read~~in this prospectus, ~~any~~in ~~post-effective~~making ~~amendment,~~your ~~and~~investment ~~any~~decision. ~~applicable~~You ~~prospectus~~should ~~supplement,~~also ~~together~~read ~~with~~and consider the ~~additional~~ information ~~described~~in the documents to which we have referred you under the ~~headings~~captions “Where You Can Find ~~More~~Additional Information” ~~and~~in ~~“Incorporation~~this ~~by Reference~~prospectus.”

Neither we, nor the ~~Selling~~placement ~~Securityholders,~~agent have authorized anyone to provide you with any information or to make any representations other than ~~those~~that contained in this prospectus, ~~any post-effective amendment,~~ or in any ~~applicable~~free writing prospectus ~~supplement~~we ~~prepared~~may byauthorize orto onbe ~~behalf~~delivered ofor usmade oravailable to ~~which we have referred~~ you. We ~~and the Selling Securityholders~~ take no responsibility for, and can provide no assurance as to the reliability of, any other information that others may give you. ~~The~~This ~~Selling~~prospectus ~~Securityholders~~does ~~will~~ not ~~make~~constitute an offer to sell ~~these~~or ~~securities~~the insolicitation ~~any~~of ~~jurisdiction~~an ~~where the~~ offer orto ~~sale~~buy isany ~~not~~of ~~permitted.~~our ~~You~~securities ~~should~~other ~~assume~~than ~~that~~ the ~~information~~securities ~~appearing~~covered inhereby. ~~this~~Neither ~~prospectus,~~we ~~any~~nor ~~post-effective~~the ~~amendment~~placement ~~and~~agent ~~any~~are ~~applicable~~making ~~prospectus~~an ~~supplement~~offer to ~~this~~sell ~~prospectus~~securities isin ~~accurate~~any ~~only~~jurisdiction asin ofwhich the ~~date~~offer onor ~~its~~sale ~~respective~~is ~~cover~~not ~~and~~permitted. ~~that~~The ~~any~~ information ~~incorporated~~in bythis ~~reference~~prospectus is accurate only as of the date ofon the ~~document~~front ~~incorporated~~cover byof ~~reference~~this orprospectus, inregardless ~~each~~of ~~case,~~the ~~any~~time ~~earlier~~of ~~date~~delivery ~~specified~~of ~~for~~this ~~such~~prospectus ~~information,~~or ~~unless~~of weany ~~indicate~~sale ~~otherwise.~~of ~~Our~~our ~~business,~~shares ~~financial condition, results~~ of ~~operations~~common stock and ~~prospects may have changed since those dates. To~~ the ~~extent there is a conflict between the~~ information ~~contained~~ in ~~this~~any ~~prospectus,~~free onwriting ~~the~~prospectus ~~one~~that ~~hand,~~we ~~and~~may ~~the~~provide ~~information~~to ~~contained~~you in ~~any~~connection ~~document~~with ~~incorporated~~this byoffering ~~reference~~is ~~filed~~accurate ~~with~~only ~~the~~as ~~SEC~~of ~~before~~ the date of ~~this~~that ~~prospectus,~~free onwriting ~~the other hand, you should rely on the information in this~~ prospectus. IfOur ~~any~~business, ~~statement~~financial ~~in a document incorporated by reference is inconsistent with a statement in another document incorporated by reference having a later date~~condition, ~~the~~results ~~statement~~of inoperations ~~the~~and ~~document~~prospects ~~having~~may ~~the~~have ~~later~~changed ~~date~~since ~~modifies~~those ~~or supersedes the earlier statement~~dates.

~~This~~For ~~prospectus~~investors ~~incorporates~~outside bythe ~~reference,~~United ~~and~~States: ~~any~~We ~~post-effective~~have ~~amendment~~not, orand ~~any~~the ~~prospectus~~placement ~~supplement~~agent ~~may~~has ~~contain or incorporate by reference~~not, ~~market~~done ~~data~~anything ~~and industry statistics and forecasts~~ that ~~are~~would ~~based~~permit onthis ~~independent industry publications and other publicly available information. Although we believe these sources are reliable~~offering, ~~neither~~or wepossession ~~nor the Selling Securityholders guarantee the accuracy~~ or ~~completeness~~distribution of this ~~information~~prospectus, ~~and~~in ~~neither~~any wejurisdiction ~~nor~~where ~~the~~action ~~Selling~~for ~~Securityholders~~that ~~have~~purpose ~~independently~~is ~~verified~~required, ~~this~~other ~~information.~~than Inin ~~addition,~~ the ~~market~~United ~~and~~States. ~~industry~~Persons ~~data~~outside ~~and~~the ~~forecasts~~United ~~that~~States ~~may~~who become ~~included~~into orpossession ~~incorporated~~of ~~by reference in~~ this prospectus, ~~any~~must ~~post-effective~~inform ~~amendment~~themselves ~~or any prospectus supplement may involve estimates~~about, ~~assumptions~~ and ~~other~~observe ~~risks~~any ~~and~~restrictions ~~uncertainties~~relating ~~and are subject~~ to ~~change based on various factors~~, ~~including~~the ~~those~~offering ~~discussed~~of ~~under~~ the ~~heading~~shares ~~“Risk~~of ~~Factors”~~common ~~contained~~stock ~~in this prospectus, any post-effective amendment~~ and ~~any~~the ~~applicable~~distribution ~~prospectus~~of ~~supplement, and under similar headings in other documents that are incorporated by reference into~~ this prospectus. ~~Accordingly,~~outside ~~investors~~of ~~should~~the ~~not~~United ~~place undue reliance on this information~~States.

We obtained certain statistical data, market data and other industry data and forecasts used in this prospectus from publicly available information. While we believe that the statistical data, industry data, forecasts and market research are reliable, we have not independently verified the data, and we do not make any representation as to the accuracy of the information.

This prospectus contains forward-looking statements that are subject to a number of risks and uncertainties, many of which are beyond our control. Please read “~~Cautionary~~Special Note Regarding Forward- Looking Statements” and “Risk Factors”.

Table of Contents

SUMMARY This summary is not complete and does not contain all of the information that you should consider before investing in the securities offered by this prospectus. You should read this summary together with the entire prospectus carefully, including “Risk Factors” and our financial statements and the related notes incorporated by reference into this prospectus, before making an investment decision. See “Risk Factors” for a discussion of the risks involved in investing in our securities. Corporate Overview We incorporated in the State of Nevada on May 2, 2011, and are presently based in the County of San Diego, California. We are a clinical stage biopharmaceutical company focused on the development and commercialization of therapeutics that target lipid-signaling modulation pathways, including the endocannabinoid system (the “ECS”), a network of receptors and neurotransmitters that form a biochemical communication system throughout the body. Our product candidate pipeline broadly leverages leading scientific methodologies and balances risk across mechanisms of action and stages of development. Our programs represent a comprehensive approach in utilizing the power and promise of lipid signaling to develop pharmaceuticals for patients with unmet healthcare needs. We are currently developing a novel, benzimidazole dual cannabinoid (CB) agonist that targets both the CB1 and CB2 peripheral receptors. This synthetic small molecule program is a G protein-coupled receptor (“GPCR”) designated ART27.13 and was initially developed by AstraZeneca plc. We are developing ART27.13 as a potential treatment for cancer-related anorexia and it is currently in a Phase 1b/2a trial, titled the Cancer Appetite Recovery Study (“CAReS”). In an interim analysis of the on-going Phase 2a CAReS trial, patients with cancer anorexia receiving ART27.13 demonstrated a mean weight gain of over 6% compared to a 5% loss in the placebo group, while maintaining a safety profile similar to the Phase 1b despite doses up to twice the previous maximum. Currently there is no FDA approved treatment for cancer anorexia cachexia syndrome. Our second program, ART26.12 is a small molecule and the lead product candidate from our chemical library of inhibitors of fatty acid binding proteins, notably Fatty Acid Binding Protein 5 (“FABP5”). We received U.S. Food & Drug Administration (the “FDA”) clearance for our Investigational New Drug (“IND”) application for ART26.12 in July 2024 and have completed enrolment to a Phase 1 clinical trial in healthy subjects to support the development towards an agent intended to treat chemotherapy-induced peripheral neuropathy (“CIPN”). In addition, ART26.12 may have broad applications as a cancer therapeutic, as a treatment for dermatologic conditions, such as psoriasis, as a treatment for pain and inflammation, and potential use in anxiety-related disorders, including post-traumatic stress disorder. In June 2025, we announced favorable results from our first-in-human study evaluating ART26.12. The Phase 1 Single Ascending Dose (SAD) study was designed to assess the safety, tolerability, and pharmacokinetics of ART26.12 in healthy volunteers and enrolled 49 subjects. All adverse events (AEs) were mild, transient, and self-resolving. No drug-related AEs were observed in the blinded dataset, and no tolerability issues or safety signals were detected across multiple assessments (vital signs, ECGs, clinical laboratory tests, physical examinations, and visual analogue mood scales). In addition, full dose-exposure profiles were successfully explored. Plasma analysis confirmed dose-dependent, linear absorption across the evaluated range. A wide safety margin was observed between estimated therapeutic plasma concentrations and the highest exposure levels achieved, supporting potential titration for maximum efficacy in future studies. WeIn ~~are~~addition ~~also~~to ~~developing~~ART26.12 in CIPN, our ~~own~~extensive ~~invention~~library ~~ART12.11~~of ~~(the~~small ~~“CBD~~molecule ~~cocrystal~~inhibitors of Fatty Acid Binding Proteins (“FABPs”) has shown therapeutic potential for the treatment of certain cancers, neuropathic and nociceptive pain, psoriasis, and anxiety disorders. ART12.11 is our ~~patented~~wholly ~~solid-state~~owned, proprietary cocrystal composition of cannabidiol (“CBD”) and tetramethylpyrazine (“TMP”). ~~TMP~~Isolated ~~serves~~ as ~~the~~a ~~coformer~~single incrystalline ~~the~~form, ART12.11 has exhibited better pharmacokinetics and improved efficacy compared to other forms of CBD ~~cocrystal~~in nonclinical studies. Greatly enhanced pharmaceutical properties, including physicochemical, pharmacokinetic, and pharmacodynamic advantages have been observed with ART12.11. We believe a more consistent and improved bioavailability profile may beultimately ~~considered~~lead byto ~~the~~increased ~~regulatory~~safety ~~authorities~~and asefficacy in humans, thus making ART12.11 a ~~fixed~~preferred ~~drug~~CBD ~~combination~~pharmaceutical ~~instead~~composition. The U.S. issued composition of amatter ~~new~~patent ~~chemical~~for ~~entity~~ART12.11 ~~(“NCE”)~~is enforceable until December 10, 2038 and has now been granted or validated in 21 additional countries. We obtained two of our patent protected product candidates through our in-licensing activities. Our first in-licensed program, ART27.13, is being developed for cancer-related anorexia. ART27.13 is a peripherally-selective high-potency dual CB1 and CB2 full-receptor agonist, which was originally invented at AstraZeneca plc ~~(“AstraZeneca”)~~. We exercised our option to exclusively license this product candidate through the NEOMED Institute (“NEOMED”), a Canadian not-for-profit corporation, renamed adMare Bioinnovations (“adMare”) in June 2019, which had obtained rights to ART27.13 from AstraZeneca plc. In Phase 1, single dose studies in healthy volunteers and a multiple ascending dose study in individuals with chronic low back pain conducted by AstraZeneca plc, ART27.13 exhibited an attractive pharmacokinetic and absorption, distribution, metabolism, and excretion profile and was well tolerated within the target exposure range. It also exhibited dose-dependent and potentially clinically meaningful increases in body weight. Importantly, the changes in body weight were not associated with fluid retention or other adverse effects and occurred at exposures without central nervous system (“CNS”) side effects. Discussions with United Kingdom (“UK”), U.S. and Canadian regulators ~~indicate~~indicated there is a potential pathway for development of ART27.13 for the treatment of cancer-related anorexia, which affects approximately 60% of advanced stage cancer patients.

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We commenced enrollment and dosed the first patient in CAReS, our Phase 1b/2a clinical study of cancer-related anorexia with ART27.13 in April 2021 and completed enrolling patients in the Phase 1b during the first quarter of 2023. Data from the Phase 1b stage was used to determine the most effective and safe dose selected as the starting dose for the Phase 2a portion of CAReS. We received approval from the regulatory authorities in the UK, Ireland and Norway to increase the daily dose from the starting dose of 650 micrograms to 1,000 micrograms after 4 weeks and up to 1,300 micrograms initiated at 8 weeks in patients for whom intra-patient dose escalation is expected to be well tolerated. We also received approval from the regulatory authorities to enroll 40 evaluable patients into the Phase 2a stage with a 3:1 randomization of ART27.13 to placebo. We initiated the Phase 2a portion of CAReS during April 2023. Aswith ~~of May 6, 2025,~~ 18 clinical sites across five countries ~~were open for enrollment~~. As of ~~June~~December 3031, 2025, 32 participants have been enrolled. On September 3, 2025, we announced interim results from the Phase 2a CAReS trial. In the interim analysis, 18 evaluable patients-—primarily with lung and gastrointestinal cancers not receiving cyclic chemotherapy-—were included. After 12 weeks of treatment in patients who were titrated to the top dose evaluated of 1300 micrograms (n=5), ART27.13 demonstrated compelling increases in mean body weight of 6.38% (Standard Deviation or SD 9.50) compared to patients on placebo (n=6) who lost -5.42% (SD 8.17). The maximum weight gain in the ART27.13 group reached 18.5%, versus only 0.4% in placebo. The maximum weight loss in the placebo arm was -17.4%, compared to just -3.0% in the ART27.13 group. Additional benefits were seen in lean body mass, with a +4.23% increase (SD 5.37) in the treatment group versus a -3.15% loss (SD 4.89) in placebo at one month, as well as qualitative improvements in total and weekly activity scores. Safety results were consistent with prior findings. Among the 32 participants enrolled in the CAReS Phase 2 trial to date, 7 patients (22%) experienced adverse events that may be related to ART27.13. All were mild or moderate, with the exception of a single case of severe malaise, and no drug-related serious adverse events were reported. These data are aligned with safety outcomes observed in Phase 1 of CAReS, supporting ART27.13’s overall favorable tolerability and acceptable safety profile. Our second in-licensed patented program is being advanced from our platform of small-molecule inhibitors of ~~fatty acid binding proteins~~FABPs, notably FABP5. ~~Fatty acid binding proteins (“~~FABPs”) are attractive therapeutic targets, however, the high degree of sequence and structural similarities among family members made the creation of drugs targeting specific FABPs challenging. FABP5 is believed to specifically target and regulate one of the body’s endogenous cannabinoids, anandamide (“AEA”). While searching for a FABP5 inhibitor to regulate AEA, researchers at Stony Brook University (“SBU”) discovered the chemistry for creating a large library of compounds which we believe to be highly specific and potent small molecule inhibitors of FABP5 and other isoforms. SBU received approximately $8.0 million in funding from the National Institutes of Health to develop FABP5 inhibitor candidates including a $4.2 million grant in 2020 to advance research of FABP5 inhibition in prostate cancer. We licensed the rights to world-wide intellectual property in all fields and certain know-how to these inhibitors from SBU. Our lead FABP5 inhibitor program is designated ART26.12. Preclinical research with ART26.12 showed evidence of activity in multiple pain models including osteoarthritis, cancer bone pain, and neuropathic pain. Based upon positive preclinical evidence from five separate studies showing promising activity and a differentiated mechanism-of-action for the prevention and treatment of painful neuropathies, including diabetic neuropathy and ~~Chemotherapy Induced Peripheral Neuropathy (“~~CIPN”), we prioritized CIPN as the initial indication for development of ART26.12. Treatment and/or prevention of CIPN is a significant unmet need, often resulting in anti-cancer treatment delays or discontinuations, and there are currently no approved treatments for CIPN by the regulatory authorities in the U.S., UK or EU. We submitted an IND application for ART26.12 to the FDA on ~~10th of~~ June 10, 2024, and received a study may proceed notice from the FDA on ~~the 8th of~~ July 8, 2024. First-in-human studies for ART26.12 began in Q4 of 2024 and we successfully completed dosing all 48 healthy volunteers planned for the Phase 1 Single Ascending Dose study at the end of April 2025. In addition to its potential as a synthetic endocannabinoid modulator with development targeting pain, inflammation, dermatologic conditions such as psoriasis, FABP5 is understood to play an important role in lipid signaling and is believed to be an attractive strategy for drug development in oncology. Large amounts of human biomarker and animal model data support FABP5 as an oncology target, including triple negative breast cancer, ovarian cancer, cervical cancer, and castration-resistant prostate cancer. Through our sponsored research we have also subsequently identified a potential role for FABP5 inhibition to treat anxiety disorders, such as Post Traumatic Stress Disorder (“PTSD”). We have been awarded a research grant in Canada to expand on our earlier research at the University of Western Ontario in this new development area.

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In addition to our in-licensed programs, we have internal discovery research initiatives which resulted in ART12.11, a proprietary cocrystal composition of CBD and TMP. The crystal structure of CBD is known to exhibit solid polymorphism, or the ability to manifest in different forms. Polymorphism can adversely affect stability, dissolution, and bioavailability of a drug product and thus may affect its quality, safety, and efficacy. Based upon our research, we believe our CBD cocrystal exists as a single crystal form and as such is anticipated to have advantages over other solid forms of CBD that exhibit polymorphism. Emerging data demonstrates potential advantages of this single crystal structure, including improved stability, solubility, and a more consistent absorption profile. We believe these features have contributed to a more consistent and improved bioavailability and pharmacokinetic profile which may ultimately lead to improved safety and efficacy in human therapeutics, as already demonstrated in animal studies. Presently, we have two U.S. patents, one pending U.S. patent application, six foreign patents (Australia, Brazil, China, Mexico, Japan and Taiwan) and three pending foreign patent applications (Canada, Europe, and South Korea) directed to our cocrystal composition of CBD. Composition claims are generally known in the pharmaceutical industry as the most desired type of intellectual property and should provide for long lasting market exclusivity for our synthetic CBD cocrystal drug product candidate. In addition, due to the reasons outlined above, we believe that our synthetic CBD cocrystal will continue to demonstrate a superior set of pharmaceutical properties compared to non-cocrystal CBD compositions. We plan to develop ART12.11 for multiple potential indications where CBD has shown activity of such anxiety disorders, including PTSD, depression, and other possible uses such as epilepsy and insomnia. We are developing our product candidates in accordance with traditional regulated drug development standards and expect to make them available to patients via prescription or physician orders only after obtaining marketing authorization from a country’s regulatory authority, such as the FDA. Our management team has experience developing, commercializing, and partnering ethical pharmaceutical products, including several first-in-class therapeutics. Based upon our current management’s capabilities and the future talent we may attract, we plan to retain rights to internally develop and commercialize products; however, we may seek collaborations with partners in the biopharmaceutical industry when a partnering strategy serves to maximize value for our stockholders. Risk Factor Summary Investing in our securities involves a high degree of risk. You should carefully consider the risks described in the section entitled “Risk Factors” below, as well as other information and risk factors included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2024, as updated or supplemented on our quarterly reports on Form 10-Q or current reports on Form 8-K, including our financial statements and the related notes, and the section titled “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” any of which may be relevant to decisions regarding an investment in or ownership of our securities. The occurrence of any of these risks could have a significant adverse effect on our reputation, business, financial condition, results of operations, growth and ability to accomplish our strategic objectives. We have organized the description of these risks into groupings in an effort to enhance readability, but many of the risks interrelate or could be grouped or ordered in other ways, so no special significance should be attributed to the groupings or order below. Risks Related to This Offering
	·	Our financial condition raises substantial doubt as to our ability to continue as a going concern.
	·	Our Common Stock may be delisted from Nasdaq if we fail to regain and maintain compliance with continued listing standards.
	·	The sale or availability for sale of shares issuable pursuant to this prospectus may depress the price of our Common Stock, dilute the interest of our existing stockholders, and encourage short sales by third parties, which could further depress the price of our Common Stock.
	·	Any market activity involving short selling or other market making activities could result in negative impact to the market price for our Common Stock.
	·	We will need to raise additional capital to fund our planned future operations, and we may be unable to secure such capital without significant dilutive financing transactions, or at all. If we are not able to raise additional capital, we may not be able to complete the development, testing and commercialization of our drug candidates and will not be able to continue as a going concern.
	·	We have never paid dividends on our capital stock, and we do not anticipate paying dividends in the foreseeable future.
	·	The market price of our shares may be subject to fluctuation and volatility. You could lose all or part of your investment.

In addition to our in-licensed programs, we have internal discovery research initiatives which resulted in ART12.11, a proprietary cocrystal composition of CBD and TMP. The crystal structure of CBD is known to exhibit solid polymorphism, or the ability to manifest in different forms. Polymorphism can adversely affect stability, dissolution, and bioavailability of a drug product and thus may affect its quality, safety, and efficacy. Based upon our research, we believe our CBD cocrystal exists as a single crystal form and as such is anticipated to have advantages over other solid forms of CBD that exhibit polymorphism. Emerging data demonstrates potential advantages of this single crystal structure, including improved stability, solubility, and a more consistent absorption profile. We believe these features have contributed to a more consistent and improved bioavailability and pharmacokinetic profile which may ultimately lead to improved safety and efficacy in human therapeutics, as already demonstrated in animal studies.

Presently, we have two U.S. patents, one pending U.S. patent application, six foreign patents (Australia, Brazil, China, Mexico, Japan and Taiwan) and three pending foreign patent applications (Canada, Europe, and South Korea) directed to our cocrystal composition of CBD. Composition claims are generally known in the pharmaceutical industry as the most desired type of intellectual property and should provide for long lasting market exclusivity for our synthetic CBD cocrystal drug product candidate. In addition, due to the reasons outlined above, we believe that our synthetic CBD cocrystal will continue to demonstrate a superior set of pharmaceutical properties compared to non-cocrystal CBD compositions. We plan to develop ART12.11 for multiple potential indications where CBD has shown activity of such anxiety disorders, including PTSD, depression, and other possible uses such as epilepsy and insomnia.

We are developing our product candidates in accordance with traditional regulated drug development standards and expect to make them available to patients via prescription or physician orders only after obtaining marketing authorization from a country’s regulatory authority, such as the FDA. Our management team has experience developing, commercializing, and partnering ethical pharmaceutical products, including several first-in-class therapeutics. Based upon our current management’s capabilities and the future talent we may attract, we plan to retain rights to internally develop and commercialize products; however, we may seek collaborations with partners in the biopharmaceutical industry when a partnering strategy serves to maximize value for our stockholders.

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Risks Related to our Business and Product Candidates
Risk Factor Summary Investing in our securities involves a high degree of risk. You should carefully consider the risks described in the section entitled “Risk Factors” below, as well as other information and risk factors included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2025, as updated or supplemented on our Quarterly Reports on Form 10-Q or Current Reports on Form 8-K, including our financial statements and the related notes, and the section titled “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” any of which may be relevant to decisions regarding an investment in or ownership of our securities. The occurrence of any of these risks could have a significant adverse effect on our reputation, business, financial condition, results of operations, growth and ability to accomplish our strategic objectives. Risks Related to This Offering
	·	WeThe ~~will~~public ~~need~~offering toprice ~~raise additional financing to support our business objectives. We cannot be sure we~~ will be ~~able~~set toby ~~obtain~~our ~~additional~~board ~~financing~~of ondirectors ~~terms~~and ~~favorable~~does tonot usnecessarily ~~when~~indicate ~~needed,~~the actual or atmarket ~~all.~~value Ifof ~~we are unable to obtain additional financing to meet~~ our ~~needs,~~shares ~~our~~of ~~operations~~common ~~may be adversely affected or terminated~~stock.
	·	WeOur ~~are~~management ~~currently~~will ~~receiving~~have ~~Research~~broad ~~and~~discretion ~~Development,~~as orto ~~R&D, tax credits from~~ the UKuse inof ~~connection with our clinical trials being conducted in~~ the ~~UK.~~proceeds ~~With~~from ~~effect~~this ~~for accounting periods starting on or after April 1~~offering, ~~2024,~~and ~~expenditure~~may onnot ~~certain~~use ~~staffing costs in connection with activities which take place outside~~ the UKproceeds ~~as part of our clinical trials, will not qualify for R&D tax credits unless restrictive conditions are met~~effectively.
	·	IfThere weis ~~fail~~no topublic ~~comply~~market ~~with~~for ~~our~~the ~~obligations~~pre-funded ~~under~~warrants ~~our~~being ~~patent~~offered ~~licenses~~in ~~with~~this ~~third parties, we could lose license rights that are vital to our business~~offering.
	·	~~Changes~~Holders of pre-funded warrants purchased in ~~regulatory~~this ~~requirements~~offering orwill ~~other~~have ~~unforeseen~~no ~~circumstances~~rights ~~may~~as ~~impact~~stockholders ~~the~~of ~~timing~~shares of ~~the~~common ~~initiation~~stock oruntil ~~completion~~such ofholders exercise their pre-funded warrants and acquire our ~~clinical~~shares ~~trials~~of common stock, except as set forth in the pre-funded warrants.
	·	WeThe ~~face~~pre-funded ~~many~~warrants ofare ~~the~~speculative ~~risks~~in ~~and difficulties frequently encountered by relatively new companies with respect to our operations~~nature.
	·	WeThis ~~have~~is a best efforts offering, no ~~mature~~minimum ~~product~~amount ~~candidates~~of securities is required to be sold, and we may not beraise ~~successful~~the inamount ~~licensing~~of ~~any~~capital we believe is required for our business plans.
	·	~~Even~~You ifwill weexperience ~~are~~immediate ~~successful~~and insubstantial ~~licensing~~dilution ~~lead~~as ~~product~~a ~~candidates,~~result ~~resource~~of ~~limitations~~this ~~may~~offering ~~limit~~and ~~our~~may ~~ability~~experience toadditional ~~successfully~~dilution ~~develop~~in ~~them~~the future.
Risks Related to our Intellectual Property
	·	Our common stock may be delisted from Nasdaq if we fail to comply with continued listing standards.
	·	IfPurchasers wewho ~~are~~purchase ~~unable to obtain and maintain patent protection for~~ our ~~products,~~securities ~~our~~in ~~competitors~~this ~~could~~offering ~~develop~~pursuant ~~and~~to ~~commercialize~~a ~~products~~securities ~~and~~purchase ~~technology~~agreement ~~similar~~may orhave ~~identical~~rights tonot ~~our~~available ~~product candidates, and our ability~~ to ~~successfully~~purchasers ~~commercialize~~that ~~any~~purchase ~~product~~without ~~candidates~~the webenefit ~~may~~of ~~develop,~~a ~~and~~securities ~~our~~purchase ~~science may be adversely affected~~agreement.
	·	~~Obtaining~~The ~~and~~market ~~maintaining~~price of our ~~patent~~shares ~~protection~~may ~~depends~~be onsubject ~~compliance~~to ~~with~~fluctuation ~~various procedural measures, document submissions, fee payments~~ and ~~other~~volatility. ~~requirements~~You ~~imposed by government patent agencies, and our patent protection~~ could belose ~~reduced~~all or ~~eliminated~~part ~~for~~of ~~non-compliance~~your ~~with these requirements~~investment.
	·	We may be subject to claims challenging the inventorship of our patents and other intellectual property.
	·	Intellectual property rights do not necessarily address all potential threats.
	·	Intellectual property litigation could cause us to spend substantial resources and distract our personnel from their normal responsibilities.
Risks Related to our Securities
	·	If we sell securities in future financings stockholders may experience immediate dilution and, as a result, our stock price may decline.
	·	The price of our securities may be volatile, and you could lose all or part of your investment. Further, we do not know whether an active, liquid and orderly trading market will continue for our securities or what the market price of our securities will be and as a result it may be difficult for you to sell your shares of our securities.
	·	Shares of our Common Stock that have not been registered under federal securities laws are subject to resale restrictions imposed by Rule 144, including those set forth in Rule 144(i) which apply to a former “shell company.”
	·	Sales of our currently issued and outstanding stock may become freely tradable pursuant to Rule 144 and sales of such shares may have a depressive effect on the share price of its Common Stock.

