UNITED STATES SECURITIES AND EXCHANGE COMMISSION

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

~~PURSUANT~~Date TOof ~~SECTION 13~~report ~~OR 15~~(dDate of earliest event reported): November OF15, ~~THE~~2012

SECURITIES EXCHANGE ACT OF 1934

Date of report (Date of earliest event reported): August 31, 2012

HELICOS BIOSCIENCES CORPORATION

(Exact Name of Registrant as Specified in Charter)

Delaware		001-33484		05-0587367
(State or Other Jurisdiction of Incorporation)		(Commission File Number)		(IRS Employer Identification No.)

One Kendall Square Building 200 Cambridge, Massachusetts		02139
(Address of Principal Executive Offices)		(Zip Code)

(617) 264-1800

(Registrant’s telephone number, including area code)

Not applicable

(Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

o Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425).

o Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12).

o Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)).

o Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)).

Item 51.0203 ~~Departure~~Bankruptcy ~~of Directors~~ or ~~Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers~~Receivership.

On ~~August~~November 3115, 2012, ~~Ivan~~ ~~Trifunovich~~Helicos ~~resigned~~BioSciences ~~from~~Corporation ~~his~~(the ~~position~~“Company”) asfiled ~~Executive~~a ~~Chairman~~voluntary ~~and~~petition ~~member~~for ofrelief ~~the~~under ~~Company’s~~Chapter ~~board~~11 of ~~directors. Mr. Trifunovich~~the ~~also~~United ~~gave~~States ~~his~~Bankruptcy ~~resignation~~Code ~~effective~~(the ~~September 14,~~“Code”) ~~2012~~in ~~from~~the ~~his~~United ~~position~~States asBankruptcy ~~President~~Court ~~and~~for ~~Chief~~the ~~Executive~~District ~~Officer~~ of Massachusetts (the ~~Company. Neither~~“Bankruptcy MrCourt”). ~~Trifunovich’s~~ ~~decision~~The toChapter ~~resign~~11 ~~from~~case ~~his~~is ~~position~~being onadministered under Case No. 12-19091 (the ~~board~~“Case”). The ofCompany ~~directors~~continues orto ~~from~~operate ~~his~~its ~~position~~business as andebtor ~~officer~~in ofpossession under the ~~Company~~jurisdiction ~~arose~~of orthe ~~resulted~~Bankruptcy ~~from~~Court ~~any~~and ~~disagreement~~in accordance with the ~~Company~~applicable onprovisions ~~any~~of ~~matters~~the ~~relating~~Code toand the ~~Company’s~~orders ~~operations,~~of ~~policies~~the orBankruptcy ~~practices~~Court.

Item 2.04 Triggering Events that Accelerate or Increase a Direct Financial Obligation or and Obligation under and Off-Balance Sheet Arrangement.

~~SIGNATURES~~The filing of the Case created an event of default under the Subordinated Secured Note Purchase Agreement, dated November 16, 2010, by and among the Company and each of the Purchasers identified therein (the “Purchase Agreement”). The Company currently has $2,375,000 of convertible promissory notes (the “Notes”) outstanding under the Purchase Agreement. The Company’s obligations under the Notes are secured by a security interest in all of the Company’s assets, including its intellectual property, that, with regard to all of the Company’s assets other than the Company’s ongoing litigation against Illumina, Inc. (the “Cause of Action”) is a first priority security interest and with regard to the Cause of Action, is junior to the first priority security interest of its outside legal counsel that is representing the Company in the Cause of Action.

~~Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.~~2

	HELICOS BIOSCIENCES CORPORATION
	By:	/s/ Jeffrey R. Moore
Date: September 6, 2012	Name:	Jeffrey R. Moore
	Title:	Senior Vice President and
		Chief Financial Officer

SIGNATURES

3Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

	HELICOS BIOSCIENCES CORPORATION


	By:	/s/ Jeffrey R. Moore
Date: November 15, 2012	Name:	Jeffrey R. Moore
	Title:	Senior Vice President and Chief Financial Officer

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