UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 OR 15(d)

of The Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): ~~June~~August 1314, 2023

ZYNERBA PHARMACEUTICALS, INC.

(Exact name of registrant as specified in its charter)

Delaware		001-37526		26-0389433
(State or other jurisdiction of incorporation)		(Commission File Number)		(I.R.S. Employer Identification No.)

80 W. Lancaster Avenue, Suite 300
Devon, PA	19333
(Address of principal executive offices)	(Zip Code)

80 W. Lancaster Avenue, Suite 300

Devon, PA 19333

(Address of principal executive offices)

(484) 581-7505

(Registrant’s telephone number, including area code)

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8–K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

¨	Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

¨	Soliciting material pursuant to Rule 14a–12 under the Exchange Act (17 CFR 240.14a–12)

¨	Pre–commencement communications pursuant to Rule 14d–2(b) under the Exchange Act (17 CFR 240.14d–2(b))

¨	Pre–commencement communications pursuant to Rule 13e–4(c) under the Exchange Act (17 CFR 240.13e–4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class		Trading Symbol(s)		Name of each exchange on which registered
Common Stock, $0.001 par value per share		ZYNE		The Nasdaq Capital Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company ¨

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ¨

Item 51.0701. ~~Submission~~Entry ofinto ~~Matters to~~ a ~~Vote~~Material ofDefinitive ~~Security Holders~~Agreement.

OnMerger June 13, 2023, Zynerba Pharmaceuticals, Inc. (the “Company”) held its 2023 Annual Meeting of Stockholders (the “Annual Meeting”). The following is a brief description of the final voting results for each of the proposals submitted to a vote of the stockholders at the Annual Meeting. Pursuant to the Company’s Amended and Restated Bylaws, the Company’s stockholders approved an adjournment of the Annual Meeting to 9:00 A.M. EDT on June 28, 2023 to allow additional time for stockholders to vote on Proposal 2.Agreement

On August 14, 2023, Zynerba Pharmaceuticals, Inc., a Delaware corporation (the “Company” or “Zynerba”), Harmony Biosciences Holdings, Inc., a Delaware corporation (“Parent” or “Harmony”) ~~Proposal~~, 1and —Xylophone ~~Election~~Acquisition ofCorp., ~~Seven~~a Delaware corporation and a wholly owned subsidiary ~~Directors~~of Parent (“Merger Sub”), entered into an Agreement and Plan of Merger (the “Merger Agreement”). ~~Each~~Pursuant ~~director~~to ~~nominee~~the Merger ~~was~~Agreement, ~~elected~~and upon the terms and subject to the ~~Board~~conditions therein, Purchaser will commence a tender offer (the “Offer”) to acquire all of ~~Directors~~the issued and outstanding shares of common stock, par value $0.001 per share, of the Company to(“Company ~~serve~~Common Stock”), asfor a(i) ~~director~~approximately ~~until~~$1.1059 per share of Company Common Stock (the ~~2024~~“Common ~~Annual~~Cash Amount”), in cash, subject ~~Meeting~~to any applicable withholding of ~~Stockholders~~taxes and without interest, plus (ii) one contingent value right (each, a “CVR”) per share of Company Common Stock (the “Common CVR Amount”), which represents the right to receive up to approximately $2.5444 per share of Company orCommon ~~until~~Stock ~~his~~in the form of one or ~~her~~more ~~respective~~potential ~~successor~~contingent ispayments, ~~elected~~in ~~and~~cash, ~~qualified.~~subject ~~The~~to ~~results~~any applicable withholding of taxes and without interest, upon the ~~votes~~achievement ~~cast~~of certain milestones as set forth in, and subject to and in accordance with the terms ~~were~~and conditions of, the CVR Agreement (as ~~follows~~defined below) (the Common Cash Amount plus the Common CVR Amount, collectively, or any different amount per share paid pursuant to the Offer to the extent permitted by the Merger Agreement, being the “Offer Price”). The Offer will initially expire at 5:00 p.m. (New York City time) on the date that is 21 business days following the commencement of the Offer, subject to extension under certain circumstances.