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~~May~~Recent ~~2025~~Developments ~~Private~~We ~~Placement~~reconvened ~~Effective~~our ~~May~~Annual 1Meeting of Stockholders (the “Annual Meeting”) on January 30, 2026, which was previously convened on December 31, 2025, weand ~~entered~~then ~~into~~adjourned, without conducting any business, due to insufficient votes to constitute a quorum. Of the ~~May~~2,018,746 ~~2025~~shares ~~Subscription~~of ~~Agreement~~our ~~with~~Common ~~each~~Stock, outstanding as of the ~~Selling~~record ~~Securityholders~~date ~~named~~of inDecember ~~this~~10, ~~prospectus~~2025, ~~pursuant~~1,017,816 toshares ~~which~~of wecommon ~~issued~~stock ~~and~~were ~~sold~~represented toat the ~~Selling~~Annual ~~Securityholders~~Meeting, ~~and~~either ~~the~~by ~~Selling~~proxy ~~Securityholders~~or ~~purchased~~by ~~convertible~~attending ~~notes (~~the ~~“May~~virtual ~~2025~~annual ~~Notes”)~~meeting, inconstituting, anof ~~aggregate~~the ~~principal~~shares ~~amount~~entitled ofto ~~$900~~vote,~~000.~~ Aapproximately ~~portion~~50.4% of the ~~May~~outstanding ~~2025~~shares ~~Notes~~of ~~was~~common ~~convertible~~stock. ~~into~~On ~~Common~~February ~~Stock~~2, at2026, ~~the~~Nasdaq’s ~~election~~Hearings ofPanel ~~each~~granted ~~Selling~~us ~~Securityholders,~~an ~~pursuant~~exception to ~~the~~cure ~~Voluntary~~our ~~Conversion~~continued listing deficiencies, requiring that we regain compliance with Nasdaq Listing Rule 5550(~~defined~~b)(1) ~~below~~(stockholders’ equity of at least $2,500,000) ~~and~~by ~~the~~March ~~remaining~~30, ~~portion~~2026, ofand ~~each~~cure ~~May~~our 2025 ~~Note~~annual ~~was~~meeting ~~converted~~deficiency ~~into~~under ~~the~~Nasdaq ~~$6.24~~Listing ~~Warrants~~Rule 5620(a). The ~~sale~~2025 ~~and~~annual ~~issuance~~meeting ofdeficiency ~~the~~was ~~May~~cured ~~2025~~as ~~Notes~~described ~~closed~~above. onOn ~~May~~March 15, ~~2025.~~2026, ~~The~~we ~~May~~filed ~~2025~~with ~~Notes~~the ~~accrued~~Secretary ~~interest~~of atState of the State of Nevada a ~~rate~~Certificate of ~~12%~~Change ~~per~~(the ~~annum.~~“Certificate ~~All~~of ~~unpaid~~Change”), ~~principal~~pursuant to Nevada Revised Statutes 78.209, ~~together~~to ~~with~~effect ~~any~~a ~~then~~one-for-three ~~unpaid~~(1-for-3) ~~and~~reverse ~~accrued~~stock ~~interest~~split (the “Reverse Split”) of the Company’s issued and ~~other~~outstanding ~~amounts~~common ~~payable~~stock. ~~thereunder,~~The Reverse Split was ~~due~~effective ~~and~~as ~~payable~~of 12:01 a.m. Eastern Time on ~~October~~March 2810, ~~2025~~2026 (~~the~~March ~~“May~~9, ~~2025~~2026, ~~Notes’~~at ~~Maturity~~9:01 ~~Date”)~~p.m. OnPacific Time) (the ~~May~~“Effective ~~2025~~Time”). ~~Notes’~~As ~~Maturity~~a ~~Date,~~result of the ~~Selling~~Reverse ~~Securityholder~~Split, ~~had~~each ~~the~~three ~~right~~ (at3) ~~the~~pre-split ~~Selling~~shares ~~Securityholder’s~~of ~~sole~~common ~~option)~~stock tooutstanding ~~convert~~automatically ~~all~~combined ofinto ~~that~~one ~~certain~~(1) ~~unpaid~~new ~~portions~~share of ~~principal~~common ~~and~~stock ~~accrued~~without ~~interest~~any action on the part of the ~~Selling~~holders, ~~Securityholder’s~~and ~~May~~the ~~2025~~number ~~Note~~of ~~into~~outstanding shares of ~~Common~~common ~~Stock~~stock ~~(the~~was ~~“Voluntary~~reduced ~~Conversion”)~~from 2,124,772 asto ~~provided~~approximately in736,127. ~~the~~The ~~May~~number ~~2025~~of ~~Notes.~~authorized ~~Should~~shares ~~the~~of ~~Selling~~common ~~Securityholder~~stock ~~not~~was ~~elect~~reduced ~~Voluntary~~from ~~Conversion~~500,000,000 ~~such~~to ~~portion~~166,666,667, ofwhile the ~~unpaid~~number ~~principal~~of ~~balance~~authorized ~~and~~shares ~~any~~of ~~accrued~~preferred ~~interest~~stock ofwas ~~each~~reduced ~~May~~from ~~2025~~69,444 ~~Note~~to ~~subject~~23,148. toThe ~~Voluntary~~common ~~Conversion~~stock ~~would~~par bevalue ~~immediately~~of ~~due~~$0.001 ~~and~~per ~~payable~~share inremained ~~cash~~unchanged after the Reverse Split. NoThe ~~Selling~~Reverse ~~Securityholder~~Split ~~elected~~was ~~their~~effected ~~right~~in order to ~~Voluntary~~improve ~~Conversion~~the marketability and liquidity of the Company’s common stock. ~~Further,~~On ~~each~~March ~~Selling~~12, ~~Securityholder~~2026, we entered into ~~the~~a ~~October~~securities ~~2025~~purchase ~~Subscription~~agreement ~~Agreement~~with ~~(as~~Vanquish ~~defined~~Funding ~~below)~~Group Inc., pursuant to which ~~they~~we ~~agreed~~issued toa ~~convert~~12% ~~all~~bridge ornote athat ~~portion~~matures ofon ~~the~~January ~~unconverted~~15, ~~“Voluntary~~2027, ~~Conversion”~~in ~~portion~~the aggregate principal amount of ~~unpaid~~$237,300, ~~principal~~which ~~balance~~includes ~~and~~an ~~accrued~~original ~~interest~~issue ~~due~~discount toof ~~the~~$27,300, ~~Selling~~for ~~Securityholders~~an aggregate purchase price of $210,000. Solely upon the ~~maturity~~occurrence and continuation of ~~the~~an ~~May~~Event ~~2025~~of ~~Notes~~Default ~~into~~(as defined in the ~~Notes.~~bridge Onnote), the ~~May~~buyer ~~2025~~shall ~~Notes’~~have ~~Maturity~~the ~~Date~~right, ~~that~~but not the obligation, to convert all or any portion of the ~~unpaid~~outstanding ~~principal~~ balance ~~and~~of ~~any~~the bridge note, including principal, accrued interest, ofand ~~each~~any ~~Note~~applicable ~~not~~default ~~subject~~amount, tointo ~~the~~shares ~~Voluntary~~of ~~Conversion~~our ~~was~~common ~~automatically~~stock. ~~converted~~The ~~into~~conversion price is the ~~$6.24~~greater ~~Warrants.~~of ~~Each~~(i) $60.24125 ~~Warrant~~and ~~shall~~(ii) be75% ~~immediately~~of ~~exercisable~~the ~~after~~lowest ~~issuance~~trading ~~for~~price ~~five~~of ~~(5)~~our ~~years.~~common ~~Each~~stock ~~$6.24~~during ~~Warrant~~the ~~will~~ten be(10) ~~exercisable~~trading bydays ~~payment~~immediately ofpreceding the ~~exercise~~applicable ~~price~~conversion indate. ~~cash~~On orMarch on12, 2026, we entered into a ~~cashless~~securities ~~basis~~purchase ifagreement atwith ~~the~~Boot ~~time~~Capital ofLLC, ~~exercise~~pursuant ~~there~~to iswhich nowe ~~effective~~issued ~~resale~~a ~~registration~~12% ~~statement~~bridge ~~and~~note ~~will~~that ~~contain~~matures ~~customary~~on ~~anti-dilution~~January ~~provisions~~15, (2027, in the ~~case~~aggregate ofprincipal ~~stock~~amount ~~splits,~~of ~~dividends~~$113, ~~recapitalizations~~000, ~~mergers~~which ~~and~~includes ~~similar~~an ~~transactions).~~original Aissue ~~holder~~discount of a $~~6.24~~13,000, ~~Warrant~~for ~~may~~an ~~not~~aggregate ~~exercise~~purchase ~~any~~price ~~such~~of $6100,000.24 ~~Warrant~~Solely toupon the ~~extent~~occurrence ~~that~~and ~~such~~continuation ~~conversion~~of oran ~~exercise~~Event ~~would~~of ~~result~~Default (as defined in the ~~number~~bridge note), the buyer shall have the right, but not the obligation, to convert all or any portion of ~~shares~~the outstanding balance of ~~Common~~the ~~Stock~~bridge ~~beneficially~~note, ~~owned~~including byprincipal, ~~such~~accrued ~~holder~~interest, and ~~its~~any ~~affiliates~~applicable ~~exceeding~~default 9amount, into shares of our common stock.9 The conversion price is the greater of (i) $0.125 and (ii) 75% of the ~~total~~lowest ~~number~~trading price of ~~shares~~our ofcommon ~~Common~~stock ~~Stock~~during ~~outstanding~~the ~~immediately~~ten ~~after~~(10) ~~giving~~trading ~~effect~~days toimmediately preceding the applicable conversion ordate. ~~exercise,~~Corporate ~~which~~Information ~~percentage~~We ~~may~~were beincorporated ~~increased~~in orthe ~~decreased~~State atof ~~the~~Nevada ~~holder’s~~on ~~election~~May ~~not~~2, to2011, ~~exceed~~as 19Knight Knox Development Corp.~~9%.~~ ~~Pursuant~~On January 19, 2017, we changed our name to ~~the~~Reactive ~~May~~Medical, ~~2025~~Inc. ~~Subscription~~and ~~Agreement~~on April 14, 2017, we ~~agreed~~changed ~~(i)~~our name to ~~file~~Artelo aBiosciences, ~~registration~~Inc. ~~statement~~Our ~~(the~~principal ~~“May~~executive ~~2025~~office ~~Registration~~is ~~Statement”)~~located ~~with~~at ~~the~~505 ~~SEC~~Loma ~~under~~Santa ~~the~~Fe, ~~Securities~~Suite ~~Act~~160, ofSolana ~~1933~~Beach, asCalifornia ~~amended~~92075 ~~(the~~and ~~“Securities~~our ~~Act”~~telephone number is (858) 925-7049. Our corporate website address is www.artelobio.com. Information contained on, or ~~before~~that ~~the~~can ~~45th~~be ~~calendar~~accessed ~~day~~through, ~~following~~our ~~the~~website ~~May~~is ~~2025~~not ~~Notes’~~incorporated ~~Maturity~~by ~~Date~~reference ~~(subject~~into tothis ~~certain~~prospectus, ~~exceptions)~~and ~~for~~you ~~purposes~~should not consider information on our website to be part of ~~registering~~this ~~the~~prospectus. ~~resale~~Implications of ~~the~~Being ~~shares~~a Smaller Reporting Company Additionally, we are a “smaller reporting company” as defined in Rule 10(f)(1) of ~~Common~~Regulation ~~Stock~~S-K. ~~issuable~~Smaller ~~upon~~reporting ~~Conversion~~companies may take advantage of ~~the~~certain ~~May~~reduced ~~2025~~disclosure ~~Notes~~obligations, ifincluding, ~~any~~among other things, ~~and~~providing ~~the~~only ~~shares~~two years of ~~Common~~audited ~~Stock~~financial ~~issuable~~statements. ~~pursuant~~We towill remain a smaller reporting company until the ~~$6.24~~last ~~Warrants~~day ~~(collectively,~~of the ~~“May~~fiscal ~~2025~~year ~~Registrable~~in ~~Shares”),~~which (ii1) tothe ~~use~~market ~~our~~value ~~reasonable~~of ~~best~~our ~~efforts~~common tostock ~~have~~held ~~such~~by ~~registration~~non-affiliates ~~statement~~equals ~~declared~~or ~~effective~~exceeds ~~within~~$250 ~~the~~million ~~time~~as ~~period~~of ~~set~~the ~~forth~~end inof ~~the~~that ~~May~~year’s ~~2025~~second ~~Subscription~~fiscal ~~Agreement~~quarter, ~~and~~or (~~iii~~2) toour ~~keep~~annual ~~the~~revenues ~~May~~equaled ~~2025~~or ~~Registration~~exceeded ~~Statement~~$100 ~~effective~~million ~~until~~during ~~the~~such ~~May~~completed ~~2025~~fiscal ~~Registrable~~year ~~Shares~~and ~~covered~~the bymarket ~~such~~value ~~May~~of ~~2025~~our ~~Registration~~common ~~Statement~~stock ~~may~~held beby ~~sold~~non-affiliates ~~without~~equals ~~volume~~ or ~~manner-of-sale~~exceeds ~~restrictions~~$700 ~~pursuant~~million toas ~~Rule~~of ~~144,~~the ~~subject~~end toof ~~certain~~that ~~conditions~~year’s second fiscal quarter.

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The offer and sale of the securities pursuant to the May 2025 Subscription Agreement were not registered under the Securities Act, or any state securities laws. We relied on an exemption from the registration requirements of the Securities Act provided by Section 4(a)(2) thereof and Rule 506(b) of Regulation D promulgated thereunder. Each of the Selling Securityholders has represented to us that such Selling Securityholder is an “accredited investor,” as defined in Regulation D of the Securities Act, and that the securities purchased by such Selling Securityholder were being acquired solely for such selling stockholder’s own account and for investment purposes and not with a view to its future sale or distribution. The description of the May 2025 Subscription Agreement, the May 2025 Notes and $6.24 Warrants are not complete and are qualified in their entirety by reference to the subscription agreement, form of convertible note and the form of warrant, which were filed as exhibits to our Current Report on Form 8-K, filed on May 1, 2025. See “Where You Can Find More Information” and “Information Incorporated by Reference.” The representations, warranties and covenants made by us in such agreements were made solely for the benefit of the parties to such agreements, including, in some cases, for the purpose of allocating risk among the parties thereto, and should not be deemed to be a representation, warranty or covenant to you. Moreover, such representations, warranties or covenants were made as of an earlier date. Accordingly, such representations, warranties and covenants should not be relied on as accurately representing the current state of our affairs. October 2025 Private Placement Effective October 28, 2025, we entered into the October 2025 Subscription Agreement with the Selling Securityholders named in this prospectus, pursuant to which we issued and sold to the Selling Securityholders, and the Selling Securityholders purchased (by converting all or a portion of the unconverted “Voluntary Conversion” portion of unpaid principal balance and accrued interest due to the Selling Securityholders upon the maturity of the May 2025 Notes): (i) The Notes in an aggregate principal amount of $690,154.69; and (ii) the $3.40 Warrants to purchase an aggregate of 438,182 shares of Common Stock, at an exercise price of $3.40 per share. The sale and issuance of the Notes and $3.40 Warrants closed effective as of October 28, 2025 (the “Closing Date”). The Notes will accrue interest at a rate of 12% per annum, which will adjust to 20% upon an Event of Default (as defined in the Notes). All unpaid principal, together with any then unpaid and accrued interest and other amounts payable thereunder, shall be due and payable six months after the Closing Date (the “Maturity Date”). At any time prior to the Maturity Date, all or any portion of the outstanding principal amount of the Notes, together with the accrued and unpaid interest, shall be convertible, in whole or in part, into shares of Common Stock, at a conversion price of $3.40. Each $3.40 Warrant shall be immediately exercisable after issuance for five (5) years. Each $3.40 Warrant will be exercisable by payment of the exercise price in cash or on a cashless basis if at the time of exercise there is no effective resale registration statement and will contain customary anti-dilution provisions (in the case of stock splits, dividends, recapitalizations, mergers A holder of a Note or $3.40 Warrant may not convert or exercise any such Note or $3.40 Warrant to the extent that such conversion or exercise would result in the number of shares of Common Stock beneficially owned by such holder and its affiliates exceeding 4.9% of the total number of shares of Common Stock outstanding immediately after giving effect to the conversion or exercise, which percentage may be increased or decreased at the holder’s election not to exceed 19.9%. Pursuant to the Subscription Agreement, the Company agreed (i) to file a registration statement (the “October 2025 Registration Statement”) with the with the SEC under the Securities Act on or before the 20th calendar day following the Closing Date (subject to certain exceptions) for purposes of registering the resale of the shares of Common Stock issuable upon Conversion of the Notes, if any, and the shares of Common Stock issuable pursuant to the $3.40 Warrants (collectively, the “October 2025 Registrable Shares”), (ii) to use its reasonable best efforts to have such registration statement declared effective within the time period set forth in the Subscription Agreement, and (iii) to keep the October 2025 Registration Statement effective until the October 2025 Registrable Shares covered by such October 2025 Registration Statement may be sold without volume or manner-of-sale restrictions pursuant to Rule 144, subject to certain conditions.

The Offering

Shares offered by us	1,641,587 shares of common stock at a price of $7.31 per share.

Pre-funded warrants offered by us	We are also offering to those purchasers, if any, whose purchase of shares of common stock in this offering would otherwise result in the purchaser, together with its affiliates and certain related parties, beneficially owning more than 4.99% (or, at the election of the purchaser, 9.99%) of our outstanding shares of common stock immediately following the consummation of this offering, the opportunity to purchase, if such purchasers so choose, pre-funded warrants to purchase shares of common stock in lieu of shares of common stock that would otherwise result in any such purchaser’s beneficial ownership exceeding 4.99% (or, at the election of the purchaser, 9.99%) of our outstanding shares of common stock. The purchase price of each pre-funded warrant will equal the public offering price at which the shares of common stock are being sold to the public in this offering, minus $0.001, and the exercise price of each pre-funded warrant will be $0.001 per share. The pre-funded warrants will be immediately exercisable and may be exercised at any time until all of the pre-funded warrants are exercised in full. For each pre-funded warrant we sell, the number of shares of common stock we are offering will be decreased on a one-for-one basis. This prospectus also relates to the offering of the shares of common stock issuable upon exercise of the pre-funded warrants.

Shares of common stock to be outstanding after this offering	2,377,714 shares of common stock (assuming the sale of all shares of common stock covered by this prospectus and no sale of pre-funded warrants, no exercise of the Placement Agent Warrants included in this offering and no exercise of outstanding options issued under our equity incentive plans, and based on 736,127 shares outstanding as of March 18, 2026).

Placement Agent Warrants	We have agreed to issue to the placement agent the Placement Agent Warrants, which are initially exercisable to purchase up to 131,327 shares of common stock, as a portion of the compensation payable to the placement agent in connection with this offering, assuming a public offering price of $7.31 per share of common stock, which was the last reported sale price of our common stock on Nasdaq on March 18, 2026. The Placement Agent Warrants will be exercisable upon issuance at an exercise price equal to $7.31 per share of common stock (or 100% of the assumed public offering price per share). See “Description of Securities–Placement Agent Warrants” and “Plan of Distribution”.

Best efforts offering	We have agreed to offer and sell the securities offered hereby directly to the purchasers. We have retained Craft Capital to act as our exclusive placement agent to use its reasonable best efforts to solicit offers to purchase the securities offered by this prospectus. The placement agent is not required to buy or sell any specific number of the securities offered hereby. See “Plan of Distribution” beginning on page 40 of this prospectus.

Use of proceeds	Assuming we sell all securities offered pursuant to this prospectus, we estimate the net proceeds from this offering will be approximately $10.8 million, based on an assumed public offering price of $7.31 per share (the last reported sale price of our shares of common stock on Nasdaq on March 18, 2026), after deducting placement agent fees and estimated offering expenses payable by us. However, this is a best efforts offering with no minimum number of securities or amount of proceeds as a condition to closing, and we may not sell all or any of these shares or pre-funded warrants offered pursuant to this prospectus; as a result, we may receive significantly less in net proceeds. We intend to use the net proceeds of this offering for working capital and general corporate purposes. See “Use of Proceeds” on page 13 of this prospectus for more information.

Dividend policy	We have never declared or paid any cash dividends on our shares of common stock. We do not anticipate paying any cash dividends in the foreseeable future.

Risk factors	You should carefully consider the risk factors described in the section of this prospectus entitled “Risk Factors,” together with all of the other information included in this prospectus, before deciding to purchase our securities.

Market and trading symbol	Our shares of common stock are traded on Nasdaq under the symbol “ARTL.” We do not intend to list the pre-funded warrants on Nasdaq or any other national securities exchange or nationally recognized trading system. Without an active trading market, the liquidity of the pre-funded warrants will be limited.

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The offer and sale of the securities pursuant to the October 2025 Subscription Agreement were not registered under the Securities Act, or any state securities laws. We relied on an exemption from the registration requirements of the Securities Act provided by Section 3(a)(9) and/or Section 4(a)(2) thereof and Rule 506(b) of Regulation D promulgated thereunder. Each of the Selling Securityholders has represented to us that such Selling Securityholder is an “accredited investor,” as defined in Regulation D of the Securities Act, and that the securities purchased by such Selling Securityholder were being acquired solely for such selling stockholder’s own account and for investment purposes and not with a view to its future sale or distribution. The description of the October 2025 Subscription Agreement, the Notes and $3.40 Warrants are not complete and are qualified in their entirety by reference to the subscription agreement, form of convertible note and the form of warrant, which were filed as exhibits to our Current Report on Form 8-K, filed on October 31, 2025. See “Where You Can Find More Information” and “Information Incorporated by Reference.” The representations, warranties and covenants made by us in such agreements were made solely for the benefit of the parties to such agreements, including, in some cases, for the purpose of allocating risk among the parties thereto, and should not be deemed to be a representation, warranty or covenant to you. Moreover, such representations, warranties or covenants were made as of an earlier date. Accordingly, such representations, warranties and covenants should not be relied on as accurately representing the current state of our affairs. Recent Developments On October 26, 2025, our board of directors appointed Mark Spring, effective November 1, 2025, as our Chief Financial Officer and Treasurer as well as its principal financial officer and principal accounting officer. Mr. Spring replaced Gregory Gorgas in the roles of Treasurer, principal financial officer and principal accounting officer. On October 15, 2025, we entered into a cooperation letter agreement (the “Cooperation Agreement”) with Daniel S. Farb and certain of his affiliates (collectively, the “Farb Parties”). Pursuant to the Cooperation Agreement, Mr. Farb agreed to irrevocably withdraw his nomination of candidates for election to our board of directors at the 2025 annual meeting of stockholders. Additionally, the Farb Parties agreed to certain standstill restrictions and voting commitments during the Restricted Period (as defined in the Agreement), including, among other things, (i) an obligation to vote shares of our common stock beneficially owned by the Farb Parties, and that the Farb Parties have the right to vote, subject to certain limited exceptions, in favor of the election of each person nominated by our board of directors for election as a director, against any proposals to remove any member of our board of directors, and in accordance with the recommendation of our board of directors on all other proposals or business, and (ii) a restriction on the ability of the Farb Parties to acquire beneficial ownership of more than 8.0% of the then-outstanding shares of the Company’s common stock. Corporate Information We were incorporated in the State of Nevada on May 2, 2011, as Knight Knox Development Corp. On January 19, 2017, we changed our name to Reactive Medical, Inc. and on April 14, 2017, we changed our name to Artelo Biosciences, Inc. Our principal executive office is located at 505 Loma Santa Fe, Suite 160, Solana Beach, California 92075 and our telephone number is (858) 925-7049. Our corporate website address is www.artelobio.com. Information contained on, or that can be accessed through, our website is not incorporated by reference into this prospectus, and you should not consider information on our website to be part of this prospectus. Implications of Being a Smaller Reporting Company Additionally, we are a “smaller reporting company” as defined in Rule 10(f)(1) of Regulation S-K. Smaller reporting companies may take advantage of certain reduced disclosure obligations, including, among other things, providing only two years of audited financial statements. We will remain a smaller reporting company until the last day of the fiscal year in which (1) the market value of our Common Stock held by non-affiliates equals or exceeds $250 million as of the end of that year’s second fiscal quarter, or (2) our annual revenues equaled or exceeded $100 million during such completed fiscal year and the market value of our Common Stock held by non-affiliates equals or exceeds $700 million as of the end of that year’s second fiscal quarter.

Assumptions Used Throughout This Prospectus Unless otherwise stated in this prospectus, the total number of shares of common stock outstanding as of the date of this prospectus and after this offering is based on 736,127 shares of common stock outstanding as of March 18, 2025 (giving effect to the one-for-three reverse stock split of our common stock effected on March 10, 2026), and excludes the following:

	·	75,998 shares of our common stock issuable upon the exercise of options or restricted stock awards granted under our 2018 Equity Incentive Plan (the “2018 Plan”), with a weighted-average exercise price of $33.09 per share;

	·	466,263 shares of our common stock issuable upon the exercise of warrants, with a weighted-average exercise price of $16.89 per share issued prior to January 2026;

	·	41,089 shares of common stock issuable upon the voluntary conversion of convertible notes issued in our October 2025 private placement;

	·	35,857 shares of our common stock reserved for future issuance under our 2018 Plan;

	·	62,124 shares of our common stock issuable upon the exercise of pre-funded warrants issued pursuant to our Equity Purchase Agreement, dated as of January 30, 2026 (the “ELOC Purchase Agreement”), at an exercise price of $0.003 per share; and

	·	up to $25 million in shares of common stock that may be issued and sold by us pursuant to the ELOC Purchase Agreement, which at the Company’s sole discretion can be increased by an additional $25 million once the initial $25 million is exhausted.

Except as otherwise noted, all information in this prospectus reflects and assumes (i) no sale or issuance of pre-funded warrants in this offering, which, if sold, would reduce the number of shares of common stock that we are offering on a one-for-one basis, (ii) no exercise of outstanding options issued under our equity incentive plans, and (iii) no exercise of any of our outstanding warrants or the Placement Agent Warrants.

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The Offering
Shares of Common Stock Offered by the Selling Securityholders	899,972 shares of Common Stock, consisting of: (i) 215,292 shares of Common Stock issuable upon the conversion of the Notes, (ii) 246,498 shares of Common Stock issuable upon the exercise of the $6.24 Warrants, and (iv) 438,182 shares of Common Stock issuable upon the exercise of the $3.40 Warrants.
Use of proceeds	We will not receive any proceeds from any sale of the shares being offered for sale by the Selling Securityholders. We will, however, receive the net proceeds of any Warrants exercised for cash. See “Use of Proceeds” for additional information
Dividend policy	We have never declared or paid any cash dividends on our shares of Common Stock. We do not anticipate paying any cash dividends in the foreseeable future.
Risk factors	You should carefully consider the risk factors described in the section of this prospectus entitled “Risk Factors,” together with all of the other information included in this prospectus, before deciding to purchase our shares of Common Stock.
Market and trading symbol	Our shares of Common Stock are traded on the Nasdaq Capital Market under the symbol “ARTL.”

SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

This prospectus and the information incorporated by reference contains forward-looking statements that are based on our management’s beliefs and assumptions and on information currently available. This section should be read in conjunction with our financial statements and related notes included in our Annual Report on Form 10-K for the year ended December 31, 2025. The statements contained or incorporated by reference in this prospectus that are not historical facts are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended.

Forward-looking statements can be identified by words such as “believe,” “anticipate,” “may,” “might,” “can,” “could,” “continue,” “depends,” “expect,” “expand,” “forecast,” “intend,” “predict,” “plan,” “rely,” “should,” “will,” “may,” “seek,” or the negative of these terms and other similar expressions, although not all forward-looking statements contain these words. You should read these statements carefully because they discuss future expectations, contain projections of future results of operations or financial condition, or state other “forward-looking” information. These statements relate to our future plans, objectives, expectations, intentions and financial performance and the assumptions that underlie these statements.

