UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 10-K

x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE

SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended December 31, ~~2013~~2014

¨ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE

SECURITIES EXCHANGE ACT OF 1934

For the transition period from __________ to __________

COMMISSION FILE NUMBER 333-158474

SIGNPATH PHARMA INC.

(Exact name of Registrant as Specified in Its Charter)

DELAWARE		20-5079533
Delaware	20-5079533
(State or other jurisdiction of incorporation or organization)	(I.R.S. Employer Identification No.)	~~(I.R.S. Employer Identification No.)~~
1375 CALIFORNIA ROAD
3477 Corporate Parkway, Suite 100
QUAKERTOWN, PENNSYLVANIA		18951
Center Valley, PA	18034
(Address of principal executive offices)	(Zip Code)	~~(Zip Code)~~

Registrant’s telephone number, including area code: (215) 538-9996

SECURITIES REGISTERED PURSUANT TO SECTION 12(B) OF THE EXCHANGE ACT: NONE

SECURITIES REGISTERED PURSUANT TO SECTION 12(G) OF THE EXCHANGE ACT: NONE

Indicate by check mark if the registrant is a well-known seasoned issuer. ¨ Yes þ No

Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Exchange Act. þ Yes o ¨ No

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. þ Yes o ¨ No

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). þ Yes ¨ No.

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best of the registrant’s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form 10-K. þ

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act

Large accelerated filer ¨ Accelerated filer ¨ Non-accelerated filer ¨ Smaller Reporting ~~Company þ~~Companyþ

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). ¨ ~~Yes~~Yesþ þ No

As of March 2831, ~~2014~~2015, 1214,~~877~~163,~~500~~ 887 shares of the Registrant’s common stock, par value $0.001 per share, were issued and outstanding.

On June 2830, ~~2013~~2014, the aggregate market value of voting stock (based upon the closing price of the Registrant’s common stock on that date) held by non-affiliates of the Registrant was $0, as there is no public market for the Company’s Common Stock.

Documents Incorporated By Reference: None.

FORM 10-K ANNUAL REPORT

FOR THE FISCAL YEAR ENDED DECEMBER 31, 2014

TABLE OF CONTENTS

PART I

Item 1. Business	1

Item 1A. Risk Factors	15

Item 2. Description of Properties	29

Item 3. Legal Proceedings	29

Item 4. Mining Safety Disclosures	29

PART II

Item 5. Price Range of Common Stock, Related Stockholder Matters and Issuer Purchases of Equity Securities	30

Item 6. Selected Financial Data	31

Item 7. Management’s Discussion and Analysis of Financial Condition and Results of Operations	31

Item 7A. Quantitative and Qualitative Disclosure About Market Risk	34

Item 8. Financial Statements and Supplementary Data	34

Item 9. Changes in and Disagreements with Accountants on Accounting and Financial Disclosure	34

Item 9A Controls and Procedures	34

Item 9B. Other Information	35

PART III

Item 10. Directors and Executive Officers and Corporate Governance	35

Item 11. Executive Compensation	39

Item 12. Security Ownership of Certain Beneficial Owners and Management	41

Item 13. Certain Relationships and Related Transactions and Director Independence	42

Item 14. Principal Accountant Fees and Services	44

PART IV

Item 15. Exhibits and Financial Statement Schedules	62

CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING INFORMATION

Except for historical information, the matters discussed in this document may be considered “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. Such statements include declarations regarding the intent, belief or current expectations of SignPath Pharma Inc., and its management and are valid only as of today, and we disclaim any obligation to update this information. These statements are only predictions and involve known and unknown risks, uncertainties and other factors that may cause the Company’s or its industry’s actual results, levels of activity, performance or achievements to be materially different from any future results, levels of activity, performance or achievements expressed or implied by such forward-looking statements. Important factors to consider and evaluate that could cause actual results to differ materially from those predicted in any such forward-looking statements include: (i) the general economic conditions and changes in the external competitive market factors which might impact the Company’s results of operations; (ii) unanticipated working capital or other cash requirements including those created by the failure of the Company to adequately anticipate the costs associated with clinical trials, manufacturing and other critical activities; (iii) changes in the Company’s business strategy or an inability to execute its strategy due to unanticipated changes in the therapeutic drug industry; (iv) the inability or failure of the Company’s management to devote sufficient time and energy to the Company’s business; and (v) the failure of the Company to successfully complete clinical trials described herein on the terms currently contemplated. In light of these risks and uncertainties, many of which are described in greater detail under “Risk Factors” below and other reports filed with the Securities and Exchange Commission (“SEC”), there can be no assurance that the forward-looking statements contained in this report will in fact transpire. Although the Company believes that the expectations reflected in the forward-looking statements are reasonable, the Company cannot guarantee future results, levels of activity, performance or achievements. Moreover, neither the Company nor any other person assumes responsibility for the accuracy and completeness of such statements. We do not undertake any duty to update any of the forward-looking statements after the date of this report to conform such statements to actual results or changes in our expectations.

PART I

ITEM 1. DESCRIPTION OF BUSINESS

~~Overview~~Throughout this report, the terms “we,” “us,” “our,” “registrant,” “Company” refer to SignPath Pharma Inc.

SignPath Pharma Inc. (“us”, “we”, “SignPath” or the “Company”) is a development stage biotechnology company founded in May 2006 to develop synthesized proprietary formulations of curcumin, a naturally occurring compound found in the root of the Curcuma longa Linn (turmeric) plant, for applications in human diseases. The Company is a publicly held non-traded Delaware corporation.Business

~~Curcumin~~SignPath ~~has~~is ana ~~extensive~~clinical ~~history~~stage asbiotechnology ancompany ~~oral~~founded ~~medicinal~~in ~~product~~May ~~with~~2006 ~~safe~~to ~~human~~develop ~~use,~~synthesized ~~but~~proprietary ~~its~~formulations ~~potential therapeutic benefits have been limited by its low absorption (the amount~~ of ~~active drug reaching lesioned tissue) when taken orally~~curcumin, asa ~~well~~naturally asoccurring ~~its~~compound ~~inactivation~~found in the ~~liver~~root ~~(due~~of tothe ~~hepatic~~Curcuma ~~glucuronidation~~longa orLinn ~~sulfation~~(turmeric) ~~and~~plant, ~~“hydro-phobic”~~for ~~nature~~applications ~~whereby it is not soluble~~ in ~~water~~human ordiseases Good ~~blood.~~Manufacturing ~~SignPath~~Practice ~~has developed and submitted Investigative New Drug~~ (~~“IND”~~GMP), ~~and~~synthesis ~~Investigated~~renders ~~Medical Product Dossier (“IMPD”) applications and clinical trials for parenterally (taken into~~ the ~~body~~curcumin inactive apharmaceutical ~~manner~~ingredient ~~other than the digestive tract~~(API) ~~administered curcumin, allowing curcumin to be administered intravenously and delivered to diseased sites with minimal inactivation~~99.2% We believe that the liposomes, liposomal curcumin, and liposomal-PLGA-curcumin formulations we have licensed based on management’s experience and the opinions of our consultants may be useful in the treatment of cancer, diabetes and neurologic disorderspure. The Company is ~~developing two different intravenous/subcutaneous nano-particle sized formulations and~~ a ~~specific~~publicly ~~liposome~~held ~~application. Proof of efficacy of these compounds against human tumor xenografts in mice and prevention of cardiac arrhythmias was patent submitted and published. During IND mandated pre~~non-~~clinical~~traded ~~toxicity~~Delaware trials in dogs with liposomal curcumin, a dose-dependent hemolysis was observed, allowing us to identify a safe dose level, hence, allowing specific dose/schedules of administration for clinical trials in dogs and humanscorporation.

~~SignPath~~Curcumin has ~~licensed~~an ~~three~~extensive ~~proprietary~~history ~~intravenous~~as ~~formulations~~an ~~containing~~oral ~~curcumin~~medicinal asproduct ~~the~~with ~~active~~safe human use, but its potential therapeutic ~~agent.~~benefits ~~The~~have ~~first~~been islimited aby ~~liposomal~~its ~~version~~low ~~licensed~~absorption ~~from~~(the ~~University~~amount of ~~Texas~~active MDdrug ~~Anderson~~reaching ~~Cancer~~lesioned ~~Center (“UTMDACC”~~tissue); ~~the~~when ~~second~~taken isorally, aas ~~nanosized~~well ~~version~~as ~~licensed~~its ~~from~~inactivation in the ~~Johns~~liver ~~Hopkins University~~ (~~“JHU”~~due to hepatic glucuronidation or sulfation); and ~~the~~“hydro-phobic” ~~third~~nature whereby it is annot ~~extended~~soluble ~~release~~in ~~Liposomal-PLGA~~water ~~formulation~~or ~~(curcumin-ER)~~blood. ~~licensed~~SignPath ~~from~~has ~~the~~developed ~~University~~and ofreceived ~~North~~approval ~~Texas~~in ~~Health~~June ~~Science~~2014 ~~Center~~from the U. ~~The~~S. ~~Company’s~~Food ~~near~~and ~~term~~Drug Administration (~~next~~the ~~12 months~~“FDA”) ~~goals~~of ~~are~~its toInvestigational ~~complete~~New ~~preclinical~~Drug ~~development~~(“IND”) ~~of curcumin-ER~~application, toand ~~file~~in anEurope ~~IND~~for ~~and~~an toInvestigated ~~begin~~Medical ~~Phase~~Product IDossier ~~trials~~(“IMPD”) for ~~safety~~parenterally ~~and~~(taken ~~dosage~~into ~~studies~~the body in ~~patients~~a ~~with~~manner ~~cancer. The~~other ~~complete~~than ~~dossier~~the ~~for~~digestive ~~liposomal~~tract) administered curcumin, ~~our~~allowing ~~first~~curcumin ~~formulation~~to ~~was~~be ~~submitted~~administered tointravenously ~~the~~and ~~European~~delivered ~~Medicines~~to ~~Agency~~diseased ~~(the~~sites ~~“EMA”)~~with onminimal ~~June~~inactivation. 8,We ~~2011~~believe ~~for~~that ~~Phase~~the Ialiposomes, ~~clinical~~liposomal ~~trials~~curcumin, and ~~was~~liposomal-PLGA-curcumin ~~completed~~formulations inwe ~~October~~have ~~2012. The~~licensed ~~Company~~based ~~believes~~on ~~its~~management’s ~~licensed~~experience ~~synthetic~~and ~~chemical~~the ~~formulations~~opinions of ~~curcumin~~our ~~will~~consultants ~~replace~~may ~~the~~be ~~naturally~~useful ~~occurring~~in ~~extract~~the ~~mixture~~treatment of ~~curcuminoids~~cancer, diabetes immunologic, cardiac and ~~its~~neurologic ~~discovery~~disorders. ofThe ~~the~~Company ~~anti~~is developing two different intravenous/subcutaneous nano-~~arrythmia~~particle ~~effects~~sized offormulations ~~its~~and ~~liposomes~~a ~~will~~specific ~~render~~liposome ~~them~~application. ~~potentially~~Proof ~~patentable;~~of ~~patents~~efficacy ~~for~~of ~~liposomal~~these ~~curcumin~~compounds against human tumor xenografts in mice and ~~nanocurcumin~~prevention ~~have~~of ~~already~~cardiac ~~been~~arrhythmias ~~issued.~~was ~~The~~patent ~~Company~~submitted ~~plans~~and topublished. ~~develop~~During ~~these~~IND ~~new~~mandated ~~products~~pre-clinical ~~which~~toxicity ~~potentially~~trials ~~will~~in ~~give~~dogs ~~SignPath~~with ~~proprietary~~liposomal curcumin, ~~preparations~~a ~~with~~dose-dependent ~~applications~~hemolysis inwas ~~the~~observed, ~~treatment~~allowing ~~for~~us ato ~~broad~~identify ~~spectrum~~a ofsafe ~~neoplastic~~dose level, ~~neurologic~~hence, ~~and~~allowing ~~metabolic~~specific ~~indications~~dose/schedules of administration for clinical trials in dogs and humans.