Name	Votes For	Votes Withheld	Broker Non- Votes
Armando Anido	12,938,151	1,143,437	13,009,267
John P. Butler	12,878,583	1,202,005	13,009,267
Warren D. Cooper, MB, BS, BSc, MFPM	13,011,158	1,069,430	13,009,267
William J. Federici	13,251,468	829,120	13,009,267
Daniel L. Kisner, MD	12,908,484	1,172,104	13,009,267
Kenneth I. Moch	12,937,608	1,142,980	13,009,267
Pamela Stephenson	11,784,624	2,295,964	13,009,267

Merger Sub’s obligation to accept for payment shares of Company Common Stock validly tendered (and not validly withdrawn) pursuant to the Offer is subject to the satisfaction or waiver of certain conditions set forth in the Merger Agreement, including that (i) the number of shares of Company Common Stock that have been validly tendered in accordance with the terms of the Offer and not validly withdrawn prior to the expiration of the Offer, when considered together with all other shares of Company Common Stock (if any) beneficially owned by Parent and its controlled affiliates, representing at least one share more than 50% of the total number of outstanding shares of Company Common Stock at the time of the expiration of the Offer (excluding any shares of Company Common Stock tendered pursuant to guaranteed delivery procedures that have not yet been “received” (as such term is defined in Section 251(h)(6)(f) of the DGCL)), (ii) there is no governmental entity of competent and applicable jurisdiction having enacted, issued, promulgated, enforced or entered any order or law that is in effect and restrains, enjoins or otherwise prohibits or makes illegal consummation of the Offer or the Merger, (iii) the representations and warranties of the Company contained in the Merger Agreement are accurate, subject to customary thresholds and exceptions, (iv) the Company has performed or complied with in all material respects its obligations or covenants required to be performed or complied with under the Merger Agreement, (v) there has not been nor will there be a continuing Company Material Adverse Effect (as defined in the Merger Agreement) and (vi) other customary conditions set forth in Annex I of the Merger Agreement have been satisfied.

~~(b) Proposal~~Following 2the —consummation ~~Approval~~ of ~~Amendment~~the Offer, upon tothe terms and conditions set forth in the ~~Sixth~~Merger ~~Amended~~Agreement and ~~Restated~~in ~~Certificate~~accordance ofwith ~~Incorporation~~the ofDGCL, ~~the~~Merger ~~Company. As~~Sub ~~noted~~will ~~above,~~merge ~~the~~with ~~Company~~and ~~adjourned~~into the ~~Annual~~Company ~~Meeting~~(the ~~solely~~“Merger”), with ~~respect~~the toCompany ~~Proposal~~continuing 2as tothe ~~allow~~surviving ~~additional~~corporation ~~time~~(the ~~for~~“Surviving ~~stockholders~~Corporation”) toin ~~consider~~the Merger. ~~and~~The ~~vote~~Merger onwill ~~Proposal~~be 2.governed Atby ~~the~~and ~~adjourned meeting,~~effected ~~only~~under ~~Proposal~~Section 251(h) 2of ~~will~~the beDGCL, ~~presented~~with ~~for~~no stockholder ~~consideration~~vote required to consummate the Merger.

Pursuant to the Merger, each issued and outstanding share of Company Common Stock (cother than shares of Company Common Stock (a) ~~Proposal~~held 3in —the ~~Ratification~~treasury of ~~Independent~~ ~~Registered~~the ~~Public~~Company, ~~Accountant.~~(b) that ~~The~~as of ~~appointment~~the commencement of ~~KPMG~~the ~~LLP~~Offer aswere ~~the~~owned ~~Company’s~~by ~~independent~~Parent ~~registered~~or ~~public~~Merger ~~accounting firm~~Sub (c) irrevocably accepted for payment in the ~~2023~~Offer, ~~fiscal~~or ~~year~~(d) ~~was~~held by ~~ratified.~~holders ~~The~~who ~~results~~have ofproperly exercised their appraisal rights (collectively, the ~~votes~~“Excluded ~~cast~~Shares”)) ~~were~~will asbe ~~follows:~~automatically cancelled and converted into the right to receive an amount in cash and CVR equal to the Offer Price.

