4 1 b430102.txt BROWN FORM 4 U.S. SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 4 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b). Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(f) of the Investment Company Act of 1940 1. Name and Address of Reporting Person* Paul G. Brown, III 4200 Research Forest Drive The Woodlands, Texas 77380 2. Issuer Name and Ticker or Trading Symbol Enchira Biotechnology Corporation ("ENBC") 3. IRS or Social Security Nummber of Reporting Person (Voluntary) 4. Statement for Month/Year March 2002 5. If Amendment, Date of Original (Month/Year) 6. Relationship of Reporting Persons to Issuer (Check all applicable) [ ] Director [ ] 10% Owner [X] Officer (give title below) [ ] Other (specify below) Vice President, Finance and Administration and CFO 7. Individual or Joint/Group Filing (Check Applicable Line) [X] Form filed by One Reporting Person [ ] Form filed by More than One Reporting Person

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Explanation of Responses: Reminder: Report a separate line for each class of securities beneficially owned. * If the form is filed by more than one reporting person, see Instruction 4(b)(v). ** Intentional misstatments or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a). Date: March 12, 2002 By: /s/ Paul G. Brown, III ------------------------------- Paul G. Brown, III Page 2 of 2 pages

ENCHIRA BIOTECHNOLOGY CORP 4