UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): ~~August 8~~September 1, 2023

Horizon Therapeutics Public Limited Company

(Exact name of registrant as specified in its charter)

Ireland

001-35238

98-1195602

(State or other jurisdiction

of incorporation)

(Commission

File No.)

(IRS Employer

Identification No.)

70 St. Stephen’s Green, Dublin 2, D02 E2X4, Ireland (Address of principal executive offices)

~~(Address~~Registrant’s oftelephone ~~principal~~number, ~~executive~~including ~~offices)~~area code: 00-353-1-772-2100

Registrant’s telephone number, including area code: 011-353-1-772-2100

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐	Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐	Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐	Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐	Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class		~~Trading Symbol~~TradingSymbol(s)		Name of each exchange on which registered
Ordinary shares, nominal value $0.0001 per share		HZNP		The Nasdaq Global Select Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 or Rule 12b-2 of the Securities Exchange Act of 1934.

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 2 8.0201 ~~Results~~Other ~~of Operations and Financial Condition.~~Events

OnAs ~~August~~previously disclosed, on December 811, ~~2023~~2022, Horizon Therapeutics plc ~~issued~~(“Horizon”), Amgen Inc. (“Amgen”) and Pillartree Limited, a ~~press~~wholly ~~release~~owned ~~announcing~~subsidiary ~~its~~of ~~financial~~Amgen ~~results~~(“Acquirer ~~for~~Sub”), ~~the~~entered ~~second~~into ~~quarter~~a ~~ended~~Transaction ~~June 30~~Agreement pursuant to which, ~~2023. A~~among ~~copy~~other things, Acquirer Sub will acquire the entire issued ordinary share capital of ~~this~~Horizon ~~press~~(the ~~release~~“Acquisition”) isthrough ~~attached~~a ~~hereto~~court-sanctioned asscheme ~~Exhibit~~of ~~99.~~arrangement under Chapter 1 of Part 9 of the Irish Companies Act 2014.

~~Item~~On May 716, 2023, the U.01S. ~~Regulation~~Federal FDTrade ~~Disclosure~~Commission (“FTC”) filed a complaint in the U.S. District Court for the Northern District of Illinois seeking a temporary restraining order and preliminary injunction enjoining the Acquisition. Horizon, Amgen and the FTC then submitted a stipulated proposed temporary restraining order to the district court providing that Horizon and Amgen would not close the Acquisition until the earlier of October 31, 2023 or the second business day after the district court rules on the FTC’s request for a preliminary injunction (the “TRO”) and the district court issued an order granting the TRO on June 2, 2023.

~~Also~~On ~~on August~~June 822, 2023, ~~Horizon~~the ~~made~~FTC ~~available~~filed ona ~~its~~complaint ~~corporate~~in ~~website an investor presentation containing additional information about~~ its ~~business. A~~administrative ~~copy~~court ofopposing ~~this~~the ~~presentation~~Acquisition isand ~~attached~~an ~~hereto~~amended ascomplaint ~~Exhibit~~was ~~99.2~~filed ~~and~~in the ~~contents~~district ofcourt ~~the~~adding ~~presentation~~several ~~are~~states ~~hereby~~as ~~incorporated~~additional ~~by reference~~plaintiffs.

~~The~~On ~~information~~August 30, in2023, ~~Items~~Horizon, ~~2.02~~Amgen, ~~and 7.01 and~~ the ~~exhibits~~Bureau ~~hereto~~of ~~are~~Competition ~~being furnished~~ and ~~shall~~several ~~not~~state beplaintiffs ~~deemed~~(the ~~to be~~ “~~filed~~State Plaintiffs”) ~~for~~entered ~~purposes~~into ofan ~~Section 18~~Agreement ofContaining ~~the~~Consent ~~Securities~~Order ~~Exchange Act of 1934, as amended~~ (the “~~Exchange~~Consent ~~Act~~Agreement”), orwhich ~~otherwise~~contains ~~subject~~a toproposed ~~the~~Decision ~~liability~~and ofOrder ~~that~~and ~~section,~~resolves ~~nor shall they be deemed incorporated by reference in any filing under~~ the ~~Securities~~FTC ~~Act~~administrative ofcase. ~~1933~~On September 1, ~~as amended~~2023, or the ~~Exchange~~FTC ~~Act,~~announced ~~except~~that asit ~~expressly~~had ~~set~~accepted ~~forth~~the byConsent ~~specific~~Agreement ~~reference~~following ina ~~such~~vote aof ~~filing~~the commissioners.

~~Item 9.01~~As ~~Financial~~a ~~Statements~~result of the Consent Agreement, Horizon and ~~Exhibits~~Amgen expect that the parties will jointly file stipulated proposed orders to dissolve the TRO and dismiss the litigation.

~~(d)~~In ~~Exhibits~~light of the Consent Agreement and the anticipated dissolution of the TRO, Horizon plans to request that the Irish High Court schedule a new sanction hearing for purposes of sanctioning the scheme of arrangement contemplated by the Transaction Agreement. Horizon and Amgen anticipate closing the Acquisition early in the fourth quarter of 2023.