SignPath has licensed three proprietary intravenous formulations containing curcumin as the active therapeutic agent. The ~~Company~~first ~~has~~is ~~assembled~~a ~~leaders~~liposomal ~~experienced~~version inlicensed ~~pharmacologic~~from ~~development~~University of ~~natural~~Texas ~~products~~MD toAnderson ~~advise~~Cancer itCenter on(“UTMDACC”) which is currently in Phase Ib clinical trials in Salzburg, Austria; the ~~development~~second ofis ~~its~~a ~~curcumin~~nanosized ~~formulations.~~version ~~This~~licensed ~~Scientific~~from ~~Advisory~~the ~~Board~~Johns Hopkins University (“JHU”); and the third is ~~comprised~~an extended release Liposomal-PLGA formulation (curcumin-ER) licensed from the University of ~~individuals~~North ~~with~~Texas ~~specific~~Health ~~experience~~Science ~~with~~Center. ~~natural~~The ~~products,~~Company’s ~~formulation~~near term (next 12 months) goals are to complete preclinical development, ~~neoplastic~~of curcumin-ER, ~~metabolic~~to file a second IND and ~~neurologic~~to ~~disorders.~~begin ~~Expertise~~Phase inI ~~analytical~~trials ~~chemistry~~for ~~will~~safety ~~come~~and ~~from~~dosage ~~commercially~~studies ~~based~~in ~~product~~patients ~~chemists.~~with ~~Drug~~cancer ~~development~~under ~~will~~its beinitial ~~overseen~~IND byapproved ~~Lawrence~~in ~~Helson~~June ~~MD,~~2014. ~~Chief~~The ~~Executive~~complete ~~Officer~~dossier for liposomal curcumin, anour ~~oncologist~~first ~~with~~formulation 25was ~~years~~submitted ofto ~~pharmaceutical~~the ~~development~~European ~~experience;~~Medicines ~~Anirban~~Agency ~~Maitra,~~(the ~~PhD~~“EMA”) on June 8, ~~MPPH~~2011, offor ~~JHU,~~Phase ~~who~~Ia ~~has~~clinical ~~expertise~~trials and was completed in ~~nanotechnology,~~October ~~development~~2012. ofThe ~~nano,~~Company ~~and~~believes ~~liposomal~~its licensed synthetic chemical formulations of curcumin ~~testing~~will ~~for~~replace ~~antitumor~~the ~~effects;~~naturally ~~Judith~~occurring A.extract ~~Smith,~~mixture ~~PhD~~of curcuminoids, ~~director~~and its discovery of the ~~UTMDACC~~anti-arrhythmia ~~preclinical~~effects ~~development~~of ~~group~~its ~~for~~liposome ~~the~~and analogs will render them potentially patentable; patents for liposomal ~~formulation~~curcumin and ~~Jamboor~~nanocurcumin ~~Vishwanatha~~have ofalready ~~University~~been ofissued. ~~North~~The ~~Texas~~Company ~~Health~~plans ~~Science~~to ~~Center~~develop ~~who~~these ~~has~~new ~~experience~~products which potentially will give SignPath proprietary curcumin preparations with ~~extended~~applications ~~release~~in ~~formulations~~the treatment for a broad spectrum of neoplastic, neurologic, cardiac, and immunologic indications.

The Company’s ~~Scientific~~has ~~Advisory~~assembled ~~Board~~leaders ~~members~~experienced ~~all~~in ~~bring~~pharmacologic ~~relevant~~development ~~experience~~of natural products to advise it on the ~~Company~~development of its curcumin formulations. ~~Professor~~This ~~Tauseef~~Scientific ~~Ahmad,~~Advisory MDBoard is ancomprised ~~experienced~~of ~~principal~~individuals ~~investigator~~with ~~for~~specific ~~lymphoma~~experience with natural products, ~~myeloma~~formulation ~~and~~development, ~~solid~~neoplastic, ~~tumor~~immunologic ~~studies.~~and Drneurologic disorders. ~~Peter~~Expertise Pin analytical chemistry will come from commercially based product chemists. ~~Sordillo,~~Drug ~~who~~development ~~joined~~will ~~our~~be ~~Scientific~~overseen ~~Advisory~~by ~~Board~~Lawrence inHelson ~~2013~~MD, isChief onExecutive ~~the~~Officer, ~~Staff~~an oncologist with 25 years of ~~Medical~~pharmaceutical ~~Oncology~~development ~~and~~experience; ~~Hematology~~Anirban atMaitra, ~~Lenox~~PhD, ~~Hill~~MPPH, ~~Hospital~~of UTMDACC, ~~New~~who ~~York~~has asexpertise anin ~~experienced~~nanotechnology, ~~Oncologist. See~~development ~~“Management”~~of ~~below~~nano, and liposomal curcumin testing for ~~more~~antitumor ~~information~~effects; ~~about~~Judith ~~our~~A. ~~management~~Smith, ~~team~~PhD, director of the UTMDACC preclinical development group for the liposomal formulation and ~~Scientific~~Jamboor ~~Advisory~~Vishwanatha ~~Board~~of ~~members~~University of North Texas Health Science Center who has experience with extended release formulations.

The Company’s Scientific Advisory Board members all bring relevant experience to the Company. Professor Tauseef Ahmad, MD is an experienced principal investigator for lymphoma, myeloma and solid tumor studies. Dr. Peter P. Sordillo, who joined our Scientific Advisory Board in 2013, was on the Staff of Medical Oncology and Hematology at Lenox Hill Hospital, New York as an experienced Oncologist. George Shopp, PhD, is an experienced toxicologist. See “Management” below for more information about our management team and Scientific Advisory Board members.

Clinical application strategies will be based upon the advice of the individuals serving on the Scientific Advisory Board, all of whom have academic and practical experience in biopharmaceutical development. As described below, we expect that our Phase I and II clinical trials will be run by contract clinical research organizations in Europe and the United states.

During the fiscal years ended December 31, 2013 and ~~2012~~2014, the Company expended $841,502, and $~~939~~1,~~296~~927,851, respectively, for net research and development. None of these expenses were borne by customers as the final products are not commercially available. They consisted primarily of payments made to commercial and academic institutions.

Target Markets

The anticipated markets for therapeutic curcumin are diseases for which current therapeutic alternatives are not satisfactory or unavailable. There are several malignant diseases which are classified as orphan indications, defined by the U.S. Food and Drug Administration (the “FDA”) as conditions with less than 200,000 patients in the United States. Some of these conditions exhibit dependency upon NF-kB (NF-kappaB, a family of intracellular proteins), a signaling pathway component inhibited by curcumin.1 Two such indications are lung and pancreatic cancers. The Company currently plans to pursue the development and testing of therapies with parenterally-administered curcumin to address non-small cell lung and other cancers, in which current treatment is only marginally effective or could be greatly improved. Additional indications are Parkinson’s disease, drug-induced cardiac arrhythmias and an infection or drug-induced immunologic disorders (cytokine storm).

Preclinical and animal studies conducted by other scientists of curcumin-based treatments in cancer therapy suggest it may have an application as a parenteral drug for both prophylaxis and therapy.2 While these preclinical data show potentially beneficial activity and exhibit multiple mechanisms of action, the parenteral route has not yet been tried in controlled human clinical trials. Current trials with oral curcumin by academic research groups at various stages of pre-clinical and clinical development have limited efficacy. The Company’s goals differ in that it intends to establish the safety and efficacy of parenteral curcumin in patients.

While our focus is on non-small cell lung cancer, subsequent studies may consider pancreatic cancer an unmet clinical need and the fifth leading cause of cancer deaths, accounting for an estimated 45,600 deaths annually in the United States, according to published reports found in Burro, H.A. et al. This cancer is largely resistant to the current approved drug, gemcitabine, and results in an objective tumor response in less than 10% of patients resulting in a minor impact on survival.3 Most patients with this diagnosis could be candidates for trials in combination with gemcitabine, or trials of curcumin alone as a second line therapy.

The annual incidence of lung cancer is approximately over 200,000 cases in the United States and about 170,000 deaths. Lung cancer researchers have shown an increased expression of curcumin-sensitive signaling pathways, which the Company believes may make it susceptible to therapy with our product candidate. Based upon pre-clinical studies conducted by SignPath scientists with our active principle and other scientists with curcumin extracts, we believe the potential patient population could include the majority of these patients following failure of standard treatment, or as testing advances, in combination therapy or as a first line single-agent.

Other potential susceptible tumor types are primary and metastatic brain tumors and lymphoma in adults. The market for glioblastoma multiforme and other malignant gliomas has an incidence of about 17,000 per year, or 59 per million of the population, according to the scientific literature.4 Although this represents just 2% of cancer deaths in the United States, survival rates are low and cost of treatment is high. Following standard therapy, the median survival of glioblastoma patients is 9 to 11 months with less than 5% of patients alive after 5 years. In addition, metastases to the brain from other sites affect an estimated 75,000 patients per year and have very poor survival rates, making primary and metastatic brain tumors a clear unmet need. The annual incidence of lymphoma is approximately 66,000 cases in the United States. Multiple myeloma is responsible for 10% to 20% of the lymphoma malignancies, with skeletal involvement in about 80% of the patients.5 Lymphoma researchers have shown an increased expression of the curcumin-sensitive signaling pathway, which the Company believes may make it susceptible to therapy with our product candidates. In our drug distribution trials in dogs we observed large amounts of liposomal curcumin collected in the lung tissues following 8 hour infusions, suggesting that lung disorders would be appropriate clinical targets. Lung cancer affects 175,000 persons in the United States.

The Company believes that its parenteral formulations of curcumin can be compared with standard of care when used in combination with front line standard chemotherapy in a number of diseases. Given the aging of the population with annual incremental growth in the number of prospective patients in chronic and acute disease categories, the Company believes a minimally toxic agent like curcumin could gain wide acceptance and usage.