These forward-looking statements are subject to a number of risks, uncertainties, and assumptions, including, but not limited to, those described in “Risk Factors.” These forward-looking statements reflect our beliefs and views with respect to future events and are based on estimates and assumptions as of the date of this prospectus and are subject to risks and uncertainties. We discuss many of these risks in greater detail in the section entitled “Risk Factors” and elsewhere in this prospectus, including the information incorporated by reference. Given these uncertainties, you should not place undue reliance on these forward-looking statements. We qualify all of the forward-looking statements in this prospectus by these cautionary statements. Except as required by law, we assume no obligation to update these forward-looking statements publicly, or to update the reasons actual results could differ materially from those anticipated in any forward-looking statements, whether as a result of new information, future events or otherwise.

In addition, statements that “we believe” and similar statements reflect our beliefs and opinions on the relevant subject. These statements are based upon information available to us as of the date of this prospectus, and although we believe such information forms a reasonable basis for such statements, such information may be limited or incomplete, and our statements should not be read to indicate that we have conducted a thorough inquiry into, or review of, all potentially available relevant information. These statements are inherently uncertain and investors are cautioned not to unduly rely upon these statements.

This prospectus and the information incorporated by reference also contains estimates, projections and other information concerning our industry, our business, and the markets for certain diseases, including data regarding the estimated size of those markets. Information that is based on estimates, forecasts, projections, market research or similar methodologies is inherently subject to uncertainties and actual events or circumstances may differ materially from events and circumstances reflected in this information. Unless otherwise expressly stated, we obtained this industry, business, market, and other data from reports, research surveys, studies, and similar data prepared by market research firms and other third parties, industry, medical and general publications, government data, and similar sources.

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RISK FACTORS

An investment in our securities involves a high degree of risk. Our business, financial condition or results of operations could be materially and adversely affected by any of these risks. If any of these risks occur, the value of our shares of ~~Common~~common ~~Stock~~stock and our other securities may decline. Before making your investment decision, you should carefully consider the risks together with all of the other information contained or incorporated by reference in this prospectus, including any risks in the section entitled “Risk Factors” contained in any supplements to this prospectus, in our Annual Report on Form 10-K filed with the SEC on ~~March~~February 324, ~~2025~~2026, as updated or supplemented on our Quarterly Reports on Form 10-Q or Current Reports on Form 8-K, and in our subsequent filings with the SEC. Each of the referenced risks and uncertainties could adversely affect our business, operating results and financial condition, as well as adversely affect the value of an investment in our securities. Additional risks not known to us or that we believe are immaterial may also adversely affect our business, operating results and financial condition and the value of an investment in our securities. These disclosures reflect our beliefs and opinions as to factors that could materially and adversely affect us and our securities in the future. References to past events are provided by way of example only and are not intended to be a complete listing or a representation as to whether or not such factors have occurred in the past or their likelihood of occurring in the future.

Risks Related to This Offering

WeThe ~~may~~public beoffering ~~required~~price towill ~~raise~~be ~~additional~~set ~~financing~~ by ~~issuing~~our ~~new~~board ~~securities with terms or rights superior to those~~ of ~~our~~directors ~~existing~~and ~~securityholders,~~does ~~which~~not ~~could~~necessarily ~~adversely~~indicate ~~affect~~ the actual or market ~~price~~value of our shares of common stock ~~and our business~~.

WeOur ~~will~~board ~~require~~of ~~additional~~directors, ~~financing~~or toa ~~fund~~committee ~~future~~designated ~~operations,~~by ~~including~~the ~~for~~board ~~research~~of ~~and development~~directors, ~~clinical~~will ~~trials,~~approve ~~expansion~~the inpublic ~~current~~offering price and ~~new~~other ~~markets,~~terms ~~development~~of ~~and~~this ~~acquisition~~offering after considering, ~~capital~~among ~~costs~~other ~~and~~things: the ~~costs~~current ofmarket ~~any~~price ~~necessary~~of ~~implementation~~our shares of ~~technological~~common ~~innovations~~stock; ortrading ~~alternative~~prices ~~technologies.~~of Weour ~~may~~common ~~not~~stock beover ~~able~~time; tothe ~~obtain~~volatility ~~financing~~of onour ~~favorable~~shares ~~terms,~~of ifcommon atstock; ~~all.~~our Ifcurrent wefinancial ~~raise~~condition ~~additional~~and ~~funds~~the byprospects ~~issuing~~for ~~equity~~our ~~securities,~~future cash flows; the ~~percentage~~availability ~~ownership~~of and likely cost of ~~our~~capital ~~current~~of ~~stockholders~~other ~~will~~potential besources ~~reduced,~~of capital; the characteristics of interested investors and market and economic conditions at the ~~holders~~time of the ~~new~~offering. ~~equity~~The ~~securities~~public ~~may~~offering ~~have~~price ~~rights~~is ~~superior~~not intended to ~~those~~bear any relationship to the book value of our ~~existing~~assets ~~securityholders~~or our past operations, ~~which~~cash ~~could~~flows, ~~adversely~~losses, ~~affect~~financial ~~the~~condition, ~~market~~net ~~price~~worth ofor ~~our~~any ~~common~~other ~~stock~~established ~~and~~criteria ~~the~~used ~~voting~~to ~~power~~value securities. The public offering price may not be indicative of ~~shares~~the fair value of ~~our~~the common stock.

Our ~~financial~~management ~~condition~~will ~~raises~~have ~~substantial~~broad ~~doubt~~discretion as to ~~our~~the ~~ability~~use toof ~~continue~~the asproceeds afrom ~~going~~this ~~concern~~offering, and may not use the proceeds effectively.

AsOur ofmanagement ~~September~~will ~~30, 2025, we had approximately $1.7 million in cash and cash equivalents, and working capital of negative $3.0 million, and we~~ have ~~incurred~~broad ~~and~~discretion ~~expect~~as to ~~continue~~the toapplication ~~incur significant costs in pursuit~~ of ~~our drug candidates. For~~ the ~~nine months ended September 30, 2025, we recorded a~~ net ~~loss~~proceeds offrom ~~approximately~~this ~~$8.7~~offering ~~million~~ and ~~used~~could ~~cash~~use inthem ~~operations~~for ofpurposes ~~approximately~~other ~~$8.6~~than ~~million.~~those ~~Our~~contemplated ~~financial~~at ~~statements for~~ the ~~nine~~time ~~months~~of ~~ended~~the ~~September~~offering. 30Currently, ~~2025 have been prepared assuming that~~ we ~~will~~intend ~~continue~~ to ~~operate~~use asthe anet ~~going~~proceeds ~~concern,~~from ~~which~~this ~~contemplates~~offering ~~the~~primarily ~~realization~~for ofworking ~~assets~~capital and ~~the~~general ~~satisfaction~~corporate ofpurposes. ~~liabilities~~See in“Use ~~the normal course~~ of ~~business~~Proceeds.” ToYou ~~date,~~will wenot have ~~not~~the ~~generated~~opportunity, ~~substantial~~as ~~product~~part ~~revenues~~of ~~from~~your ~~our~~investment ~~activities~~decision, ~~and~~to ~~have~~assess ~~incurred~~whether ~~substantial~~these ~~operating~~proceeds ~~losses.~~are Webeing ~~expect~~used ~~that~~appropriately. weOur ~~will~~management ~~continue~~may touse ~~generate~~the ~~substantial~~net ~~operating~~proceeds ~~losses~~ for ~~the~~corporate ~~foreseeable~~purposes ~~future~~that ~~until~~may wenot ~~complete~~improve ~~development and approval of one of~~ our ~~product~~financial ~~candidates.~~condition Weor ~~expect~~market tovalue, ~~continue~~which tocould ~~fund~~cause ~~our~~the ~~operations~~price ~~primarily through utilization~~ of our ~~current~~shares ~~financial~~of ~~resources~~common ~~and~~stock ~~additional~~to ~~raises of capital~~decline.

~~These~~There conditions raise substantial doubt about our ability to continue as a going concern. We have evaluated the significance of the uncertainty regarding our financial condition in relation to our ability to meet our obligations, which has raised substantial doubt about our ability to continue as a going concern. While it is very difficult to estimate our future liquidity requirements, we believe if we are unable to obtain additional financing, existing cash resources will not be sufficient to enable us to fund the anticipated level of operations through one year from the date the accompanying financial statements are issued. There can be no ~~assurances~~public ~~that~~market wefor ~~will be able to secure additional financing on acceptable terms. In~~ the event we do not secure additional financing, we will be forced to delay, reduce, or eliminate some or all of its discretionary spending, which could adversely affect our business prospects, ability to meet longpre-~~term~~funded ~~liquidity~~warrants ~~needs~~being ~~and~~offered ~~the~~in ~~ability~~this ~~to continue operations~~offering.

There is no established public trading market for the pre-funded warrants being offered in this offering, and we do not expect such a market to develop. In addition, we do not intend to apply to list the pre-funded warrants on any securities exchange or nationally recognized trading system, including Nasdaq. Without an active market, the liquidity of the pre-funded warrants will be limited.

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~~Risks~~Holders ~~Related~~of topre-funded ~~Our~~warrants ~~Common~~purchased ~~Stock~~in this offering will have no rights as stockholders of shares of common stock until such holders exercise their pre-funded warrants and acquire our shares of common stock, except as set forth in the pre-funded warrants.

~~Our~~Except ~~Common~~as ~~Stock~~set ~~may~~forth in the pre-funded warrants, until holders of pre-funded warrants acquire our shares of common stock upon exercise of the pre-funded warrants, holders of pre-funded warrants have no rights with respect to our shares of common stock underlying such pre-funded warrants. Upon exercise of the pre-funded warrants, the holders will be ~~delisted~~entitled ~~from~~to ~~Nasdaq~~exercise ifthe werights ~~fail~~of a stockholder of shares of common stock only as to ~~comply~~matters ~~with~~for ~~continued~~which ~~listing~~the ~~standards~~record date occurs after the exercise date.

~~Our~~The Common Stock is currently traded on Nasdaq under the symbol “ARTL.” If we fail to comply with Nasdaq’s continued listing standards, we may be delisted and our Common Stock will trade, if at all, only on the overpre-~~the-counter~~funded ~~market,~~warrants ~~such~~are asspeculative the OTC Bulletin Board or OTCQX market, and then only if one or more registered broker-dealer market makers comply with quotation requirements. In addition, delisting of our Common Stock could depress our stock price, substantially limit liquidity of our Common Stock and materially adversely affect our ability to raise capital on terms acceptable to us, or at all. Further, delisting of our Common Stock would likely result in ~~our Common Stock becoming a “penny stock” under the Exchange Act~~nature.

OnThe ~~May~~pre-funded ~~22,~~warrants ~~2025,~~offered wehereby ~~received~~do anot ~~notice~~confer ~~from~~any ~~the~~rights ~~Staff~~of ~~notifying~~share usof ~~that,~~common ~~because~~stock ~~our~~ownership ~~stockholders’~~on ~~equity~~their ~~was~~holders, ~~below~~such ~~$2.5 million~~ as ~~reported~~voting onrights ~~our~~or ~~Quarterly Report on Form 10-Q for~~ the ~~quarter~~right ~~ended~~to ~~March~~receive 31dividends, ~~2025,~~but werather nomerely ~~longer~~represent ~~meet~~ the ~~minimum~~right ~~stockholders’~~to ~~equity~~acquire ~~requirement~~shares ~~for~~of ~~continued~~common ~~listing~~stock onat ~~Nasdaq~~a ~~under~~fixed ~~Nasdaq Rule 5550(b)(1)~~price. ~~Pursuant~~Specifically, tocommencing ~~the~~on ~~notice and~~ the ~~Listing~~date ~~Rules~~ of ~~Nasdaq~~issuance, weholders ~~submitted~~of athe ~~plan~~pre-funded towarrants ~~regain~~may ~~compliance~~acquire ~~with~~ the ~~minimum~~shares ~~stockholders’~~of ~~equity~~common ~~requirement~~stock ~~within~~issuable 45upon ~~calendar~~exercise ~~days~~ of ~~receiving the letter from the Staff. If~~ such ~~compliance~~warrants ~~plan~~at ~~is accepted, Nasdaq may grant~~ an ~~extension~~exercise price of ~~180~~$0.001 ~~calendar~~per ~~days~~share ~~from the date~~ of ~~the~~common ~~notice~~stock. ~~This~~Moreover, ~~plan~~following ~~was~~this ~~updated and resubmitted to Nasdaq on August 29~~offering, ~~2025. If~~ the ~~updated~~market ~~plan~~value isof ~~not accepted, we may appeal~~ the ~~Staff’s~~pre-funded ~~determination~~warrants tois auncertain ~~Nasdaq Hearings Panel. We are currently evaluating options to regain compliance~~ and ~~intend~~there tocan ~~timely~~be ~~submit~~no aassurance ~~plan~~that tothe ~~regain~~market ~~compliance~~value ~~with~~of the ~~minimum~~pre-funded ~~stockholders’~~warrants ~~equity~~will ~~requirement.~~equal ~~Although~~or weexceed ~~intend~~their torespective ~~use~~public ~~all~~offering ~~reasonable~~prices. ~~efforts~~There ~~to achieve compliance with all Nasdaq listing standards, there~~ can be no assurance that wethe ~~will~~market beprice ~~able~~of ~~to regain compliance with~~ the ~~listing~~shares ~~standards~~of orcommon ~~that~~stock we will ~~otherwise~~ever beequal inor ~~compliance~~exceed ~~with~~the ~~other~~exercise ~~applicable~~price ~~Nasdaq~~of ~~listing~~the ~~criteria.~~pre-funded ~~Furthermore~~warrants, ~~Nasdaq~~and ~~may~~consequently, ~~delist~~whether ~~our~~it ~~common~~will ~~stock~~ever ~~for~~be ~~public~~profitable ~~interest~~for ~~concerns,~~holders ~~even~~of ifthe wepre-funded ~~are~~warrants ~~able~~ to ~~regain~~exercise ~~compliance for continued listing on Nasdaq under~~ the ~~listing~~pre-funded ~~requirements~~warrants.

IfThis ~~our~~is ~~Common~~a ~~Stock~~best ~~were~~efforts ~~to be delisted by Nasdaq~~offering, itno ~~may~~minimum beamount ~~eligible for quotation on an over-the-counter quotation system or on the pink sheets. Upon any such delisting, our Common Stock would become subject to the regulations~~ of ~~the~~securities ~~SEC relating to the market for penny stocks. A penny stock~~ is ~~any~~required ~~equity security not traded on a national securities exchange that has a market price of less than $5.00 per share. The regulations applicable~~ to ~~penny~~be ~~stocks~~sold, ~~may severely affect the market liquidity for our Common Stock~~ and ~~could~~we ~~limit the ability of stockholders to sell securities in the secondary market. In such a case, an investor~~ may ~~find~~not itraise ~~more difficult to dispose of or obtain accurate quotations as to~~ the ~~market~~amount ~~value~~ of ~~our~~capital ~~Common~~we ~~Stock,~~believe ~~and~~is ~~there~~required ~~can~~for ~~be no assurance that~~ our ~~Common~~business ~~Stock will be eligible for trading or quotation on any alternative exchanges or markets~~plans.

~~Delisting~~The ~~from~~placement ~~Nasdaq~~agent ~~could~~has ~~adversely~~agreed ~~affect~~to ~~our~~use ~~ability~~its reasonable best efforts to ~~raise~~solicit ~~additional~~offers ~~financing~~to ~~through~~purchase ~~public~~the orshares ~~private~~of ~~sales~~common stock and pre-funded warrants in this offering. The placement agent has no obligation to buy any of ~~equity~~the securities, ~~would~~from ~~significantly~~us ~~affect~~or to arrange for the ~~ability~~purchase or sale of ~~investors~~any specific number or dollar amount of the securities. There is no required minimum number of securities or amount of proceeds that must be sold as a condition to ~~trade~~completion ~~our~~of this offering. Because there is no minimum number of securities ~~and~~or ~~would~~amount ~~negatively~~of ~~affect~~proceeds required as a condition to the ~~value~~closing of this offering, the actual offering amount, placement agent fees and ~~liquidity~~proceeds ofto ~~our~~us ~~Common~~are ~~Stock~~not presently determinable and may be substantially less than the maximum amounts set forth above. ~~Delisting~~We ~~could~~may ~~also~~sell ~~have~~fewer ~~other~~than ~~negative~~all ~~results~~of the securities offered hereby, ~~including~~which ~~the~~may ~~potential~~significantly ~~loss~~reduce the amount of ~~confidence~~proceeds received by ~~employees~~us, and investors in this offering will not receive a refund in the ~~loss~~event that we do not sell an amount of ~~institutional~~securities ~~investor~~sufficient ~~interest~~to ~~and~~fund ~~fewer~~our business ~~development opportunities~~plans.

~~The~~You ~~sale~~will orexperience ~~availability~~immediate ~~for~~and ~~sale~~substantial ofdilution ~~shares~~as ~~issuable~~a ~~pursuant~~result toof this ~~prospectus~~offering ~~may depress the price of our Common Stock, dilute the interest of our existing stockholders,~~ and ~~encourage~~may ~~short~~experience ~~sales~~additional bydilution ~~third~~in ~~parties, which could further depress~~ the ~~price of our Common Stock~~future.

AsYou ofwill ~~November~~incur ~~10,~~immediate ~~2025, there were 2,018,746 total shares outstanding~~ and ~~the~~substantial ~~Selling~~dilution ~~Securityholders~~as ~~may~~a ~~sell~~result ~~up to 899,972 shares~~ of ~~Common Stock pursuant to~~ this ~~prospectus~~offering. ~~(assuming~~After ~~they~~giving ~~choose~~effect to ~~convert all outstanding principal, together with~~ the ~~accrued~~sale ~~and~~by ~~unpaid~~us ~~interest~~ of ~~their~~shares ~~Notes and exercise all~~ of ~~their~~common ~~$6.24~~stock ~~Warrants~~in ~~and~~this ~~$3.40~~offering ~~Warrants).~~at Toan ~~the~~assumed ~~extent~~public ~~that~~offering ~~the~~price ~~Selling Securityholders sell shares~~ of ~~our~~$7.31 ~~Common~~per ~~Stock~~share, ~~the~~and ~~market~~after ~~price~~deducting ofplacement ~~our~~agent ~~Common~~fees ~~Stock~~and ~~may~~estimated ~~decrease~~offering ~~due~~expenses topayable ~~the~~by ~~additional~~us, ~~selling~~investors ~~pressure~~ in ~~the~~this ~~market.~~offering Incan ~~addition,~~expect ~~the~~an immediate dilution ~~from exercise~~ of ~~the~~$4.07 ~~Warrants~~per ~~may~~share. ~~cause stockholders to sell their shares of our Common Stock~~Additionally, ~~which could further contribute~~ to ~~any decline in~~ the ~~price~~extent ofthat ~~our~~any ~~Common~~pre-funded ~~Stock.~~warrants ~~Any~~or ~~downward~~Placement ~~pressure~~Agent onWarrants ~~the~~issued ~~price~~in ofthis ~~our~~offering, ~~Common~~any ~~Stock~~outstanding ~~caused~~warrants, byor ~~the~~outstanding ~~sale~~ or ~~potential~~to ~~sale~~be ofgranted ~~such~~options ~~shares~~to ~~could~~officers, ~~encourage~~directors ~~short~~and ~~sales~~employees, byare ~~third~~ultimately ~~parties.~~exercised, ~~Such~~you ~~sales~~will ~~could~~sustain ~~place~~future ~~downward~~dilution. ~~pressure~~See on the ~~price~~section ofentitled ~~our~~“Dilution” ~~Common~~for ~~Stock~~additional byinformation ~~increasing~~on ~~the~~how ~~number~~this ofoffering ~~shares~~may ofaffect ~~our~~current ~~Common~~and ~~Stock~~prospective ~~being sold, which could further contribute to any decline in the market price of our Common Stock~~shareholders.

We will likely need to offer and issue additional shares of our common stock or other equity or convertible debt securities in order to raise additional capital. Future equity offerings or other equity issuances may be at a price per share that is equal to or greater than the price per share paid by investors in this offering. Future investors in such offerings may have rights superior to existing stockholders, and the price per share at which we sell additional shares of common stock or other equity or convertible debt securities in future transactions may be at a higher or lower price per share than the price per share in this offering.

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~~Any~~Our ~~market~~common ~~activity~~stock ~~involving~~may ~~short~~be ~~selling~~delisted orfrom ~~other~~Nasdaq ~~market~~if ~~making~~we ~~activities~~fail ~~could result in negative impact~~ to ~~the~~comply ~~market~~with ~~price~~continued ~~for~~listing ~~our Common Stock~~standards.

~~Short~~Our ~~selling~~common stock is acurrently ~~method~~traded ~~used to capitalize~~ on anNasdaq ~~expected~~under ~~decline in~~ the ~~market~~symbol ~~price~~“ARTL.” ofIf awe ~~security~~fail ~~and~~to ~~could~~comply ~~depress~~with ~~the~~Nasdaq’s ~~price~~continued oflisting ~~our Common Stock~~standards, ~~which~~we ~~could~~may ~~further~~be ~~increase~~delisted ~~the~~and ~~potential~~our ~~for~~common ~~future~~stock ~~short~~will ~~sales.~~trade, ~~Sales~~if ofat ~~our~~all, ~~Common~~only ~~Stock~~on ~~could~~the ~~encourage~~over-the-counter ~~short sales by~~ market ~~participants~~, ~~which~~such ~~could~~as ~~create~~the ~~negative~~OTC ~~market~~Bulletin ~~momentum.~~Board ~~Continued~~or ~~short~~OTCQX ~~selling~~market, ~~may~~and ~~bring~~then ~~about~~only aif ~~temporary,~~one or ~~possibly~~more ~~long~~registered ~~term,~~broker-dealer ~~decline in the~~ market ~~price~~makers ofcomply ~~our~~with ~~Common~~quotation ~~Stock~~requirements. ~~The~~In ~~Company~~addition, ~~cannot~~delisting ~~predict the size~~ of ~~future~~our ~~issuances~~common orstock ~~sales~~could ofdepress ~~Common~~our ~~Stock~~stock orprice, ~~the~~substantially ~~effect,~~limit ifliquidity ~~any,~~of ~~that~~our ~~future~~common ~~issuances~~stock and ~~sales~~materially ofadversely ~~Common~~affect ~~Stock~~our ~~will~~ability ~~have~~to onraise ~~its~~capital ~~market~~on ~~price~~terms oracceptable ~~the~~to ~~activities~~us, ofor ~~short~~at ~~sellers~~all. ~~Sales involving significant amounts of Common Stock~~Further, ~~including~~delisting ~~issuances made in the ordinary course~~ of ~~the~~our ~~Company’s~~common ~~business,~~stock orwould ~~the~~likely ~~perception~~result ~~that~~in ~~such~~our ~~sales~~common ~~could~~stock ~~occur,~~becoming ~~may~~a ~~materially~~“penny ~~and~~stock” ~~adversely~~under ~~affect prevailing market prices of~~ the ~~Common~~Exchange ~~Stock~~Act.

WeOn ~~have~~May ~~never~~22, ~~paid~~2025, ~~dividends~~we received a notice from the Nasdaq staff notifying us that, because our stockholders’ equity was below $2.5 million as reported on our ~~capital~~Quarterly ~~stock~~Report on Form 10-Q for the quarter ended March 31, 2025, we no longer meet the minimum stockholders’ equity requirement for continued listing on Nasdaq under Nasdaq Rule 5550(b)(1). Pursuant to the notice and the Listing Rules of Nasdaq, we dosubmitted a plan to regain compliance with the minimum stockholders’ equity requirement within 45 calendar days of receiving the letter from the Staff. This plan was updated and resubmitted to Nasdaq on August 29, 2025. The Nasdaq staff determined that the Company has not ~~anticipate~~completed ~~paying~~the ~~dividends~~capital raising that was discussed in the ~~foreseeable~~materials ~~future~~submitted to Nasdaq on July 7, 2025, and August 29, 2025, which the Company expected would enable it to demonstrate compliance with the Rule. As a result, on November 19, 2025, the Company received a delist determination letter from Nasdaq advising the Company that the Nasdaq staff had determined that the Company had not satisfied the conditions set forth in the May 22 letter to regain compliance. The Company appealed Nasdaq’s determination to a hearing panel on January 15, 2026, to stay any further delisting actions. On February 2, 2026, the hearing panel issued an extension to March 30, 2026, for the Company to resolve the minimum shareholders’ equity deficiency. The Company held its annual meeting on January 30, 2026, and cured the annual meeting deficiency. Following the hearing panel’s extension, the Company’s Common Stock will continue to trade on Nasdaq under the symbol “ARTL.”

WeAlthough ~~have~~we ~~never paid dividends on any of our capital stock and currently~~ intend to ~~retain~~use ~~any~~all ~~future~~reasonable ~~earnings~~efforts to ~~fund~~achieve ~~the~~compliance ~~growth~~with ofall ~~our~~Nasdaq ~~business.~~listing Westandards, ~~may~~there ~~also~~can ~~enter~~be ~~into~~no ~~credit~~assurance ~~agreements or other borrowing arrangements in the future~~ that we will ~~restrict~~be ~~our~~able ~~ability~~ to ~~declare~~regain orcompliance ~~pay~~with ~~cash~~the ~~dividends~~listing onstandards ~~our~~or ~~Common~~that ~~Stock.~~we ~~Any~~will ~~determination~~otherwise tobe ~~pay dividends~~ in ~~the~~compliance ~~future~~with ~~will~~other beapplicable atNasdaq ~~the~~listing ~~discretion~~criteria. ~~of our board of directors and will depend on our financial condition~~Furthermore, ~~operating~~Nasdaq ~~results,~~may ~~capital~~delist ~~requirements, general business conditions and other factors that~~ our ~~board~~common ofstock ~~directors~~for ~~may~~public ~~deem~~interest ~~relevant. As a result~~concerns, ~~capital~~even ~~appreciation,~~ if ~~any,~~we ofare ~~the~~able ~~securities~~to ~~will~~regain becompliance ~~the~~for ~~sole~~continued ~~source~~listing ofon ~~gain,~~Nasdaq ifunder ~~any, for~~ the ~~foreseeable~~listing ~~future~~requirements.

If the Company is unable to maintain compliance with Nasdaq’s continued listing requirements, delisting from The Nasdaq Capital Market or any Nasdaq market could make trading our Common Stock more difficult for investors, potentially leading to declines in our share price and liquidity. In addition, without a Nasdaq market listing, stockholders may have a difficult time getting a quote for the sale or purchase of our ~~shares~~stock, the sale or purchase of our stock would likely be made more difficult and the trading volume and liquidity of our stock could decline. Delisting from Nasdaq could also result in negative publicity and could also make it more difficult for us to raise additional capital. The absence of such a listing may adversely affect the acceptance of our Common Stock as currency or the value accorded by other parties. Further, if the Company is delisted, the Company would also incur additional costs under state blue sky laws in connection with any sales of our securities. These requirements could severely limit the market liquidity of our Common Stock and the ability of our stockholders to sell our Common Stock in the secondary market. If our Common Stock is delisted by Nasdaq, our Common Stock may be ~~subject~~eligible to ~~fluctuation~~trade on an over-the-counter quotation system, such as the OTCQB market, where an investor may find it more difficult to sell our stock or obtain accurate quotations as to the market value of our Common Stock. The Company cannot assure you that our Common Stock, if delisted from Nasdaq, will be listed on another national securities exchange or quoted on an over-the counter quotation system. If our Common Stock is delisted, it may come within the definition of “penny stock” as defined in the Securities Exchange Act of 1934, as amended (the “Exchange Act”) and ~~volatility~~would be covered by Rule 15g-9 of the Exchange Act. ~~You~~That ~~could~~Rule ~~lose~~imposes ~~all~~additional sales practice requirements on broker-dealers who sell securities to persons other than established customers and accredited investors. For transactions covered by Rule 15g-9, the broker-dealer must make a special suitability determination for the purchaser and receive the purchaser’s written agreement to the transaction prior to the sale. Consequently, Rule 15g-9, if it were to become applicable, would affect the ability or ~~part~~willingness of ~~your~~broker-dealers ~~investment~~to sell our securities, and accordingly would affect the ability of stockholders to sell their securities in the public market. These additional procedures could also limit our ability to raise additional capital in the future.