Votes For		Votes Against		Abstentions		Broker Non-Votes
26,635,253		2,563,770		372,735		0

In addition, immediately prior to the effective time of the Merger (the “Effective Time”), by virtue of, and as a condition to, the Merger and without any action on the part of any holder thereof:

· Each option to purchase Company Common Stock (d“Company Option”) ~~Proposal~~, 4whether —vested ~~Approval~~or unvested, onthat has a ~~Non-Binding Advisory~~per ~~Basis,~~share ofexercise price that is less than the ~~Compensation~~Common ofCash Amount that is outstanding and unexercised immediately prior to the ~~Company’s~~Effective ~~Named~~Time ~~Executive~~will ~~Officers.~~be ~~The~~cancelled and automatically converted into the right to receive for each share of Company’s ~~stockholders~~Common ~~approved~~Stock underlying such Company Option, ~~on a~~without ~~non-binding~~interest ~~advisory~~and ~~basis~~subject to deduction for any required withholding under applicable tax law, (A) an amount in cash from Parent or the ~~compensation~~Surviving Corporation equal to the excess of the ~~Company’s~~Common ~~named~~Cash ~~executed~~Amount ~~officers.~~over ~~The~~the ~~results~~per share exercise price of ~~the~~such ~~votes~~Company ~~cast~~Option ~~were~~and as(B) ~~follows:~~one CVR;

Votes For		Votes Against		Abstentions		Broker Non-Votes
12,758,175		1,113,986		188,426		13,009,268

Each Company Option that has a per share exercise price that is equal to or greater than the Common Cash Amount but less than $2.71, whether vested or unvested, that is outstanding and unexercised immediately prior to the Effective Time will be cancelled and automatically converted into the right to receive for each share of Company Common Stock underlying such Company Option, without interest and subject to deduction for any required withholding under applicable tax law, upon the occurrence of any Milestone Payment (as defined in the CVR Agreement) a cash payment, if any, equal to (A) the amount, if any, by which (i) the Common Cash Amount plus the applicable Milestone Payment plus any Milestone Payment that was previously paid in respect of such share of Company Common Stock underlying such Company Option that exceeds (ii) the per share exercise price of such Company Option, minus (B) the gross amount of Milestone Payments previously paid with respect to such share of Company Common Stock underlying such Company Option;

~~(e) Proposal~~· 5Each —Company ~~Approval~~Option ofthat ~~the Zynerba~~has ~~Pharmaceuticals, Inc.~~a ~~2023~~per ~~Stock~~share ~~Option~~exercise ~~and~~price ~~Incentive~~equal ~~Plan~~to or greater than $2.71 ~~The~~will ~~Company’s~~be ~~stockholders~~cancelled ~~approved~~at the ~~Zynerba~~Effective ~~Pharmaceuticals, Inc. 2023~~Time ~~Stock~~without ~~Option~~any ~~and~~consideration ~~Incentive~~payable ~~Plan.~~therefor ~~The~~(whether ~~results~~in the form of ~~the~~cash ~~votes~~or ~~cast~~a ~~were~~CVR asor ~~follows:~~otherwise); and

Votes For		Votes Against		Abstentions		Broker Non-Votes
11,333,412		2,551,729		195,446		13,009,268

Each restricted stock award of the Company subject to vesting conditions based solely on continued employment or service to the Company and its subsidiary (“Company Restricted Stock Award”) that is outstanding immediately prior to the Effective Time, whether vested or unvested, will be cancelled and automatically converted into the right to receive for each share of Company Common Stock underlying such Company Restricted Stock Award, without interest and subject to deduction for any required withholding under applicable tax law, (i) an amount in cash from Parent or the Surviving Corporation equal to the Common Cash Amount and (ii) one CVR.

~~(f) Proposal~~The 6Merger —Agreement ~~Approval,~~includes ~~for~~customary ~~purposes~~representations, ofwarranties ~~complying~~and ~~with~~covenants ~~applicable Nasdaq Listing Rules,~~ of the ~~potential~~Company, ~~issuance~~Parent and ~~sale~~Merger ofSub ~~20%~~for ora ~~more~~transaction of ~~the~~this ~~Company’s common stock pursuant to the Purchase Agreement with Lincoln Park Capital Fund~~nature, ~~LLC.~~including ~~The~~covenants ~~Company’s~~regarding ~~stockholders approved~~ the ~~potential issuance~~operation ~~and sale~~ of ~~20% or more of~~ the Company’s ~~common~~business ~~stock~~prior ~~pursuant~~ to the ~~Purchase~~Effective ~~Agreement with Lincoln Park Capital Fund, LLC~~Time. ~~The results of the votes cast were as follows:~~

Votes For		Votes Against		Abstentions		Broker Non-Votes
13,305,251		676,111		99,226		13,009,267

The Company has agreed to customary restrictions on its ability to solicit alternative takeover proposals from third parties and engage in discussions or negotiations with third parties regarding acquisition proposals. Notwithstanding these restrictions, the Company may under certain circumstances provide information to and participate in discussions or negotiations with third parties in response to a bona fide, unsolicited written acquisition proposal that the Board of Directors of the Company (the “Company Board”) has determined in good faith (i) constitutes or could reasonably be expected to lead to a Superior Proposal (as such term is defined in the Merger Agreement) and (ii) failure to engage in such discussions or negotiations and provide any such information would be inconsistent with its fiduciary obligations under applicable law.