____________________

1 Ahn KS, Aggarwal BB., 2005 Transcription factor NF-(kappa)B; A sensor for smoke and stress Signals. Ann N.Y. Acad Sci 1056:218-233.

2 Aggarwal B.B., Kumar A, Bharti C 2003. Anticancer potential of curcumin. Pre-clinical and clinical studies. Anticancer Research 23:363-398.

3 See footnote 1 above.

4 See footnote 2 above.

5 Burris H.A. et al. 1997 Improvements in survival and clinical benefit with gemcitabine as first line therapy for patients with advanced pancreatic cancer: a randomized trial. J Clinical Oncology 15:2403-2413.

Marketing Strategies

Company Strategies and Status

Business Concept

SignPath is a clinical phase biotech company. We in-license formulated curcumin (API) compounds based upon intellectual property, manufacturing capability, acceptable toxicity, parenteral administration feasibility, unmet clinical needs, and extensive data documenting efficacy of curcumin in disease indications. Our modus operandi is to demonstrate safety and efficacy of the formulated compounds in Phase 1 and 2 clinical trials in order to facilitate Phase 3 clinical trials and registration approvals. Following Phase 2 trials, we plan to partner, joint venture and/or independently complete Phase 3 clinical trials, and upon approval commercialize the products. The possibilities of selling or licensing territory for our liposome indication, or curcumin products, to other Pharma prior to completion of clinical Phase 3 of any of the products is not excluded.

Goals and Objectives

Following in-licensing of these formulations of curcumin we expect to develop a robust IP profile, and complete requirements for an IND in the United States. Upon IND approval we plan to complete a phase 2a trial of advanced Parkinson’s disease in the US. We have an approved IMPD in Europe. Our immediate goals are to complete phase 1b clinical trials with liposomal curcumin by December 2014 for omnibus cancer indications in Austria. We have completed pre-clinical studies of liposomal mitigation of QTc prolongation by several currently marketed drugs, including nilotinib and crizotinib. Liposomal mitigation of QTc prolongation and sensitization in alloxinized rabbit diabetic models is under study. This cardian arrhythmia risk is observed in 25-31% of humans with diabetes.

Target Market

The anticipated markets for therapeutic curcumin are diseases for which current therapeutic alternatives are not satisfactory or unavailable. There are several malignant diseases which are classified as orphan indications, defined by the U.S. Food and Drug Administration (the "FDA") as conditions with less than 200,000 patients in the United States. Some of these conditions exhibit dependency upon NF-kB (NF-kappaB, a family of intracellular proteins), a signaling pathway component inhibited by curcumin.(1) Two such indications are lung and pancreatic cancers. The Company currently plans to pursue the development and testing of therapies with parenterally-administered curcumin to address non-small cell lung and other cancers, in which current treatment is only marginally effective or could be greatly improved. Three additional indications are Parkinson’s disease, Type 2 diabetes, and drug-induced cardiac arrhythmias.

Preclinical animal studies conducted by other scientists of curcumin-based treatments in cancer(2) therapy suggest it may have an application as a parenteral drug for both prophylaxis and therapy. While these preclinical data show potentially beneficial activity and exhibit multiple mechanisms of action,(2) the parenteral route has not yet been tried in controlled human clinical trials. Current trials with oral curcumin by academic research groups at various stages of pre-clinical and clinical development have limited efficacy. The Company’s goals differ in that it intends to establish the safety and efficacy of parenteral curcumin in patients.

In the United States an estimated 221,130 cases of lung cancer were diagnosed in 2011 with an estimated 156,940 deaths, accounting for approximately 27% of all cancer deaths. Despite incremental advances in treatment over many years, the 5-year survival rate for all stages combined remains unacceptably low at 16%. Lung cancer researchers have reported an increased expression and number of curcumin-sensitive signaling pathways, which the Company believes may make it susceptible to therapy with liposomal curcumin. This is further supported by pre-clinical studies conducted by SignPath scientists with our synthesized curcumin and other scientists with curcumin extracts. Our planned clinical trial of liposomal curcumin as second line therapy will focus on patients who have failed standard treatment, or as a controlled first line therapy in combination with standard drugs.

Pancreatic cancer, an unmet clinical need, is the fifth leading cause of cancer deaths, accounting for an estimated 45,600 deaths annually in the United States. This cancer is largely resistant to the current approved drug, gemcitabine, and results in an objective tumor response in less than 10% of patients resulting in a minor impact on survival. Most patients with this diagnosis could be candidates for trials in combination with gemcitabine, or trials of curcumin alone as second line therapy.

_________

1Ahn KS, AggarwalBB., 2005 Transcription factor NF-(kappa)B; A sensor for smoke and stress Signals. Ann N.Y. AcadSci 1056:218-233.

2Aggarwal B.B., Kumar A, Bharti C 2003. Anticancer potential of curcumin.Pre-clinical and clinical studies.nticancer Research 23:363-398.

Other potential susceptible tumor types are primary tumors. The incidence of glioblastoma multiforme and other malignant gliomas is 17,000 patients per year, or 59 per million of the population, according to the literature.(3) Although this represents just 2% of cancer deaths in the United States, survival rates and duration are low and cost of treatment is high. Following standard therapy, the median survival of glioblastoma patients is 9 to 11 months with less than 5% of patients alive after 5 years. In addition, metastases to the brain from other sites affect an estimated 75,000 patients per year who have poor survival rates, making primary and metastatic brain tumors a clear unmet need.

The Company believes that its parenteral formulations of curcumin can be compared or combined with standard of care when used in combination with front line standard chemotherapy in a number of other diseases. Given the aging of the population and annual incremental growth in the number of prospective patients in chronic disease categories such as Parkinson’s disease, the Company believes a minimally toxic agent like curcumin could gain wide acceptance and usage. In screening for an additional clinical indication in a review of the literature, we identified a compelling array of documented beneficial effects of curcumin and erythropoietin on Type 2 diabetes and insulin resistance. To date we noted 34 islet cell molecular, and tissue targets beneficially responding to curcumin and/or erythropoietin, eight possible drug actions either not impacting or potentially exacerbating the diabetic state, and five molecular targets with unreported interaction with curcumin.

Unlike insulin replacement treatment of diabetic disorders, our working hypothesis addresses diabetes as a disease characterized by heterogeneous intricacies. SignPath is investigating curcumin and cEPO-Fc in combination assuming the combination can navigate the transcription factor expression levels in appropriate sequences and within an appropriate timeline required for β-cell differentiation, insulin secretion, and the molecular regulation of β-cell mass maintenance, and expansion, i.e. differentiating β-cells from precursor populations in vivo and returning islets to a normal insulin-responsive homeostatic state. An additional related extra-islet goal is to mitigate pathologic causes of insulin resistance.

SWOT Analysis

Strength: Currently, six liposomal chemotherapeutics have received clinical approval and others are in clinical trials or undergoing preclinical evaluation. Liposomes exhibit low toxicity and improve the biopharmaceutical features and therapeutic index of drugs, thereby increasing efficacy and reducing side effects. Liposomal incorporation offers advantages for the delivery of chemotherapeutics which are metabolically unstable or poorly water-soluble. SignPath is a unique company developing parenteral curcumin administration methods because the oral route of administration of this compound lacks sufficient bioavailability for systemic disease therapy. The phase 1b liposomal curcumin formulation was initiated a cancer patient in Salzburg in October 2013. Based upon initial observations we altered the infusion delivery method and shortened the infusion duration from 24 to 8 hours, the same procedure we plan to use in clinical trials in the United States. SignPath has a strong relationship with curcumin manufacture, analytics, regulatory and CRO groups in Canada, Europe, and in the United States.

	Strength:	Currently, six liposomal chemotherapeutics have received clinical approval and others are in clinical trials or undergoing preclinical evaluation. Liposomes exhibit low toxicity and improve the biopharmaceutical features and therapeutic index of drugs, thereby increasing efficacy and reducing side effects. Liposomal incorporation offers advantages for the delivery of chemotherapeutics which are metabolically unstable or poorly water-soluble. SignPath is developing parenteral curcumin administration methods because the oral route of administration of this compound lacks sufficient bioavailability for systemic disease therapy. The Phase Ib liposomal curcumin formulation was initiated in a cancer patient in Salzburg, Austria in October 2013. Based upon initial observations we altered the infusion delivery method and shortened the infusion duration from 24 to 8 hours, the same procedure we plan to use in clinical trials in the United States. SignPath has a strong relationship with curcumin manufacture, analytics, regulatory and CRO groups in Canada, Europe, and in the United States.

		There are 42 publications (See “Business” below) regarding our products, eight patents pending and three issued. The formulations may be applicable for diseases affecting large numbers of people.

	Weakness:	Contraindicated in patients with a pre-existing bleeding diathesis. When solubilized in alkaline media, and at high ambient light conditions it is instable. Intravenous administration can be safely done using controlled syringe infusions rather than electronic impellent pumps which cause the product to precipitate in the infusion line.

	Opportunity:	Curcumin can be applicable to unmet clinical indications including cancer, and neurologic disorders. It can also be used in auto-immune, inflammatory diseases, mycoses, and parasitic diseases alone or in combination with other treatment modalities such as cytotoxics, and ionizing radiation.

	Threat:	None from established pharmaceutical companies worldwide.

There are 34 publications regarding our products, 9 patents pending (and two issued). The formulations may be applicable for diseases affecting large numbers of people. GMP synthesis renders the curcumin API 99.2% pure.

Weakness: Contraindicated in patients with a pre-existing bleeding diathesis. When solubilized in alkaline media, and at high ambient light conditions it is instable. Intravenous administration can be safely done using gravity drip rather than electronic impellent pumps which cause the product to precipitate in the infusion line.

Opportunity: Curcumin can be applicable to unmet clinical indications including cancer, neurologic and diabetic disorders. It can also be used in auto-immune, inflammatory diseases, mycoses, and parasitic diseases alone or in combination with other treatment modalities such as cytotoxics, and ionizing radiation.

Threat: None from established pharmaceutical companies worldwide.

Marketing Strategies

Curcumin has potential utility in over 5,000,000 patients in multiple clinical disorders assuming penetration in all potential markets. Our initial plan is to determine its efficacy in lung cancer, ~~Type~~ ~~2 diabetes~~ and Parkinson’s disease (over 1,200,000 patients). Used alone or in combination with other drugs or radiation treatments, we anticipate being able to market, when approved by the FDA, to between 10-% and 50% of ~~market~~eligible ~~share~~patients depending upon the indications chosen and responses in ~~phase~~Phase II and ~~phase~~Phase III clinical trials.