~~The~~Purchasers ~~market~~who ~~price~~purchase of our ~~common~~securities ~~stock~~in isthis ~~subject~~offering topursuant ~~wide fluctuations in response~~ to ~~various~~a ~~factors,~~securities ~~some~~purchase ofagreement ~~which~~may ~~are~~have ~~beyond~~rights ~~our~~not ~~control.~~available ~~The~~to ~~market~~purchasers ~~price~~that ofpurchase ~~our~~without ~~shares on~~ the ~~Nasdaq~~benefit ~~Capital Market may fluctuate as a result~~ of a ~~number~~securities ofpurchase ~~factors, some of which are beyond our control, including, but not limited to:~~agreement.

·In ~~actual~~addition orto ~~anticipated~~rights ~~variations in our~~ and ~~our~~remedies ~~competitors’~~available ~~results~~to ofall ~~operations~~purchasers ~~and financial condition · changes~~ in ~~earnings~~this ~~estimates~~offering orunder ~~recommendations~~federal by securities ~~analysts,~~and ifstate ~~our shares are covered by analysts; · market acceptance of our product candidates; · our obligation to use commercially reasonable efforts to use $250~~law,~~000~~ of the ~~net~~purchasers ~~proceeds~~that ~~from~~enter ~~our~~into ~~June~~a ~~2025~~securities ~~private placement to~~ purchase ~~Solana,~~agreement aswill ~~required~~also bybe ~~the~~able ~~related~~to ~~purchase~~bring ~~agreement;~~claims ~~· development~~ of ~~technological~~breach ~~innovations or new competitive products by others; · announcements~~ of ~~technological~~contract ~~innovations~~against ~~or new products by~~ us;. ·The ~~publication~~ability ~~of the results of preclinical or clinical trials for our product candidates; · failure by us~~ to ~~achieve~~pursue a ~~publicly~~claim ~~announced~~for ~~milestone;~~breach ~~· delays between our expenditures to develop and market new or enhanced products and the generation~~ of ~~sales~~contract ~~from~~provides those ~~products;~~investors ·with ~~developments~~the ~~concerning~~means ~~intellectual~~to ~~property~~enforce ~~rights, including our involvement in litigation brought by or against us; · regulatory developments and~~ the ~~decisions~~covenants ofuniquely ~~regulatory~~available ~~authorities as~~ to ~~the~~them ~~approval~~under ~~or rejection of new or modified products; · changes in~~ the ~~amounts~~securities ~~that~~purchase weagreement ~~spend to develop~~including, ~~acquire~~but ornot ~~license~~limited ~~new products, technologies or businesses; · changes in our expenditures~~ to ~~promote~~(i) ~~our~~timely ~~product~~delivery ~~candidates;~~of ~~· our sale or proposed sale~~securities, or(ii) ~~the~~agreement ~~sale~~to bynot ~~our~~issue ~~significant~~any ~~stockholders, of our~~ shares or ~~other~~ securities inconvertible ~~the~~into ~~future;~~shares ·for ~~changes~~a inperiod ~~key personnel; · success or failure~~ of ~~our~~days ~~research~~from ~~and~~closing ~~development projects or those~~ of ~~our competitors; ·~~ the ~~trading~~offering, ~~volume~~subject ofto ~~our~~certain ~~shares;~~exceptions and ·(iii) ~~general~~indemnification ~~economic~~for ~~and~~breach ~~market~~of ~~conditions and other factors, including factors unrelated to our operating performance~~contract.

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The market price of our shares may be subject to fluctuation and volatility. You could lose all or part of your investment.

The market price of our common stock is subject to wide fluctuations in response to various factors, some of which are beyond our control. The market price of our shares on Nasdaq may fluctuate as a result of a number of factors, some of which are beyond our control, including, but not limited to:

	·	actual or anticipated variations in our and our competitors’ results of operations and financial condition

	·	changes in earnings estimates or recommendations by securities analysts, if our shares are covered by analysts;

	·	market acceptance of our product candidates;

	·	development of technological innovations or new competitive products by others;

	·	announcements of technological innovations or new products by us;

	·	publication of the results of preclinical or clinical trials for our product candidates;

	·	failure by us to achieve a publicly announced milestone;

	·	delays between our expenditures to develop and market new or enhanced products and the generation of sales from those products;

	·	developments concerning intellectual property rights, including our involvement in litigation brought by or against us;

	·	regulatory developments and the decisions of regulatory authorities as to the approval or rejection of new or modified products;

	·	changes in the amounts that we spend to develop, acquire or license new products, technologies or businesses;

	·	changes in our expenditures to promote our product candidates;

	·	our sale or proposed sale, or the sale by our significant stockholders, of our shares or other securities in the future;

	·	changes in key personnel;

	·	success or failure of our research and development projects or those of our competitors;

	·	the trading volume of our shares; and

	·	general economic and market conditions and other factors, including factors unrelated to our operating performance.

These factors and any corresponding price fluctuations may materially and adversely affect the market price of our shares and result in substantial losses being incurred by our investors. In the past, following periods of market volatility, public company stockholders have often instituted securities class action litigation. If we were involved in securities litigation, it could impose a substantial cost upon us and divert the resources and attention of our management from our business.

We were obligated to use commercially reasonable efforts to invest $250,000 of our cash to purchase Solana, a cryptocurrency, the price of which has been, and will likely continue to be, highly volatile.

As a condition of our June 2025 private placement, we were obligated to use commercially reasonable efforts to use $250,000 of the net proceeds from the private placement to purchase Solana, a cryptocurrency, which we purchased on August 6, 2025. Solana is a highly volatile asset. Solana does not pay interest, but if management determines to stake the Solana tokens in treasury, certain rewards can be earned on Solana. The ability to generate a return on investment from the purchase of Solana will depend on whether there is appreciation in the value of Solana. Future fluctuations in Solana’s trading prices may result in our converting Solana into cash with a value substantially below the value at which such Solana was purchased.

Any Solana we purchase may be less liquid than our existing cash and cash equivalents and may not be able to serve as a source of liquidity for us to the same extent as cash and cash equivalents.

Historically, the crypto markets have been characterized by: significant volatility in price, limited liquidity and trading volumes compared to sovereign currencies markets; relative anonymity; a developing regulatory landscape; potential susceptibility to market abuse and manipulation; compliance and internal control failures at exchanges; and various other risks inherent in its entirely electronic, virtual form and decentralized network. During times of market instability, we may not be able to sell our Solana at favorable prices or at all. Further, Solana which we may hold with a custodian does not enjoy the same protections as are available to cash or securities deposited with or transacted by institutions subject to regulation by the Federal Deposit Insurance Corporation or the Securities Investor Protection Corporation. If we are unable to sell our Solana or otherwise generate funds using our Solana holdings, or if we are forced to sell our Solana at a significant loss, in order to meet our working capital requirements, our business and financial condition could be negatively impacted.

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SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

This prospectus and the information incorporated by reference contains forward-looking statements that are based on our management’s beliefs and assumptions and on information currently available. This section should be read in conjunction with our financial statements and related notes included in our Annual Report on Form 10-K for the year ended December 31, 2024. The statements contained or incorporated by reference in this prospectus that are not historical facts are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended.

These forward-looking statements are subject to a number of risks, uncertainties, and assumptions, including, but not limited to, those described in “Risk Factors.” These forward-looking statements reflect our beliefs and views with respect to future events and are based on estimates and assumptions as of the date of this prospectus and are subject to risks and uncertainties. We discuss many of these risks in greater detail in the section entitled “Risk Factors” and elsewhere in this prospectus, including the information incorporated by reference. Given these uncertainties, you should not place undue reliance on these forward-looking statements. We qualify all of the forward-looking statements in this prospectus by these cautionary statements. Except as required by law, we assume no obligation to update these forward-looking statements publicly, or to update the reasons actual results could differ materially from those anticipated in any forward-looking statements, whether as a result of new information, future events or otherwise.

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USE OF PROCEEDS

~~All~~Assuming we sell all shares of ~~our~~common ~~Common~~stock ~~Stock~~ offered bypursuant to this prospectus, ~~are~~we ~~being~~estimate ~~registered~~the ~~for~~net ~~resale~~proceeds byfrom ~~the~~this ~~Selling~~offering ~~Securityholders~~will ~~identified~~be ~~herein~~approximately $10.8 Wemillion, ~~will~~based ~~not~~on ~~receive~~an ~~any~~assumed public offering price of $7.31 per share (the last reported sale price of our shares of common stock on Nasdaq on March 18, 2026), after deducting placement agent fees and estimated offering expenses payable by us as described in “Plan of Distribution” and excluding the proceeds, if any, from the ~~sale~~exercise of the ~~Shares~~pre-funded ~~being~~warrants ~~offered~~sold ~~for~~in ~~sale~~this byoffering and the ~~Selling~~Placement ~~Securityholders~~Agent Warrants. However, this is a best efforts offering with no minimum number of securities or amount of proceeds as a condition to closing, and we may not sell all or any of these shares or pre-funded warrants offered pursuant to this prospectus; as a result, we may receive significantly less in net proceeds.

~~The~~We ~~Shares~~intend ~~covered~~to byuse the ~~registration~~net ~~statement~~proceeds of ~~which~~ this ~~prospectus~~offering isfor aworking ~~part~~capital ~~includes~~and 684,680 shares of Common Stock issuable upon exercise of the Warrants. If all such warrants are exercised in cash, then we will receive gross proceeds of approximately $3.0 Million. Proceeds to us from the exercise of such warrants will be used for general corporate purposes~~, including working capital~~.

The ~~Selling~~amounts ~~Securityholders~~and ~~will~~timing ~~pay~~of ~~any~~our ~~underwriting~~actual ~~discounts~~use ~~and~~of ~~commissions~~the ~~and~~net ~~expenses~~proceeds ~~incurred~~from bythis ~~the~~offering ~~Selling~~will ~~Securityholders~~vary ~~for~~depending ~~brokerage,~~on ~~accounting~~numerous factors, ~~tax~~including orthe ~~legal~~factors ~~services~~described orunder ~~any~~“Risk ~~other~~Factors” ~~expenses~~located ~~incurred~~elsewhere byin ~~the~~this ~~Selling~~prospectus ~~Securityholders~~or in ~~disposing~~the ofinformation ~~the~~incorporated ~~securities.~~by Wereference ~~will~~herein ~~bear~~or ~~the~~therein. ~~costs~~As a result, ~~fees~~our ~~and~~management ~~expenses~~will ~~incurred~~have inbroad ~~effecting~~discretion in the ~~registration~~application of the ~~Shares~~net ~~covered by this prospectus~~proceeds, ~~including all registration~~ and ~~filing~~investors ~~fees,~~will ~~Nasdaq~~be ~~listing~~relying ~~fees~~on ~~and~~our ~~fees~~judgment ~~and~~regarding ~~expenses~~the application of ~~our~~the ~~counsel~~net ~~and~~proceeds ~~our~~from ~~independent~~this ~~registered public accounting firm~~offering.

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DIVIDEND POLICY

We have never declared or paid any cash dividends on our ~~Common~~common ~~Stock~~stock and do not anticipate paying any cash dividends on our ~~Common~~common ~~Stock~~stock at any time in the foreseeable future. We currently intend to retain all available funds and any future earnings for use in the operation of our business and do not anticipate paying any dividends on our ~~Common~~common ~~Stock~~stock in the foreseeable future. Any future determination to declare dividends will be made at the discretion of our board of directors and will depend on, among other factors, our financial condition, operating results, capital requirements, general business conditions, the terms of any future credit agreements and other factors that our board of directors may deem relevant. See the section captioned “Management’s Discussion and Analysis of Financial Condition and Results of Operations” contained in our Annual Report on Form 10-K and in our Quarterly Reports on Form 10-Q for additional information regarding our financial condition.

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CAPITALIZATION

The following table sets forth our cash and cash equivalents, short-term investments and capitalization as of December 31, 2025:

	·	On an actual basis; and

	·	On an as adjusted basis to give effect to this offering at an assumed public offering price of $7.31 per share, which is the last reported sale price of our shares of common stock on Nasdaq on March 18, 2026, assuming no sale of any pre-funded warrants in this offering and after deducting the estimated placement agent fees and estimated offering expenses payable by us as described under “Use of Proceeds.”

The as adjusted information below is illustrative only. You should read this table together with the information contained in this prospectus and the information incorporated by reference from our Annual Report on Form 10-K for the year ended December 31, 2025, including the historical financial statements and related notes included therein.

	As of December 31, 2025
	Actual			As Adjusted (Unaudited)
	(U.S. $ in thousands)
Cash and cash equivalents	$	600		$	11,400
Total current liabilities	$	4,044		$	4,044
Stockholders’ equity
Preferred Stock, par value $0.001, 23,148 shares authorized, 0 shares issued and outstanding as of December 31, 2025		-			-
Common Stock, par value $0.001, 166,666,667 shares authorized and 673,008 shares issued and outstanding as of December 31, 2025		1			3
Additional paid in capital		62,014			72,814
Accumulated deficit		(63,015	)		(63,015	)
Accumulated other comprehensive loss		(272	)		(272	)
Total stockholders’ (deficit) equity	$	(1,272	)	$	9,530

A $1.00 increase or decrease in the assumed public offering price of $7.31 per share, which is the last reported sale price of our shares of common stock on Nasdaq on March 18, 2026, would increase or decrease, as appropriate, our pro forma as-adjusted cash and cash equivalents, additional paid-in capital, total stockholders’ equity and total capitalization by approximately $1.5 million, assuming the number of shares offered by us as set forth on the cover page of this prospectus remains the same, and after deducting the estimated placement agent fees and estimated offering expenses payable by us.

Similarly, an increase or decrease of 100,000 in the number of shares offered by us, based on the assumed public offering price of $7.31 per share, would increase or decrease our pro forma as-adjusted cash and cash equivalents, total assets and total shareholders’ equity by approximately $0.7 million, after deducting the placement agent fees and estimated offering expenses payable by us. The information discussed above is illustrative only and will adjust based on the actual offering price, the actual number of units we offer in this offering, and other terms of this offering determined at pricing.

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The table and discussion above are based on 673,008 shares of common stock outstanding as of December 31, 2025 (giving effect to the one-for-three reverse stock split of our common stock effected on March 10, 2026), and excludes the following:

	·	75,998 shares of our common stock issuable upon the exercise of options or restricted stock awards granted under the 2018 Plan, with a weighted-average exercise price of $33.09 per share;

	·	466,263 shares of our common stock issuable upon the exercise of warrants, with a weighted-average exercise price of $16.89 per share issued prior to January 2026;

	·	41,089 shares of common stock issuable upon the voluntary conversion of convertible notes issued in our October 2025 private placement;

	·	35,857 shares of our common stock reserved for future issuance under our 2018 Plan;

	·	62,124 shares of our common stock issuable upon the exercise of pre-funded warrants issued pursuant to our ELOC Purchase Agreement, at an exercise price of $0.003 per share; and

	·	up to $25 million in shares of common stock that may be issued and sold by us pursuant to the ELOC Purchase Agreement, which at the Company’s sole discretion can be increased by an additional $25 million once the initial $25 million is exhausted.

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~~SELLING SECURITYHOLDERS~~DILUTION

~~This~~If ~~prospectus~~you ~~covers~~invest ~~the~~in ~~resale~~our orsecurities ~~other~~in ~~disposition~~this byoffering, ~~the~~your ~~Selling~~ownership ~~Securityholders~~interest ofwill ~~the~~be ~~Shares.~~diluted ~~The~~immediately ~~Selling~~to ~~Securityholders listed in~~ the ~~table~~extent ~~below may from time to time offer and sell any or all~~ of the ~~Shares~~difference ~~set~~between ~~forth below pursuant to this prospectus. When we refer to~~ the ~~“Selling~~public ~~Securityholders”~~offering inprice ~~this~~per ~~prospectus,~~share weand ~~refer to~~ the ~~persons~~as ~~listed~~adjusted innet ~~the~~tangible ~~table~~book ~~below~~value ~~and~~per ~~the~~share ~~permitted transferees that hold any~~ of ~~the~~our ~~Selling~~common ~~Securityholders’~~stock ~~interest~~immediately ~~in the Shares~~ after ~~the date of~~ this ~~prospectus~~offering.

~~The~~As ~~following table sets forth certain information concerning the Shares that may be offered from time to time by each Selling Securityholder pursuant to this prospectus. The number~~ of ~~shares~~December ~~beneficially~~31, ~~owned~~2025, byour ~~each~~net ~~Selling~~tangible ~~Securityholder~~book isvalue ~~determined~~was ~~under rules issued by the SEC~~$(3.3) ~~Under these rules~~million, ~~beneficial ownership includes any shares as to which the individual~~ or ~~entity~~$(4.92) ~~has~~per ~~sole~~share orof ~~shared~~our ~~voting~~common ~~power~~stock, ~~or investment power. Percentage ownership is~~ based onupon 2673,~~018,746~~008 shares of ~~Common~~common ~~Stock~~stock outstanding as of ~~November 10, 2025. In computing the number of shares beneficially owned by an individual or entity and the percentage ownership of~~ that person or entity, shares of Common Stock subject to warrants or other rights held by such person or entity that are currently exercisable or convertible or will become exercisable or convertible or will vest within 60 days of such date ~~are considered outstanding, although these shares are not considered outstanding for purposes of computing the percentage ownership of any other person~~. ~~The~~Historical ~~percentages~~net ~~included~~tangible inbook ~~the~~value ~~table~~per ~~below~~share ~~take~~is ~~into~~equal account the beneficial ownership limitations included in the Notes, the $6.24 Warrants and the $3.40 Warrants, which provide that a holder of such notes and warrants may not exercise any portion of such holder’s Notes, the $6.24 Warrants and the $3.40 Warrants to ~~the~~our ~~extent~~total ~~that~~tangible ~~the holder~~assets, ~~together~~less ~~with~~total ~~its affiliates~~liabilities, ~~would~~divided ~~beneficially~~by ~~own more than 4.9% (or 9.9%, in~~ the ~~case~~number of ~~the $6.24 Warrants) of the Company’s~~ outstanding shares of ~~Common~~our ~~Stock~~common ~~immediately~~stock. ~~after~~Dilution ~~exercise,~~per ~~except~~share ~~that upon at least 61 days’ prior notice from the holder~~ to ~~the~~new ~~Company,~~investors ~~the~~purchasing ~~holder~~common ~~may~~stock ~~increase~~in ~~the~~this ~~beneficial~~offering ~~ownership~~is ~~limitation~~determined toby upsubtracting toas ~~19.9%~~adjusted ofnet ~~the~~tangible ~~number~~book ofvalue ~~shares~~per ofshare ~~Common Stock outstanding immediately~~ after ~~giving~~this ~~effect~~offering tofrom the ~~exercise.~~public ~~Except~~offering asprice ~~otherwise~~per ~~indicated,~~share topaid ~~our knowledge, each of the Selling Securityholders listed has sole voting and investment power with respect to the shares beneficially owned~~ by ~~the~~new ~~Selling Securityholder, subject to community property laws where applicable~~investors.

~~The~~After ~~Selling~~giving ~~Securityholders~~effect ~~identified~~to ~~below~~our ~~may~~issuance ~~have~~and ~~sold,~~sale ~~transferred~~of orsecurities ~~otherwise~~in ~~disposed~~this ofoffering ~~all~~at oran aassumed ~~portion~~public ofoffering ~~their~~price ~~securities~~of ~~included~~$7.31 inper share (the ~~table~~closing ~~below~~sale inprice ~~transactions~~of ~~exempt~~our ~~from~~common ~~the~~stock ~~registration~~on ~~requirements~~Nasdaq ofon ~~the~~March ~~Securities~~18, ~~Act.~~2026), ~~Any~~assuming ~~changed~~no orpre-funded ~~new~~warrants ~~information~~are ~~provided~~sold toin usthis byoffering ~~the~~and ~~Selling~~after ~~Securityholders,~~deducting ~~including~~placement ~~regarding~~agent ~~the~~fees ~~identity of,~~ and ~~the~~estimated ~~securities~~offering ~~held~~expenses payable by, ~~each Selling Securityholder~~us, ~~will~~our bepro ~~set~~forma ~~forth~~as inadjusted anet ~~prospectus~~tangible ~~supplement~~book orvalue ~~amendments~~as toof ~~the~~December ~~registration~~31, ~~statement~~2025 ofwould ~~which~~have ~~this~~been ~~prospectus~~approximately is$9.5 ~~a part~~million, ifor ~~and~~approximately ~~when~~$4.12 ~~necessary~~per share. AThis ~~Selling~~represents ~~Securityholder~~an ~~may~~immediate ~~sell~~increase ~~all,~~in ~~some~~actual ornet ~~none~~tangible ofbook ~~such~~value ~~securities~~per inshare ~~this~~of ~~offering~~$8.16 ~~See~~to ~~“Plan~~our ofexisting ~~Distribution.”~~stockholders ~~For~~and ~~purposes~~an ofimmediate ~~this~~dilution ~~table,~~in weactual ~~have~~net ~~assumed~~tangible ~~that~~book ~~the~~value ~~Selling~~per ~~Securityholders~~share ~~will~~of ~~have~~approximately ~~sold~~$4.07 ~~all~~to ofnew ~~the~~investors ~~securities~~purchasing ~~covered~~units byin this ~~prospectus~~offering, ~~upon~~as ~~the~~illustrated ~~completion~~by of the ~~offering.~~following table:

As detailed below, certain of the Selling Securityholders have a position, office or other material relationship with us:

Public offering price per share	$	7.31
Net tangible book value per share as of December 31, 2025	$	(4.92	)
Increase in net tangible book value per share attributable to this offering	$	8.16
As adjusted net tangible book value per share after giving effect to this offering	$	3.24
Dilution per share to new investors participating in this offering	$	(4.07	)

~~Selling~~If ~~Securityholders~~we ~~Affiliation~~only ~~with~~sell 75% or 50% of the ~~Company~~maximum ~~Connie~~offering ~~Matsui~~amount, ~~Director~~our ~~Tamara~~as ~~Favorito~~adjusted ~~Director~~net ~~Gregory~~tangible ~~Gorgas~~book ~~Director~~value after this offering would be approximately $4.8 million or $2.1 million, respectively, and ~~Officer~~the ~~Peter~~dilution ~~O’Brien~~per ~~Consultant~~share ~~Chris~~to ~~Duncan~~investors ~~Consultant~~purchasing ~~Jason~~securities ~~Baybutt~~in ~~Consultant~~this ~~PubCo~~offering ~~Reporting~~would ~~Solutions,~~be ~~Inc~~$5.24 ~~Service~~or ~~Provider~~$6.41, respectively, assuming no pre-funded warrants are sold and after deducting placement agent fees and estimated offering expenses payable by us.

The information discussed above is illustrative only and will be adjusted based on the actual public offering price, the actual number of securities that we offer in this offering, and other terms of this offering determined at the time of pricing. The foregoing discussion and table assumes no sale of pre-funded warrants, which if sold, would reduce the number of shares that we are offering on a one-for-one basis. In addition, we may choose to raise additional capital due to market conditions or strategic considerations. To the extent that additional capital is raised through the sale of equity or convertible debt securities, the issuance of these securities could result in further dilution to our stockholders.

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Selling Securityholder(1)	Number of Shares of Common Stock Beneficially OwnedPrior to Offering	Percentage of Shares Beneficially Owned Prior to Offering %	Maximum Number of Shares of Common Stock to be Sold Pursuant to this Prospectus		Number of Sharesof Common Stock Beneficially Owned After Offering		Percentage of Shares Beneficially Owned after Shares are Sold
3i, LP(2)	98,919	4.9%		255,893		-		-	%
Donal Hamill(3)	98,919	4.9%		225,180		547		*	%
Equity Trust Company Custodian FBO Donal F. Hamill IRA(4)	98,919	4.9%		112,590		-		-	%
Connie Matsui(5)	98,919	4.9%		143,300		3,970		*	%
Eamonn O’Kane(6)	71,649	3.5%		71,649		-		-	%
Peter O’Brien(7)	21,709	1.1%		19,728		1,981		*	%
David Waldman(8)	51,177	2.5%		51,177		-		-	%
Gregory Gorgas(9)	88,558	4.4%		35,822		52,736		2.6	%
Tamara Favorito(10)	27,864	1.4%		25,586		2,278		*
PubCo Reporting Solutions, Inc.(11)	25,586	1.3%		25,586		-		-
Troy Norris(12)	18,082	*		15,352		2,730		*
Jason Baybutt(13)	10,963	*		10,233		730		*
John Brady(14)	10,319	*		10,233		86		*
Chris Duncan(15)	10,366	*		10,233		133		*

*· ~~Less~~75,998 ~~than~~shares 1of our common stock issuable upon the exercise of options or restricted stock awards granted under the 2018 Plan, with a weighted-average exercise price of $33.0%09 per share; · 466,263 shares of our common stock issuable upon the exercise of warrants, with a weighted-average exercise price of $16.89 per share issued prior to January 2026; · 41,089 shares of common stock issuable upon the voluntary conversion of convertible notes issued in our October 2025 private placement;

(1)	This table and the information in the notes below are based upon information supplied by the Selling Securityholders.
(2)	Consists of (i) 61,747 shares of Common Stock issuable upon conversion of the Notes, (ii) 68,474 shares of Common Stock issuable upon exercise of the $6.24 Warrants and (iii) 125,672 shares of Common Stock issuable upon exercise of the $3.40 Warrants. As a result of the beneficial ownership limitation of the Notes, the $6.24 Warrants and the $3.40 Warrants, the “Shares of Common Stock Beneficially Owned Prior to Offering” excludes an aggregate of 156,974 shares of Common Stock issuable upon the conversion or exercise, as applicable, of the Notes, the $6.24 Warrants and $3.40 Warrants due to the beneficial ownership limitation. 3i Management LLC is the general partner of 3i, LP, and Maier Joshua Tarlow is the manager of 3i Management LLC. As such, Mr. Tarlow exercises sole voting and investment discretion over securities beneficially owned directly or indirectly by 3i, LP and 3i Management LLC. Mr. Tarlow disclaims beneficial ownership of the securities beneficially owned directly by 3i, LP and indirectly by 3i Management LLC. The business address of each of the aforementioned parties is 2 Wooster Street, 2nd Floor, New York, NY 10013. We have been advised that none of Mr. Tarlow, 3i Management LLC, or 3i, LP is a member of the Financial Industry Regulatory Authority, or FINRA, or an independent broker-dealer, or an affiliate or associated person of a FINRA member or independent broker-dealer.
(3)	Consists of (i) 27,168 shares of Common Stock issuable upon conversion of the Notes, (ii) 30,128 shares of Common Stock issuable upon exercise of the $6.24 Warrants, (iii) 55,294 shares of Common Stock issuable upon exercise of the $3.40 Warrants and (iv) 112,590 shares of Common Stock held by Equity Trust Company Custodian FBO Donal F. Hamill IRA. As a result of the beneficial ownership limitation of the Notes, the $6.24 Warrants and the $3.40 Warrants, the “Shares of Common Stock Beneficially Owned Prior to Offering” excludes an aggregate of 126,808 shares of Common Stock issuable upon the conversion or exercise, as applicable, of the Notes, the $6.24 Warrants and $3.40 Warrants due to the beneficial ownership limitation. The principal address of Donal Hamill is 683 SE 27th Street, #207, Mercer Island, WA 98040.
(4)	Consists of (i) 27,168 shares of Common Stock issuable upon conversion of the Notes, (ii) 30,128 shares of Common Stock issuable upon exercise of the $6.24 Warrants and (iii) 55,294 shares of Common Stock issuable upon exercise of the $3.40 Warrants. As a result of the beneficial ownership limitation of the Notes, the $6.24 Warrants and the $3.40 Warrants, the “Shares of Common Stock Beneficially Owned Prior to Offering” excludes an aggregate of 13,671 shares of Common Stock issuable upon the exercise of the Warrants due to the beneficial ownership limitation. Donal Hamill has voting and investment power with respect to the securities beneficially owned by Equity Trust Company Custodian FBO Donal F. Hamill IRA. The principal address of Equity Trust Company Custodian FBO Donal F. Hamill IRA is 683 SE 27th Street, #207, Mercer Island, WA 98040.
(5)	Consists of (i) 34,578 shares of Common Stock issuable upon conversion of the Notes, (ii) 38,346 shares of Common Stock issuable upon exercise of the $6.24 Warrants, (iii) 70,376 shares of Common Stock issuable upon exercise of the $3.40 Warrants, (iv) 630 shares held directly by Connie Matsui and (v) 3,340 shares of Common Stock issuable pursuant to options held directly by Connie Matsui exercisable within 60 days of November 10, 2025. As a result of the beneficial ownership limitation of the Notes, the $6.24 Warrants and the $3.40 Warrants, the “Shares of Common Stock Beneficially Owned Prior to Offering” excludes an aggregate of 48,351 shares of Common Stock issuable upon the conversion or exercise, as applicable, of the Notes, the $6.24 Warrants and $3.40 Warrants due to the beneficial ownership limitation. The principal address of Connie Matsui is c/o Artelo Biosciences, Inc., 505 Lomas Santa Fe, Suite 160, Solana Beach, California 92075.