The Merger Agreement provides for certain termination rights for both of the Company and Harmony, including (ga) ~~Proposal~~ 7by —mutual ~~Approval~~written agreement of the Company and Harmony prior to the Acceptance ~~adjournment~~Time of(as defined in the ~~Annual~~Merger ~~Meeting~~Agreement), to(b) by either the Company or Harmony, if the Acceptance Time has not occurred by November 12, 2023 (the “End Date”), (c) by either the Company or Harmony, if the Offer or the Merger has been made illegal or permanently enjoined from occurring, (d) by either the Company or Harmony, if the Offer expires as a ~~later~~result ~~date~~of tothe ~~permit~~non-satisfaction ~~further~~of ~~solicitation~~one or more of ~~additional~~the ~~proxies~~Offer inConditions, (e) by Harmony, if the ~~event~~board ~~there~~of ~~are~~directors ~~insufficient~~of the Company has effected a Change in Recommendation (as defined ~~votes~~in tothe ~~approve~~Merger ~~Proposal~~Agreement), 2.(f) ~~The~~by either the Company’s ~~stockholders~~or ~~approved~~Harmony, upon the ~~adjournment~~other party’s uncured breach of the ~~Annual~~Merger ~~Meeting~~Agreement, ~~solely~~(g) by ~~with~~the ~~respect~~Company, in order to enter into an Alternative Acquisition Agreement (as defined in the Merger Agreement), or (h) by the Company, ~~Proposal~~if 2.Merger ~~The~~Sub ~~results~~fails to commence the Offer within 10 Business Days of the ~~votes~~date ~~cast~~of ~~were~~the Merger Agreement. In addition, if the Merger Agreement is terminated in certain circumstances as ~~follows:~~more fully described in the Merger Agreement, the Company will be required to pay the Company a termination fee in the amount of $4,500,000.

Votes For		Votes Against		Abstentions		Broker Non-Votes
24,903,280		1,708,912		477,663		0

The Company Board has unanimously (i) adopted the Merger Agreement and approved and declared advisable the execution, delivery and performance by the Company of the Merger Agreement and the consummation of the transactions contemplated thereby, including the Offer and the Merger, on the terms and subject to the conditions set forth in the Merger Agreement, (ii) determined that the transactions contemplated by the Merger Agreement, including the Offer and the Merger, are in the best interests of the Company and its stockholders, (iii) resolved that the Merger Agreement will be governed by and effected under Section 251(h) of the DGCL, and (iv) resolved to recommend that the stockholders of the Company accept the Offer and tender their shares of Company Common Stock to Merger Sub pursuant to the Offer.

~~Accordingly,~~The ~~the~~foregoing ~~Annual~~description ~~Meeting~~of ~~was~~the ~~adjourned~~Merger toAgreement ~~9:00~~is ~~A.M. EDT~~not oncomplete ~~June 28,~~and ~~2023~~is inqualified ~~the same virtual format described~~ in ~~the~~its ~~Definitive~~entirety ~~Proxy~~by ~~Statement.~~reference ~~Only~~to ~~stockholders of record as of April 17, 2023,~~ the ~~record~~Merger ~~date for the Annual Meeting~~Agreement, ~~are~~which ~~entitled~~is toattached ~~vote~~as atExhibit ~~the reconvened Annual Meeting~~2.1 ~~Proxies previously submitted with respect~~ to ~~Proposal~~this ~~2 will be voted at the reconvened Annual Meeting unless properly revoked; stockholders who~~report ~~have previously submitted their proxy or otherwise voted with respect to Proposal 2~~ and ~~who~~incorporated doherein ~~not~~by ~~want to change their vote need not take any action~~reference.

