UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

PURSUANT TO SECTION 13 OR 15(d)

OF THE SECURITIES EXCHANGE ACT OF 1934

Date of Report (Date of Earliest Event Reported): March 2129, 2013

PolyMedix, Inc.

(Exact Name of Registrant as Specified in Charter)


Delaware	000-51895	27-0125925
(State or Other Jurisdiction of Incorporation or Organization)	(Commission File Number)	(I.R.S. Employer Identification Number)


170 N. Radnor-Chester Road; Suite 300 Radnor, Pennsylvania		19087
(Address of Principal Executive Offices)		(Zip Code)

(484) 598-2400

(Registrant’s Telephone Number, Including Area Code)

(Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

Written communications pursuant to Rule 425 under the Securities Act

Soliciting material pursuant to Rule 14a-12 under the Exchange Act

Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act

Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act

Item 81.~~01.~~03 ~~Other~~Bankruptcy ~~Events~~or Receivership.

InOn ~~connection~~April ~~with~~1, ~~its~~2013, ~~planned~~registrant, ~~underwritten~~PolyMedix, ~~public~~Inc., ~~offering~~and ofits ~~securities~~subsidiary, PolyMedix Pharmaceuticals, Inc., isfiled ~~filing~~voluntary aspetitions ~~Exhibit~~under ~~99.1~~Chapter to7 ~~this~~of ~~current~~the ~~report~~United onStates ~~Form~~Bankruptcy ~~8-K,~~Code in the ~~form~~United States Bankruptcy Court, District of ~~warrant~~Delaware, ~~agency~~case ~~agreement~~numbers by13-10689 and ~~between PolyMedix~~13-10690, ~~Inc~~respectively. A ~~and~~trustee ~~American~~will ~~Stock~~be ~~Transfer~~appointed &to ~~Trust~~serve ~~Company,~~as ~~LLC~~the Chapter 7 trustee for the debtors' estates.

~~The~~Item ~~offering of securities will be made under the company’s shelf registration statement, which was previously filed with, and declared effective by, the Securities and Exchange Commission~~2. ~~The~~04 ~~offering~~Triggering ~~may~~Events beThat ~~made~~Accelerate ~~only~~or byIncrease ~~means of~~ a ~~preliminary~~Direct ~~prospectus~~Financial ~~supplement~~Obligation ~~and~~or an ~~accompanying~~Obligation ~~prospectus,~~under ~~copies~~an ~~of which may be obtained from Aegis Capital Corp., Prospectus Department, 810 Seventh Avenue, 18th Floor, New York, NY 10019, telephone: 212~~Off-~~813-1010~~Balance orSheet ~~email: prospectus@aegiscap~~Arrangement.~~com.~~

The ~~preliminary~~filings ~~prospectus~~of ~~supplement,~~ the ~~accompanying~~bankruptcy ~~prospectus~~petitions ~~and~~referenced ~~this~~in ~~report~~Item ~~are~~1.03 ~~not~~of ~~offers~~this toreport ~~sell~~trigger ~~any~~an ~~securities~~event of default under the ~~company~~loan and ~~are~~security ~~not~~agreement ~~soliciting~~dated anApril ~~offer~~5, to2012, ~~buy~~as ~~such~~amended, ~~securities~~by inand ~~any~~among ~~state~~PolyMedix, ~~where~~Inc., ~~such~~PolyMedix ~~offer~~Pharmaceuticals, Inc., and ~~sale~~MidCap Financial SBIC, LP, as administrative agent, and the lenders listed thereto from time to time. Approximately $6.8 million is ~~not~~due ~~permitted~~to the lenders by the registrant and its subsidiary. Substantially all of the assets of the registrant and its subsidiary have been pledged to secure their obligations to the lenders.

Item 95.0102 ~~Financial~~Departure ~~Statements~~of ~~and~~Directors ~~Exhibits~~or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

~~(d)~~On ~~Exhibits~~March 29, 2013, Michael E. Lewis resigned his position as a director of registrant.

Exhibit No.	Description
99.1	Form of Warrant Agency Agreement by and between PolyMedix, Inc. and American Stock Transfer & Trust Company, LLC

On April 1, 2013, Brian Anderson resigned his position as a director of registrant.

On April 1, 2013, Edward F. Smith resigned his positions as acting president and chief executive officer, chief financial officer, and secretary of registrant, in which he was serving as the registrant’s principal executive officer, president, principal financial officer, principal accounting officer and principal operating officer.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

	POLYMEDIX, INC.
Date: March 21, 2013	By:	/s/ Edward F. Smith
Date: April 1, 2013	By:	/s/ Edward F. Smith
		Edward F. Smith Chief Executive Officer, Chief Financial Officer and Secretary
		Edward F. Smith Acting President and Chief Executive Officer, Chief Financial Officer and Secretary

Filing Compare · POLYMEDIX, INC