~~_________~~Curcumin is not a branded name because of extensive use as a spice for over 3,000 years. As data is developed we anticipate presenting this information at large international and disease specialty meetings, e.g., ASCO, and EMSO. The cardiac arrhythmia action of the liposome and its analogs has been presented, and its effects published in 9th International Conference of Anticancer Research, Sithonia, Greece, and Safety Pharmacology Society, Washington, D.C. Pricing and sales are too early to identify at this stage of development.

3Product Burris H.A. et al. 1997 Improvements in survival and clinical benefit with gemcitabine as first line therapy for patients with advanced pancreatic cancer: a randomized trial. J Clinical Oncology 15:2403-2413.Overview

Background on Curcumin

Curcumin has been used primarily in its natural state in turmeric as an ingredient in foods for hundreds of years in India and the Asian subcontinent where it grows naturally. It also has a history of use as a medicinal extract. 6

The history of curcumin includes oral human use for a variety of benign and malignant diseases. A body of published research explaining curcumin’s mechanisms of action at the cellular level supports its potential application in humans.7 8 In addition, there have been parenteral curcumin toxicology studies in mice and rats published by other researchers which support a finding of curcumin’s safety after oral application.

________________

6 See footnote 2 above.

7 Reddy RC, Vatsala PG, Keshamouni VG et al, 2005. Curcumin for Malaria Therapy Biochemical and Biophysical Research Communications 326:472-474; see footnotes 1 and 2 above.

8 Li,L., Brairteh, F. Kurzrock,R 2005. Liposome Encapsulated Curcumin. In Vitro Effects on proliferation, apoptosis, signaling and angiogenesis. Cancer, 104:1322-1331.

The problem that has limited the therapeutic potential of curcumin is that it is orally delivered and the curcumin has limited bioavailability. This is because curcumin is inactivated as it passes through the intestinal wall and the liver. Lymphoma researchers have attributed its low efficacy to low levels of active drug reaching the bloodstream. Yet, uncontrolled clinical trials conducted by third parties have indicated that oral curcumin may have preventative clinical activity in several diseases, when taken over long periods of time, but not in established systemic diseases.

To address this problem, SignPath has developed parenteral formulations (administration that bypasses the gastrointestinal system) in the form of a liposomal version, a nanosized version, and a delayed release version. Predicated upon the dosage schedules, needs, and population demographics of different disease entities, the Company believes these curcumin-based treatments will be applicable for a broad spectrum of systemic diseases, i.e., proliferative malignant diseases and neurologic disorders. In addition, curcumin is believed to work as a chemopreventive agent in cancers of the bladder, colon, stomach, and skin based upon its established antioxidant and anti-inflammatory properties. 9

Brief Technology Background: Signal Transduction and Cellular Pathways Cells carry out many of their functions by responding to signals transmitted from the external environment. The surface of a cell has receptor proteins that span or cross the cell surface and bind to their targets with high specificity. When an external molecule binds to a surface receptor, it provides the signal to activate (turn on or turn off) critical cell processes.

Recent scientific breakthroughs have enabled these surface receptors and the internal pathways they control to become targets for drug development. Several companies have used these mechanisms to develop products that have reached the market or advanced to late stage clinical trials.

Once a cell signaling pathway is activated, a series of reactions (or cascade) occurs within the cell. Each step activates a specific protein in the pathway, and its active products initiate the activation of the next protein in the process. Some of the cellular processes that are controlled in this manner include inflammatory pathways, cell proliferation, cell survival, and cell death (apoptosis). Elevated levels of activated inflammatory and survival pathways have been correlated with many types of tumors,10 and can also be markers for more severe disease and/or poor prognosis. Some pathways are associated with resistance to chemotherapy, translated as tumor cell survival in the presence of conventional chemotherapy. These are some of the many tumor cell characteristics that can make cancer a fatal disease.

SignPath is developing curcumin, a compound for which there are early indicators that it may be a compound that inhibits several cell survival pathways via blockade of specific signaling proteins called activating kinases. Two established pathway targets are known as NF-kB and AKT(1). The net effect when these pathways are inactivated is to turn off signals leading to cell metabolism, protein synthesis, proliferation and to activate signals leading to cell death via activation of downstream processes. These changes also alter other pathways, including STAT3, Survivin, TNFalpha, and MDR-1 pathways conferring resistance to chemotherapy.

SignPath believes inhibition of these critical intracellular survival pathways are good targets for drug development, and our management believes that curcumin is an attractive lead compound for further development due to its inhibition of major survival pathways and collateral effects of activating death pathways. It also prohibits inflammation and release of inflammatory cytokines such as tumor necrosis factor-ά (alpha), inflammatory cells such as macrophages which are required for the development and spread of tumors. Recently it has been shown that activation of NF-kB (an intracellular protein) is a critical component in cellular responses to TOLL-receptor ligands (receptors that activate immune cell responses) and Interleukin-1 (a cytokine). The latter are implicated in the innate immune response promoting murine hepatocellular and colon carcinoma. 11 One of the established effects of curcumin is to inhibit NF-kB and subsequent TOLL-receptor ligand activity. Scientific studies have suggested that a drug that can inhibit these activated survival and inflammatory pathways should be able to stop the growth of cancer cells. Blocking inhibitors of death pathways are believed to shorten the cell’s ability to survive.12

Liposome Encapsulation and Nanocurcumin

SignPath was developing nanosized formulations of curcumin which are now a fail-safe drug after development of the other formulations. The liposomal version is a phospholipid coating that encases the molecule. This increases solubility in serum, and increases the drug’s circulation time allowing more drug to reach tumor sites. In an extended release modification, pre-clinical studies of curcumin with human lung cancer xenotransplants in mice have been completed at the University of North Texas (see below).

_________________

9 See footnote 1 above.

10 Rakoff-Nahoum Seth, and Medzitof, Rusian 2007 Regulation of Spontaneous Intestinal Tumorigenesis Through the Adaptor Protein MyD88. Science 317: 124-127.

11 See footnote 2 above.

12 See footnote 8 above.

~~Curcumin~~ Mechanism ~~is not a branded name because~~ of extensive use as a spice for over 3,000 years. As data is developed we anticipate presenting this information at large international and disease specialty meetings, e.g., ASCO, and EMSO. Pricing and sales are too early to identify at this stage of development.Action

~~Potential~~Curcumin’s ~~Products~~molecular mechanisms of action involve direct and indirect inhibition or activation of multiple biochemical targets in cells. These include genes, enzymes, proteins, and, particularly, many components of up-regulated cell survival and down-regulated cell death pathways. These activities result in decreased inflammatory and/or oxidative damage, decreased migration, proliferation and invasion of tumor cells, decreased radio- and chemoresistance, and increased chemosensitivity to cytotoxic drugs. These observations suggest the potential to treat several diseases with large potential markets, with an economically feasible product.

AsCancer: aLess ~~drug~~than ~~development~~1% ~~pharma,~~of wean ~~have~~oral ~~three~~dose ~~lead~~of ~~candidates: liposomal~~ curcumin ~~(Lipocurc),~~is ~~Liposomal-PLGA-Curcumin~~absorbed; ~~(Curcumin-ER),~~yet ~~and~~in ~~Liposomes~~spite ~~alone.~~of ~~The~~this ~~liposomal~~extreme ~~curcumin~~limitation, ~~development~~there isare ~~the~~publications ~~most~~that ~~advanced~~suggest ~~with~~preventative aanti-cancer ~~completed~~activity ~~Phase~~of 1aorally inadministered 45curcumin ~~normal subjects~~13. More ~~Phase~~substantial 1bevidence ~~trials~~for inanticancer ~~cancer~~activity ~~patients~~is ~~were~~suggested ~~initiated~~from in ~~Europe~~vitro inand ~~October~~animal ~~2013~~experiments. ~~Manufacturing~~Its ofanticancer ~~the~~effects ~~active~~include ~~pharmaceutical~~promoting ~~ingredient~~apoptosis is(cell bydeath ~~Sami~~pathways) ~~Labs, Bangalore, India~~ and ~~the~~down ~~final~~regulation ~~liposomal~~of ~~product~~major ispro-survival ~~made~~factors, byincluding ~~Polymun GmbH~~AKT, ~~Klosterneuburg~~NF-kB, ~~Austria. All required blood analyses~~STAT-3, and ~~pharmacokinetics~~Survivin ofsignaling ~~Phase~~pathways. 1aWe, ~~1b and Phase 2 studies have been~~therefore, orbelieve ~~are~~that tocommercial beapplication ~~outsourced~~of toparenteral ~~Dalton~~curcumin ~~Inc.~~formulations ~~and Nucro~~for ~~Technics~~cancers inwhich ~~Ontario,~~depend ~~Canada.~~upon ~~Clinical~~NF-kB 1a(such ~~studies~~as inpancreatic 45cancer) ~~normal~~represent ~~subjects~~prime ~~have~~candidates ~~been~~for ~~completed~~Phase ~~under~~II ~~the~~trials ~~supervision~~assuming ofsuccessful ~~Dr.~~preclinical ~~M.Wolzt at the University of Vienna hospital Phase1 clinic~~ and ~~reported~~Phase atI ~~the~~trials. ~~April~~Many ~~2013~~other ~~AACR~~cancers ~~convention~~such inas ~~Washington,~~brain ~~D.C.~~tumors ~~There~~ are noalso ~~known~~dependent ~~risks~~upon ~~regarding~~AKT, ~~competition~~NF-kB, ~~since~~and ~~SignPath~~survival ispathways ~~the~~which ~~only~~may ~~company~~render ~~developing~~them ~~parenteral~~additional ~~synthesized~~potential ~~99.2%~~clinical ~~pure curcumin formulations~~targets. 14

A liposomal curcumin for cancer patent was issued on June 29, 2011; a nanocurcumin patent was issued on November 20, 2012 and an additional nine curcumin-related patents have been submitted to the US Patent and Trademark Office.

Liposomal curcumin is planned to be used as a cancer therapeutic alone or in combination with other anti-cancer agents, as an anti-Parkinson’s disease, and an anti-diabetic, therapeutic. The liposome is planned to be used to mitigate current drug induced QTc prolonging toxicity. The nanosized formulation of curcumin composed of a lipid coating that encases the curcumin molecule increases solubility in blood, and distribution in the lungs, allowing more drug to reach pulmonary tumor sites. In a proof of principle study, positive pre-clinical studies of subcutaneous curcumin in human lung tumor xenotransplants, have been completed at the University of North Texas Health Sciences Center.

Product Risks

To date, at estimated therapeutic dosages of liposomal curcumin, no life threatening adverse events have been observed in 45 normal healthy subjects in a Phase 1a ascending dose trial. Intravenous curcumin causes dose dependent red blood cell membrane alterations, dose-dependent hemolysis, and increased bleeding diathesis.

Nanocurcumin

Nanocurc™, a polymeric parenteral formulation of curcumin has been found in human pancreatic cancer xenografts in nude mice to have anti-cancer effects which are synergistic when co-administered with Gemcitabine. This formulation also has activity against breast cancer and passes the blood brain barrier. This formulation is relegated to serve as a fail-safe drug.

