UNITEDTable STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934Contents

~~Date~~UNITED ofSTATES ~~Report (Date of earliest event reported): January 8, 2019~~

~~SHIRE~~SECURITIES ~~PLC~~AND ~~(Exact~~EXCHANGE ~~name~~COMMISSION ~~of registrant as specified in its charter)~~

Jersey, Channel Islands	0-29630	98-0601486
(State or other jurisdiction of incorporation)	(Commission File Number)	(IRS Employer Identification No.)

WASHINGTON, D.C. 20549

~~Block~~FORM ~~2 Miesian Plaza 50~~8-58K ~~Baggot Street Lower Dublin 2 Republic of Ireland (Address of principal executive offices)~~

~~Registrant’s~~CURRENT REPORT ~~telephone number, including area code: +353 1 609 6000~~

~~(Former~~Pursuant ~~name or former address, if changed since last report) Check the appropriate box below if the Form 8-K filing is intended~~ to ~~simultaneously~~Section 13 ~~satisfy~~or ~~the filing obligation of the registrant under any of the following provisions~~ 15(~~see General Instruction A.2.~~d): ☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities ~~Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities~~ Exchange Act of 1934 (17 CFR §240.12b-2). Emerging growth company ☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

~~Item~~Date ~~8.01.~~of ~~Other~~Report ~~Events~~(Date of earliest event reported): January 11, 2019

~~Shire~~SHIRE PLC ~~plc has issued the press release attached hereto as Exhibit 99.1, which is incorporated by reference herein.~~

~~Item~~(Exact name ~~9.01.~~of ~~Financial~~registrant ~~Statements~~as ~~and~~specified ~~Exhibits~~in its charter)

(d) Exhibits. The following exhibit is filed herewith:


Jersey, Channel Islands	0-29630	98-0601486
(State or other jurisdiction of incorporation)	(Commission File Number)	(IRS Employer Identification No.)

~~99.1 Press Release~~Block ~~dated~~2 ~~January 8, 2019~~

~~EXHIBIT~~Miesian ~~INDEX~~Plaza

Exhibit No.		Description
99.1		Press Release dated January 8, 2019

50-58 Baggot Street Lower

~~SIGNATURE~~Dublin 2

~~Pursuant~~Republic ~~to the requirements~~ of ~~the~~Ireland ~~Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.~~

~~Shire~~(Address ~~plc~~of ~~By:~~principal ~~/s/~~executive ~~Susan~~offices) ~~O’Reilly Name: Susan O’Reilly Title: Company Secretary~~

~~Date:~~Registrant’s ~~January~~telephone 9number, ~~2019~~including area code: +353 1 429 7700

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐	Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐	Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐	Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐	Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (17 CFR §230.405) or Rule 12b-2 of the Securities Exchange Act of 1934 (17 CFR §240.12b-2).

Emerging growth company ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 8.01

Other Events

Shire plc and Shire Acquisitions Investments Ireland DAC have issued the press release attached hereto as Exhibit 99.1, which is incorporated by reference herein.

Item 9.01

Financial Statements and Exhibits

(d)

Exhibits


Exhibit No.		Description

99.1		Press Release dated January 11, 2019.

EXHIBIT INDEX


Exhibit No.		Description

99.1		Press Release dated January 11, 2019.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.


	SHIRE PLC

Date: January 11, 2019	By:	/s/ Susan O’Reilly
		Name:	Susan O’Reilly
		Title:	Company Secretary

UNITEDTable STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934Contents

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