	·	35,857 shares of our common stock reserved for future issuance under our 2018 Plan;

	·	62,124 shares of our common stock issuable upon the exercise of pre-funded warrants issued pursuant to our ELOC Purchase Agreement, at an exercise price of $0.003 per share; and

	·	up to $25 million in shares of common stock that may be issued and sold by us pursuant to the ELOC Purchase Agreement, which at the Company’s sole discretion can be increased by an additional $25 million once the initial $25 million is exhausted.

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(6)	Consists of (i) 17,289 shares of Common Stock issuable upon conversion of the Notes, (ii) 19,172 shares of Common Stock issuable upon exercise of the $6.24 Warrants and (iii) 35,188 shares of Common Stock issuable upon exercise of the $3.40 Warrants. The principal address of Eamonn O’Kane is Arabella, Claremont Road, Foxrock, Dublin D18A090.
(7)	Consists of (i) 2,890 shares of Common Stock issuable upon conversion of the Notes, (ii) 10,956 shares of Common Stock issuable upon exercise of the $6.24 Warrants, (iii) 5,882 shares of Common Stock issuable upon exercise of the $3.40 Warrants, (iv) 1,400 shares held directly by Peter O’Brien and (v) 581 shares of Common Stock issuable pursuant to options held directly by Peter O’Brien exercisable within 60 days of November 10, 2025. The principal address of Peter O’Brien is 1 Albert Tce, Mesrh Rd, Bray, Co Wicklow Ireland.
(8)	Consists of (i) 12,349 shares of Common Stock issuable upon conversion of the Notes, (ii) 13,694 shares of Common Stock issuable upon exercise of the $6.24 Warrants and (iii) 25,134 shares of Common Stock issuable upon exercise of the $3.40 Warrants. The principal address of David Waldman is 995 Orion Court, Merrick, NY 11566.
(9)	Consists of (i) 8,644 shares of Common Stock issuable upon conversion of the Notes, (ii) 9,586 shares of Common Stock issuable upon exercise of the $6.24 Warrants, (iii) 17,592 shares of Common Stock issuable upon exercise of the $3.40 Warrants, (iv) 3,008 shares of Common Stock held directly by Gregory D. Gorgas, (v) 400 shares of Common Stock held indirectly by Gorgas Family Trust and (vi) 49,328 shares of Common Stock issuable pursuant to options held directly by Gregory D. Gorgas exercisable within 60 days of November 10, 2025. The principal address of Gregory D. Gorgas is c/o Artelo Biosciences, Inc., 505 Lomas Santa Fe, Suite 160, Solana Beach, California 92075.
(10)	Consists of (i) 6,174 shares of Common Stock issuable upon conversion of the Notes, (ii) 6,846 shares of Common Stock issuable upon exercise of the $6.24 Warrants, (iii) 12,566 shares of Common Stock issuable upon exercise of the $3.40 Warrants and (iv) 2,278 shares of Common Stock issuable pursuant to options held directly by Tamara A. Favorito exercisable within 60 days of November 10, 2025. The principal address of Tamara A. Favorito is c/o Artelo Biosciences, Inc., 505 Lomas Santa Fe, Suite 160, Solana Beach, California 92075.
(11)	Consists of (i) 6,174 shares of Common Stock issuable upon conversion of the Notes, (ii) 6,846 shares of Common Stock issuable upon exercise of the $6.24 Warrants and (iii) 12,566 shares of Common Stock issuable upon exercise of the $3.40 Warrants. Nanuk Warman has voting and investment power with respect to the securities beneficially owned by PubCo Reporting Solutions, Inc. The principal address of PubCo Reporting Solutions, Inc is 610 - 475 W. Georgia Street, Vancouver, BC Canada V6B 4M9.
(12)	Consists of (i) 3,704 shares of Common Stock issuable upon conversion of the Notes, (ii) 4,108 shares of Common Stock issuable upon exercise of the $6.24 Warrants, (iii) 7,540 shares of Common Stock issuable upon exercise of the $3.40 Warrants and (iv) 2,730 shares of Common Stock issuable pursuant to options held directly by Troy Norris exercisable within 60 days of November 10, 2025. The principal address of Troy Norris is 6 Bethany, Laguna Niguel, CA 92677.
(13)	Consists of (i) 2,469 shares of Common Stock issuable upon conversion of the Notes, (ii) 2,738 shares of Common Stock issuable upon exercise of the $6.24 Warrants, (iii) 5,026 shares of Common Stock issuable upon exercise of the $3.40 Warrants and (iv) 730 shares of Common Stock issuable pursuant to options held directly by Jason Baybutt exercisable within 60 days of November 10, 2025. The principal address of Jason Baybutt is c/o PubCo Reporting Solutions, Inc., 610 - 475 W. Georgia Street, Vancouver, BC Canada V6B 4M9.
(14)	Consists of (i) 2,469 shares of Common Stock issuable upon conversion of the Notes, (ii) 2,738 shares of Common Stock issuable upon exercise of the $6.24 Warrants and (iii) 5,026 shares of Common Stock issuable upon exercise of the $3.40 Warrants. The principal address of John Brady is 1 Vernon, Rise, Clontarf, Dublin 3,Ireland.
(15)	Consists of (i) 2,469 shares of Common Stock issuable upon conversion of the Notes, (ii) 2,738 shares of Common Stock issuable upon exercise of the $6.24 Warrants, (iii) 5,026 shares of Common Stock issuable upon exercise of the $3.40 Warrants and (iv) 133 shares of Common Stock issuable pursuant to options held directly by Chris Duncan exercisable within 60 days of November 10, 2025. The principal address of Chris Duncan is c/o Artelo Biosciences, Inc., 505 Lomas Santa Fe, Suite 160, Solana Beach, California 92075.

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PLAN OF DISTRIBUTION

Each Selling Securityholder of the shares of the securities and any of their pledgees, assignees and successors-in-interest may, from time to time, sell any or all of their securities covered hereby on Nasdaq or any other stock exchange, market or trading facility on which the securities are traded or in private transactions. These sales may be at fixed or negotiated prices. A Selling Securityholder may use any one or more of the following methods when selling securities:

· ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers; · block trades in which the broker-dealer will attempt to sell the securities as agent but may position and resell a portion of the block as principal to facilitate the transaction; · purchases by a broker-dealer as principal and resale by the broker-dealer for its account; · an exchange distribution in accordance with the rules of the applicable exchange; · privately negotiated transactions; · settlement of short sales; · in transactions through broker-dealers that agree with the Selling Securityholders to sell a specified number of such securities at a stipulated price per security; · through the writing or settlement of options or other hedging transactions, whether through an options exchange or otherwise; · to or through one or more underwriters or dealers in a public offering and sale by them, whether individually or through an underwriting syndicate led by one or more managing underwriters; · through agents; · a combination of any such methods of sale; or · any other method permitted pursuant to applicable law.

The Selling Securityholders may also sell securities under Rule 144 or any other exemption from registration under the Securities Act, if available, rather than under this prospectus.

If underwriters are used in the sale of any securities, such securities will be acquired by the underwriters for their own account and may be resold from time to time in one or more transactions described above. Securities may be either offered to the public through underwriting syndicates represented by managing underwriters or directly by underwriters.

If a dealer is used in an offering of securities, the dealer may purchase the securities, as principal. The dealer may then resell the securities to the public at varying prices to be determined by the dealer at the time of sale.

Securities may be sold directly or through agents designated from time to time. We will name any agent involved in the offering and sale of such securities and we will describe any commissions paid to the agent in the prospectus supplement. Unless the prospectus supplement states otherwise, the agent will act on a best-efforts basis for the period of its appointment.

19 Table of Contents

Underwriters, dealers and agents may be entitled to indemnification by the Selling Securityholders and/or us against certain civil liabilities, including liabilities under the Securities Act, or to contribution with respect to payments which the agents, broker-dealers or underwriters may be required to make in respect thereof.

Underwriters, dealers or agents may receive compensation in the form of discounts, concessions or commissions from the Selling Securityholders or the purchasers, as their agents in connection with the sale of securities. If the shares are sold through underwriters, broker-dealers or agents, the Selling Securityholders will be responsible for underwriting discounts or commissions or agent’s commissions. These underwriters, dealers or agents may be considered to be underwriters under the Securities Act. As a result, discounts, commissions or profits on resale received by the underwriters, dealers or agents may be treated as underwriting discounts and commissions. Each accompanying prospectus supplement will identify any such underwriter, dealer or agent and describe any compensation received by them from the Selling Securityholders. Any initial public offering price and any discounts or concessions allowed or re-allowed or paid to dealers may be changed from time to time.

In connection with the sale of the securities or interests therein, the Selling Securityholders may enter into hedging transactions with broker-dealers or other financial institutions, which may in turn engage in short sales of the securities in the course of hedging the positions they assume. The Selling Securityholders may also sell securities short and deliver these securities to close out their short positions, or loan or pledge the securities to broker-dealers that in turn may sell these securities. The Selling Securityholders may also enter into option or other transactions with broker-dealers or other financial institutions or create one or more derivative securities which require the delivery to such broker-dealer or other financial institution of securities offered by this prospectus, which securities such broker-dealer or other financial institution may resell pursuant to this prospectus (as supplemented or amended to reflect such transaction).

The Selling Securityholders and any broker-dealers or agents that are involved in selling the securities may be deemed to be “underwriters” within the meaning of the Securities Act in connection with such sales. In such event, any commissions received by such broker-dealers or agents and any profit on the resale of the securities purchased by them may be deemed to be underwriting commissions or discounts under the Securities Act. If the Selling Securityholders are deemed to be underwriters, the Selling Securityholders may be subject to certain liabilities under statutes including, but not limited to, Section 11, 12 and 17 of the Securities Act and Section 10(b) and Rule 10b-5 under the Exchange Act.

The Company is required to pay certain fees and expenses incurred by the Company incident to the registration of the securities. The Company has agreed to indemnify the Selling Securityholders against certain losses, claims, damages and liabilities, including liabilities under the Securities Act.

We have agreed to keep this prospectus effective until all of the securities have been sold pursuant to this prospectus or Rule 144 under the Securities Act or any other rule of similar effect.

In order to comply with the securities laws of some states, if applicable, the shares may be sold in these jurisdictions only through registered or licensed brokers or dealers. In addition, in some states the shares may not be sold unless they have been registered or qualified for sale or an exemption from registration or qualification requirements is available and is complied with.

Under applicable rules and regulations under the Exchange Act, any person engaged in the distribution of the resale securities may not simultaneously engage in market making activities with respect to the Common Stock for the applicable restricted period, as defined in Regulation M, prior to the commencement of the distribution. In addition, the Selling Securityholders will be subject to applicable provisions of the Exchange Act and the rules and regulations thereunder, including Regulation M, which may limit the timing of purchases and sales of the Common Stock by the Selling Securityholders or any other person. We will make copies of this prospectus available to the Selling Securityholders and have informed them of the need to deliver a copy of this prospectus to each purchaser at or prior to the time of the sale (including by compliance with Rule 172 under the Securities Act).

20 Table of Contents

PRINCIPAL STOCKHOLDERS

The following table sets forth certain information with respect to the beneficial ownership of our ~~Common~~common ~~Stock~~stock as of ~~November~~March 1018, ~~2025~~2026, for (i) each of our executive officers and directors; (ii) all of our executive officers and directors as a group; and (iii) each other shareholder known by: us to be the beneficial owner of more than 5% of any class of our voting securities.

·The ~~each~~percentage ~~person~~beneficial ownership information prior to the offering shown in the table is based on an aggregate of 736,127 orshares ~~group~~of our common stock outstanding as of ~~affiliated~~March ~~persons~~18, ~~who~~2026. weThe ~~know~~percentage toof ~~beneficially~~beneficial ~~own~~ownership ~~more~~after ~~than~~this 5%offering ofshown ~~our~~in ~~Common~~the ~~Stock;~~table ·is ~~each~~based on shares of ~~our~~common ~~named~~stock ~~executive~~outstanding ~~officers;~~after ·the ~~each~~closing of ~~our~~this ~~directors;~~offering, ~~and~~assuming ·no ~~all~~sale of pre-funded warrants, no exercise of outstanding options issued under our ~~executive~~equity ~~officers~~incentive plans and ~~directors~~no asexercise aof ~~group~~any outstanding warrants.

~~The~~Beneficial ~~percentage~~ownership is determined according to the rules of the SEC, which generally provide that a person has beneficial ownership ~~information~~of ~~shown~~a insecurity if he, she or it possesses sole or shared voting or investment power over that security. Under those rules, beneficial ownership includes securities that the ~~table~~individual isor ~~based~~entity onhas anthe ~~aggregate~~right to acquire, such as through the exercise of 2stock options,~~018~~ within 60 days of March 18,~~746~~ ~~shares~~2026. Shares subject to options that are currently exercisable or exercisable within 60 days of ~~our~~March ~~Common~~18, ~~Stock~~2026 are considered outstanding and beneficially owned by the person holding such options for the purpose of computing the percentage ownership of that person but are not treated as ~~November~~outstanding ~~10,~~for ~~2025~~the purpose of computing the percentage ownership of any other person. Unless otherwise indicated, and subject to community property laws where applicable, based on the information provided to us, we believe that the persons and entities named in the table below have sole voting and investment power with respect to all shares shown as beneficially owned by them.

~~Beneficial~~17 ~~ownership~~Table ~~is determined according to the rules~~ of the SEC, which generally provide that a person has beneficial ownership of a security if he, she or it possesses sole or shared voting or investment power over that security. Under those rules, beneficial ownership includes securities that the individual or entity has the right to acquire, such as through the exercise of stock options, within 60 days of November 10, 2025. Shares subject to options that are currently exercisable or exercisable within 60 days of November 10, 2025 are considered outstanding and beneficially owned by the person holding such options for the purpose of computing the percentage ownership of that person but are not treated as outstanding for the purpose of computing the percentage ownership of any other person. Except as noted by footnote, and subject to community property laws where applicable, based on the information provided to us, we believe that the persons and entities named in the table below have sole voting and investment power with respect to all shares shown as beneficially owned by them.Contents

Unless otherwise indicated, the persons or entities identified in this table have sole voting and investment power with respect to all shares shown as beneficially owned by them, subject to applicable community property laws. Except as otherwise noted below, the address of each of the individuals and entities named in the table below is c/o Artelo Biosciences, Inc., 505 Lomas Santa Fe, Suite 160, Solana Beach, California 92075.

Name and Address of Beneficial Owner	Shares		Percentage
	Number of Shares of Common Stock Beneficially Owned Prior to this Offering					Number of Shares of Common Stock Beneficially Owned After this Offering
5% Stockholders:
Name and Address of Beneficial Owner	Shares		Percentage (%)			Shares		Percentage (%)
None
5% Stockholders:
Other Directors and Named Executive Officers:
None					%
Gregory D. Gorgas(1)		88,558		4.4	%
Directors and Named Executive Officers:
Connie Matsui(2)		98,919		4.9	%
Gregory D. Gorgas(1)		32,138		4.2	%		32,138		1.3	%
Steven Kelly(3)		3,346	*
Connie Matsui(2)		48,702		6.2	%		48,702		2.0	%
Douglas Blayney, M.D.(4)		3,282	*
Steven Kelly(3)		669	*				669	*
R. Martin Emanuele, Ph.D.(5)		3,238	*
Douglas Blayney, M.D.(4)		695	*				695	*
Gregory R. Reyes M.D., Ph.D.(6)		2,886	*
R. Martin Emanuele, Ph.D.(5)		688	*				688	*
Tamara A. Favorito(7)		27,864		1.4	%
Gregory R. Reyes M.D., Ph.D.(6)		546	*				546	*
Mark Spring(8)		1,562	*
Tamara A. Favorito(7)		8,836		1.2	%		8,836	*
All directors and executive officers as a group (8 persons)(9)		229,655		11.4	%
Mark E. Spring(8)		556	*				556	*
All directors and executive officers as a group (8 persons)		92,830		11.2	%		92,830		3.8	%

_________________

* Less than 1%

(1)	Consists of (i) 1,003 shares held directly by Gregory D. Gorgas, (ii) 134 shares held indirectly by Gorgas Family Trust, (iii) 19,059 shares of common stock issuable pursuant to options held directly by Gregory D. Gorgas exercisable within 60 days, (iv) 2,882 shares issued on the conversion of an outstanding note payable, (v) 3,196 warrants representing 3,196 shares of common stock which have an exercise price of $18.72 per common share and expire in October 2030, and (vi) 5,864 warrants representing 5,864 shares of common stock which have an exercise price of $10.20 per common share and expire in October 2030.	Consists of (i) 8,644 shares of Common Stock issuable upon conversion of the Notes, (ii) 9,586 shares of Common Stock issuable upon exercise of the $6.24 Warrants, (iii) 17,592 shares of Common Stock issuable upon exercise of the $3.40 Warrants, (iv) 3,008 shares of Common Stock held directly by Gregory D. Gorgas, (v) 400 shares of Common Stock held indirectly by Gorgas Family Trust and (vi) 49,328 shares of Common Stock issuable pursuant to options held directly by Gregory D. Gorgas exercisable within 60 days of November 10, 2025.
(2)	Consists of (2i) 210 shares held directly by Connie Matsui, (ii) 725 shares of common stock issuable pursuant to options held directly by Connie Matsui exercisable within 60 days, (iii) 11,526 shares issued on the conversion of an outstanding note payable, (v) 12,782 warrants representing 12,782 shares of common stock which have an exercise price of $18.72 per common share and expire in October 2030, and (vi) 23,459 warrants representing 23,459 shares of common stock which have an exercise price of $10.20 per common share and expire in October 2030.	Consists of (i) 34,578 shares of Common Stock issuable upon conversion of the Notes, (ii) 38,346 shares of Common Stock issuable upon exercise of the $6.24 Warrants, (iii) 70,376 shares of Common Stock issuable upon exercise of the $3.40 Warrants, (iv) 6.30 shares held directly by Connie Matsui and (v) 3,340 shares of Common Stock issuable pursuant to options held directly by Connie Matsui exercisable within 60 days of November 10, 2025.
(3)	Consists of (i) 47 shares held by Steven Kelly, and (ii) 622 shares of common stock issuable pursuant to options held directly by Steven Kelly exercisable within 60 days.
(4)	Consists of (i) 47 shares held by Douglas Blayney, M.D., and (ii) 648 shares of common stock issuable pursuant to options held directly by Douglas Blayney, M.D. exercisable within 60 days.
(5)	Consists of (i) 47 shares held by R. Marty Emanuele, Ph.D., and (ii) 641 shares of common stock issuable pursuant to options held directly by R. Marty Emanuele, Ph.D. exercisable within 60 days.
(6)	Consists of 546 shares of common stock issuable pursuant to options held directly by Gregory R. Reyes M.D., Ph.D. exercisable within 60 days.
(7)	Consists of (i) 307 shares of common stock issuable pursuant to options held directly by Tamara A. Favorito exercisable within 60 days, (ii) 2,058 shares issued on the conversion of an outstanding note payable, (iii) 2,282 warrants representing 2,282 shares of common stock which have an exercise price of $18.72 per common share and expire in October 2030, and (vi) 4,189 warrants representing 4,189 shares of common stock which have an exercise price of $10.20 per common share and expire in October 2030.
(8)	Consists of 556 shares of common stock issuable pursuant to options held directly by Mark E. Spring, exercisable within 60 days.

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	(3)	Consists of (i) 139 shares held by Steven Kelly, and (ii) 3.207 shares of Common Stock issuable pursuant to options held directly by Steven Kelly exercisable within 60 days of November 10, 2025.
	(4)	Consists of (i) 139 shares held by Douglas Blayney, M.D., and (ii) 3,143 shares of Common Stock issuable pursuant to options held directly by Douglas Blayney, M.D. exercisable within 60 days of November 10, 2025.
	(5)	Consists of (i) 139 shares held by R. Marty Emanuele, Ph.D., and (ii) 3,099 shares of Common Stock issuable pursuant to options held directly by R. Marty Emanuele, Ph.D. exercisable within 60 days of November 10, 2025.
	(6)	Consists of 2,886 shares of Common Stock issuable pursuant to options held directly by Gregory R. Reyes M.D., Ph.D. exercisable within 60 days of November 10, 2025.
	(7)	Consists of (i) 6,174 shares of Common Stock issuable upon conversion of the Notes, (ii) 6,846 shares of Common Stock issuable upon exercise of the $6.24 Warrants, (iii) 12,566 shares of Common Stock issuable upon exercise of the $3.40 Warrants and (iv) 2,278 shares of Common Stock issuable pursuant to options held directly by Tamara A. Favorito exercisable within 60 days of November 10, 2025.
	(8)	Consists of 1,562 shares of Common Stock issuable pursuant to options held directly by Mark Spring exercisable within 60 days of November 10, 2025
	(9)	Includes 68,843 shares of Common Stock subject to options exercisable within 60 days of November 10, 2025.

DESCRIPTION OF SECURITIES WE ARE OFFERING

22The ~~Table~~following description summarizes certain terms of ~~Contents~~our capital stock, certain provisions of our articles of incorporation and bylaws and certain terms of the pre-funded warrants included in this offering. This summary does not purport to be complete and is qualified in its entirety by the provisions of our articles of incorporation and bylaws and the provisions of the pre-funded warrants, copies of which are filed with the SEC as exhibits to the Registration Statement on Form S-1 of which this prospectus forms a part, and to the applicable provisions of Nevada law.

~~DESCRIPTION~~We OFare ~~CAPITAL~~offering ~~STOCK~~shares of common stock and pre-funded warrants to purchase up to an aggregate of 1,641,587 shares of common stock. For each pre-funded warrant we sell, the number of shares of common stock we are offering will be decreased on a one-for-one basis. We are also registering the shares of common stock issuable from time to time upon exercise of the pre-funded warrants.

~~The~~Our ~~following~~authorized ~~description summarizes certain terms of our~~ capital stock ~~and~~consists ~~certain provisions~~ of ~~our~~166,689,815 ~~Articles~~shares of ~~Incorporation~~capital ~~and~~stock, ~~Bylaws.~~of ~~This~~which ~~summary~~166,666,667 ~~does~~shares ~~not~~are ~~purport~~designated toas becommon ~~complete~~stock, ~~and~~$0.001 ispar ~~qualified~~value inper ~~its~~share, ~~entirety~~and by23,148 ~~the~~shares ~~provisions~~are ofdesignated ~~our~~as ~~Articles~~preferred ~~of Incorporation and Bylaws~~stock, ~~copies~~$0.001 ofpar ~~which~~value ~~are~~per ~~filed~~share. ~~with~~As ~~the~~of ~~SEC~~March as18, ~~exhibits~~2026, tothere ~~the~~were ~~registration~~736,127 ~~statement~~shares ~~on Form S-1~~ of ~~which~~common ~~this~~stock ~~prospectus~~issued ~~forms~~and ~~a part~~outstanding, and tono ~~the~~outstanding ~~applicable~~shares ~~provisions~~ of ~~Nevada~~preferred ~~law~~stock.

Authorized Capital Stock

Our authorized capital stock consists of 500,069,445 shares of capital stock, of which 500,000,000 shares are designated as common stock, $0.001 par value per share, and 69,445 shares are designated as preferred stock, $0.001 par value per share. As of November 10, 2025, there were 2,018,746 shares of Common Stock issued and outstanding held by approximately 166 holders of record of our Common Stock, and no outstanding shares of preferred stock.

Common Stock

The holders of our ~~Common~~common ~~Stock~~stock (i) have equal ratable rights to dividends from funds legally available, ~~therefor~~therefore, when, as and if declared by our board of directors; (ii) are entitled to share in all of our assets available for distribution to holders of ~~Common~~common ~~Stock~~stock upon liquidation, dissolution or winding up of our affairs; (iii) do not have preemptive, subscription or conversion rights and there are no redemption or sinking fund provisions or rights; and (iv) are entitled to one non-cumulative vote per share on all matters submitted to a vote of stockholders. The rights, preferences and privileges of the holders of our ~~Common~~common ~~Stock~~stock are subject to, and may be adversely affected by, the rights of the holders of shares of any series of preferred stock that we may designate in the future.

Preferred Stock

The Company has authorized 6923,~~445~~148 shares of preferred stock. There is no preferred stock outstanding.

Anti-Takeover Effects of Nevada Law and our Articles of Incorporation and Bylaws.

Certain provisions of Nevada law and certain provisions that are included in our Articles of Incorporation and our Bylaws may have the effect of delaying, deferring or discouraging another party from acquiring control of us. These provisions, which are summarized below, are intended to discourage coercive takeover practices and inadequate takeover bids. These provisions are also designed to encourage persons seeking to acquire control of us to first negotiate with our ~~board of directors~~Board. We believe that the benefits of the increased protection of our potential ability to negotiate with the proponent of an unfriendly or unsolicited proposal to acquire or restructure us outweigh the disadvantages of discouraging these proposals because negotiation of these proposals could result in an improvement of their terms.

Classified Board. Our amended and restated certificate of incorporation provides that our board of directors is divided into three classes, designated Class I, Class II, and Class III. Each class will be an equal number of directors, as nearly as possible, consisting of one third of the total number of directors constituting the entire board of directors. The term of Class I directors shall terminate on the date of the 2027 annual meeting, the term of the Class II directors shall terminate on the date of the ~~2025~~2028 annual meeting, and the term of the Class III directors shall terminate on the date of the 2026 annual meeting. At each annual meeting of stockholders, successors to the class of directors whose term expires at that annual meeting will be elected for a three-year term.

~~Stockholder~~19 ~~Meetings.~~Table ~~Our Bylaws provide that a special meeting~~ of stockholders may be called only by our president, by all of the directors when there are no more than three directors, or if there are more than three directors, by any three directors, or by the holder of a majority share of our capital stock.Contents

~~Stockholders~~Stockholder ~~Not Entitled to Cumulative Voting~~Meetings. Our Bylaws doprovide ~~not~~that ~~permit~~a ~~stockholders~~special tomeeting ~~cumulate~~of ~~their~~stockholders ~~votes~~may inbe ~~the~~called ~~election~~only ofby ~~directors.~~our ~~Accordingly~~president, ~~the~~by ~~holders~~all of ~~a majority of~~ the ~~outstanding~~directors ~~shares~~provided ofthat ~~our~~there ~~Common~~are ~~Stock~~no ~~entitled~~more tothan ~~vote~~three ~~in any election of~~ directors, ~~could~~or ~~elect~~if ~~all~~more ofthan ~~the~~three, ~~directors~~by ~~standing~~any ~~for~~three ~~election~~directors, ifor ~~they~~by ~~chose,~~the ~~other~~holder ~~than~~of ~~any~~a ~~directors~~majority ~~that~~share ~~holders~~ of our ~~preferred~~capital stock ~~may be entitled to elect~~.

