UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

Current Report

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

Date of Report (Date of Earliest Event Reported): ~~June 11~~August 4, 2025

Mural Oncology plc

(Exact name of Registrant as Specified in Its Charter)

Ireland

001-41837

98-1748617

(State or Other Jurisdiction
of Incorporation)

(Commission

File Number)

(IRS Employer
Identification No.)

10 Earlsfort Terrace

Dublin 2, D02 T380, Ireland

Not Applicable

(Address of Principal Executive Offices)

(Zip Code)

Registrant’s Telephone Number, Including Area Code: +353- 1-905-8020

Not Applicable

(Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instructions A.2. below):

☐	Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐	Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐	Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐	Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:


Title of each class	Trading Symbol(s)	Name of each exchange on which registered
Ordinary Shares, nominal value $0.01	MURA	The Nasdaq Global Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 52.0702. ~~Submission~~Results of ~~Matters~~Operations toand aFinancial ~~Vote of Security Holders~~Condition.

On ~~June~~August 114, 2025, Mural Oncology plc (the “Company”) ~~held~~issued ~~its~~a ~~2025~~press ~~annual~~release ~~general~~announcing ~~meeting (~~the ~~“AGM”).~~Company’s ~~Below~~financial ~~are~~results for the ~~voting~~three ~~results~~months ~~for~~ended ~~the~~June 30, ~~proposals~~2025. ~~submitted~~A tocopy of the ~~Company’s~~press ~~shareholders~~release ~~for~~is afurnished ~~vote~~herewith atas ~~the~~Exhibit ~~AGM~~99.1 and is incorporated herein by reference.

~~PROPOSAL~~The 1information in this Form 8-K, including Exhibit 99.1, –attached ~~ELECTION~~hereto, OFis ~~DIRECTORS~~being furnished and shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing by the Company under the Securities Act of 1933, as amended, or the Exchange Act, except as shall be expressly set forth by specific reference in such a filing.

InItem ~~accordance~~9.01 ~~with~~Financial ~~the~~Statements ~~Company’s~~and ~~Constitution, as amended, the Company’s shareholders elected, by separate resolutions, six directors to serve until the Company’s 2026 annual general meeting, as set forth below:~~ Exhibits

Director Nominees	For		Against		Abstain		Broker Non-Votes
Francis Cuss, M.B., B.Chir., FRCP		5,883,909		596,030		2,488		5,657,632
George Golumbeski, Ph.D.		5,713,441		764,765		4,221		5,657,632
Benjamin Hickey, MBA		5,884,908		594,065		3,454		5,657,632
Scott Jackson, MBA		5,879,630		601,008		1,789		5,657,632
Caroline Loew, Ph.D.		5,886,901		614,239		1,287		5,657,632
Sachiyo Minegishi, MBA		5,883,528		593,623		5,276		5,657,632

(d) Exhibits

PROPOSAL 2. – RATIFICATION OF SELECTION OF INDEPENDENT AUDITOR


Exhibit No.		Description

99.1		Press release issued by Mural Oncology plc on August 4, 2025.

104		Cover Page Interactive Data File (embedded within the Inline XBRL document)

The Company’s shareholders ratified, in a non-binding vote, the selection of PricewaterhouseCoopers LLP as the Company’s independent auditor for the fiscal year ending December 31, 2025 and authorized, in a binding vote, the Company’s board of directors, acting through the audit committee, to set the independent auditor’s remuneration, as set forth below:

For		Against		Abstain		Broker Non-Votes
11,918,446		190,443		31,171		—

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

	Mural Oncology plc	~~Mural Oncology plc~~
Dated: June 12, 2025		By:	/s/ Maiken Keson-Brookes
Dated: August 4, 2025	By:	/s/ Adam Cutler
		Name:	~~Maiken~~Adam ~~Keson-Brookes~~Cutler
		Title:	Chief ~~Legal~~Financial Officer

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