~~SIGNATURES~~The Merger Agreement and the foregoing description thereof have been included to provide investors and stockholders with information regarding the terms of the Merger Agreement. They are not intended to provide any other factual information about Parent, Merger Sub or the Company. The representations, warranties and covenants contained in the Merger Agreement were made only as of specified dates for the purposes of such agreement, were solely for the benefit of the parties to such agreement and may be subject to qualifications and limitations agreed upon by such parties. In particular, in reviewing the representations, warranties and covenants contained in the Merger Agreement and discussed in the foregoing description, it is important to bear in mind that such representations, warranties and covenants were negotiated with the principal purpose of allocating risk between the parties, rather than establishing matters as facts. Such representations, warranties and covenants may also be subject to a contractual standard of materiality different from those generally applicable to stockholders and reports and documents filed with the SEC (as defined below), and are also qualified in important part by confidential disclosure schedules delivered by the Company to Parent in connection with the Merger Agreement. Investors and stockholders should not rely on such representations, warranties and covenants as characterizations of the actual state of facts or circumstances described therein. Information concerning the subject matter of such representations, warranties and covenants may change after the date of the Merger Agreement, which subsequent information may or may not be fully reflected in the parties’ public disclosures.

~~Pursuant~~Contingent toValue ~~the~~Rights ~~requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.~~Agreement

			ZYNERBA PHARMACEUTICALS, INC.
Date:	June 14, 2023	By:	/s/ Albert P. Parker
			Name: Albert P. Parker
			Title: Chief Legal Officer

At or prior to the Acceptance Time (as defined in the Merger Agreement), Parent and the Rights Agent (as defined in the CVR Agreement) will enter into a Contingent Value Rights Agreement (the “CVR Agreement”) governing the terms of the CVRs to be received by the Company’s stockholders and holders of certain Company Options and Company Restricted Stock Awards. The CVRs represent the right to receive contingent payments, payable to the Rights Agent for the benefit of the holders of CVRs, if the following milestones are achieved (each, a “Milestone”):

Milestone 1: An aggregate milestone payment of $15,000,000, payable upon the completion of the last patient’s last visit in the RECONNECT (ZYN2-CL-033) clinical trial (the “Pivotal Study”) for Zygel™ (ZYN002) (the “Product”) by or before June 30, 2026;

Milestone 2: upon the completion of the Pivotal Study for the Product and a finding that the data from such Pivotal Study meet the primary end point(s) with statistical significance as set forth in the protocol of such Pivotal Study (“Milestone 2”), an aggregate milestone payment of (i) $30,000,000, with respect to the achievement of Milestone 2 by or before December 31, 2024; (ii) $20,000,000, with respect to the achievement of Milestone 2 between January 1, 2025 and June 30, 2025; or (iii) $10,000,000, with respect to the achievement of Milestone 2 on or after July 1, 2025;

Milestone 3: An aggregate milestone payment of $35,000,000, payable upon the achievement of NDA Approval (as defined in the CVR Agreement) with respect to the Product in the First Indication (as defined in the CVR Agreement) (“Milestone 3”);

Milestone 4: An aggregate milestone payment of $15,000,000, payable upon the achievement of NDA Approval (as defined in the CVR Agreement) with respect to the Product in the Second Indication (as defined in the CVR Agreement);

Milestone 5: An aggregate milestone payment of $15,000,000, payable upon the achievement of worldwide aggregate Net Sales (as defined in the CVR Agreement) of the Product (inclusive of all Indications (as defined in the CVR Agreement)) of at least $250,000,000, calculated on a cumulative basis for all Calendar Years (as defined in the CVR Agreement) (or portion thereof), provided that Milestone 3 is achieved by or before December 31, 2030 (“Milestone 5”); and

Milestone 6: An aggregate milestone payment of $30,000,000, payable upon the achievement of worldwide aggregate Net Sales of the Product (inclusive of all Indications) prior to of at least $500,000,000, calculated on a cumulative basis for all Calendar Years (or portion thereof) and inclusive of all Net Sales applied toward achievement of Milestone 5, provided that Milestone 3 is achieved by or before December 31, 2030.

The right to the contingent consideration as evidenced by the CVR Agreement is a contractual right only. The CVRs will not be transferable, except in the limited circumstances specified in the CVR Agreement, will not be evidenced by certificate or other instrument and will not be registered or listed for trading. The CVRs will not have any voting or dividend rights and will not represent any equity or ownership interest in Parent or the Company.

