UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

Form 6-K

REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16

UNDER THE SECURITIES EXCHANGE ACT OF 1934

For the month of ~~September~~October 2025

Commission File Number 000-30902

COMPUGEN LTD.

(Translation of registrant’s name into English)

26 Harokmim Street ~~Holon 5885849, Israel (Address of Principal Executive Offices)~~

Holon 5885849, Israel

(Address of Principal Executive Offices)

Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F:

Form 20-F ☒ Form 40-F ☐

Compugen Ltd.

On ~~September~~October 1613, 2025, Compugen Ltd. (the “Company”) ~~held~~issued ~~its~~a ~~2025~~press ~~Annual~~release ~~General Meeting of Shareholders~~ (the “~~Meeting~~Press Release”)., ~~The~~a ~~Company~~copy ~~filed the notice~~ of ~~the~~which ~~Meeting,~~is ~~the~~furnished ~~proxy statement and the proxy card with the Securities and Exchange Commission~~ as Exhibit 99.1 to ~~the~~this ~~Company’s~~ Report on Form 6-K onand ~~August 6, 2025 (File No. 000-30902), which is~~ incorporated ~~herein~~ by reference. ~~All proposals brought before the shareholders at the Meeting were approved by the requisite majority vote of the Company’s shareholders~~herein.

~~The~~With the exception of the third, fourth, and fifth paragraphs of the Press Release, the information ~~contained~~incorporated by reference in this Report on Form 6-K is hereby incorporated by reference into the Company’s Registration Statement on Form F-3, ~~as amended,~~ File No. 333-270985.

Exhibit

Number

Description of Exhibit

99.1	Press Release dated October 13, 2025 – “Compugen to Present Pooled Analysis of COM701 in Three Phase 1 Trials in Patients with Platinum Resistant Ovarian Cancer at ESMO 2025”

Signatures

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

	COMPUGEN LTD.
Date: September 17, 2025	By:	/s/ Eran Ben Dor
Date: October 14, 2025	By:	/s/ Eran Ben Dor
		Eran Ben Dor General Counsel

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