23Stockholder ~~Table~~Action by Written Consent. Our Bylaws allow for any action that may be taken at any annual or special meeting of ~~Contents~~the stockholders to be taken without a meeting and without prior notice, if a consent in writing, setting forth the action so taken, is signed by the holders of outstanding shares having not less than the minimum number of votes that would be necessary to authorize or take such action at a meeting at which all shares entitled to vote thereon were present and voted.

~~Nevada~~Stockholders ~~Business~~Not ~~Combination~~Entitled ~~Statutes.~~to ~~The~~Cumulative ~~“business combination” provisions of Sections 78~~Voting.~~411~~ toOur ~~78.444,~~Bylaws ~~inclusive,~~do ofnot ~~the~~permit ~~Nevada Revised Statutes, (the “NRS”), generally prohibit a Nevada corporation with at least 200~~ stockholders ofto ~~record~~cumulate ~~from~~their ~~engaging~~votes in ~~various~~the ~~“combinations”~~election ~~with any interested stockholder for a period~~ of ~~two~~directors. ~~years~~Accordingly, ~~after~~ the ~~date~~holders of ~~the~~a ~~transaction~~majority inof ~~which~~ the ~~person~~outstanding ~~became~~shares anof ~~interested~~our ~~stockholder,~~Common ~~unless~~Stock ~~(a)~~entitled ~~such transaction or combination is approved by the Board prior~~ to ~~the~~vote ~~date~~in ~~the~~any ~~interested~~election ~~stockholder obtained such status, or (b) the combination is approved by the Board and thereafter is approved at a meeting~~ of ~~the~~directors ~~stockholders~~can byelect ~~the~~all ~~affirmative vote~~ of ~~stockholders representing at least 60% of~~ the ~~outstanding~~directors ~~voting~~standing ~~power~~for ~~held~~election, byif ~~disinterested~~they ~~stockholders. The~~choose, ~~prohibition~~other onthan ~~“combinations”~~any ~~with~~directors anthat ~~interested~~holders ~~stockholder~~of ~~extends~~our ~~beyond~~preferred ~~the~~stock ~~expiration~~may ofbe ~~the~~entitled ~~two-year~~to ~~period, unless:~~elect.

·Nevada ~~the~~Business ~~combination~~Combination ~~was~~Statutes. ~~approved~~The by“business ~~the~~combination” ~~Board~~provisions ~~prior~~of toSections ~~the~~78.411 ~~person~~to ~~becoming~~78.444, aninclusive, ~~interested~~of ~~stockholder or~~ the ~~transaction~~Nevada byRevised ~~which~~Statutes, (the ~~person~~“NRS”), ~~first~~generally ~~became~~prohibit ana ~~interested~~Nevada ~~stockholder~~corporation ~~was~~with ~~approved~~at byleast ~~the~~200 ~~Board~~stockholders ~~before~~of ~~the~~record ~~person~~from ~~became~~engaging anin ~~interested~~various ~~stockholder~~“combination” ortransactions ~~the~~with ~~combination~~any isinterested ~~later~~stockholder ~~approved~~for by a ~~majority~~period of ~~the~~two ~~voting~~years ~~power~~after ~~held~~the bydate ~~disinterested~~of ~~stockholders;~~the ortransaction ·in ifwhich the ~~consideration~~person tobecame bean ~~paid by the~~ interested stockholder, isunless ~~at least equal to~~ the ~~highest~~transaction ~~of:~~is ~~(a)~~approved ~~the highest price per share paid~~ by the ~~interested~~Board ~~stockholder~~prior ~~within~~to the ~~two years immediately preceding the~~ date of the ~~announcement~~interested ofstockholder ~~the~~obtained ~~combination~~such status or in the ~~transaction~~combination inis ~~which~~approved itby ~~became~~the anBoard ~~interested~~and ~~stockholder,~~thereafter ~~whichever~~ is ~~higher,~~approved ~~(b)~~at ~~the~~a ~~market~~meeting ~~value per share~~ of ~~Common~~the ~~Stock~~stockholders onby the ~~date~~affirmative ofvote ~~announcement~~ of ~~the~~stockholders ~~combination~~representing ~~and~~at ~~the~~least ~~date~~60% of the ~~interested~~outstanding ~~stockholder~~voting ~~acquired~~power ~~the~~held ~~shares,~~by ~~whichever~~disinterested ~~is higher~~stockholders, orand ~~(c)~~extends ~~for~~beyond ~~holders of preferred stock,~~ the ~~highest~~expiration ~~liquidation value~~ of the ~~preferred~~two-year ~~stock~~period, ~~if it is higher.~~unless:

	·	the combination was approved by the Board prior to the person becoming an interested stockholder or the transaction by which the person first became an interested stockholder was approved by the Board before the person became an interested stockholder or the combination is later approved by a majority of the voting power held by disinterested stockholders; or

	·	if the consideration to be paid by the interested stockholder is at least equal to the highest of: (a) the highest price per share paid by the interested stockholder within the two years immediately preceding the date of the announcement of the combination or in the transaction in which it became an interested stockholder, whichever is higher, (b) the market value per share of common stock on the date of announcement of the combination and the date the interested stockholder acquired the shares, whichever is higher, or (c) for holders of preferred stock, the highest liquidation value of the preferred stock, if it is higher.

A “combination” is generally defined to include mergers or consolidations or any sale, lease exchange, mortgage, pledge, transfer, or other disposition, in one transaction or a series of transactions, with an “interested stockholder” having: (a) an aggregate market value equal to 5% or more of the aggregate market value of the assets of the corporation, (b) an aggregate market value equal to 5% or more of the aggregate market value of all outstanding voting shares of the corporation, (c) more than 10% of the earning power or net income of the corporation, and (d) certain other transactions with an interested stockholder or an affiliate or associate of an interested stockholder.

In general, an “interested stockholder” is a person who, together with affiliates and associates, beneficially owns (or within two years, did own) 10% or more of the voting power of the outstanding voting shares of a corporation. The statute could prohibit or delay mergers or other takeover or change in control attempts and, accordingly, may discourage attempts to acquire us even though such a transaction may offer our stockholders the opportunity to sell their stock at a price above the prevailing market price.

Nevada Control Share Acquisition Statutes. The “control share” provisions of Sections 78.378 to 78.3793, inclusive, of the NRS apply to “issuing corporations” that are Nevada corporations with at least 200 stockholders of record, including at least 100 stockholders of record who are Nevada residents, and that conduct business in Nevada directly or through an affiliated corporation. The control share statute prohibits an acquirer, under certain circumstances, from voting its shares of a target corporation’s stock after crossing certain ownership threshold percentages, unless the acquirer obtains approval of the target corporation’s disinterested stockholders. The statute specifies three thresholds: one-fifth or more but less than one-third, one-third or more but less than a majority, and a majority or more, of the outstanding voting power. Generally, once an acquirer crosses one of the above thresholds, those shares ~~acquired~~in ~~within~~an 90offer ~~days~~or ~~prior~~acquisition toand ~~the~~acquired ~~shareholder~~within ~~crossing~~90 ~~the~~days ~~relevant~~thereof ~~threshold~~ become “control shares” and such control shares are deprived of the right to vote until disinterested stockholders restore the right. These provisions also provide that if control shares are accorded full voting rights and the acquiring person has acquired a majority or more of all voting power, all other stockholders who do not vote in favor of authorizing voting rights to the control shares are entitled to demand payment for the fair value of their shares in accordance with statutory procedures established for dissenters’ rights.

~~Our~~20 ~~Bylaws~~Table ~~provide that we shall be considered an “issuing corporation” as defined in such statutes, irrespective~~ of whether we, as of any date, (i) have 200 or more stockholders of record, at least 100 of whom have had addresses in Nevada appearing on our stock ledger at all times during the 90 days immediately preceding such date, and/or (ii) does business in Nevada directly or through an affiliated corporation.Contents

24A ~~Table~~corporation may elect to not be governed by, or “opt out” of, ~~Contents~~the control share provisions by making an election in its articles of incorporation or bylaws, provided that the opt-out election must be in place on the 10th day following the date an acquiring person has acquired a controlling interest, that is, crossing any of the three thresholds described above. We have not opted out of the control share statutes and will be subject to these statutes if we are an “issuing corporation” as defined in such statutes.

The effect of the Nevada control share statutes is that the acquiring person, and those acting in association with the acquiring person, will obtain only such voting rights in the control shares as are conferred by a resolution of the stockholders at an annual or special meeting. The Nevada control share law, if applicable, could have the effect of discouraging takeovers of us.

Amendment of ~~Articles~~Charter ~~of Incorporation~~ and Bylaw Provisions. The amendment of any ~~provision~~ of ~~our Articles of Incorporation (other than~~ the ~~name~~above ofprovisions ~~the~~would ~~Company)~~require ~~must~~approval ~~be approved~~ by ~~the~~holders ~~board~~ of ~~directors~~at ~~and~~least ~~shareholders holding~~ a ~~majority~~35% of the total voting power of ~~the~~all ~~issued and outstanding shares~~ of ~~the Company’s capital stock. The amendment of any provision of~~ our ~~Bylaws~~outstanding ~~may~~voting ~~be made by majority vote of the shareholders at any annual meeting or special meeting called for that purpose or by the board of directors~~stock, ~~but~~except ~~the~~in ~~board~~certain ~~of directors may not alter or repeal any Bylaws adopted by the shareholders~~circumstances.

The provisions of Nevada law, our Articles of Incorporation, and our Bylaws could have the effect of discouraging others from attempting hostile takeovers and, as a consequence, they may also inhibit temporary fluctuations in the market price of our ~~Common~~common ~~Stock~~stock that often result from actual or rumored hostile takeover attempts. These provisions may also have the effect of preventing changes in the composition of our board and management. It is possible that these provisions could make it more difficult to accomplish transactions that stockholders may otherwise deem to be in their best interests.

Transfer Agent and Registrar

The transfer agent and registrar for our ~~Common~~common ~~Stock~~stock is Equiniti Trust Company, LLC. The transfer agent’s address is 48 Wall Street, 23rd floor, New York, NY 10043.

Market Listing

Our ~~Common~~common ~~Stock~~stock is listed on ~~the~~ Nasdaq ~~Capital Market~~ under the symbol “ARTL.”

Pre-Funded Warrants

The following description of the pre-funded warrants we are offering is a summary and is qualified in its entirety by reference to the provisions of the pre-funded warrant, the form of which is filed as an exhibit to the registration statement of which this prospectus forms a part.

Duration and Exercise Price. Each pre-funded warrant offered hereby will have an initial exercise price per share equal to $0.001. The pre-funded warrants will be immediately exercisable and may be exercised at any time until the pre-funded warrants are exercised in full. The exercise price and number of shares of common stock issuable upon exercise is subject to appropriate adjustment in the event of stock dividends, stock splits, reorganizations or similar events affecting our shares of common stock and the exercise price.

Exercisability. The pre-funded warrants will be exercisable, at the option of the holder, in whole or in part, by delivering to us a duly executed exercise notice accompanied by payment in full for the number of shares of common stock purchased upon such exercise (except in the case of a cashless exercise as discussed below). Purchasers of the pre-funded warrants in this offering may elect to deliver their exercise notice following the pricing of the offering and prior to the issuance of the pre-funded warrants at closing to have their pre-funded warrants exercised immediately upon issuance and receive shares of common stock underlying the pre-funded warrants upon closing of this offering. A holder (together with its affiliates) may not exercise any portion of the pre-funded warrant to the extent that the holder would own more than 4.99% (or, at the election of the holder, 9.99%) of the outstanding shares of common stock immediately after exercise. However, upon notice from the holder to us, the holder may decrease or increase the beneficial ownership limitation, which may not exceed 9.99% of the number of shares of common stock outstanding immediately after giving effect to the exercise, as such percentage ownership is determined in accordance with the terms of the pre-funded warrants, provided that any increase in the beneficial ownership limitation will not take effect until 61 days following notice to us. No fractional shares of common stock will be issued in connection with the exercise of a pre-funded warrant. In lieu of fractional shares, we will either pay the holder an amount in cash equal to the fractional amount multiplied by the exercise price or round up to the next whole share.

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Cashless Exercise. At any time, in lieu of making the cash payment otherwise contemplated to be made to us upon such exercise, the holder may elect instead to receive upon such exercise (either in whole or in part) the net number of the shares of common stock determined according to a formula set forth in the pre-funded warrants.

Transferability. Subject to applicable laws, a pre-funded warrant may be transferred at the option of the holder upon surrender of the pre-funded warrant to us together with the appropriate instruments of transfer.

Exchange Listing. There is no trading market available for the pre-funded warrants on any securities exchange or nationally recognized trading system. We do not intend to list the pre-funded warrants on any securities exchange or nationally recognized trading system.

Right as a Shareholder. Except as otherwise provided in the pre-funded warrants or by virtue of such holder’s ownership of our shares of common stock, the holders of the pre-funded warrants do not have the rights or privileges of holders of our shares of common stock, including any voting rights, until they exercise their pre-funded warrants.

Fundamental Transaction. In the event of a fundamental transaction, as described in the pre-funded warrants and generally including any reorganization, recapitalization or reclassification of our shares of common stock, the sale, transfer or other disposition of all or substantially all of our properties or assets, our consolidation or merger with or into another person, the acquisition of more than 50% of our outstanding shares of common stock, or any person or group becoming the beneficial owner of 50% of the voting power represented by our outstanding shares of common stock, the holders of the pre-funded warrants will be entitled to receive upon exercise of the pre-funded warrants the kind and amount of securities, cash or other property that the holders would have received had they exercised the pre-funded warrants immediately prior to such fundamental transaction.

Placement Agent Warrants

The following description of the Placement Agent Warrants we are offering is a summary and is qualified in its entirety by reference to the provisions of the Placement Agent Warrants, the form of which is filed as an exhibit to the registration statement of which this prospectus forms a part.

General. We have agreed to issue to the placement agent the Placement Agent Warrants initially exercisable to purchase up to 131,327 shares of common stock as a portion of the compensation payable to the placement agent in connection with this offering, assuming a public offering price of $7.31 per share of common stock, which was the last reported sale price of our common stock on Nasdaq on March 18, 2026.

Duration and Exercise Price. Each Placement Agent Warrant offered hereby will have an initial exercise price per share equal to $7.31, which equals 100% of the public offering price per share, assuming a public offering price of $7.31 per share of common stock, which was the last reported sale price of our common stock on Nasdaq on March 18, 2026. The Placement Agent Warrants will be immediately exercisable and will expire five (5) years following the date of issuance. The exercise price and number of shares of common stock issuable upon exercise is subject to appropriate adjustment in the event of stock dividends, stock splits, reorganizations or similar events affecting our shares of common stock and the exercise price.

Exercisability. The Placement Agent Warrants will be exercisable, at the option of the holder, in whole or in part, from the date of issuance until the earlier of full exercise or the expiration date, by delivering to us a duly executed exercise notice accompanied by payment in full for the number of shares of common stock purchased upon such exercise (except in the case of a cashless exercise as discussed below). No fractional shares of common stock will be issued in connection with the exercise of the Placement Agent Warrants. In lieu of fractional shares, we will round to the nearest whole share.

Cashless Exercise. At any time, in lieu of making the cash payment otherwise contemplated to be made to us upon such exercise, the holder may elect instead to receive upon such exercise (either in whole or in part) the net number of the shares of common stock determined according to a formula set forth in the Placement Agent Warrants.

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Transferability. Subject to applicable laws, the Placement Agent Warrant may be transferred at the option of the holder upon surrender of the Placement Agent Warrants to us together with the appropriate instruments of transfer.

Exchange Listing. There is no trading market available for the Placement Agent Warrants on any securities exchange or nationally recognized trading system. We do not intend to list the Placement Agent Warrants on any securities exchange or nationally recognized trading system.

Right as a Shareholder. Except as otherwise provided in the Placement Agent Warrants or by virtue of such holder’s ownership of our shares of common stock, the holders of the Placement Agent Warrants do not have the rights or privileges of holders of our shares of common stock, including any voting rights, until they exercise their Placement Agent Warrants.

Fundamental Transaction. In the event of a fundamental transaction, as described in the Placement Agent Warrants and generally including any reorganization, recapitalization or reclassification of our shares of common stock, the sale, transfer or other disposition of all or substantially all of our properties or assets, our consolidation or merger with or into another person, the acquisition of more than 50% of our outstanding shares of common stock, or any person or group becoming the beneficial owner of 50% of the voting power represented by our outstanding shares of common stock, the holders of the Placement Agent Warrants will be entitled to receive upon exercise of the Placement Agent Warrants the kind and amount of securities, cash or other property that the holders would have received had they exercised the Placement Agent Warrants immediately prior to such fundamental transaction.

PLAN OF DISTRIBUTION

We have engaged Craft Capital Management LLC to act as our exclusive placement agent to solicit offers to purchase the securities offered pursuant to this prospectus on a “reasonable best efforts” basis. The engagement agreement does not give rise to any commitment by the placement agent to purchase any of our securities, and the placement agent will have no authority to bind us by virtue of the engagement agreement. The placement agent is not purchasing or selling any of the securities offered by us under this prospectus, nor is it required to arrange for the purchase or sale of any specific number or dollar amount of securities. This is a best efforts offering and there is no minimum offering amount required as a condition to the closing of this offering. The placement agent has agreed to use reasonable best efforts to arrange for the sale of the securities by us. Therefore, we may not sell all of the shares of common stock and pre-funded warrants being offered. The terms of this offering are subject to market conditions and negotiations between us, the placement agent and prospective investors. The placement agent does not guarantee that it will be able to raise new capital in any prospective offering. The placement agent may engage sub-agents or selected dealers to assist with the offering.

Investors purchasing securities offered hereby will have the option to execute a securities purchase agreement with us. In addition to rights and remedies available to all purchasers in this offering under federal securities and state law, the purchasers which enter into a securities purchase agreement will also be able to bring claims of breach of contract against us. The ability to pursue a claim for breach of contract is material to larger purchasers in this offering as a means to enforce the following covenants uniquely available to them under the securities purchase agreement: (i) a covenant to not enter into variable rate financings for a period of one year following the closing of the offering, subject to certain exceptions; and (ii) a covenant to not enter into any equity financings for 30 days from closing of the offering, subject to certain exceptions. The nature of the representations, warranties and covenants in the securities purchase agreements shall include:

	·	standard issuer representations and warranties on matters such as organization, qualification, authorization, no conflict, no governmental filings required, current in SEC filings, no litigation, labor or other compliance issues, environmental, intellectual property and title matters and compliance with various laws such as the Foreign Corrupt Practices Act; and

	·	covenants regarding matters such as registration of pre-funded warrant shares, no integration with other offerings, no stockholder rights plans, no material nonpublic information, use of proceeds, indemnification of purchasers, reservation and listing of shares of common stock, and no subsequent equity sales for 30 days, subject to certain exceptions.

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This offering will terminate on March [●], 2026, unless we decide to terminate the offering (which we may do at any time in our discretion) prior to that date. We will have one closing for all the securities purchased in this offering. The public offering price per share (or pre-funded warrant) will be fixed for the duration of this offering.

Delivery of the securities offered hereby is expected to occur on or about March [ ], 2026, subject to satisfaction or waiver of customary closing conditions.

Placement Agent Fees and Expenses

We have agreed to pay the placement agent a cash fee equal to 8.0% of the gross proceeds received from the sale of securities in the offering. We have also agreed to reimburse the placement agent in connection with this offering for its reasonable accountable expenses incurred in connection with this offering, including legal expenses in an amount up to $100,000. We estimate the total offering expenses of this offering that will be payable by us, excluding the placement agent’s fees and expenses, will be approximately $140,000. After deducting the placement agent’s fees and our estimated offering expenses, we expect the net proceeds from this offering to be approximately $10.8 million.

The following table shows the public offering price, placement agent fees and proceeds, before expenses, to us, assuming the purchase of all the securities we are offering.

Per Share

Per Pre-

Funded

Warrant

Total⁽²⁾

Public offering price

Placement agent cash fee (8.0%)

Proceeds, before expenses, to us⁽¹⁾

_______________

	(1)	The amount of offering proceeds, before expenses, to us does not give effect to any exercise of the pre-funded warrants being offered in this offering.

	(2)	Because there is no minimum number of securities or amount of proceeds required as a condition to closing in this offering, the actual public offering amount, placement agent fees, and proceeds to us, if any, are not presently determinable and may be substantially less than the total maximum offering amounts set forth above.

Placement Agent Warrants

We have agreed to issue to the Placement Agent Warrants to purchase a number of shares of our common stock equal to 8.0% of the aggregate number of shares of common stock (including shares of common stock underlying the pre-funded warrants) sold to the investors in this offering. The Placement Agent Warrants will have an exercise price equal to 100% of the public offering price per share of common stock in this offering. The Placement Agent Warrants are exercisable immediately after issuance and will expire five (5) years following the date of issuance. The Placement Agent Warrants will be issued pursuant to this registration statement and are registered hereunder. The form of the Placement Agent Warrant is included as an exhibit to the registration statement of which this prospectus forms a part. The Placement Agent Warrants and the shares of our common stock issuable upon exercise of the Placement Agent Warrants have been included in the registration statement of which this prospectus forms a part.

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Indemnification

We have agreed to indemnify the placement agent and specified other persons against certain liabilities, including certain liabilities arising under the Securities Act, or to contribute to payments that the placement agent or such other persons may be required to make in respect of such liabilities.

Lock-Up Agreements

We have agreed that for a period of 30 days from the closing of this offering, neither we nor any subsidiary may (i) offer, pledge, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any option, right or warrant to purchase, lend, or otherwise transfer or dispose of, directly or indirectly, any shares of our common stock or any securities convertible into or exercisable or exchangeable for shares of our common stock; or (ii) file or caused to be filed any registration statement with the SEC other than this registration statement, subject to certain exceptions. In addition, we have agreed not to effect or enter into an agreement to effect any issuance by us or our subsidiaries of any securities that involve a variable rate transaction (as defined in the securities purchase agreement) for a period of one year following the closing date of this offering, subject to certain exceptions. The placement agent may waive this prohibition in its sole discretion and without notice.

Additionally, each of our executive officers and directors has agreed with the placement agent, subject to certain exceptions, not to offer, sell, dispose of or hedge any shares of our common stock or common stock equivalents, for a period of 90 days from the closing of the offering pursuant to this prospectus.

Right of First Refusal

We have granted the placement agent a right of first refusal for a period of 12 months following the closing of this offering to act as sole book-running manager, sole underwriter or sole placement agent, as applicable, for each and every future public and private equity offering, debt financing or refinancing, or acquisition or disposition by us or any of our successors or subsidiaries.

Tail

We have also agreed to pay the placement agent a tail fee equal to the full cash fee and warrant compensation described above if any investor who was contacted or introduced to us by the placement agent during this offering provides us with capital in any public or private offering or other financing or capital raising transaction during the 12-month period following the expiration or termination of our engagement with the placement agent.

Regulation M Compliance

The placement agent may be deemed to be an underwriter within the meaning of Section 2(a)(11) of the Securities Act, and any fees received by it and any profit realized on the resale of the securities sold by it while acting as principal might be deemed to be underwriting discounts or commissions under the Securities Act. As an underwriter, the placement agent would be required to comply with the requirements of the Securities Act and the Exchange Act, including, without limitation, Rule 415(a)(4) under the Securities Act and Rule 10b-5 and Regulation M under the Exchange Act. These rules and regulations may limit the timing of purchases and sales of our securities by the placement agent. Under these rules and regulations, the placement agent may not (i) engage in any stabilization activity in connection with our securities and (ii) bid for or purchase any of our securities or attempt to induce any person to purchase any of our securities, other than as permitted under the Exchange Act, until it has completed its participation in the distribution.

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~~MATERIAL~~Determination ~~U.S.~~of ~~FEDERAL~~Offering ~~INCOME TAX CONSEQUENCES TO~~ Price

~~NON-U~~The actual public offering price of the securities we are offering will be negotiated between us and the investors, in consultation with the placement agent, based on the trading of our common stock prior to the offering, among other things.S Other factors considered in determining the public offering price of the securities we are offering include our history and prospects, the stage of development of our business, our business plans for the future and the extent to which they have been implemented, an assessment of our management, the general conditions of the securities markets at the time of the offering and such other factors as were deemed relevant. ~~HOLDERS~~The public offering price per share (or pre-funded warrant) will be fixed for the duration of this offering.

~~The~~Electronic following is a general discussion of the material U.S. holders (as defined below) with respect to their purchase, ownership and disposition of our convertible notes and warrants purchased in this offering. This discussion is for general information only, is not tax advice and does not purport to be a complete analysis of all the potential tax considerations. This discussion is based upon the provisions of the United States Internal Revenue Code of 1986, as amended, or the Code, existing and proposed Treasury Regulations promulgated thereunder, current administrative rulings and judicial decisions, all in effect as of the date hereof. These authorities may be changed, possibly retroactively, so as to result in U.S. federal income tax consequences different from those set forth below. We have not sought any ruling from the Internal Revenue Service, or IRS, with respect to the statements made and the conclusions reached in the following summary, and there can be no assurance that the IRS will agree with such statements and conclusions.Distribution

~~This~~A ~~discussion~~prospectus ~~does~~in ~~not~~electronic ~~address~~format ~~the~~may ~~tax~~be ~~considerations~~made ~~arising~~available ~~under~~on ~~the~~a ~~laws~~website ofmaintained ~~any non-U.S., state~~by orthe ~~local~~placement ~~jurisdiction~~agent, orand ~~under~~the ~~U.S.~~placement ~~federal~~agent ~~gift~~may ~~and~~distribute ~~estate~~prospectuses ~~tax laws~~electronically. InOther ~~addition,~~than ~~this~~the ~~discussion~~prospectus ~~does~~in ~~not~~electronic ~~address~~format, the information on any ~~tax~~such ~~considerations~~website ~~applicable~~is tonot anpart ~~investor’s~~of ~~particular~~this ~~circumstances~~prospectus or tothe ~~investors~~registration ~~that~~statement ~~may~~of bewhich ~~subject~~this toprospectus ~~special~~forms ~~tax~~a ~~rules~~part, ~~including~~has not been approved or endorsed by us or the placement agent, ~~without~~and ~~limitation:~~should not be relied upon by investors.

·Other banks, insurance companies, regulated investment companies, real estate investment trusts or other financial institutions; · persons subject to the alternative minimum tax or the Medicare contribution tax on net investment income; · tax-exempt organizations or governmental organizations; · controlled foreign corporations, passive foreign investment companies and corporations that accumulate earnings to avoid U.S. federal income tax; · brokers or dealers in securities or currencies; · traders in securities that elect to use a mark-to-market method of accounting for their securities holdings; · persons that own, or are deemed to own, more than five percent of our capital stock (except to the extent specifically set forth below); · certain former citizens or long-term residents of the United States; · partnerships or other entities or arrangements classified as partnerships for U.S. federal income tax purposes or other pass-through entities (and investors therein); · persons whose functional currency is not the U.S. dollar; · persons who hold our convertible notes or warrants as a position in a hedging transaction, “straddle,” “conversion transaction” or other risk reduction transaction or integrated investment; · persons who hold or receive our convertible notes or warrants pursuant to the exercise of any warrant or option or otherwise as compensation; · persons who hold or receive our convertible notes or warrants pursuant to conversion rights under convertible instruments; · persons who do not hold our convertible notes or warrants as a capital asset within the meaning of Section 1221 of the Code; or · persons deemed to sell our convertible notes or warrants under the constructive sale provisions of the Code.Relationships

From time to time, the placement agent may provide, in the future, various advisory, investment and commercial banking and other services to us in the ordinary course of business, for which it may receive customary fees and commissions. Except as disclosed in this prospectus, we have no present arrangements with the placement agent for any services. In addition, in the ordinary course of their business activities, the placement agent and its affiliates may make or hold a broad array of investments and actively trade debt and equity securities (or related derivative securities) for their own account and for the accounts of their customers. Such investments and securities activities may involve securities and/or instruments of ours or our affiliates. The placement agent and its affiliates may also make investment recommendations and/or publish or express independent research views in respect of such securities or financial instruments and may hold, or recommend to clients that they acquire, long and/or short positions in such securities and instruments.