The CVR Agreement and the rights of holders of CVRs to receive Milestone payments thereunder will terminate on December 31, 2040. There can be no assurance whether or when any of the Milestones will be achieved and that any of the resulting Milestone payments will be required of Parent. Each Milestone with respect to a CVR may only be achieved one time. The minimum payment on the CVR is zero and the maximum payment is $2.5444 in cash per CVR.

The foregoing description of the CVR Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the form of CVR Agreement, which is provided as Exhibit B of the Merger Agreement, which is attached to this Current Report on Form 8-K as Exhibit 2.1 and incorporated herein by reference.

Tender and Support Agreements

On August 14, 2023, in connection with the execution of the Merger Agreement, the directors and executive officers of Zynerba (the “Supporting Stockholders”), entered into Tender and Support Agreements with Harmony and Merger Sub (the “Support Agreements”). Under the terms of the Support Agreements, each Supporting Stockholder has agreed, among other things, to tender, pursuant to the Offer, their shares of Company Common Stock in the Offer, vote their shares of Company Common Stock in favor of the Merger, if applicable, and, subject to certain exceptions, not to transfer any of the shares of Company Common Stock.

As of August 14, 2023, the Supporting Stockholders beneficially owned an aggregate of approximately 6.9% of the outstanding shares of Company Common Stock. The Support Agreements will terminate upon termination of the Merger Agreement and certain other specified events.

The foregoing description of the Support Agreements does not purport to be complete and is qualified in its entirety by reference to the full text of the form of Support Agreement, which is attached to this Current Report on Form 8-K as Exhibit 99.1 and incorporated herein by reference.

Item 5.02. Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

Concurrently with the signing of the Merger Agreement, the Company entered into amendments to the employment agreements previously entered into with each of the following executive officers (the “Executive Employment Agreements”): (i) Armando Anido, the Company’s Chief Executive Officer, (ii) Terri Sebree, the Company’s President, and (iii) James Fickenscher, the Company’s Chief Financial Officer and Vice President, Corporate Development (each, an “Executive”, and, together, the “Executives” and, such amendments, the “Amendments”)).

Each Amendment revises the severance benefits payable to the applicable Executive pursuant to his or her Executive Employment Agreement in the event of such Executive’s termination without Cause (as defined therein) or resignation for Good Reason (as defined therein) (collectively, a “qualifying termination”) within the ninety day period preceding a Change of Control (as defined therein) or within twelve months following a Change of Control (the “CIC Period”) to provide for (i) a lump sum cash payment equal to the full monthly COBRA premium applicable to such Executive multiplied by the number of months in such Executive’s applicable severance period (whereas prior to such amendment, the applicable Executive Employment Agreement provided for a monthly COBRA continuation subsidy during the applicable severance period equal to 90% of the total COBRA premium applicable thereto) and (ii) vesting of such Executive’s performance awards at target (if such award specifies a target). In addition, with respect to the Amendments to the Executive Employment Agreements for each of Mr. Anido and Ms. Sebree, the minimum share price related to their target bonus severance payment was removed, such that each of Mr. Anido and Ms. Sebree will be entitled to receive 100% of his or her target bonus in the event of a qualifying termination during the CIC Period.

All other material terms and conditions of each Executive’s respective Executive Employment Agreement will continue in full force and effect.

The foregoing description of each Amendment for each of Messrs. Anido and Fickenscher and Ms. Sebree is qualified in its entirety by the full text of the applicable Amendment, each of which us attached hereto as Exhibits 10.1, 10.2 and 10.3, respectively, and incorporated herein by reference.

Item 7.01. Regulation FD Disclosure.

On August 14, 2023, the Company and Parent issued a joint press release announcing the execution of the Merger Agreement. A copy of the press release is hereby furnished as Exhibit 99.2 to this Current Report on Form 8-K.

The information contained in this Item 7.01 and in Exhibit 99.2 of this Report shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be incorporated by reference into any filing under the Securities Act of 1933, as amended (the “Securities Act”), or the Exchange Act, except as expressly set forth by specific reference in such filing.

