UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 OR 15(d)

of ~~The~~the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): ~~February~~March 1230, 2026

ANNEXON, INC.

(Exact name of registrant as specified in its charter)

Delaware	001-39402	~~001~~27-~~39402~~5414423	~~27-5414423~~
(State or other jurisdiction of incorporation)		(Commission File Number)	(IRS Employer Identification No.)
(State or other jurisdiction	(Commission	(IRS Employer
of incorporation)	File Number)	Identification No.)

1400 Sierra Point Parkway, Bldg C, Suite 200 Brisbane, California		94005
(Address of principal executive offices)		(Zip Code)

1400 Sierra Point Parkway, Bldg C, Suite 200

Brisbane, California 94005

(Address of principal executive offices) (Zip Code)

Registrant’s telephone number, including area code: (650) 822-5500

Not Applicable

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:


☐	Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)


☐	Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)


☐	Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))


☐	Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class		~~Trading Symbol~~TradingSymbol(s)		Name of each ~~exchange~~exchangeon on which registered
Common Stock, par value $0.001 per share		ANNX		The Nasdaq Stock Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 52.02. ~~Departure~~Results of ~~Directors~~Operations orand ~~Certain~~Financial ~~Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers~~Condition.

On ~~February 12~~March 30, 2026, ~~Thomas G. Wiggans, Chairman of the Board of Directors (the “Board”) of~~ Annexon, Inc. (the “Company”), ~~notified~~announced ~~the~~certain ~~Company~~financial ofresults ~~his~~for ~~intent~~the tofourth ~~retire~~quarter asand ~~a member of~~ the ~~Board~~year ~~and~~ended ~~therefore~~December ~~not~~31, ~~stand~~2025. ~~for~~A ~~reelection~~copy atof the Company’s ~~2026~~press ~~annual~~release, ~~meeting~~titled ~~of stockholders (the~~ “~~2026~~Annexon ~~Annual~~Reports ~~Meeting”).~~Fourth ~~Accordingly,~~Quarter ~~Mr. Wiggans’ term as a director will end when his current term expires at the 2026 Annual Meeting. Mr. Wiggans will remain in his roles as the Chairman of the Board~~ and asYear-End a2025 ~~member~~Financial ofResults, ~~the~~Portfolio ~~Compensation~~Progress ~~Committee~~ and ~~Nominating~~Key ~~and~~Anticipated ~~Corporate~~Milestones” ~~Governance~~is ~~Committee~~furnished ofpursuant ~~the~~to ~~Board~~Item ~~until the conclusion of the 2026 Annual Meeting~~2.02 ~~The~~as ~~Company’s~~Exhibit ~~management and the Board thank Mr~~99. ~~Wiggans~~1 ~~for his eight years of dedicated service on the Board and many positive contributions to the Company~~hereto.

MrThe information in Item 2. ~~Wiggans’s~~02 ~~resignation~~of ~~was~~this Current Report on Form 8-K, including Exhibit 99.1, shall not ~~the~~be ~~result~~deemed to be “filed” for purposes of ~~any~~Section ~~disagreement~~18 ~~with~~of the ~~Company~~Securities onExchange ~~any~~Act ~~matter~~of ~~related~~1934, as amended, or otherwise subject to the ~~Company’s~~liabilities ~~operations~~of that section or Section 11 and 12(a)(2) of the Securities Act of 1933, ~~policies~~as amended. The information contained in Item 2.02 of this Current Report on Form 8-K, ~~practices~~including orExhibit ~~strategy~~99.1, shall not be incorporated by reference into any filing with the U.S. Securities and Exchange Commission made by the Company’s, ~~management~~whether made before or after the ~~Board.~~date hereof, regardless of any general incorporation language in such filing, except as expressly set forth by specific reference in such a filing.

Item 9.01. Financial Statements and Exhibits.

(d)

Exhibits.


Exhibit		Description

99.1		Press Release, dated March 30, 2026, titled “Annexon Reports Fourth Quarter and Year-End 2025 Financial Results, Portfolio Progress and Key Anticipated Milestones”
104		Cover Page Interactive Data File (embedded within the Inline XBRL document)

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Annexon, Inc.

Dated: March 30, 2026

Annexon, Inc.

Date: February 17, 2026

/s/ Jennifer Lew

/s/ Jennifer Lew

Jennifer Lew

~~Jennifer Lew~~

Executive Vice President and Chief Financial Officer

~~Executive Vice President and Chief Financial Officer~~

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