UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the
Securities Exchange Act of 1934

Date of report (Date of earliest event reported): November 1225, 2025

Silexion Therapeutics Corp
(Exact name of registrant as specified in its charter)

Cayman Islands	001-42253	N/A
(State or other jurisdiction	(Commission File Number)	(I.R.S. Employer
of incorporation)		Identification No.)

12 Abba Hillel Road Ramat-Gan, Israel		5250606
(Address of principal executive offices)		(Zip Code)

+972-3-756-4999

(Registrant’s telephone number, including area code)

N/A

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐	Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐	Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐	Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐	Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class	Trading Symbol(s)	Name of each exchange on which registered
Ordinary Shares, par value $0.0135 per share	SLXN	The Nasdaq Stock Market LLC
Warrants exercisable for Ordinary Shares at an exercise price of $1,552.50 per share	SLXNW	The Nasdaq Stock Market LLC

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Item 27.0201 Regulation ~~Results~~FD ~~of Operations and Financial Condition~~Disclosure.

On November 1225, 2025, Silexion Therapeutics Corp issued a press release ~~announcing~~entitled ~~its~~“Silexion ~~financial~~Therapeutics ~~results~~Successfully Completes Toxicology Studies for ~~the third~~SIL204, ~~quarter~~Next-Generation ~~ended~~RNA ~~September~~Silencing 30Therapy, ~~2025~~Ahead of Phase 2/3 Clinical Trial in Pancreatic Cancer”. A copy of the press release is furnished as Exhibit 99.1 ~~hereto~~to this Form 8-K and is incorporated herein by reference ~~into this Item 2~~.02

The information ~~contained~~in Item 7.01 of this Form 8-K, including the information in the press release furnished pursuant to this Item 27.0201 ~~and~~of ~~Exhibit~~Form ~~99.1~~8-K, ~~hereto~~ shall not be deemed ~~to be~~ “filed” for the purposes of Section 18 of the Securities Exchange Act of 1934, as amended ~~(the “Exchange Act”)~~, or otherwise subject to the liabilities of ~~such~~that section. Furthermore, ~~nor will~~the ~~such~~ information bein ~~deemed~~Item ~~incorporated~~7.01 byof ~~reference~~this inForm 8-K, ~~any~~including ~~filing~~the ~~under~~information in the ~~Securities~~press ~~Act~~release, ofshall ~~1933,~~not asbe ~~amended,~~deemed orto ~~under~~be ~~the~~incorporated ~~Exchange~~by ~~Act,~~reference ~~except~~in asthe ~~may~~filings beof ~~expressly~~the ~~set~~registrant ~~forth~~under bythe ~~specific~~Securities ~~reference~~Act inof ~~such~~1933, ~~filing~~as amended.

Item 9.01 Financial Statements and Exhibits

(d) Exhibits

99.1 Press Release, dated November 12, 2025, titled “Silexion Therapeutics Reports Third Quarter 2025 Financial Results and Provides Business Update”


99.1		Press Release dated November 25, 2025

104		Cover Page Interactive Data File (formatted in Inline XBRL)

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

	SILEXION THERAPEUTICS CORP
Date: November 12, 2025	By:	/s/ Ilan Hadar
Date: November 25, 2025	/s/ Ilan Hadar
	Name:	Ilan Hadar
	Title:	Chief Executive Officer

Filing Compare · Silexion Therapeutics Corp