Forward Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements. These forward-looking statements, including as they relate to Harmony and Zynerba, the anticipated occurrence, manner and timing of the proposed transaction, the future development of their technologies and product candidates, including the development of and market opportunities for Zynerba’s technology and product candidates, the future value (if any) of the contingent value rights, Harmony’s strategy, and the anticipated synergies and benefits from the proposed transaction, are neither promises nor guarantees, but involve known and unknown risks, uncertainties and other important factors that may cause actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Potential risks, uncertainties and other factor to be considered include, among others, that Zynerba stockholders may not tender a sufficient number of shares in the tender offer; the length of time necessary to consummate the proposed transaction may be longer than anticipated, or it may not be consummated at all; problems may arise in successfully integrating the business and technologies of Harmony and Zynerba, and Harmony may not realize the expected benefits of the proposed transaction; the proposed transaction may involve unexpected costs; the businesses may suffer as a result of uncertainty surrounding the proposed transaction, including difficulties in maintaining relationships with third parties or retaining key employees; and even if the transaction is consummated no contingent consideration may become payable. For further discussion of these and other risks and uncertainties, see Harmony’s and Zynerba’s most recent Form 10-K and Form 10-Q filings with the United States Securities and Exchange Commission (the "SEC"), including under the headings “Risk Factors.” You are cautioned to not place undue reliance on forward-looking statements, which speak only as of the date of this document. Except as required by law, neither Harmony nor Zynerba is under any duty to update any of the information in this document.

Additional Information And Where To Find It

In connection with the proposed acquisition, Harmony will commence a tender offer for the outstanding shares of Zynerba. The tender offer has not yet commenced. This document is for informational purposes only and is neither an offer to purchase nor a solicitation of an offer to sell shares of Zynerba, nor is it a substitute for the tender offer materials that Harmony and Xylophone Acquisition Corp. (“Purchaser”) will file with the SEC upon commencement of the tender offer. At the time the tender offer is commenced, Harmony and Purchaser will file tender offer materials on Schedule TO, and Zynerba will file a Solicitation/Recommendation Statement on Schedule 14D-9 with the SEC with respect to the tender offer. Holders of shares of Zynerba common stock are urged to read the tender offer materials (including an Offer to Purchase, a related Letter of Transmittal and certain other tender offer documents) and the Solicitation/Recommendation Statement when they become available (as each may be amended or supplemented from time to time) because they will contain important information that holders of shares of Zynerba common stock should consider before making any decision regarding tendering their shares. The Offer to Purchase, the related Letter of Transmittal and certain other tender offer documents, as well as the Solicitation/Recommendation Statement, will be made available to all holders of shares of Zynerba at no expense to them. The tender offer materials and the Solicitation/Recommendation Statement will be made available for free at the SEC’s website at www.sec.gov. In addition, these materials will be available at no charge on the Enhanced SEC Filings section of the Investor Relations page of Zynerba’s website at www.zynerba.com and by directing a request to the information agent for the tender offer, whose contact information will be set forth in the Offer to Purchase.

Item 9.01. Financial Statements and Exhibits.

(d) Exhibits

Exhibit No.		Description
2.1		Agreement and Plan of Merger, dated as of August 14, 2023, by and among Harmony Biosciences Holdings, Inc., Xylophone Acquisition Corp. and Zynerba Pharmaceuticals, Inc.*

10.1		Amendment to the Employment Agreement, dated as of August 14, 2023, by and between Zynerba Pharmaceuticals, Inc. and Armando Anido.

10.2		Amendment to the Employment Agreement, dated as of August 14, 2023, by and between Zynerba Pharmaceuticals, Inc. and Terri B. Sebree.

10.3		Amendment to the Employment Agreement, dated as of August 14, 2023, by and between Zynerba Pharmaceuticals, Inc. and James E. Fickenscher.

99.1		Form of Tender and Support Agreement, dated as of August 14, 2023, by and among Harmony Biosciences Holdings, Inc., Xylophone Acquisition Corp. and the Supporting Stockholder.

99.2		Joint Press Release issued on August 14, 2023 by Harmony Biosciences Holdings, Inc. and Zynerba Pharmaceuticals, Inc.**

104		Cover Page Interactive Data File – the cover page XBRL tags are embedded within the Inline XBRL document.

Schedules have been omitted pursuant to Item 601(b)(2) of Regulation S-K. The Company hereby undertakes to furnish supplemental copies of any of the omitted schedules upon request by the SEC; provided, however, that the Company may request confidential treatment pursuant to Rule 24b-2 of the Securities Exchange Act of 1934 for any schedules so furnished.

Furnished herewith.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

	ZYNERBA PHARMACEUTICALS, INC.

Date: August 14, 2023	By:	/s/ Albert P. Parker
		Name: Albert P. Parker
		Title: Chief Legal Officer

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