Liposomal PLGA Curcumin (curcumin-ER)

This is an extended release formulation, (designed to prevent curcumin-induced QTc prolongation and possible cardiac adverse events by the incorporation of liposomes). It has activity with human lung cancer (A453) xenotransplants in nude mice.

Research

The Company currently outsources all of its preclinical research. This research is performed at a number of universities including with experienced investigators at Johns Hopkins University, MD Anderson Cancer Center, Univ., North Texas Health Science Center, U. Vienna, Austria, A.I. Dupont Hospital, DE Bostyr Univ. CA, N.Y. Medical College, N.Y. State Medical school at Buffalo. In addition, research is also performed at a number of private corporations with which the Company has relationships, including Dalton Inc. for stability testing and drug storage; Nucro Technics for analysis of human tissue samples, and animal toxicological studies; IPS -Therapeutics for hERG assays; Sabinsa Inc./Sami Labs. for curcumin manufacture and Sorosa product; Polymun GmbH for liposomal formulation manufacture; Chemic Inc. for analytics of the API; Clinipace for regulatory in the USA; Dry Heinz and Partner CRO in Europe; Schiff &Co for CRO( (for Phase 2) in the USA and Central European Society for Anticancer Research (CESAR) for Phase 1b -2 clinical trials in the EU.

The Company has a Scientific Advisory Board which helps oversee the preclinical research. A number of specialists in pre-clinical and clinical medicine sit on the Scientific Advisory Board, including Drs. T. Ahmed, R. Horne, A Maitre, J.A. .Smith, G. Shopp and Peter Sordillo.

Government Regulation

Regulation by governmental authorities in the United States and other countries is a significant hurdle in the development, manufacture and marketing of pharmaceuticals, and in our ongoing research and development activities. All of our products will require regulatory approval by governmental agencies prior to commercialization. In particular, pharmaceutical drugs are subject to rigorous preclinical testing and clinical trials and other pre-marketing approval requirements by the U.S. Food and Drug Administration (“FDA”) and regulatory authorities in other countries. In the United States, various federal, and in some cases, state statutes and regulations also govern or impact upon the manufacturing, safety, labeling, storage, record-keeping and marketing of pharmaceutical products. The lengthy process of seeking required approvals and the continuing need for compliance with applicable statutes and regulations, require the expenditure of substantial resources.

Regulatory approval, when obtained for any of our product candidates may be limited in scope which may significantly restrict the indicated uses for which our product candidates may be marketed. Further, approved drugs and manufacturers are subject to ongoing review and discovery of previously unknown problems that may result in restrictions on their manufacture, sale or use or in their withdrawal from the market.

FDA Approval & Developmental Milestones

There are four primary phases of FDA clinical trials for an FDA new drug application (NDA) and approval for commercial sale. Before these can begin, non-clinical/pre-clinical laboratory studies are conducted and an Investigational New Drug application (IND) is submitted to the FDA. After FDA approval, the Company may begin Phase I clinical safety and dosage estimation studies, followed by Phase II studies to evaluated clinical efficacy in selected diseases, then Phase III testing to demonstrate statistically significant safety and efficacy and Phase IV pharmacovigilence designed to identify long-term effects of treatment.

During the pre-clinical phase (non-clinical and pre-clinical), a compound is studied in-vitro in a laboratory and in-vivo in laboratory animals to establish its stability, manufacturing feasibility, bioavailability, absorption, distribution, metabolism and elimination. This phase of testing establishes pre-clinical parameters for clinical safety and efficacy. Results of these pre-clinical trials comprise the IND that is submitted to the FDA for review before the drug is tested in humans. Phase I testing is a basic safety and dosage study to determine if the drug is safe enough to administer to patients with advanced diseases such as pancreatic cancers, lymphomas and brain tumors.

During the initial Phase I, the drug must be tested in healthy human volunteers to determine a tolerable dosage regimen that is sufficiently safe to proceed with further testing in a larger group of diseased patients. Testing in disease-free volunteers can supply accurate estimates of safety and tolerability for application in persons with non-cancer indications, while testing in patients with pre-treated cancers designated Phase 1bIb can indicate different degrees of tolerance depending upon their past medical history.

____________________

13 See footnote 2 above.

14 See footnote 1 above.

In Phase II studies, the drug is tested in small number of patients with benign and/or malignant forms of disease to determine the doses at which the drug has clinical activity and to characterize the drug’s effects on the body. These effects include the drug’s dosage, efficacy, and side effect profiles.

Drugs that have a clinical benefit in Phase II trials move forward to additional clinical testing with a larger number of patients in Phase III trials. These trials verify Phase II results in a larger patient sample and must demonstrate statistically significant clinical benefits, as well as safety. Trial endpoints are designed to show a meaningful clinical effect over a predetermined timeframe. These timeframes depend on the disease being tested and can be in weeks, months, or years of treatment.

The drug being tested is typically compared with a placebo or the current standard of treatment to show that the drug is equal to (or an improvement upon) existing treatments. Once those studies have been completed, a new drug application (NDA) is prepared and submitted to the FDA for approval. Under FDA guidelines, the NDA should be answered within 10 months. At such time, the FDA may inform the Company that a drug is approved or the application is approvable pending resolution of certain issues, or may require additional studies to be completed for approval.

Other Regulatory Requirements

Any products that are manufactured or distributed under FDA approvals are subject to pervasive and continuing regulation by the FDA, including record-keeping requirements and reporting of adverse experiences with the products. Drug manufacturers and their subcontractors are required to register with the FDA and, where appropriate, state agencies, and are subject to periodic unannounced inspections by the FDA and state agencies for compliance with cGMP regulations which impose procedural and documentation requirements. Before approving a biologics license application, the FDA will inspect the facilities at which the product is manufactured (including both those of the applicant and any third-party component manufacturers) and will not approve the product unless the manufacturing facilities are in compliance with FDA’s cGMP, which are regulations that govern the manufacture, storage and distribution of a product. Manufacturers of biologics also must comply with FDA’s general biological product standards.

Following approval, the FDA periodically inspects drug and biologic manufacturing facilities to ensure continued compliance with the cGMP regulations. We must ensure that any third-party manufacturers continue to expend time, money and effort in the areas of production, quality control, record keeping and reporting to ensure full compliance with those requirements. Failure to comply with these requirements subjects the manufacturer to possible legal or regulatory action, such as suspension of manufacturing or recall or seizure of product. Adverse experiences with the product must be reported to the FDA and could result in the imposition of marketing restrictions through labeling changes or market removal. Product approvals may be withdrawn if compliance with regulatory requirements is not maintained or if problems concerning safety or efficacy of the product occur following approval.

The FDA also closely regulates the marketing and promotion of drugs. A company can make only those claims relating to safety and efficacy that are approved by the FDA. Failure to comply with these requirements can result in adverse publicity, warning letters, corrective advertising and potential civil and criminal penalties. Physicians may prescribe legally available drugs for uses that are not described in the product’s labeling and that differ from those tested by us and approved by the FDA. Such off-label uses are common across medical specialties. Physicians may believe that such off-label uses are the best treatment for many patients in varied circumstances. The FDA does not regulate the behavior of physicians in their choice of treatments. The FDA does, however, restrict manufacturer’s communications on the subject of off-label use.

The FDA’s policies may change and additional government regulations may be enacted which could prevent or delay regulatory approval of product candidates or approval of new indications for our existing products. We cannot predict the likelihood, nature or extent of adverse governmental regulations that might arise from future legislative or administrative action, either in the United States or abroad.

In addition, the labeling, advertising, promotion, marketing and distribution of a drug or biologic product also must be in compliance with FDA and U.S. Federal Trade Commission (“FTC”) requirements which include, among others, standards and regulations for off-label promotion, industry sponsored scientific and educational activities, promotional activities involving the internet, and direct-to-consumer advertising. The FDA and FTC have very broad enforcement authority, and failure to abide by these regulations can result in penalties, including the issuance of a warning letter directing the Company to correct deviations from regulatory standards and enforcement actions that can include seizures, injunctions and criminal prosecution.

~~Raw~~Other ~~Materials;~~Uses ~~Supplies~~of Curcumin

~~Liposomal~~There ~~curcumin~~are ~~was~~other ~~manufactured~~potential ~~for~~uses ~~the Company by Polymun, Inc.,~~ of ~~Vienna,~~curcumin ~~Austria under the agreement described~~ in ~~the~~addition ~~prior~~to ~~section.~~our ~~Curcumin~~initial ~~was~~focus ~~obtained~~on ~~initially~~lung ~~from~~cancer and aParkinson’s Udisease.S. ~~chemical~~Following ~~supplier,~~our ~~Sigma~~clinical ~~Aldrich~~trials ~~Fine~~in ~~Chemicals~~these ~~(“SAFC”).~~two ~~The~~categories, ~~Company~~we ~~obtained~~will ~~one~~seek ~~batch~~to ofstudy ~~200~~other ~~grams~~cancer ofcandidates ~~GMP~~which ~~manufactured~~have ~~liposomal curcumin under~~ an ~~agreement~~AKT ~~dated~~or ~~June 30, 2007 with SAFC. The total cost to the Company was $98,350. Sabinsa Inc. subsequently scaled~~NF-upkB ~~manufacture~~requirement ~~of 98.2% pure curcumin under GMP~~ for ~~human~~survival ~~use~~and ~~in Bangalore~~proliferation, ~~India.~~such ~~FDA~~as ~~and~~breast ~~EMA (European Medicines Agency) compliance~~ and ~~validations~~brain ~~audits~~cancers. ~~relating~~The tounique ~~the~~protean ~~curcumin~~activity ~~manufacturing facility in India were performed by Topaz Technology, Inc.~~ of ~~Bryn~~curcumin ~~Mawr,~~also PAsuggests ~~under~~its anuse ~~agreement~~ with ~~the~~other ~~Company~~cancer ~~dated~~treatment ~~June~~modalities. ~~30,~~For ~~2009~~example, atit amay ~~total~~increase ~~cost~~tumor ofcell ~~$24,500~~susceptibility ~~which~~to ~~has~~standard ~~been~~treatment ~~paid.~~with ~~Analysis~~radiation ofor ~~the 0.1% residue was completed at Chemic Labs~~chemotherapy, ~~Massachusetts.~~and ~~GMP~~prevent ~~grade~~adverse ~~Nanocurcumin~~reactions ~~will be manufactured for the Company by Regis Pharmaceuticals. The Company’s supply~~ from ~~Sabinsa~~other ~~was~~drugs ~~made~~used ~~pursuant~~ to ~~purchase~~treat ~~orders~~non-cancer ~~without a contract~~conditions. ~~There are very stringent new regulations concerning GMP by the EMA and the FDA.~~

At UTMDCC, GLP pharmacokinetic and toxicity studies of single and multi-dose intravenous liposomal curcumin in mice and rats were without evidence of toxicity at a maximal injectible volume. Dog pharmacokinetics and single ascending dose toxicity studies identified reversible hemolysis at a maximum tolerated dose (MTD) and irreversible hemolysis at a significantly higher dose limiting level. In vitro studies with dog and human RBCs corroborated these observations using annexin V biomarker (a biochemical feature used to measure the progress of diseases or the effects of treatment), and a second independent set of studies at Xenometrics, USA indicated hemolytic sensitivity only at at multiples of concentrations above those necessary for therapeutic effect. Multidose toxicological canine studies were completed at Nucro Technics, Canada based upon these studies, and were devoid of tissue toxicity. Currently body tissue distribution of liposmal curcumin and repeat pharmacokinetic studies of two hour and eight hour infusions are being analyzed with a novel validated (patent being applied) method for drug levels.6

~~SignPath~~Because isof ~~collaborating~~the ~~with~~protean ~~Gibralter~~nature ~~Labs,~~of ~~Regis~~curcumin’s ~~Pharmaceuticals,~~interaction ~~Johns~~with ~~Hopkins~~different ~~University~~cell components, ~~Chemic~~ and ~~the~~based ~~NCI~~upon ~~Nanocharacterization~~data ~~Laboratory~~derived ~~for~~from ~~corroborative~~traditional use and non-clinical and pre-clinical laboratory studies, ofwe ~~polymeric~~believe ~~nanocurcumin.~~it ~~GMP~~may ~~production~~have isa ~~being~~therapeutic ~~done~~role atin ~~Regis~~numerous ~~Pharmaceuticals~~non-cancer indications, including neurologic disorders, immunologic disorders and cardiac arrhythmias.

