UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

~~Washington~~WASHINGTON, D.C. 20549

_______________________________________________________

FORM 8-K

_______________________________________________________

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the

~~of the~~ Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): ~~August~~November 276, 2025

_______________________________________________________

PROTHENA CORPORATION PUBLIC LIMITED COMPANY

(Exact name of registrant as specified in its charter)

Ireland		001-35676		98-1111119
(State or other jurisdiction of incorporation)		(Commission File Number)		(I.R.S. Employer Identification Number)

_______________________________________________________

77 Sir John Rogerson’s Quay, Block C Grand Canal Docklands Dublin 2, D02 VK60, Ireland (Address of principal executive offices including Zip Code)

Ireland

001-35676

98-1111119

(State or Other Jurisdiction
of Incorporation)

(Commission
File Number)

(IRS Employer
Identification No.)

77 Sir John Rogerson's Quay, Block C

Grand Canal Docklands

Dublin 2,

D02 VK60,

Ireland

(Address of principal executive offices, including Zip Code)

Registrant’s telephone number, including area code: 011-353-1-236-2500

~~(Registrant’s telephone number, including area code)~~___________________________________________________

~~N/A~~(Former Name or Former Address, if Changed Since Last Report.)

~~(Former name or former address, if changed since last report)~~___________________________________________________

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below):


☐			Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)


☐			Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)


☐			Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))


☐			Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class	Trading Symbol(s)		Name of each exchange on which registered
Title of Each Class		Trading Symbol		Name of Each Exchange on Which Registered
Ordinary Shares, par value $0.01 per share	~~PRTA~~	PRTA	~~The Nasdaq Global Select Market~~	The Nasdaq Global Select Market

Indicate by check mark whether the registrant is an emerging growth company as defined in as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 82.0102. ~~Other~~Results ~~Events~~of Operations and Financial Condition.

On The ~~August~~information in Item ~~27,~~2.02 ~~2025,~~of ~~Prothena~~this ~~Corporation~~Current ~~plc~~Report ~~issued~~on aForm ~~press~~8-K ~~release~~and ~~announcing~~Exhibit an99.1 ~~update~~attached onhereto ~~its~~shall ~~PRX012~~not ~~investigational~~be ~~drug~~deemed ~~and~~“filed” ~~results~~for ~~from~~purposes of Section 18 of the ~~Phase~~Securities 1Exchange ~~ASCENT~~Act ~~clinical~~of ~~program.~~1934, Aas ~~copy~~amended (the “Exchange Act”), or otherwise subject to the liabilities of that ~~press~~section. ~~release~~It ismay ~~attached~~only asbe ~~Exhibit~~incorporated ~~99.1~~by toreference ~~this~~in ~~Current~~another ~~Report~~filing onunder ~~Form~~the ~~8-K~~Exchange ~~and~~Act isor ~~incorporated~~the ~~herein~~Securities Act of 1933, as amended, if such subsequent filing specifically incorporate by reference the information furnished pursuant to Item 2.02 (including Exhibit 99.1) of this Current Report.

~~Item~~ On 9November 6, 2025, Prothena Corporation plc issued a press release announcing its financial results for the third quarter ended September 30, 2025.01 ~~Financial~~A ~~Statements~~copy of that press release is furnished as Exhibit 99.1 to this Current Report on Form 8-K and ~~Exhibits~~is incorporated herein by reference.

~~(d)~~Item ~~Exhibits~~9.01. Financial Statements and Exhibits

ExhibitNo.		Description
99.1		Press Release dated August 27, 2025
104		Cover Page Interactive Data File (embedded within the Inline XBRL document)

(d) Exhibits.


Exhibit No.						Description
99.1						Press Release dated November 6 , 2025
104						Cover Page Interactive Data File (embedded within the Inline XBRL document)

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

PROTHENA CORPORATION PLC

Date:

November 6, 2025

PROTHENA CORPORATION PLC

Dated: August 27, 2025

By:

/s/ Tran B. Nguyen

By:

/s/ Tran B. Nguyen

~~Name:~~

~~Tran B. Nguyen~~Name:

Tran B. Nguyen

~~Title:~~

~~Chief Strategy Officer and Chief Financial Officer~~Title:

Chief Financial Officer and Chief Strategy Officer

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