SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934

~~REPORT~~For OFthe ~~FOREIGN~~month ~~ISSUER~~of ~~PURSUANT~~September, ~~TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934~~2005

~~For~~ISOTIS ~~the~~S.A. ~~month~~(Exact name of ~~August,~~registrant ~~2005~~as specified in its charter)

~~ISOTIS S.A. (Exact name of registrant as specified in its charter)~~ 1 Rue de Sébeillon, 1004, Lausanne Switzerland (Address of Principal Executive Offices)

(Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.)

Form 20-F

Form 40-F

(Indicate by check mark whether the registrant by furnishing the information contained in this form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.)

Yes

(If “Yes” is marked, indicate below the file number assigned to the registrant in connection with Rule 12g3-2(b).)

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

August 9, 2005 IsoTis S.A.

September 6, 2005
	IsoTis S.A.

	By	/s/ Robert J. Morocco

	Name:	Robert J. Morocco
	Title:	Chief Financial Officer

By /s/ ROBERT J. MOROCCO Name: Robert J. Morocco Title: Chief Financial Officer

EXHIBIT INDEX

Exhibit No.		Description
99.1		Press Release: IsoTis ~~Reports~~OrthoBiologics ~~Solid~~and Q2PLUS ~~2005~~Orthopedics ~~Results~~in Global Distribution Agreement

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