To expand its use for Parkinson’s disease, a research grant was received for approximately $82,000 from the Michael J. Fox Parkinson’s Disease Foundation to measure parenteral liposomal curcumin and the other two formulations passage across the blood brain barrier and focal cerebral distributions in rat brains in collaboration with Dr. S. Chiu at the Department of Pharmacology and Toxicology, University of Western Ontario, Canada. Data, to date, has revealed intravenous curcumin localized in specific brain regions associated with Parkinson’s disease (striatum and substantial nigra pars compacta) and memory processing (hippocampus). In a subsequent study based upon these data an intravenous liposomal curcumin formulation was effective in blocking progression of brain neuronal death in DJ-1 knockout rats (genetically designed to develop early Parkinson’s disease signs and symptoms). Metabolomic analyses of Parkinson’s-related brain domains in these same rats has been completed and showed significant and specific effects related to amelioration of the disease. These observations indicate that curcumin may be effective in patients with Parkinson’s disease and potentially in other neurologic disorders, such as trauma brain injury, and post-traumatic stress disorder. The Company’s three different (liposomal, polymeric and slow release PLGA) intravenous nanoparticle size formulations have demonstrated proof of efficacy of these formulations against human tumor xenografts in mice. During IND pre-clinical toxicity trials in dogs, with liposomal curcumin, a dose-dependent hemolysis was observed. It suggested specific dose/schedules of administrations might be required for trials in humans. Follow up studies included in vitro testing of curcumin with human red blood cells revealed the concentrations of curcumin inducing hemolysis were greater than that necessary to mitigate tumors. A patent for preventing this activity has been issued.

The Company has reached an agreement in principle to enter into a Clinical Trial Research Agreement with Thomas Jefferson University in Philadelphia, Pennsylvania (“TJU”). Upon approval by the TJU board, and the FDA, TJU will study (the “Study”) the safety and/or efficacy of liposomal curcumin for progressive Parkinson’s disease. The Study will be conducted by Dr. Jay Schneider at TJU’s Parkinson’s Disease Research Unit. The Company is providing TJU with a protocol and supporting information necessary for TJU to conduct the Study. All research data and results generated during the Study are the property of the Company. The Company will make available sufficient quantities of curcumin to carry out the Study. The Company shall retain all right, title and interest in any invention, discovery or improvement made during the course of, or as a result of, the Study. The Company has the sole right to obtain patent protection, although any invention that extends beyond the research performed with the protocol shall belong to TJU with the Company negotiating an exclusive, royalty-bearing license to any invention for which a patent application is filed for a period of six (6) months commencing on the date of disclosure.

To broaden the intellectual property profile of parenteral curcumin, additional clinical uses of curcumin have been incorporated into CIP (continuation in progress) applications. Applications have been submitted to the Patent and Trademark Office which contain claims for additional therapeutic uses of curcumin. There is sufficient published data on curcumin and autoimmune diseases, degenerative diseases of the joints and the nervous system, inflammatory based diseases, aging, and diabetes to envision addressing these conditions with parenteral curcumin when final dosage and safety data from trials in disease free and cancer patients becomes available. During pre-clinical studies we observed that the liposomal component could prevent curcumin inhibition of ionic potassium currents in cell preparations. This has significant clinical implications for 175 other arrhythmia-inducing drugs which block the potassium channels.

Clinical Trials

The Company submitted an IMPD to begin human Phase I clinical trials. Regulatory clearance was received in July 2011, and the first subjects were started on August 22, 2011. The clinical trials for liposomal curcumin use curcumin formulations made under GMP conditions by Polymun GmbH. As described below, the Company entered into agreements with manufacturers of curcumin, liposomal curcumin, and polymers to produce sufficient quantities to complete all pre-clinical requirements for an IND. Agreements for additional quantities of both formulations for Phase 2 clinical trials will be initiated depending upon human dosage estimates generated in current clinical studies. The Company plans to pursue Phase 2 liposomal curcumin parenteral trials in cancer and one in neurologic diseased patients.

We have had discussions regarding participation in Phase Ib and II clinical trials during direct meetings with responsible physician investigators with the Central European Society for Anticancer Research (CESAR) and at cancer centers in the United States. All have had extensive experience with drug trials of anticancer drugs and are willing to participate in the proposed clinical studies.

These investigators include:

	New York Medical College, Dr. T. Ahmad has had extensive experience as a Phase I, II, and III clinical trial investigator.

	In Vienna, Austria, Dr. Michael Wolzt is in charge of Phase Ia clinical trials in normal volunteers. Our CEO inspected Dr. Wolzt’s facilities in December 2007. To date subjects have been entered into the clinical Phase Ia study of liposomal curcumin and a dose of 4.5 mg/kg was found to induce less than grade 1 hemolytic toxicity, and to reach blood concentrations that we estimate are within a therapeutic range.

	Phase Ib trials in cancer patients are being carried out by the CESAR group, and these data will be used to bridge studies in the United States.

	Phase Ib trials will be cancer patients who have failed standard of care therapy and elected experimental therapy.
	Provided that the safety results of Phase Ib trials in cancer patients are satisfactory andwith FDA and EMA approvals, the Company anticipates the following Phase II trials:

	Liposomal curcumin: Intravenous administration to lung cancer patients who fail standard therapy.

	Liposomal curcumin: intravenous administration to patients with Parkinson’s disease who have progressed on standard therapy.

Market Analysis

The anticipated markets for therapeutic curcumin include populations with unmet medical needs, or as combinations with established drugs to enhance their activity in the presence of drug resistance. The preclinical studies of curcumin in cancer suggest its potential applications as a parenteral drug for both prophylaxis and therapy.

Given the aging of the population with an annual increment in the number of prospective patients in chronic disease categories, the Company believes a potentially effective and tolerable parenteral curcumin could gain wide acceptance and usage.

As stated earlier, the Company is aware of pre-clinical data from other research suggesting that parenteral curcumin has anti-cancer activity. 15

The new cases of cancer in the United States in 2015 were estimated at approximately 1,660,000 per year, according to the American Cancer Society, Inc. Surveillance Research. This is a large market with substantial room for improvement over current therapies.

Potential Commercialization of Liposomal Curcumin may also prove to be effective as prevention for high-risk individuals and as a therapeutic for established disease when used alone or in combination with other agents. As an initial approach we anticipate treating diseases with unmet needs. These include lung cancer and Parkinson’s disease. While there are current clinical trials with oral preparation of curcumin, we currently know of no competitors with publicly known plans to develop parenteral forms of curcumin. Management believes that the Company is positioned to leverage its rights to its licensed intellectual property of these parenteral products in the United States and worldwide. Because the liposomal formulation and curcumin in turmeric extracts have been demonstrated by other researchers to be effective in animal studies,16 we anticipate that synthesized curcumin could be more effective than the extract from turmeric when administered parenterally.

Assuming we obtain positive results from our clinical trials and ultimately receive FDA approval, the Company believes that these formulations of curcumin may be accepted by physicians for treating cancer and other diseases that fit within the efficacy profiles established by the Company.

Modification of water-insoluble drugs such as curcumin with specific liposomes represent a novel formulation process. There may be specific pharmacological advantages which could confer clinical and/or commercial value. The final cost of drug production will depend upon usage and economies of scale; however, we intend to adopt a strategy, if possible, to result in our products having a cost competitive with current medications for the intended applications.

____________________________

15 See footnote 8 above.

16 See footnote 8 above.

The Company also expects to evaluate conducting potential additional development initiatives based on its licensed curcumin formulation to treat patients with neurologic diseases depending upon the results of the Phase Ib trials, clinical imperatives, and financial resources to carry them out.

Clinical application of parenteral administration of liposomal curcumin or nanosized curcumin may induce varied responses in the same disease or in different disease states. In addition, we anticipate different development and manufacturing costs, and ultimately different commercial remuneration in the different applications. These variations are attributed to demographic differences in applications such as pancreatic cancer and lymphoma.

The Company entered into a Liposomal Formulation Manufacturing Agreement, as amended, with Polymun Scientific Immunbiologische Forschung GmbH (“Polymun”), Vienna, Austria, dated as of September 6, 2007, which has been filed as an exhibit to the Company’s SEC filings. Pursuant to this agreement, Polymun applies their GLP process and experience to encapsulate pure synthetic curcumin provided by the Company with a layer of lipid particles (making a liposome formulation which can be injected intravenously). After testing for size, and stability, Polymun delivered the liposomal curcumin to the MD Anderson Cancer Center for intravenous animal Potential Commercialization of Liposomal Curcumin and Nanocurcumin toxicity testing. During this developmental process they have invented and developed a special assay to simultaneously quantify the content of lipids and curcumin in all batches they prepare. Polymun completed scaled-up GMP manufacture of the lipocurc formulation. The Company’s obligation to Polymun totaled €280,000 (approximately $319,000) through the first two development stages and thereafter a €130,000 (approximately $148,000) per production fee. In August 2012, the Company entered into Amendment No. III with Polymun for the production of additional GDP batches of liposomes and the parties continue to work under the terms of the original agreement. Polymun has produced liposomal curcumin for animal and human use.

Since liposomal curcumin is at an advanced stage of development and has completed EMA and IND requirements, the Company’s interest is to proceed with that product in its Phase Ib-II clinical studies.

