UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): October 21, 2025

LOGO

VIRIDIAN THERAPEUTICS, INC.

(Exact name of registrant as specified in its charter)

Delaware

001-36483

47-1187261

(State or other jurisdiction

of incorporation)

(Commission

File Number)

(IRS Employer

Identification No.)

221 Crescent Street, Suite 103A

Waltham, MA

02453

(Address of principal executive offices)

(Zip Code)

Registrant’s telephone number, including area code: (617) 272-4600

N/A

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐	Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐	Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐	Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐	Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class

Trading
Symbol(s)

Name of each exchange

on which registered

Common Stock, $0.01 par value

VRDN

The Nasdaq Stock Market LLC

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 1.01.

Entry into a Material Definitive Agreement

On October 21, 2025, Viridian Therapeutics, Inc. (the “Company”) entered into an underwriting agreement (the “Underwriting Agreement”) with Jefferies LLC, Leerink Partners LLC, Evercore Group L.L.C. and Stifel, Nicolaus & Company, Incorporated (collectively, the “Representatives”) relating to the offer and sale (the “Offering”) of 11,425,000 shares of the Company’s common stock, par value $0.01 per share (the “Common Stock”), at a public offering price of $22.00 per share. In addition, the Company granted the underwriters a 30-day option (the “Option”) to purchase up to an additional 1,713,750 shares of its Common Stock on the same terms and conditions as the Common Stock sold in the Offering.

The aggregate gross proceeds to the Company from the Offering are approximately $251.35 million, not including any exercise of the Option, before deducting underwriting discounts and commissions and estimated offering expenses. The net proceeds of this Offering together with existing cash, cash equivalents, short-term investments, the $70 million upfront payment receivable from Kissei Pharmaceuticals, Inc. (“Kissei”), which is expected to be paid in the fourth quarter 2025, the $55 million upfront payment that we received in connection with our entry into the purchase and sale agreement (the “Purchase and Sale Agreement”) with DRI Health Acquisition LP (“DRI”) and the additional near-term $115 million in potential milestones anticipated under the Purchase and Sale Agreement, the $30 million received by the Company from the term loan facility, after paying in full the prior facility’s outstanding amount, and anticipated revenue from veligrotug and VRDN-003 sales, if each is approved on our anticipated timelines, should provide us with sufficient capital to fund our currently anticipated operations. The Company has based this estimate on assumptions that may prove to be wrong, and the Company could use its available capital resources sooner than it currently expects.

The securities described above were offered pursuant to a shelf registration statement (File No. 333-290056), which was previously filed with the U.S. Securities and Exchange Commission (the “SEC”) and automatically became effective on September 5, 2025. A final prospectus supplement dated October 21, 2025 relating to and describing the terms of the Offering was filed with the SEC on October 22, 2025. The Offering is expected to close on October 23, 2025.

In the Underwriting Agreement, the Company agreed to indemnify the underwriters against certain liabilities, including liabilities under the Securities Act of 1933, as amended (the “Securities Act”), or to contribute payments that the underwriters may be required to make because of such liabilities. The foregoing description of the Underwriting Agreement is qualified in its entirety by reference to the full text of the Underwriting Agreement, which is attached to this Current Report on Form 8-K as Exhibit 1.1 and incorporated by reference herein.

A copy of the opinion of Ropes & Gray LLP relating to the validity of the securities issued in the Offering is filed herewith as Exhibit 5.1.

This Current Report shall not constitute an offer to sell or the solicitation of an offer to buy the securities discussed herein, nor shall there be any sale of such securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

Forward-Looking Statements

This Current Report on Form 8-K contains forward-looking statements. These statements may be identified by the use of words such as, but not limited to, “anticipate,” “believe,” “continue,” “could,” “estimate,” “expect,” “intend,” “may,” “might,” “plan,” “potential,” “predict,” “project,” “should,” “target,” “will,” or “would” or other similar terms or expressions that concern the Company’s expectations, plans and intentions. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based on the Company’s current beliefs, expectations, and assumptions. Forward-looking statements include, without limitation, statements regarding: the anticipated closing of the Offering and the period over which the Company estimates its existing cash and cash equivalents will be sufficient to fund its future operating expenses and capital expenditure requirements; the impact of a prolonged United States federal government shutdown; the Company’s anticipated cash resources and projected cash runway, including the Company’s expected timeline for, and anticipated revenue of, sales of veligrotug and VRDN-003, and the anticipated receipt of milestone payments in connection with the Purchase and Sale Agreement with DRI; the Company’s partnership with Kissei, including the timing of the Company’s receipt of the expected upfront payment; and the Company’s expectations related to its use of proceeds from the Offering and its existing cash resources.

New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements. Such forward-looking statements are subject to a number of material risks and

uncertainties including but not limited to: other matters that could affect the sufficiency of existing cash, cash equivalents and short-term investments to fund operations; the Company’s financial position and its projected cash runway; the Company’s future operating results and financial performance; and market conditions and satisfaction of customary closing conditions related to the Offering. There can be no assurance that the Company will be able to complete the Offering on the anticipated terms, or at all. Applicable risks also include those risks set forth under the caption “Risk Factors” in our most recent quarterly report on Form 10-Q for the quarter ended June 30, 2025, filed with the SEC on August 6, 2025, and other subsequent disclosure documents filed with the SEC. Any forward-looking statement speaks only as of the date on which it was made. Neither the Company, nor its affiliates, advisors, or representatives, undertake any obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law. These forward-looking statements should not be relied upon as representing the Company’s views as of any date subsequent to the date hereof.

Item 9.01.

Financial Statements and Exhibits

(d) Exhibits.


Exhibit Number		Exhibit Description

1.1		Underwriting Agreement, by and among the Company and the Representatives, dated as of October 21, 2025

5.1		Opinion of Ropes & Gray LLP

104		Cover Page Interactive Data File (embedded within the Inline XBRL document)

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Viridian Therapeutics, Inc.

Date: October 22, 2025

/s/ Stephen Mahoney

Stephen Mahoney

President, Chief Executive Officer, and Director

Viridian Therapeutics, Inc.\DE 8-K