Transfer Agent and Registrar

The transfer agent and registrar for our common stock is Equiniti Trust Company, LLC. The transfer agent’s address is 48 Wall Street, 23^rd floor, New York, NY 10043.

Market Listing

Our common stock is listed on Nasdaq under the symbol “ARTL.” There is no established trading market for the pre-funded warrants and we do not intend to list the pre-funded warrants on any securities exchange or nationally recognized trading system.

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In addition, if a partnership, entity or arrangement classified as a partnership for U.S. federal income tax purposes holds our convertible notes or warrants, the tax treatment of a partner generally will depend on the status of the partner and upon the activities of the partnership. Accordingly, entities classified as partnerships for U.S. federal income tax purposes and other pass-through entities that hold our convertible notes or warrants, as well as partners or members in such entities, should consult their tax advisors.

You are urged to consult your tax advisor with respect to the application of the U.S. federal income tax laws to your particular situation, as well as any tax consequences of the purchase, ownership and disposition of our convertible notes or warrants arising under the U.S. federal estate or gift tax laws or under the laws of any state, local, non-U.S. or other taxing jurisdiction or under any applicable tax treaty. In addition, significant changes in U.S. federal income tax laws were recently enacted. You should consult with your tax advisor with respect to such changes in U.S. tax law as well as potentially conforming changes in state tax laws.

Non-U.S. Holder Defined

For purposes of this discussion, you are a non-U.S. holder if you are any holder of our Common Stock, warrants other than a partnership (or other entity or arrangement classified as a partnership for U.S. federal income tax purposes) or:

· an individual who is a citizen or resident of the United States (for U.S. federal income tax purposes); · a corporation or other entity taxable as a corporation created or organized in or under the laws of the United States, any state thereof or the District of Columbia; · an estate whose income is subject to U.S. federal income tax regardless of its source; or · a trust if it (i) is subject to the primary supervision of a U.S. court and one or more U.S. persons have the authority to control all substantial decisions of the trust or (ii) has made a valid election under applicable Treasury Regulations to be treated as a U.S. person.

Distributions

As described in the section captioned “Dividend policy,” we have never declared or paid cash dividends on our capital stock and do not anticipate paying any dividends on our capital stock in the foreseeable future. However, if we do make distributions on our Common Stock, those payments will constitute dividends for U.S. tax purposes to the extent paid from our current or accumulated earnings and profits, as determined under U.S. federal income tax principles. To the extent those distributions exceed both our current and our accumulated earnings and profits, they will constitute a return of capital and will first reduce your basis in our Common Stock, but not below zero, and then will be treated as gain from the sale of stock as described below under “—Gain on Disposition of Convertible Notes or Warrants.”

Subject to the discussion below on effectively connected income, backup withholding and foreign accounts, any dividend paid to you generally will be subject to U.S. withholding tax either at a rate of 30% of the gross amount of the dividend or such lower rate as may be specified by an applicable income tax treaty. In order to receive a reduced treaty rate, you must provide us with an IRS Form W-8BEN, IRS Form W-8BEN-E or other appropriate version of IRS Form W-8 certifying qualification for the reduced rate.

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Dividends received by you that are effectively connected with your conduct of a U.S. trade or business (and, if required by an applicable income tax treaty, attributable to a permanent establishment maintained by you in the United States) are generally exempt from the withholding tax described in the previous paragraph, subject to the discussion below on backup withholding. In order to obtain this exemption, you must provide us with an IRS Form W-8ECI or other applicable IRS Form W-8 properly certifying such exemption. Such effectively connected dividends, although not subject to withholding tax, are taxed at the same graduated rates applicable to U.S. persons, net of certain deductions and credits, subject to an applicable income tax treaty providing otherwise. In addition, if you are a corporate non-U.S. holder, dividends you receive that are effectively connected with your conduct of a U.S. trade or business may also be subject to a branch profits tax at a rate of 30% or such lower rate as may be specified by an applicable income tax treaty. You should consult your tax advisor regarding any applicable tax treaties that may provide for different rules.

If you hold our Common Stock through a financial institution or other agent acting on your behalf, you will be required to provide appropriate documentation to the agent, which then will be required to provide certification to us or our paying agent, either directly or through other intermediaries. You may be eligible to obtain a refund of any excess amounts withheld by timely filing an appropriate claim for refund with the IRS.

Gain on Disposition of Convertible Notes or Warrants

Subject to the discussion below on backup withholding on convertible notes or warrants held by or through foreign entities, you generally will not be required to pay U.S. federal income tax on any gain realized upon the sale or other disposition of our convertible notes or warrants unless:

· the gain is effectively connected with your conduct of a U.S. trade or business (and, if required by an applicable income tax treaty, the gain is attributable to a permanent establishment maintained by you in the United States); · you are a non-resident alien individual who is present in the United States for a period or periods aggregating 183 days or more during the calendar year in which the sale or disposition occurs and certain other conditions are met; or · we are treated as a “United States real property holding corporation,” or USRPHC, for U.S. federal income tax purposes within the meaning of Section 897(c)(2) of the Code at any time within the shorter of the five-year period preceding your disposition of, or your holding period for, our convertible notes or warrants.

We believe that we are not currently and will not become a USRPHC. However, because the determination of whether we are a USRPHC depends on the fair market value of our U.S. real property relative to the fair market value of our other business assets, there can be no assurance that we will not become a USRPHC in the future. Even if we become a USRPHC, however, as long as our Common Stock is regularly traded on an established securities market, your Common Stock will be treated as U.S. real property interests only if you actually or constructively hold more than five percent of such regularly traded Common Stock at any time during the shorter of the five-year period preceding your disposition of, or your holding period for, our Common Stock. Special rules may apply to the determination of the five percent threshold in the case of a holder of a warrant. Non-U.S. holders are urged to consult their own tax advisors regarding the effect of holding our warrants on the calculation of such five percent threshold.

If you are a non-U.S. holder described in the first bullet above, you will be required to pay tax on the net gain derived from the sale under regular graduated U.S. federal income tax rates, and a corporate non-U.S. holder described in the first bullet above also may be subject to the branch profits tax at a 30% rate, or such lower rate as may be specified by an applicable income tax treaty. If you are an individual non-U.S. holder described in the second bullet above, you will be subject to tax at 30% (or such lower rate specified by an applicable income tax treaty) on the gain derived from the sale, which gain may be offset by U.S. source capital losses for the year (provided you have timely filed U.S. federal income tax returns with respect to such losses). You should consult any applicable income tax or other treaties that may provide for different rules.

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Warrants

Exercise of Warrants. In general, a non-U.S. holder will not recognize gain or loss for U.S. federal income tax purposes upon exercise of a warrant, except to the extent the non-U.S. holder receives a cash payment for any such fractional share that would otherwise have been issuable upon exercise of the warrant, which will be treated as a sale subject to the rules described above for “—Gain on Disposition of Convertible Notes or Warrants.” A non-U.S. holder’s initial tax basis in the share of Common Stock received upon exercise of a warrant should be equal to the sum of (i) the non-U.S. holder’s tax basis in the warrant (that is, an amount equal to the purchase price of the warrant) plus (ii) the exercise price paid by the non-U.S. holder on the exercise of the warrant. A non-U.S. holder’s holding period for shares of Common Stock received on exercise of a warrant will commence on the date following the date of exercise of the warrant and will not include the period during which the non-U.S. holder held the warrant.

In certain limited circumstances, a non-U.S. holder may be permitted to undertake a cashless exercise of warrants into our Common Stock. The U.S. federal income tax treatment of a cashless exercise of warrants into our Common Stock is unclear, and the tax consequences of a cashless exercise could differ from the consequences upon the exercise of a warrant described in the preceding paragraph. Non-U.S. holders should consult their own tax advisors regarding the U.S. federal income tax consequences of a cashless exercise of warrants.

Expiration of Warrants. Expiration of warrants will be treated as if the non-U.S. holder sold or exchanged the warrant, as applicable, and recognized a capital loss equal to the non-U.S. holder’s tax basis in such warrant. However, a non-U.S. holder will not be able to utilize a loss recognized upon expiration of a warrant against the non-U.S. holder’s U.S. federal income tax liability unless the loss is effectively connected with the non-U.S. holder’s conduct of a trade or business within the United States (and, if an income tax treaty applies, is attributable to a permanent establishment in the United States) or is treated as a U.S.-source loss and the non-U.S. holder is present 183 days or more in the taxable year of disposition and certain other conditions are met.

Certain Adjustments to the Warrants. Under Section 305 of the Code, an adjustment to the number of shares of Common Stock issued on the exercise of the warrants, or an adjustment to the exercise price of the warrants, may be treated as a constructive distribution to a non-U.S. holder of the warrants, as applicable, if, and to the extent that, such adjustment has the effect of increasing such non-U.S. holder’s proportionate interest in our “earnings and profits” or assets, depending on the circumstances of such adjustment (for example, if such adjustment is to compensate for a distribution of cash or other property to our shareholders). In addition, if we were to make a distribution in cash or other property with respect to our Common Stock after the issuance of the warrants, then we may, in certain circumstances, make a corresponding distribution to a warrant holder. The taxation of a distribution received with respect to a warrant is unclear. It is possible such a distribution would be treated as a distribution (or constructive distribution), although other treatments are possible. For more information regarding the tax considerations related to distributions, see the discussion above regarding “—Distributions.” Non-U.S. holders should consult their tax advisors regarding the proper treatment of any adjustments to and adjustments on the warrants.

Backup Withholding and Information Reporting

Generally, we must report annually to the IRS the amount of dividends paid to you, your name and address, and the amount of tax withheld, if any. A similar report will be sent to you. Pursuant to applicable income tax treaties or other agreements, the IRS may make these reports available to tax authorities in your country of residence.

Payments of dividends or of proceeds on the disposition of stock made to you may be subject to information reporting and backup withholding at a current rate of 24% unless you establish an exemption, for example, by properly certifying your non-U.S. status on an IRS Form W-8BEN, IRS Form W-8BEN-E or another appropriate version of IRS Form W-8. Notwithstanding the foregoing, backup withholding and information reporting may apply if either we or our paying agent has actual knowledge, or reason to know, that you are a U.S. person.

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Under current U.S. federal income tax law, U.S. information reporting and backup withholding requirements generally will apply to the proceeds of a disposition of our convertible notes or warrants effected by or through a U.S. office of any broker, U.S. or foreign, except that information reporting and such requirements may be avoided if the holder provides a properly executed and appropriate IRS Form W-8 or otherwise meets documentary evidence requirements for establishing non- U.S. holder status or otherwise establishes an exemption. Generally, U.S. information reporting and backup withholding requirements will not apply to a payment of disposition proceeds to a non-U.S. holder where the transaction is effected outside the U.S. through a non-U.S. office of a non-U.S. broker. Information reporting and backup withholding requirements may, however, apply to a payment of disposition proceeds if the broker has actual knowledge, or reason to know, that the holder is, in fact, a U.S. person. For information reporting purposes, certain brokers with substantial U.S. ownership or operations will generally be treated in a manner similar to U.S. brokers.

Backup withholding is not an additional tax; rather, the U.S. federal income tax liability of persons subject to backup withholding will be reduced by the amount of tax withheld. If withholding results in an overpayment of taxes, you may be able to obtain a refund or credit from the IRS, provided that the required information is furnished to the IRS in a timely manner.

Foreign Account Tax Compliance

The Foreign Account Tax Compliance Act and the rules and regulations promulgated thereunder, collectively FATCA, generally impose withholding tax at a rate of 30% on dividends on, and gross proceeds from the sale or other disposition of, our convertible notes or warrants paid to a “foreign financial institution” (as specially defined under these rules), unless such institution enters into an agreement with the U.S. government to, among other things, withhold on certain payments and to collect and provide to the U.S. tax authorities substantial information regarding the U.S. account holders of such institution (which includes certain equity and debt holders of such institution, as well as certain account holders that are foreign entities with U.S. owners) or otherwise establishes an exemption. FATCA also generally imposes a U.S. federal withholding tax of 30% on dividends on and gross proceeds from the sale or other disposition of our convertible notes or warrants paid to a “non-financial foreign entity” (as specially defined under these rules) unless such entity provides the withholding agent with a certification identifying certain substantial direct and indirect U.S. owners of the entity, certifies that there are none or otherwise establishes an exemption. The withholding provisions under FATCA generally apply to dividends on our convertible notes or warrants, and, subject to the proposed regulations described in the next sentence, will apply to gross proceeds of a sale or other disposition of our convertible notes and warrants. The Treasury Department has released proposed regulations (the preamble to which specifies that taxpayers are permitted to rely on them pending finalization) which, if finalized in their present form, would eliminate the federal withholding tax of 30% applicable to the gross proceeds of a disposition of our convertible notes or warrants. Under certain circumstances, a non-U.S. holder might be eligible for refunds or credits of such taxes. An intergovernmental agreement between the United States and an applicable foreign country may modify the requirements described in this paragraph. You should consult your tax advisors regarding the possible implications of FATCA on your investment in our convertible notes or warrants.

The preceding discussion of U.S. federal tax considerations is for general information only. It is not tax advice. Each prospective investor should consult its tax advisor regarding the particular U.S. federal, state and local and non-U.S. tax consequences of purchasing, holding and disposing of our convertible notes or warrants, including the consequences of any proposed change in applicable laws.

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LEGAL MATTERS

The validity of the securities offered by this prospectus will be passed upon for us by Fennemore Craig, P.C., Reno, Nevada. Certain other legal matters will be passed upon for us by Bevilacqua PLLC. Certain legal matters in connection with the offering will be passed upon for the placement agent by Zarif Law Group P.C.

Bevilacqua PLLC holds 2,691 shares of common stock and 8,071 shares of common stock issuable upon exercise of warrants, which it received as part of the June 2025 private placement.

EXPERTS

The consolidated financial statements of Artelo Biosciences, Inc. incorporated in this prospectus by reference to the Annual Report on Form 10-K for the year ended December 31, ~~2024~~2025, and as updated on Form 8-K filed with the SEC on ~~July~~March 1117, ~~2025~~2026, have been so incorporated in reliance on the report (which contains an explanatory paragraph regarding ~~our~~the Company’s ability to continue as a going concern) of MaloneBailey, LLP, an independent registered public accounting firm, given on the authority of said firm as experts in auditing and accounting.

WHERE YOU CAN FIND MORE INFORMATION

We have filed with the SEC a registration statement on Form S-1 under the Securities Act with respect to the ~~shares~~securities ~~of our Common Stock~~ offered ~~by this prospectus~~hereby. This prospectus, which constitutes a part of the registration statement, does not contain all of the information set forth in the registration statement, ~~some~~or ofthe ~~which is contained in~~ exhibits ~~to the registration statement as permitted by the rules~~ and ~~regulations~~schedules offiled ~~the SEC~~therewith. For further information ~~with~~about ~~respect to~~ us ~~and~~or our ~~Common~~securities ~~Stock~~offered hereby, we refer you to the registration statement, ~~including~~and the exhibits ~~filed~~and asschedules afiled ~~part of the registration statement~~thereto. Statements contained in this prospectus ~~concerning~~regarding the contents of any contract or any other document ~~are~~that ~~not~~is ~~necessarily complete. If a contract or document has been~~ filed as an exhibit to the registration statement, ~~please~~are ~~see~~not ~~the~~necessarily ~~copy~~complete, ofand ~~the~~each ~~contract~~such ~~or document that has been filed. Each~~ statement is ~~this prospectus relating to a contract or document filed as an exhibit is~~ qualified in all respects by ~~the~~reference ~~filed~~to ~~exhibit.~~the ~~The~~full ~~SEC~~text ~~maintains~~of ansuch ~~Internet~~contract ~~website~~or ~~that contains reports, proxy statements and~~ other ~~information~~document ~~about~~filed ~~issuers,~~as ~~like~~an ~~us,~~exhibit ~~that~~to ~~file electronically with~~ the ~~SEC.~~registration ~~The address of that website is www~~statement.~~sec.gov.~~

We file periodic reports, proxy statements and other information with the SEC. These periodic reports, proxy statements and other information are available for inspection and copying at the SEC’s public reference facilities and the website of the SEC at www.sec.gov. Additionally, we will make these filings available, free of charge, on our website at www.artelobio.com as soon as reasonably practicable after we electronically file such materials with, or furnish them to, the SEC.

You may request a copy of this prospectus by contacting us at: Artelo Biosciences, Inc. at 505 Lomas Santa Fe, Suite 160, Solana Beach, CA or 858-925-7049. Our website address is www.artelobio.com and such reports and documents may be accessed from https://ir.artelobio.com/. Information contained on or accessible through Artelo’s website is not a part of the registration statement of which this prospectus forms a part, and the inclusion of Artelo’s website address in this prospectus is an inactive textual reference only.

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INCORPORATION OF CERTAIN INFORMATION BY REFERENCE

The SEC allows us to incorporate by reference into this prospectus certain information we file with it, which means that we can disclose important information by referring you to those documents. The information incorporated by reference is considered to be a part of this prospectus, and information that we file later with the SEC will automatically update and supersede information contained in this prospectus. We incorporate by reference the documents listed below that we have previously filed with the SEC (excluding those portions of any Form 8-K that are not deemed “filed” pursuant to the General Instructions of Form 8-K):

· our Annual Report on Form 10-K for the year ended December 31, ~~2024, filed with the SEC on March 3,~~ 2025~~; · our Quarterly Report on Form 10-Q for the quarters ended March 31~~, ~~2025,~~ filed with the SEC on ~~May~~February 1324, ~~2025, June 30, 2025, filed with the SEC on August 13, 2025, and September 30, 2025, filed with the SEC on November 12, 2025~~2026; · our Current Reports on Form 8-K filed on ~~April~~January 292, ~~2025~~2026, ~~May~~January 116, ~~2025~~2026, ~~May~~January 2330, ~~2025~~2026, ~~June~~February 135, ~~2025~~2026, ~~June~~February ~~26, 2025, July 11, 2025, July 18, 2025, August 4, 2025, August 7, 2025, August 20, 2025, August 29, 2025, September 3, 2025, September~~ 5, ~~2025~~2026, ~~September~~March 106, ~~2025~~2026, ~~September~~March ~~15, 2025, October 1, 2025, October~~ 17, ~~2025~~2026, ~~October 27, 2025, October 31, 2025,~~ and ~~November~~March 1418, ~~2025~~2026; and · the description of our ~~Common~~common ~~Stock~~stock contained in Exhibit 4.1 to our Annual Report on Form 10-K for the year ended December 31, ~~2024~~2025, filed with the SEC on ~~March~~February 324, ~~2025~~2026, including any amendment or report filed for the purpose of updating such description.

This prospectus forms part of a registration statement on Form S-1 that we filed with the SEC. This prospectus does not contain all of the information set forth in the registration statement and the exhibits to the registration statement or the documents incorporated by reference herein and therein. For further information with respect to us and the securities that we are offering under this prospectus, we refer you to the registration statement and the exhibits and schedules filed as a part of the registration statement and the documents incorporated by reference herein and therein. You should rely only on the information incorporated by reference or provided in this prospectus and registration statement. We have not authorized anyone else to provide you with different information. You should not assume that the information in this prospectus and the documents incorporated by reference herein and therein is accurate as of any date other than the respective dates thereof.

All reports and other documents we subsequently file pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act prior to the termination of this offering, including all such documents we may file with the SEC after the date of the initial registration statement and prior to the effectiveness of the registration statement, but excluding any information furnished to, rather than filed with, the SEC, will also be incorporated by reference into this prospectus and deemed to be part of this prospectus from the date of the filing of such reports and documents.

We will provide you without charge, upon your oral or written request, with a copy of any or all reports, proxy statements and other documents we file with the SEC, as well as any or all of the documents incorporated by reference in this prospectus or the registration statement (other than exhibits to such documents unless such exhibits are specifically incorporated by reference into such documents). Requests for such copies should be directed to Artelo Biosciences, Inc., Attn: Chief Executive Officer, 505 Lomas Santa Fe, Suite 160, Solana Beach, California, 92075. You may also direct any requests for documents to us by telephone at (858) 925-7049.

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Artelo Biosciences, Inc.

Up1,641,587 Shares of Common Stock or Pre-funded Warrant to ~~899~~Purchase 1,~~972~~641,587 Shares of Common Stock,

Placement Agent Warrants to Purchase up to 131,327 Shares of Common Stock,

and

Up to 1,772,914 Shares of Common Stock Underlying the Pre-Funded Warrants and Placement Agent Warrants

PRELIMINARY PROSPECTUS

~~November~~Craft ~~17,~~Capital ~~2025~~Management LLC

~~Table~~[ of], ~~Contents~~2026

PART II

INFORMATION NOT REQUIRED IN THE PROSPECTUS

Item 13. Other Expenses of Issuance and Distribution.

The following table sets forth all expenses paid or payable by the registrant in connection with this offering. All amounts shown are estimates except for the SEC registration fee and the FINRA filing fee.

	Amount Paidor to Be Paid
	Amount Paid or to Be Paid
SEC registration fee	$	~~225~~1,789.78
Printing expenses		5,000
FINRA filing fee		2,300.00
Legal fees and expenses	$	75,000
Printing expenses		2,000.00
Accounting fees and expenses		25,000
Legal fees and expenses		80,000.00
Other fees and expenses		-
Accounting fees and expenses		40,000.00
Total	$	105,225
Other fees and expenses		13,910.22
Total	$	140,000.00

Item 14. Indemnification of Directors and Officers.

The Company’s Articles of Incorporation and Bylaws provide that, to the fullest extent permitted by the laws of the State of Nevada, the Company shall indemnify any officer or director of the Company, who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative, by reason of the fact that he/she is or was or has agreed to serve at the request of the Company as a director, officer, employee or agent of the Company, or while serving as a director or officer of the Company, is or was serving or has agreed to serve at the request of the Company as a director, officer, employee or agent (which, for purposes hereof, shall include a trustee, partner or manager or similar capacity) of another corporation, partnership, joint venture, trust, employee benefit plan or other enterprise, or by reason of any action alleged to have been taken or omitted in such capacity. For the avoidance of doubt, the foregoing indemnification obligation includes, without limitation, claims for monetary damages against the indemnitee to the fullest extent permitted under Section 78.7502 of the Nevada Revised Statutes.

The indemnification provided shall be from and against expenses (including attorneys’ fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by the indemnitee or on the indemnitee’s behalf in connection with such action, suit or proceeding and any appeal therefrom, but shall only be provided if the indemnitee acted in good faith and in a manner that the indemnitee reasonably believed to be in or not opposed to the best interests of the Company, and, with respect to any criminal action, suit or proceeding, had no reasonable cause to believe the indemnitee’s conduct was unlawful.

In the case of any threatened, pending or completed action or suit by or in the right of the Company to procure a judgment in its favor by reason of the fact that he/she is or was a director, officer, employee or agent of the Company, or while serving as a director or officer of the Company, is or was serving or has agreed to serve at the request of the Company as a director, officer, employee or agent of another corporation, partnership, joint venture, trust, employee benefit plan or other enterprise, no indemnification shall be made in respect of any claim, issue or matter as to which the indemnitee shall have been adjudged to be liable to the Company unless, and only to the extent that, the Nevada courts or the court in which such action or suit was brought shall determine upon application that, despite the adjudication of liability but in view of all the circumstances of the case, the indemnitee is fairly and reasonably entitled to indemnity for such expenses which the Nevada courts or such other court shall deem proper.

The termination of any action, suit or proceeding by judgment, order, settlement, conviction, or upon a plea of nolo contendere or its equivalent, shall not, of itself, create a presumption that he/she did not act in good faith and in a manner which the indemnitee reasonably believed to be in or not opposed to the best interests of the Company, and, with respect to any criminal action or proceeding, had reasonable cause to believe that the indemnitee’s conduct was unlawful.

II - 1 ~~Table of Contents~~

To the extent that indemnification for liabilities arising under the Securities Act may be permitted to directors, officers or persons controlling our company pursuant to the foregoing provisions, we have been informed that, in the opinion of the SEC, such indemnification is against public policy as expressed in the Securities Act and is therefore unenforceable. If a claim for indemnification against such liabilities (other than the payment by us of expenses incurred or paid by a director, officer or controlling person of our company in the successful defense of any action, suit or proceeding) is asserted by any of our directors, officers or controlling persons in connection with the securities being registered, we will, unless in the opinion of our counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by us is against public policy as expressed in the Securities Act and will be governed by the final adjudication of that issue.

The rights conferred in the Company’s Articles of Incorporation and Bylaws are not exclusive, and the Company is authorized to enter into indemnification agreements with its directors, officers, employees, and agents and to obtain insurance to indemnify such persons. The Company may not retroactively amend the Bylaws to reduce its indemnification obligations to directors, officers, employees, and agents.

The Company has entered into indemnification agreements with its directors and executive officers that provide the maximum indemnity allowed to directors and executive officers by Section 78.7502 of the Nevada Revised Statutes and also to provide for certain additional procedural protections, in addition to the indemnification provided for in the Company’s Articles of Incorporation and Bylaws, and intends to enter into indemnification agreements with any new directors and executive officers in the future.

The Company has purchased and currently intends to maintain insurance on behalf of each and any person who is or was a director or officer of the Company against any loss arising from any claim asserted against him or her and incurred by him or her in any such capacity, subject to certain exclusions.

The placement agency agreement between the Company and the placement agent (Exhibit 1.1 hereto) provides for indemnification by the Company of the placement agent for certain liabilities, including liabilities arising under the Securities Act.

See also the undertakings set out in response to Item 17 herein.

Item 15. Recent Sales of Unregistered Equity Securities.

We have sold the securities described below within the past three years which were not registered under the Securities Act. All of the sales listed below were made pursuant to an exemption from registration afforded by Section 4(a)(2) of the Securities Act (and Regulation D thereunder)~~, unless otherwise indicated~~.

On May 13, 2022, we executed a private placement to Lincoln Park Capital Fund, LLC pursuant to which we have the right to sell to Lincoln Park up to $20,000,000 in shares of our Common Stock, subject to certain limitations, from time to time over the 36-month period commencing on the date that the conditions set forth in the purchase agreement have been satisfied, which includes that a registration statement covering the resale of the shares is declared effective by the SEC. We issued 31,~~255~~086 shares of our Common Stock to Lincoln Park as consideration for its commitment to purchase our shares under the Purchase Agreement. In the Purchase Agreement, Lincoln Park represented to the Company, among other things, that it was an “accredited investor” (as such term is defined in Rule 501(a) of Regulation D under the Securities Act of 1933, or the Securities Act). The securities were sold by the Company under the Purchase Agreement in reliance upon an exemption from the registration requirements under the Securities Act afforded by Section 4(a)(2) of the Securities Act. As of December 31, 2024, in accordance with the Equity Line, the Company issued 7023,~~897~~633 shares of the Company’s Common Stock.

Between April 27, 2025 and May 1, 2025, we entered into ~~the~~subscription ~~May~~agreements ~~2025 Subscription Agreement~~ with ~~each~~various ~~of the Selling Securityholders named in this prospectus~~investors, pursuant to which wethe Company issued ~~and~~convertible ~~sold~~notes to the ~~Selling~~investors ~~Securityholders, and the Selling Securityholders purchased the May 2025 Notes~~ in an aggregate principal amount of $900,000. A portion of the ~~May~~convertible ~~2025~~notes ~~Notes~~ are convertible into shares of our Common Stock, at the election of each ~~Selling Securityholders~~investor, ~~pursuant to the Voluntary Conversion,~~ and the remaining portion of each note will be converted into ~~the~~warrants ~~$6.24~~to ~~Warrants~~purchase shares of our Common Stock. The sale and issuance of the ~~May~~convertible ~~2025~~notes ~~Notes~~ closed on May 1, 2025. The ~~May~~notes ~~2025 Notes~~ accrue interest at a rate of 12.0% per annum. All unpaid principal, together with any then unpaid and accrued interest and other amounts payable thereunder, shall be due and payable on October 28, 2025. Effective October 28, 2025 (the “closing date”), we entered into an agreement with the holders of the convertible notes, pursuant to which we issued and sold to the convertible note holders, by converting all or a portion of the unconverted “Voluntary Conversion” portion of unpaid principal balance and accrued interest due to the convertible noteholders upon the maturity of the convertible notes: (i) newly issued convertible notes in an aggregate principal amount of $690,154.69; and (ii) five-year warrants to purchase an aggregate of 146,067 shares of common stock, at an exercise price of $10.20 per share. The newly issued convertible notes will accrue interest at a rate of 12% per annum, which will adjust to 20% upon an event of default (as defined therein). All unpaid principal, together with any then unpaid and accrued interest and other amounts payable thereunder, shall be due and payable six months after the closing date.