Raw Materials; Supplies

Liposomal curcumin was manufactured for the Company by Polymun, Inc., of Vienna, Austria under the agreement described in the prior section. Curcumin was obtained initially from a U.S. chemical supplier, Sigma Aldrich Fine Chemicals (“SAFC”). The Company obtained one batch of 200 grams of GMP manufactured liposomal curcumin under an agreement dated June 30, 2007 with SAFC. The total cost to the Company was $98,350. Sabinsa Inc. subsequently scaled-up manufacture of 98.2% pure curcumin under GMP for human use in Bangalore, India. FDA and EMA (European Medicines Agency) compliance and validations audits relating to the curcumin manufacturing facility in India were performed by Topaz Technology, Inc. of Bryn Mawr, PA under an agreement with the Company dated June 30, 2009, at a total cost of $24,500 which has been paid. Analysis of the 0.1% residue was completed at Chemic Labs, Massachusetts.. The Company’s supply from Sabinsa was made pursuant to purchase orders without a contract. There are very stringent new regulations concerning GMP by the EMA and the FDA.

At UTMDCC, GLP pharmacokinetic and toxicity studies of single and multi-dose intravenous liposomal curcumin in mice and rats were without evidence of toxicity at a maximal injectable volume. Dog pharmacokinetics and single ascending dose toxicity studies identified reversible hemolysis at a maximum tolerated dose (MTD) and irreversible hemolysis at a significantly higher dose limiting level. In vitro studies with dog and human RBCs corroborated these observations using annexin V biomarker (a biochemical feature used to measure the progress of diseases or the effects of treatment), and a second independent set of studies at Xenometrics, USA indicated hemolytic sensitivity only at multiples of concentrations above those necessary for therapeutic effect. Multidose toxicological canine studies were completed at Nucro Technics, Canada based upon these studies, and were devoid of tissue toxicity. Body tissue distribution of liposomal curcumin and repeat pharmacokinetic studies of two hour and eight hour infusions were analyzed with a novel validated (patent applied) method for drug levels.

Intellectual Property

The Company has rights to ~~two~~three issued patents: the first is entitled “Liposomal Curcumin for Treatment of Cancer” (June 28, 2011), and the second is entitled: “Water Dispersible oral parenteral and Topical Nanocurcumin” (November 20, 2012). We ~~also~~The ~~have~~third ais ~~pending~~liposomal ~~patent~~prevention ~~application~~of ~~for~~cardiac ~~depocurcTM. The~~potassium Uchannel blockage.S. ~~Patent~~It ~~Office~~also has ~~returned~~a ~~office~~pending ~~action~~patent onapplication ~~the~~for ~~depocurcTM~~Curcumin-ER ~~application~~TM . ~~Five~~Additional ~~additional~~ provisional patent applications have been submitted; including ~~use of calcium channel blockers for hemolysis~~, ~~neuropathic~~neurologic disease applications, composition of matter of synthetic curcumin, ~~prevention of diabetic drug complications,~~ and ~~liposomal~~cytokine ~~prevention of cardiac potassium channel blockage~~storm.

AsInternet ~~discussed~~domains ~~above,~~have ~~SignPath~~been ~~has~~established ~~licensed~~for ~~three~~Signpathpharma.com; ~~proprietary~~lipocurc.com; ~~intravenous~~nanocurc.com ~~formulations~~and ~~containing curcumin as the active therapeutic agent~~nanocurcumin.com. The ~~first~~trademark isLipocurc a(February ~~liposomal~~16, ~~version~~2011) ~~licensed from University of Texas MD Anderson Cancer Center; the second is a nanosized version licensed from the Johns Hopkins University;~~ and ~~the third is an extended release Liposomal-PLGA formulation (~~curcumin-ER) ~~licensed~~has ~~from~~been ~~the University of North Texas Health Science Center~~registered.

~~Internet~~Agreement ~~domains have been established for SignPathpharma.com; depocurc.com, lipocurc.com; nanocurc.com and nanocurcumin.com. The trademark “Nanocurc” (Sept. 15, 2009) has been registered~~ with aUniversity ~~six-month~~of ~~extension~~Texas toMD ~~use~~Anderson inCancer ~~commerce. The trademark Lipocurc (February 16, 2011) has been registered.~~Center

The above described patent for liposomal curcumin was issued on June 28, 2011. It was submitted in 2005 by the University of Texas MD Anderson Cancer Center (the “UTMDACC”) with the title “Liposomal Curcumin for Treatment of Cancer.” On February 21, 2007, SignPath, the UTMDACC and the Board of Regents of the University of Texas System (the “Board”) entered into an exclusive license for this pending patent (the “UTMDACC License Agreement”). Pursuant to the UTMDACC License Agreement, SignPath has a royalty-bearing exclusive, worldwide license to manufacture, use, import and sell for human and animal use inventions and discoveries covered by the issued patent and associated technologies. SignPath may sublicense its rights under the UTMDACC License Agreement.

SignPath has agreed to pay all of UTMDACC’s reasonable out-of-pocket expenses of filing, prosecuting, enforcing and maintaining its patent rights. In addition, SignPath is obligated to pay a $15,000 license documentation fee and an annual maintenance fee of $10,000 for the first seven years of the UTMDACC License Agreement. If a patent is issued during the first seven years of the license, this annual fee will increase to $15,000. After the seventh anniversary of the UTMDACC License Agreement, the annual fee will increase to $30,000 a year.

In addition, SignPath is obligated to pay running royalties of 2.5% on net sales of less than $250 million for products covered by an issued patent licensed under the UTMDACC License Agreement. This royalty rate increases to 3% for sales equal to, or greater than, $250 million. A royalty of 1.5% of net sales is payable by SignPath for products covered under the license which are not protected by an issued patent. After sales to the public begin, SignPath must pay a minimum annual royalty $75,000 which can be deducted from the royalties on net sales due under the agreement. In addition, SignPath is obligated to pay 20% to 25% of all non-royalty consideration received under sublicensing agreements.

The Company will also be responsible for the following milestone payments upon the occurrence of specified events. These consist of: (1) $10,000 upon dosing the first patent with a licensed product in a Phase I Study; (2) $25,000 upon dosing the first patient within a licensed product in a Phase II study; (3) $50,000 upon dosing the first patient with a licensed product in a Phase III Study, or $40,000 if no patent has issued when this milestone is achieved; (4) $400,000 upon the first regulatory approval of a licensed product, or $200,000 if no patent has issued and (5) $15,000 upon issuance of a patent. The Company expects to fund the milestone payments when they come due from the private placement of equity securities to the extent funds are available. Further the Company has agreed to provide a minimum of $250,000 in funding for the completion of pre-clinical studies subject to completion of final reports.

The UTMDACC License Agreement survives for the period that patent rights covering the licensed intellectual property are in place, or if no patent rights are issued, 15 years with an automatic extension of 15 years upon regulatory approval of a licensed product. UTMDACC and/or the Board has the right to terminate the agreement in any jurisdiction if SignPath fails to cure within 90 days of receipt of written notice its failure to commercialize and actively attempt to commercialize sales in such jurisdiction. The UTMDACC License Agreement is terminable by UTMDACC upon 30 days’ written notice if SignPath fails to cure a breach of payment and/or fails to fund completion of pre-clinical studies or file an IND or upon 90 days’ written notice for any other breach of contract.

Agreement with Johns Hopkins University

In October, 2007, SignPath and Johns Hopkins University (“JHU”) entered into an exclusive license agreement under a provisional patent application (Serial No. 60,866/516) entitled “Biocompatible ‘Smart’ Nanogels as carriers for Hydrophobic drugs”. This application was submitted on November 20, 2006 by JHU for a nano-sized curcumin formulation called nano curcumin. Pursuant to the JHU License Agreement, SignPath has an exclusive worldwide license to manufacture, use, import and sell inventions and discoveries covered by the pending patent and associated technologies. SignPath may sublicense its rights under the JHU License Agreement, subject to terms and conditions set forth in the Agreement. The JHU License Agreement shall continue until its expiration of the last to expire patent in each country, or if no patents issue, then for 20 years from the commencement of the agreement. The agreement is terminable for a breach which is not cured within 30 days after receipt of notice or by SignPath upon 90 days’ prior written notice. Title to all inventions and discoveries made by each party resulting from their research shall belong to each respective party with joint ownership of inventions and discoveries which are made jointly.

Under the terms of the JHU License Agreement, SignPath has agreed to exercise its best efforts file an IND with the FDA and to exercise reasonable efforts to develop and introduce the licensed products and services into the commercial market. In addition, the Company entered into a sponsored research agreement (the “SRA”) with Dr. Anirban Maitra then with JHU pursuant to which SignPath provided $100,000 of funding for the continuation of non-clinical and pre-clinical studies of the nanocurcumin compound and paid JHU indirect costs of $64,000. The term of the SRA was one year ending on September 18, 2008 which was not extended. All inventions which would be filed as a continuation patent under JHU’s patent application shall be subject to the JHU License Agreement.

SignPath was obligated under the JHU License Agreement to pay $50,000 in license fees which have been paid, plus minimum annual royalties increasing from $10,000 in the first two years to $25,000 in the third and fourth years and $30,000 in the fifth year. An aggregate of approximately $160,000 has been paid under this license agreement. The JHU License Agreement also provides that we will be obligated to pay JHU running royalty rates of two percent (2%) of net sales less than $250 million for licensed products covered by one or more claims in an issued patent, and three percent (3%) of net sales equal to or greater than $250 million for licensed products covered by one or more claims in an issued patent, or one and one half percent (1.5%) of net sales of licensed products not covered by an issued patent. The running royalties payable under the agreement are subject to a minimum annual rate. SignPath is also subject to other substantial payments, including all reasonable costs of patent reimbursement. The Company is obligated to make the following payments upon development milestones to JHU regardless of whether the milestone is achieved by the Company, a sublicensee or an affiliate: (1) $25,000 upon dosing the first patient with a licensed product in a Phase I clinical trial at a site other than JHU; (2) $50,000 upon dosing the first patient with a licensed patent in a Phase II clinical trial at a site other than JHU; (3) $25,000 upon dosing the first patient with the licensed patent in a Phase III clinical trial at a site other than JHU; (4) $250,000 upon first regulatory approval of the licensed patent, or $100,000 if no patent has issued; (5) $10,000 upon issuance of a patent sublicense fees (if applicable), and reimbursement of costs reasonably incurred by JHU in connection with the patent.

SignPath and JHU entered into an Exclusive License Agreement effective June 5, 2013 (the “2013 Agreement”) as a result of an invention developed during the course of research created under the above-described JHU License Agreement. JHU granted the Company an exclusive worldwide license to use “a composite polymeric nanoparticle for overcoming multidrug resistance to cancer chemotherapeutics and treatment-related systemic toxicity.” The license fee was $10,000 upon signing; $15,000 within one year; with minimum annual royalties starting in year three at $10,000; $20,000 in year four and $30,000 in year five and onward. SignPath will also pay an earned royalty of 3% on sales to be reduced by the minimum annual royalty. Royalties will be paid for a minimum of ten years from first commercial sale of the licensed product. Milestone payments will be paid by the Company based upon dosing of first patents in Phases I, II, and III clinical trials and then upon regulatory approval, increasing from $25,000 to $150,000. The 2013 Agreement will continue with the last to expire patent in each country, or if no patents are issued then 20 years from June 5, 2013, subject to earlier termination.