Exhibit No.		Description
99.1		Press Release of Horizon Therapeutics plc, dated August 8, 2023.
99.2		Investor Presentation of Horizon Therapeutics plc, dated August 8, 2023.
104		Cover Page Interactive Data File (embedded within the Inline XBRL document).

FURTHER INFORMATION

Statement Required by the Irish Takeover Rules

The directors of Horizon accept responsibility for the information contained in this report. To the best of the knowledge and belief of the directors of Horizon (who have taken all reasonable care to ensure that such is the case), the information contained in this report is in accordance with the facts and does not omit anything likely to affect the import of such information.

Cautionary Statement Regarding Forward-looking Statements

This report contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements are often identified by words such as “anticipate,” “believe,” “intend,” “estimate,” “expect,” “see,” “continue,” “could,” “can,” “may,” “will,” “likely,” “depend,” “should,” “would,” “plan,” “predict,” “target,” and similar expressions, and may include references to assumptions and relate to Horizon’s future prospects, developments and business strategies, and the Acquisition. Such forward-looking statements include, but are not limited to, statements relating to the Acquisition, the FTC litigation and Horizon’s and Amgen’s expectations with respect to the timing of future events, including estimated timing of closing the Acquisition. Horizon’s expectations and beliefs

regarding these matters may not materialize. Actual outcomes and results may differ materially from those contemplated by these forward-looking statements as a result of uncertainties, risks, and changes in circumstances, including but not limited to risks and uncertainties related to: whether and when the district court enters an order dissolving the TRO; whether and when a new sanction hearing is scheduled by the Irish High Court; the ability of the parties to consummate the Acquisition in a timely manner or at all; the satisfaction (or waiver) of conditions to the consummation of the Acquisition; the occurrence of any event, change or other circumstance or condition that could give rise to the termination of the transaction agreement governing the Acquisition; and the outcome of any additional legal proceedings that have or may be instituted against the parties or any of their respective directors or officers related to the Acquisition. Additional risks and uncertainties that could cause actual outcomes and results to differ materially from those contemplated by the forward-looking statements are included under the caption “Risk Factors” and elsewhere in Horizon’s most recent filings with the SEC, including its Annual Report on Form 10-K for the year ended December 31, 2022, and any subsequent reports on Form 10-Q or Form 8-K filed with the SEC from time to time and available at www.sec.gov. These documents can be accessed on Horizon’s website at https://ir.horizontherapeutics.com/financial-information/sec-filings. The forward-looking statements set out in this report are made only as of the date hereof. Horizon assumes no obligation and does not intend to update these forward-looking statements, except as required by law.

Dealing Disclosure Requirements

Under the provisions of Rule 8.3(b) of the Irish Takeover Panel Act, 1997, Irish Takeover Rules, 2022 (the “Irish Takeover Rules”), if any person is, or becomes, ‘interested’ in 1% or more of any class of ‘relevant securities’ of Horizon, that person must publicly disclose all ‘dealings’ in any ‘relevant securities’ of Horizon during the ‘offer period’, by not later than 3:30 p.m. (E.T.) on the ‘business day’ following the date of the relevant transaction.

If two or more persons co-operate on the basis of any agreement either express or tacit, either oral or written, to acquire an ‘interest’ in ‘relevant securities’ of Horizon or any securities exchange offeror, they will be deemed to be a single person for the purpose of Rule 8.3 of the Irish Takeover Rules.

A disclosure table, giving details of the companies in whose ‘relevant securities’ ‘opening position’ and ‘dealings’ should be disclosed can be found on the Irish Takeover Panel’s website at www.irishtakeoverpanel.ie.

‘Interests’ in securities arise, in summary, when a person has long economic exposure, whether conditional or absolute, to changes in the price of securities. In particular, a person will be treated as having an ‘interest’ by virtue of the ownership or control of securities, or by virtue of any option in respect of, or derivative referenced to, securities.

Terms in quotation marks are defined in the Irish Takeover Rules, which can be found on the Irish Takeover Panel’s website. If you are in any doubt as to whether or not you are required to disclose a ‘dealing’ under Rule 8 of the Irish Takeover Rules, please consult the Irish Takeover Panel’s website at www.irishtakeoverpanel.ie or contact the Irish Takeover Panel on telephone number +353 1 678 9020.

General

A copy of this announcement will be available, free of charge (subject to certain restrictions relating to persons resident in certain restricted jurisdictions) on Horizon’s website at https://ir.horizontherapeutics.com/information by no later than 12:00 noon (E.T.) on the business day following this announcement and throughout the course of the pending transaction. Neither the contents of Horizon’s website nor the contents of any other website accessible from hyperlinks are incorporated into, or form part of, this announcement.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

Date: August 8, 2023

HORIZON THERAPEUTICS PUBLIC LIMITED COMPANY

Date: September 1, 2023

HORIZON THERAPEUTICS PUBLIC LIMITED COMPANY

/s/ Aaron L. Cox

Aaron L. Cox

Executive Vice President and Chief Financial Officer

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