On June 24, 2025, we entered into a securities purchase agreement with certain accredited investors for the issuance and sale in a private placement of (i) 136,843 shares of Common Stock, (ii) up to 93,180 shares of Common Stock issuable upon the exercise of preII-funded warrants (the “Pre-Funded Warrants”), (iii) up to 460,046 shares of Common Stock issuable upon the exercise of common warrants at an exercise price of $5.82 per share (the “$5.82 Warrants”), and (iv) 230,023 shares of Common Stock issuable upon the exercise of warrants at an exercise price of $10.00 per share (the “$10.00 Warrants”). The private placement was priced at the market on June 24, 2025 and closed on June 26, 2025. Each share or, in lieu of shares, each Pre-Funded Warrant, was issued and sold in the private placement along with two (2) $5.82 Warrants and one (1) $10.00 Warrant. The combined purchase price for the securities was (i) $6.195 per share of Common Stock and three accompanying warrants and (ii) $6.194 per Pre-Funded Warrant and three accompanying warrants.

IIOn June 24, 2025, the Company entered into a securities purchase agreement with certain accredited investors for the issuance and sale in a private placement of (i) 45,615 shares of Common Stock, (ii) up to 31,060 shares of Common Stock issuable upon the exercise of pre-funded warrants (the “Pre-Funded Warrants”), (iii) up to 153,351 shares of Common Stock issuable upon the exercise of common warrants at an exercise price of $17.46 per share (the “$17.46 Warrants”), and (iv) 76,678 shares of Common Stock issuable upon the exercise of warrants at an exercise price of $30.00 per share (the “$30.00 Warrants”). The private placement was priced at the market on June 24, 2025 and closed on June 26, 2025. Each share or, in lieu of shares, each Pre-Funded Warrant, was issued and sold in the private placement along with two (2) ~~Table~~$17.46 Warrants and one (1) $30.00 Warrant. The combined purchase price for the securities was (i) $18.585 per share of ~~Contents~~Common Stock and three accompanying warrants and (ii) $18.582 per Pre-Funded Warrant and three accompanying warrants.

On August 1, 2025, we entered into a securities purchase agreement (the “Purchase Agreement”) for an at-the market PIPE (private investment in public equity) for the purchase and sale of securities at a price of $1031.4535 per security, consisting of: (a) ~~906~~302,~~687~~229 shares of Common Stock (or pre-funded warrants in lieu thereof); (b) three-year warrants to purchase ~~906~~302,~~687~~229 shares of Common Stock at an exercise price of $1030.2060 per share; and (c) three-year warrants to purchase ~~906~~302,~~687~~229 shares of Common Stock at an exercise price of $50150.00 per share, for expected aggregate gross proceeds of approximately $9.475 million. We agreed that the net proceeds of the sale would be used to purchase Solana. However, on August 19, 2025, we entered into a Termination and Mutual Release Agreement (the “Purchase Termination Agreement”), which terminates in its entirety, effective as of the August 19, 2025, the Purchase Agreement, the three-year warrants, and any other certificates, agreements, or instruments executed in connection therewith. Concurrently with execution of the Purchase Termination Agreement, the Company paid $50,000 to TingleMerrett LLP, counsel to the investors, for legal fees incurred by the investors in connection with the transaction.

Effective October 28, 2025, we entered into the October 2025 Subscription Agreement with ~~the~~such ~~Selling Securityholders named in this prospectus~~investors, pursuant to which we issued and sold to ~~the~~such ~~Selling Securityholders~~investors, and ~~the~~such ~~Selling~~investors ~~Securityholders~~ purchased (by converting all or a portion of the unconverted “Voluntary Conversion” portion of unpaid principal balance and accrued interest due to ~~the~~such ~~Selling~~investors ~~Securityholders~~ upon the maturity of the May 2025 Notes): (i) ~~The~~the Notes in an aggregate principal amount of $690,154.69; and (ii) the $310.4020 Warrants to purchase an aggregate of ~~438~~146,~~182~~067 shares of Common Stock, at an exercise price of $310.4020 per share. The sale and issuance of the Notes and $310.4020 Warrants closed effective as of the Closing Date.

~~Each~~On ofJanuary ~~the~~30, ~~foregoing~~2026, ~~issuances was made~~ in aconnection ~~transaction~~with ~~not~~our ~~involving~~entry ainto ~~public~~the ~~offering~~ELOC ~~pursuant~~Purchase toAgreement anwith ~~exemption~~Square ~~from~~gate, ~~the~~we ~~registration~~issued ~~requirements~~an aggregate of ~~the~~97,466 ~~Securities~~Commitment ~~Act~~Shares inhaving ~~reliance~~a ~~upon~~stated ~~Section~~aggregate ~~4(a)(2)~~value of ~~the~~$500,000, ~~Securities~~consisting ~~Act~~of 35,342 orshares ~~Regulation~~of Dour orcommon ~~Regulation~~stock Sand ~~promulgated~~pre ~~under~~funded ~~the~~warrants ~~Securities~~to ~~Act.~~purchase ~~Any~~up to 62,124 shares of ~~Common~~our ~~Stock~~common ~~that~~stock ~~may~~at bean ~~issued~~exercise ~~upon~~price ~~conversion~~ of ~~the~~$0.001 ~~Notes~~per ~~will~~share, bewith ~~issued~~no inexpiration ~~reliance~~date. ~~upon~~These ~~Section~~securities 3(were issued as a~~)(9)~~ ofcommitment fee pursuant to the ~~Securities~~ELOC ~~Act~~Purchase asAgreement ~~involving~~with anSquare ~~exchange~~Gate. ~~exclusively~~No underwriting discounts or commissions were paid with ~~our~~respect ~~security~~to ~~holders~~these issuances.

On March 12, 2026, we entered into a securities purchase agreement with Vanquish Funding Group Inc., pursuant to which we issued a 12% bridge note that matures on January 15, 2027, in the aggregate principal amount of $237,300, which includes an original issue discount of $27,300, for an aggregate purchase price of $210,000. Solely upon the occurrence and continuation of an Event of Default (as defined in the bridge note), the buyer shall have the right, but not the obligation, to convert all or any portion of the outstanding balance of the bridge note, including principal, accrued interest, and any applicable default amount, into shares of our common stock. The conversion price is the greater of (i) $0.125 and (ii) 75% of the lowest trading price of our common stock during the ten (10) trading days immediately preceding the applicable conversion date.

On March 12, 2026, we entered into a securities purchase agreement with Boot Capital LLC, pursuant to which we issued a 12% bridge note that matures on January 15, 2027, in the aggregate principal amount of $113,000, which includes an original issue discount of $13,000, for an aggregate purchase price of $100,000. Solely upon the occurrence and continuation of an Event of Default (as defined in the bridge note), the buyer shall have the right, but not the obligation, to convert all or any portion of the outstanding balance of the bridge note, including principal, accrued interest, and any applicable default amount, into shares of our common stock. The conversion price is the greater of (i) $0.125 and (ii) 75% of the lowest trading price of our common stock during the ten (10) trading days immediately preceding the applicable conversion date.

Each of the foregoing issuances was made in a transaction not involving a public offering pursuant to an exemption from the registration requirements of the Securities Act in reliance upon Section 4(a)(2) of the Securities Act, or Regulation D or Regulation S promulgated under the Securities Act.

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Item 16. Exhibits and Financial Statement Schedules.

(a) ~~Reference is made to the attached Exhibit Index~~Exhibits. ~~(b) No financial statement schedules are provided because the information called for is not required or is shown in the financial statements or the notes thereto.~~

Exhibit No.		Description
1.1*		Form of Placement Agency Agreement
3.1		Articles of Incorporation, as amended (incorporated by reference to Exhibit 3.1 to the Quarterly Report on Form 10-Q filed on May 11, 2023)
3.2		Certificate of Change (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed on June 13, 2025)
3.3		Amended and Restated Bylaws (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed on April 21, 2023)
3.4		Certificate of Amendment to Bylaws (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed on September 10, 2025)
3.5		Certificate of Amendment to Bylaws (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed on November 14, 2025)
3.6		Certificate of Change (incorporated by reference to Exhibit 3.1 to the Current Report on Form 8-K filed on March 6, 2026)
4.1		Specimen Common Stock Certificate (incorporated by reference to Exhibit 4.1 to the Registration Statement on Form S-8 filed on December 16, 2020)
4.2		Form of Warrant (incorporated by reference to Exhibit 10.3 to the Current Report on Form 8-K filed on May 1, 2025)
4.3		Form of Pre-Funded Warrant (incorporated by reference to Exhibit 4.1 to the Current Report on Form 8-K filed on June 26, 2025)
4.4		Form of $5.82 Warrant (incorporated by reference to Exhibit 4.2 to the Current Report on Form 8-K filed on June 26, 2025)
4.5		Form of $10.00 Warrant (incorporated by reference to Exhibit 4.3 to the Current Report on Form 8-K filed on June 26, 2025)
4.6		Form of Prefunded Warrant (incorporated by reference to Exhibit 4.1 to the Current Report on Form 8-K filed on August 4, 2025)
4.7		Form of Market Priced Warrant (incorporated by reference to Exhibit 4.2 to the Current Report on Form 8-K filed on August 4, 2025)
4.8		Form of $50.00 Warrant (incorporated by reference to Exhibit 4.3 to the Current Report on Form 8-K filed on August 4, 2025)
4.9		Common Stock Warrant issued to ABK Labs, Inc., dated August 1, 2025 (incorporated by reference to Exhibit 4.1 to the Current Report on Form 8-K filed on August 7, 2025)
4.10		Form of Pre-Funded Warrant (incorporated by reference to Exhibit 4.1 to the Current Report on Form 8-K filed on September 5, 2025)
4.11		Form of Pre-Funded Warrant (incorporated by reference to Exhibit 4.1 to the Current Report on Form 8-K filed on October 1, 2025)
4.12		Form of Convertible Note (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed on October 31, 2025)
4.13		Form of Warrant (incorporated by reference to Exhibit 10.3 to the Current Report on Form 8-K filed on October 31, 2025)
4.14		Form of Pre-Funded Warrant (incorporated by reference to Exhibit 4.1 to the Current Report on Form 8-K filed on February 5, 2026)
4.15*		Form of Pre-Funded Warrant
4.16*		Form of Placement Agent Warrant
5.1*		Opinion of Fennemore Craig, P.C.
10.1		Securities Purchase Agreement by and between the Company and Gregory D. Gorgas dated April 3, 2017 (incorporated by reference to Exhibit 10.3 to the Current Report on Form 8-K filed on April 7, 2017)
10.2+		Form of Indemnification Agreement (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed on May 8, 2017)
10.3		Stock Purchase Agreement dated May 4, 2017 (incorporated by reference to Exhibit 10.4 to the Current Report on Form 8-K filed on May 8, 2017)
10.4		Form of Private Placement Subscription Agreement (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on August 4, 2017)
10.5		Form of Registration Rights Agreement (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed on August 4, 2017)
10.6		Stock Purchase Agreement dated August 1, 2017 (incorporated by reference to Exhibit 10.6 to the Current Report on Form 8-K filed on August 4, 2017)
10.7+		Material and Data Transfer, Option and License Agreement dated as of December 20, 2017 by and between the Company and NEOMED Institute (incorporated by reference to Exhibit 10.1 to the Quarterly Report on Form 10-Q filed on January 16, 2018)

II-4

10.8+				First Amendment to Material and Data Transfer, Option and License Agreement by and between the Company and NEOMED Institute, dated as of January 4, 2019 (incorporated by reference to Exhibit 10.1 to the Quarterly Report on Form 10-Q filed on April 15, 2019)
10.9+				License Agreement with Stony Brook University, by and between the Company and Stony Brook University, dated January 18, 2018 (incorporated by reference to Exhibit 10.20 to the Registration Statement on Form S-1/A filed on April 17, 2018)
10.10#				2018 Equity Incentive Plan, as amended, and Forms of Award Agreement thereunder (incorporated by reference to Exhibit 99.1 to the Registration Statement on Form S-8 filed on December 16, 2020)
10.11#				Amended and Restated Employment Agreement by and between the Company and Gregory D. Gorgas dated August 30, 2019 (incorporated by reference to Exhibit 10.3 to the Annual Report on Form 10-K filed on November 25, 2019)
10.12#				Amendment to Amended and Restated Employment Agreement by and between the Company and Gregory D. Gorgas dated October 26, 2025 (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed on October 27, 2025)
10.13				Form of Note and Warrant Subscription Agreement (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on May 1, 2025)
10.14				Form of Convertible Note (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed on May 1, 2025)
10.15				Form of Securities Purchase Agreement by and between Artelo Biosciences Inc. and the purchasers named therein (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on June 26, 2025)
10.16				At-The-Market Offering Agreement by and among the Company and R.F. Lafferty & Co., Inc., dated as of July 18, 2025 (incorporated by reference to Exhibit 1.1 to the Current Report on Form 8-K filed on July 18, 2025)
10.17				Form of Securities Purchase Agreement by and between Artelo Biosciences, Inc. and the investors named therein (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on August 4, 2025)
10.18				Form of Termination and Mutual Release Agreement by and between Artelo Biosciences, Inc. and the investors named therein (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on August 20, 2025)
10.19				Consulting Agreement by and between Artelo Biosciences, Inc. and ABK Labs, Inc., dated August 1, 2025 (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on August 7, 2025)
10.20				Termination Agreement by and between Artelo Biosciences, Inc. and ABK Labs, Inc., dated August 19, 2025 (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed on August 20, 2025)
10.21				Cooperation Letter Agreement dated October 15, 2025, among the Company and the Farb Parties (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on October 17, 2025)
10.22#				Employment Agreement by and between the Company and Mark E. Spring dated October 26, 2025 (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on October 27, 2025)
10.23				Form of Subscription Agreement by and between Artelo Biosciences Inc. and the purchasers named therein (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on October 31, 2025)
10.24				Equity Purchase Agreement, dated as of January 30, 2026, by and between Artelo Biosciences, Inc. and Square Gate Capital Master Fund, LLC - Series 5 (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on February 5, 2026)
10.25				Registration Rights Agreement, dated as of January 30, 2026, by and between Artelo Biosciences, Inc. and Square Gate Capital Master Fund, LLC - Series 5 (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed on February 5, 2026)
10.26				Securities Purchase Agreement, dated as of March 12, 2026, by and between Artelo Biosciences, Inc. and Vanquish Funding Group Inc. (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed on March 18, 2026)
10.27				Securities Purchase Agreement, dated as of March 12, 2026, by and between Artelo Biosciences, Inc. and Boot Capital LLC (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed on March 18, 2026)
10.28				Bridge Note, dated March 12, 2026, by and between Artelo Biosciences, Inc. and Vanquish Funding Group Inc. (incorporated by reference to Exhibit 10.3 to the Current Report on Form 8-K filed on March 18, 2026)
10.29				Bridge Note, dated March 12, 2026, by and between Artelo Biosciences, Inc. and Boot Capital LLC (incorporated by reference to Exhibit 10.4 to the Current Report on Form 8-K filed on March 18, 2026)
10.30*				Form of Securities Purchase Agreement
23.1*				Consent of MaloneBailey, LLP, independent registered public accounting firm
23.2*				Consent of Fennemore Craig, P.C. (included in Exhibit 5.1)
24.1*				Power of Attorney (included on the signature page to this registration statement)
107*				Filing Fee Table

___________

†	Management contracts or compensatory plans, contracts or arrangements.
#	Certain portions of this exhibit have been omitted.
*	Filed herewith.

(b) Financial Statement Schedules.

All financial statement schedules are omitted because the information called for is not required or is shown either in the financial statements or in the notes thereto.

II-5

Item 17. Undertakings.

(a) ~~The~~Insofar ~~undersigned~~as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant ~~hereby~~pursuant ~~undertakes:~~to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

(b) The undersigned registrant hereby undertakes:

(1) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

(i) To include any prospectus required by ~~section~~Section 10(a)(3) of the Securities Act ~~of 1933~~; (ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the SEC pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than 20% change in the maximum aggregate offering price set forth in the “Calculation of Registration Fee” table in the effective registration statement; and (iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement; provided, however, that paragraphs (a)(1)(i), (a)(1)(ii) and (a)(1)(iii) do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the registrant pursuant to section 13 or section 15(d) of the Securities Exchange Act of 1934 that are incorporated by reference in the registration statement.

II(ii) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective 3amendment ~~Table~~thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of ~~Contents~~securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than 20 percent change in the maximum aggregate offering price set forth in the “Calculation of Registration Fee” table in the effective registration statement;

	(2)	That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
	(3)	To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
	(4)	That, for the purpose of determining liability under the Securities Act of 1933 to any purchaser:

(iii) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement;

	(i)	Each prospectus filed by the registrant pursuant to Rule 424(b)(3) shall be deemed to be part of the registration statement as of the date the filed prospectus was deemed part of and included in the registration statement; and
	(ii)	Each prospectus required to be filed pursuant to Rule 424(b)(2), (b)(5), or (b)(7) as part of a registration statement in reliance on Rule 430B relating to an offering made pursuant to Rule 415(a)(1)(i), (vii), or (x) for the purpose of providing the information required by Section 10(a) of the Securities Act of 1933 shall be deemed to be part of and included in the registration statement as of the earlier of the date such form of prospectus is first used after effectiveness or the date of the first contract of sale of securities in the offering described in the prospectus. As provided in Rule 430B, for liability purposes of the issuer and any person that is at that date an underwriter, such date shall be deemed to be a new effective date of the registration statement relating to the securities in the registration statement to which that prospectus relates, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof. Provided, however, that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement will, as to a purchaser with a time of contract of sale prior to such effective date, supersede or modify any statement that was made in the registration statement or prospectus that was part of the registration statement or made in any such document immediately prior to such effective date.

(2) That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

	(5)	That, for the purpose of determining liability under the Securities Act to any purchaser, each prospectus filed pursuant to Rule 424(b) as part of a registration statement relating to an offering, other than registration statements relying on Rule 430B or other than prospectuses filed in reliance on Rule 430A, shall be deemed to be part of and included in the registration statement as of the date it is first used after effectiveness; provided, however, that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement will, as to a purchaser with a time of contract of sale prior to such first use, supersede or modify any statement that was made in the registration statement or prospectus that was part of the registration statement or made in any such document immediately prior to such date of first use.
	(6)	The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing of the registrant’s annual report pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan’s annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(3) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

II(4) -That, 4for ~~Table~~the purpose of ~~Contents~~determining liability under the Securities Act to any purchaser in the initial distribution of the securities, the undersigned registrant undertakes that in a primary offering of securities of the undersigned registrant pursuant to this registration statement, regardless of the method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means of any of the following communications, the undersigned registrant will be a seller to the purchaser and will be considered to offer or sell such securities to such purchaser:

	(7)	Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed by the final adjudication of such issue.
	(8)	The undersigned registrant hereby undertakes that:

(i) Any preliminary prospectus or prospectus of the undersigned registrant relating to the offering required to be filed pursuant to Rule 424 (§230.424 of this chapter);

	(i)	For purposes of determining any liability under the Securities Act of 1933, the information omitted from the form of prospectus filed as part of this registration statement in reliance upon Rule 430A and contained in a form of prospectus filed by the registrant pursuant to Rule 424(b)(1) or (4) or 497(h) under the Securities Act shall be deemed to be part of this registration statement as of the time it was declared effective.
	(ii)	For the purpose of determining any liability under the Securities Act of 1933, each post-effective amendment that contains a form of prospectus shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(ii) Any free writing prospectus relating to the offering prepared by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant;

II(iii) -The 5portion ~~Table~~of any other free writing prospectus relating to the offering containing material information about the undersigned registrant or its securities provided by or on behalf of ~~Contents~~the undersigned registrant; and

~~EXHIBIT~~(iv) ~~INDEX~~Any other communication that is an offer in the offering made by the undersigned registrant to the purchaser.

ExhibitNumber	Description	Form	File No.	FilingDate	FiledHerewith
3.1	Articles of Incorporation, as amended	10-Q	001-38951	5/11/2023
3.2	Certificate of Change	8-K	001-38951	06/13/2025
3.3	Certificate of Amendment to Articles of Incorporation				X
3.4	Amended and Restated Bylaws	8-K	001-38951	04/21/2023
3.5	Certificate of Amendment to Bylaws	8-K	001-38951	9/10/2025
3.6	Certificate of Amendment to Bylaws	8-K	001-38951	11/14/2025
4.1	Specimen Common Stock Certificate	S-8	333-251387	12/16/2020
4.2	Form of Convertible Note	8-K	001-38951	10/31/2025
4.3	Form of $3.40 Warrant	8-K	001-38951	10/31/2025
4.4	Form of $6.24 Warrant	8-K	001-38951	05/01/2025
5.1	Legal Opinion of Fennemore Craig, P.C.				X
10.1	Purchase Agreement between the Company and Lincoln Park Capital Fund, LLC, dated May 13, 2022.	8-K	001-38951	05/16/2022
10.2	Registration Rights Agreement between the Company and Lincoln Park Capital Fund, LLC, dated May 13, 2022.	8-K	001-38951	05/16/2022
10.3#	Amended and Restated Employment Agreement by and between the Company and Gregory D. Gorgas dated August 30, 2019.	10-K	001-38951	11/25/2019
10.4	Securities Purchase Agreement by and between the Company and Gregory D. Gorgas dated April 3, 2017.	8-K	001-38951	4/7/2017
10.5#	Form of Indemnification Agreement	8-K	001-38951	5/8/2017
10.6	Stock Purchase Agreement dated May 4, 2017	8-K	001-38951	5/8/2017
10.7	Form of Private Placement Subscription Agreement	8-K	001-38951	8/4/2017
10.8	Form of Registration Rights Agreement	8-K	001-38951	8/4/2017
10.9	Stock Purchase Agreement dated as of August 1, 2017	8-K	001-38951	8/4/2017
10.10+	Material and Data Transfer, Option and License Agreement dated as of December 20, 2017 by and between the Company and NEOMED Institute	10-Q	333-199213	1/16/2018
10.11+	First Amendment to Material and Data Transfer, Option and License Agreement by and between the Company and NEOMED Institute, dated as of January 4, 2019	10-Q	333-199213	4/15/2019
10.12#	2018 Equity Incentive Plan and Forms of Award Agreement Thereunder	8-K	001-38951	12/3/2020
10.13+	License Agreement with Stony Brook University, by and between the Company and Stony Brook University, dated January 18, 2018	S-1/A	333-222756	4/17/2018
10.14	Form of Note and Warrant Subscription Agreement	8-K	001-38951	5/1/2025
10.15	Form of Securities Purchase Agreement by and between Artelo Biosciences Inc. and the purchasers named therein	8-K	001-38951	6/26/2025
10.16	At-The-Market Offering Agreement by and among the Artelo Biosciences, Inc. and R.F. Lafferty & Co., Inc., dated as of July 18, 2025	8-K	001-38951	7/18/2025
10.17	Form of Securities Purchase Agreement by and between Artelo Biosciences, Inc. and the investors named therein	8-K	001-38951	8/4/2025
10.18	Consulting Agreement by and between Artelo Biosciences, Inc. and ABK Labs, Inc., dated August 1, 2025	8-K	001-38951	8/7/2025
10.19	Form of Termination and Mutual Release Agreement by and between Artelo Biosciences, Inc. and the investors named therein	8-K	001-38951	8/20/2025
10.20	Termination Agreement by and between Artelo Biosciences, Inc. and ABK Labs, Inc., dated August 19, 2025	8-K	001-38951	8/20/2025
10.21	Cooperation Letter Agreement dated October 15, 2025, among the Company and the Farb Parties	8-K	001-38951	10/17/2025
10.22#	Employment Agreement by and between the Company and Mark Spring dated October 26, 2025.	8-K	001-38951	10/27/2025
10.23#	Amendment to Amended and Restated Employment Agreement by and between the Company and Gregory D. Gorgas dated August 30, 2019.	8-K	001-38951	10/27/2025
10.24	Subscription Agreement by and between Artelo Biosciences Inc. and the purchasers named therein	8-K	001-38951	10/31/2025
23.1	Consent of Fennemore Craig, P.C. relating to opinion as to validity of the securities being registered (included in Exhibit 5.1 hereto).				X
23.2	Consent Of Independent Registered Public Accounting Firm				X
24.1	Power of Attorney (included on the signature page to this registration statement)				X
107	Calculation of Filing Fee Table				X

(5) That, for purposes of determining any liability under the Securities Act, the information omitted from the form of prospectus filed as part of this registration statement in reliance upon Rule 430A and contained in a form of prospectus filed by the registrant pursuant to Rule 424(b)(1) or (4) or 497(h) under the Securities Act shall be deemed to be part of this registration statement as of the time it was declared effective.

~~___________~~(6) That, for the purpose of determining any liability under the Securities Act, each post-effective amendment that contains a form of prospectus shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

~~# Management contracts or compensatory plans, contracts or arrangements. + Certain portions of this exhibit have been omitted.~~II-6

II - 6 Table of Contents

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S‑1 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Solana Beach, State of California, on ~~November~~ 17March 20, ~~2025~~2026.

	ARTELO BIOSCIENCES, INC.

	By:	/s/ Gregory D. Gorgas
	Name:	Gregory D. Gorgas
	Title:	President & Chief Executive Officer

POWER OF ATTORNEY

KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature appears below hereby constitutes and appoints, jointly and severally, Gregory D. Gorgas ~~and Mark Spring~~, ~~or either of them,~~ as his or her attorney-in-fact, with full power of substitution and resubstitution, for him or her and in his or her name, place, and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments), and any and all registration statements filed pursuant to Rule 462 under the Securities Act of 1933, as amended, in connection with or related to the offering contemplated by this registration statement and its amendments, if any, and to file the same, with exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorney to any and all amendments to said registration statement.

Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated:

Name	Title	Date
/s/ Gregory D. Gorgas	President, Chief Executive Officer and Director	~~November~~March 1720, ~~2025~~2026
Gregory D. Gorgas	(Principal Executive Officer)
/s/ Mark Spring	Chief Financial Officer	November 17, 2025
/s/ Mark E. Spring	Chief Financial Officer and Treasurer	March 20, 2026
Mark Spring	(Principal Financial Officer and Principal Accounting Officer)
Mark E. Spring	(Principal Financial Officer and Principal Accounting Officer)
/s/ Connie Matsui	Director, Chair of the Board	~~November~~March 1720, ~~2025~~2026
Connie Matsui
/s/ Steven Kelly	Director	~~November~~March 1720, ~~2025~~2026
Steven Kelly
/s/ Douglas Blayney	Director	~~November~~March 1720, ~~2025~~2026
Douglas Blayney, M.D.
/s/ R. Martin Emanuele	Director	~~November~~March 1720, ~~2025~~2026
R. Martin Emanuele, Ph.D.
/s/ Gregory Reyes	Director	~~November~~March 1720, ~~2025~~2026
Gregory Reyes, M.D., Ph.D.
/s/ Tamara A. Favorito	Director	~~November~~March 1720, ~~2025~~2026
Tamara A. Favorito

II-7

Filing Compare · ARTELO BIOSCIENCES, INC.