Item 2.02 Results of Operations and Financial Condition.

UNITED ~~STATESSECURITIES AND EXCHANGE COMMISSIONWASHINGTON, D.C. 20549~~STATES

~~FORM~~SECURITIES ~~8-K~~AND EXCHANGE COMMISSION

~~CURRENT~~WASHINGTON, ~~REPORT~~D.C. 20549

~~Pursuant~~FORM ~~to Section 13 or 15(d) of the Securities Exchange Act of 1934~~8-K

~~Date~~CURRENT ~~of Report (Date of earliest event reported): August 14, 2025~~REPORT

~~Tyra~~Pursuant ~~Biosciences,~~to ~~Inc.~~Section 13 or 15(d)

~~(Exact name~~ of ~~Registrant~~the asSecurities ~~Specified~~Exchange inAct ~~Its~~of ~~Charter)~~1934

Delaware	001-40800	83-1476348
(State or Other Jurisdictionof Incorporation)	(Commission File Number)	(IRS EmployerIdentification No.)
2656 State Street
Carlsbad, California		92008
(Address of Principal Executive Offices)		(Zip Code)

Date of Report (Date of earliest event reported): August 21, 2025

~~Registrant’s~~Tyra ~~Telephone Number~~Biosciences, ~~Including Area Code: (619) 728-4760~~Inc.

(~~Former~~Exact ~~Name~~name orof ~~Former~~Registrant ~~Address,~~as ifSpecified ~~Changed~~in ~~Since~~Its ~~Last Report~~Charter)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

Delaware

001-40800

83-1476348

(State or Other Jurisdiction

of Incorporation)

(Commission

File Number)

(IRS Employer

Identification No.)

☐Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)


2656 State Street
Carlsbad, California		92008
(Address of Principal Executive Offices)		(Zip Code)

~~☐Soliciting~~Registrant’s ~~material~~Telephone ~~pursuant~~Number, toIncluding ~~Rule~~Area ~~14a-12~~Code: ~~under the Exchange Act~~ (17619) ~~CFR 240.14a~~728-~~12)~~4760

~~☐Pre-commencement~~(Former ~~communications~~Name ~~pursuant~~or toFormer ~~Rule~~Address, ~~14d-2(b)~~if ~~under~~Changed ~~the~~Since ~~Exchange~~Last ~~Act (17 CFR 240.14d-2(b~~Report))

~~☐Pre~~Check the appropriate box below if the Form 8-~~commencement~~K ~~communications~~filing ~~pursuant~~is intended to ~~Rule~~simultaneously ~~13e-4(c)~~satisfy ~~under~~the filing obligation of the ~~Exchange~~registrant ~~Act~~under ~~(17~~any ~~CFR~~of ~~240.13e-4(c))~~the following provisions:

~~Securities~~☐ ~~registered~~Written communications pursuant to ~~Section~~Rule ~~12(b)~~425 ofunder the Securities Act: (17 CFR 230.425)

Title of each class		TradingSymbol(s)		Name of each exchange on which registered
Common Stock, par value $0.0001 per share		TYRA		Nasdaq Global Select Market

☐	Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

~~Indicate~~☐ byPre-commencement ~~check~~communications ~~mark~~pursuant ~~whether~~to ~~the registrant is an emerging growth company as defined in~~ Rule ~~405 of the Securities Act of 1933~~ 14d-2(~~§ 230.405 of this chapter~~b) orunder ~~Rule 12b-2 of~~ the ~~Securities~~ Exchange Act of(17 ~~1934~~CFR (§ 240.~~12b~~14d-2 ~~of this chapter~~(b). )

~~Emerging~~☐ ~~growth~~Pre-commencement ~~company~~communications ☒pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

IfSecurities anregistered ~~emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided~~ pursuant to Section 1312(ab) of the ~~Exchange~~ Act~~. ☐~~:

TYRA BIOSCIENCES, INC.

Date: August 21, 2025

/s/ Alan Fuhrman

Alan Fuhrman

Chief Financial Officer

Title of each class

Trading

Symbol(s)

Name of each exchange

on which registered

Common Stock, par value $0.0001 per share

TYRA

Nasdaq Global Select Market

OnIndicate ~~August~~by ~~14,~~check ~~2025,~~mark ~~Tyra~~whether ~~Biosciences,~~the ~~Inc.~~registrant ~~issued~~is aan ~~press~~emerging ~~release~~growth ~~announcing~~company ~~its~~as ~~financial~~defined ~~results~~in ~~for~~Rule 405 of the ~~quarter~~Securities ~~ended~~Act ~~June~~of ~~30,~~1933 ~~2025~~(§ 230.405 Aof ~~copy~~this ofchapter) ~~the~~or ~~press~~Rule ~~release~~12b-2 isof ~~attached~~the ~~hereto~~Securities asExchange ~~Exhibit~~Act ~~99.1~~of ~~and~~1934 is(§ ~~incorporated~~240.12b-2 ~~herein~~of bythis ~~reference~~chapter).

InEmerging ~~accordance~~growth ~~with~~company General Instruction B.2 of Form 8-K, the information in this Current Report on Form 8-K, including Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the Exchange Act), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, whether made before or after the date hereof, except as expressly set forth by specific reference in such filing. ☒

~~Item~~If ~~9.01~~an ~~Financial~~emerging ~~Statements~~growth ~~and~~company, ~~Exhibits~~indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

~~(d)~~Item ~~Exhibits~~8.01 Other Events.

Exhibit No.		Description
99.1		Press Release Issued on August 14, 2025
104		Cover Page Interactive Data File (embedded within the Inline XBRL document)

On August 21, 2025, Tyra Biosciences, Inc. (Tyra or the Company) announced the first child has been dosed in the BEACH301 Phase 2 clinical study of dabogratinib (formerly TYRA-300) in children with achondroplasia. The Company expects to report initial results from the safety sentinel cohort of the BEACH301 study in the second half of 2026.

~~SIGNATURES~~Forward-Looking Statements

~~Pursuant~~Tyra cautions you that statements contained in this report regarding matters that are not historical facts are forward-looking statements. The forward-looking statements are based on our current beliefs and expectations and include, but are not limited to: expected reporting of initial results from the ~~requirements~~BEACH301 study and the timing thereof. Actual results may differ from those set forth in this report due to the risks and uncertainties inherent in our business, including, without limitation: potential delays in the commencement, recruitment, enrollment, data readouts and completion of clinical trials and preclinical studies; results from preclinical studies or early clinical trials not necessarily being predictive of future results; interim results of a clinical trial are not necessarily indicative of final results and one or more of the ~~Securities~~clinical ~~Exchange~~outcomes ~~Act~~may materially change as patient enrollment continues, following more comprehensive reviews of ~~1934~~the data, as follow-up on the ~~registrant~~outcome ~~has~~of ~~duly~~any ~~caused~~particular ~~this~~patient ~~report~~continues and as more patient or final data becomes available, including the risk that unconfirmed responses may not ultimately result in confirmed responses to treatment after follow-up evaluations; the potential for proof-of-concept results to fail to result in successful subsequent development of dabogratinib; later developments with the U.S. Food and Drug Administration (FDA) may be ~~signed~~inconsistent with prior feedback from the FDA; our dependence on ~~its~~third ~~behalf~~parties in connection with manufacturing, research and preclinical testing; unexpected adverse side effects or inadequate efficacy of our product candidates that may limit their development, regulatory approval, and/or commercialization; the potential for our programs and prospects to be negatively impacted by developments relating to our competitors, including the ~~undersigned~~results ~~thereunto~~of ~~duly~~studies ~~authorized~~or regulatory determinations relating to our competitors; regulatory developments in the United States and foreign countries; and other risks described in our prior filings with the Securities and Exchange Commission (SEC), including under the heading “Risk Factors” in our annual report on Form 10-K and any subsequent filings with the SEC. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and we undertake no obligation to update such statements to reflect events that occur or circumstances that exist after the date hereof. All forward-looking statements are qualified in their entirety by this cautionary statement, which is made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.

			TYRA BIOSCIENCES, INC.
Date:	August 14, 2025	By:	/s/ Alan Fuhrman
			Alan FuhrmanChief Financial Officer

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

Filing Compare · Tyra Biosciences, Inc.