Agreements with the University of North Texas

On August 18, 2008, the Company entered into a Patent and Technology License Agreement with the University of North Texas (“UNT”) Health Science Center (the “UNT Agreement”). UNT granted the Company a royalty-bearing exclusive license to manufacture and sell products developed at UNT from depot curcumin. In consideration of the license, the Company agreed to pay an upfront license fee of $15,000, reasonable out-of-pocket expenses for patent rights; an annual maintenance fee of $10,000 commencing on the first anniversary date of when the UNT Agreement was signed until the first to occur of (i) the seventh anniversary date of the contract signing; (ii) the first sale of a product to a non-affiliated third party; or (iii) the issuance of a patent which has been issued on June 28, 2011. This Agreement was terminated effective September 24, 2012.

In November 2013, the Company entered into a Patent and Technology License Agreement (the “2013 Agreement”) with UNT on substantially the same terms as the earlier agreement for the hybrid nanoparticle liposome-PLGA and curcumin. Under the 2013 Agreement, UNT granted the Company an exclusive license to manufacture and use the patent rights to the discoveries and inventions in Liposomal sustained release compounds created by the Company and UNT, as well as a non-exclusive license to any technology derived from the patents before this Agreement anywhere in the world for human and animal use, for the term of the patents, or 15 years, whichever is longer. In exchange for the license, the Company will need to actively commercialize the patents throughout the world. SignPath agreed to pay UNT a running royalty equal to 2.5% of net sales less than $250 million for licensed products covered by an issued patent; 3% of net sales equal to or greater than $250 million for licensed products covered by an issued patent, and 1.5% of net sales of licensed products not covered by an issued patent, subject to a reduction for amounts paid by SignPath to a third party to avoid infringing such third party’s patent rights; plus 20% of all non-royalty consideration received by the Company from any sublicensee.

While the Company and UNT are equal owners of patent rights, SignPath is responsible for preparing, filing, prosecuting, defending and maintaining patent rights made in the name of both parties. The term of the agreement if for the full end of term(s) for which patent rights have not expired or for a term of 15 years, whichever is longer. UNT has the right to terminate the license upon 90 days’ written notice if SignPath has not provided written evidence it is making diligent efforts to actively commercialize licensed products in specified political jurisdictions.

In August 2013, SignPath entered into a one-year Sponsored Research Agreement with UNT, which was extended util October 2014, to study non-small cell lung cancer using curcumin ER. The program is under the direction of Dr. Jamboor Vishwanatha. SignPath agreed to pay UNT a sum of $116,000 which was paid in full by July 24, 2014. All inventions and discoveries resulting from the study shall remain with UNT.

Employees

The Company currently has one employee, Dr. Lawrence Helson, its Chief Executive Officer. The Company expects to continue to use subcontractors and independent consultants and will hire a business development director when funds are available.

811

Publications/Presentations: SignPath Pharma Curcumin Formulations

The Company has the following publications and details are available on the Company’s website, see www.signpathpharma.com.

1.	Lan Li, Fadi S, Braiteh FS et al. : Liposome encapsulated curcumin, in vitro and in vivo effects on proliferation, apoptosis, signaling and angiogenesis. Cancer 2005 104:1322-1331

2.	Lan Li, Bilal Ahmed, Kapil Mehta et al.: Liposomal curcumin with and without oxaloplatin: effects on cell growth, apoptosis and angiogenesis in colorectal cancer. Molecular Cancer Therapeutics. 2007 6:1276-1282

3.	Savita Bisht, Georg Feldman, Scheetal Soni et al.: Polymeric nanoparticle encapsulated curcumin )nanocurcumin: a novel strategy for human cancer therapy. J Nanobiotechnology 2007 5:3

4.	Claire M. Mach, Lata Matthew, Scott A. Mosley, Lawrence Helson et al.: Determination of minimum effective dosing schedule for liposomal curcumin in a mouse model of pancreatic cancer. Am Coll Clin Pharm. Annual meeting. 2008 Louisville KY. Presentation.

5.	Clair M. Mach, Lata Mathew, Scott A Mosley, et al.: Determination of minimum effective dose and optimal dosing schedule for liposomal curcumin in a xenograft human pancreatic cancer model. Journal of Anticancer Research. 2009 29: 1895-1900

6.	Clair M. Mach, J.H.Chen, Sa Mosley et al.. Evaluation of Curcumin Cytochrome p450 metabolism . Hematology Oncology Pharmacy Association(HOPA) June 17-20 ,2009. Abstract. Manuscript submitted J. Anticancer Research. 2010 in press.

7.	Vishwanatha JK.: Biodegradable Nanoparticles for Cancer Therapy. 2nd Annual Unither Nanomedical and Telemedical Conference. Oreford, Quebec, Canada Abstract presentation Feb 24-27 2009

8.	Mukerjee A. and JK Vishwanatha: Formulation, Characterization and evaluation of Curcumin loaded PLGA nanospheres for cancer therapy. Journal of Anticancer Research 2009 29:3867-3876

9.	Judith A. Smith, Lata Mathew, MS Claire, K Santiago, L. Helson: Development of Liposomal curcumin as a new potential anticancer agent. MD Anderson Cancer Center and Signpath Pharma. AACR–EORTC-NCI 2009. Abstract and presentation Nov 18

10.	Mukerjee A . Ranjan AP, Helson L et al: Formulation, Characterization and Evaluation of Annexin A2-conjugated curcumin loaded nanospheres as a targeted drug carrier system for breast cancer therapy. Proc.10 th US-Japan Symposium on Drug Delivery Systems. 2009 Maui, Hawaii. Ab no. 1468

11.	Ranjan AP, Mukerjee A, JK Vishwanatha. Optimization of curcumin loaded PLGA nanoparticle-formulation using central composite design for cancer therapy. Proc. 10th US-Japan Symposium on Drug Delivery Systems. 2009 Maui, Hawaii. Ab no 1526

12.	Mukerjee A, Luchowski R, Ranjan et al.: . Enhanced Fluorescence of curcumin on plasmonic platforms. Current Pharmaceutical Biotechnology. 2010 11:223-228.

13.	Lim KJ, Maitra A, Bisht S et al.: Using Nanocurcumin to treat Medulloblastoma and Glioblastoma, AACR Annual meeting Ab no.4440, 2010

14.	Claire M Mach, Jing Hong Chen, Scott A Mosley: Evaluation of Liposomal Curcumin Cytochrome P450 Metabolism. Anticancer Research 2010 30:811-814

15.	Mukerjee A, Sorenson T Thomas J et al.: Spectroscopic properties of curcumin, orientation of transition moments, J Physical Chemistry 2010 114:12679-12684

16.	Bisht S,Mizuma M,Feldman G. et al.: Systemic Administration of Polymeric nanoparticle –encapsulated Curcumin(Nanocurc®) blocks tumor growth and metastases in preclinical models of Pancreatic Cancer. Mol Canc Ther. 2010 9: 2255-2264

17.	Thamake S I, Iraut Sf, Ranjan AP,Gryczynski Z,and J K Vishwanatha.: Surface Functionalization of PLGA nanoparticles by non-covalent insertion of homo-bifunctional spacer for active targeting in cancer therapy. Nanotechnology 2011, 22(3):03510 (10pp)

18.	Ranjan AP, Mukerjee A, Vishwanatha JA: Optimization and in vitro characterization of CUR loaded PLGA nanoparticles for cancer therapy. 2010 Submitted.

19.	Helson L. Chiu S: Curcumin Formulations Brain Distribution. Presentation to MJFF for Parkinson’s disease NYC Sept 21, 2010.

20.	Chiu SS, Lui E, Majeed M, Vishwanatha JK, Ranjan A, Maitra A, Dipanker P, Smith JA ,Helson L: Differential distribution of intravenous curcumin formulations in the rat brain. J Anticancer Research, 2011, 31(3):907-911.

21.	Balmiki R, Bisht S, Maitra A et al. Neuroprotective and Neurorescue effects of a Novel Polymeric Nanoparticle Formulation of curcumin (NanoCurc®) in the Neuronal cell culture and Animal Model: Implications for Alzheimer’s disease. J Alzheimer’s Dis. 2011 23:61-77.

22.	Tuttle S, Hertan L, Katz JS: Indian gold treating cancer in the age of nano. Cancer Biology and Therapy, 2011, 11(5): 474-476 (a review of #22)

23.	Lim KJ, Bisht S, Bar EE, Maitra A, Eberhart CG: A polymeric nanoparticle formulation of curcumin inhibits growth, clono-genicity, and stem-like fraction in malignant brain tumors. Cancer Biology and Therapy 2011, 11(5): 1-10

24.	Savita Bisht, Mehtab A Khan, Mena Bekhit, Haibo Bai, Toby Cornish, Masamichi Mizuma, Michelle A Rudek, Ming Zhao, Amarnath Maitra, Balmiki Ray, Debomoy Lahiri, Anirban Maitra, and Robert A Anders. A polymeric nanoparticle formulation of curcumin (NanoCurc™) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation. Laboratory Investigation (2011), 1–13

25.	Lawrence Helson, George Shopp, Annie Bouchard, and Muhammad Majeed Liposome mitigation of curcumin inhibition of cardiac potassium delayed-rectifier current. Journal of Receptor, Ligand And Channel Research, 2012.5:1-8.

26.	Lawrence Helson, Gordon Bolger, Muhammad Majeed, Brigitta Vcelar, Kresimir Pucaj, and Dharmendr Matabudul Infusion Pharmacokinetics of Lipocurc™ (Liposomal Curcumin) and its Metabolite Tetrahydrocurcumin in Beagle Dogs. Anticancer Res, 2012,32 no. 10 4365-4370

27.	Amalendu P Ranjan, Anindita Mukerjee, Lawrence Helson and Jamboor K Vishwanatha Scale up, optimization and stability analysis of curcumin C3 complex-loaded nanoparticles for cancer therapy. Journal of Nanobiotechnology, 2012,10  doi:10.1186/1477-3155-10-38

28.	Dharmendr Matabudul, Kresimir Pucaj, Gordon Bolger, Brigitta Vcelar, Muhammed Majeed and Lawrence Helson: Tissue Distribution of (LipocurcTM) Liposomal Curcumin and Tetrahydrocurcumin Following Two- and Eight-hour Infusions in Beagle Dogs. Anticancer Res, 2012 32(10)4365-437010

29.	Simon Chiu, Kristen J. Terpstra ,Yves Bureau,Jirui Hou, Hana Raheb, Zack Cernvosky, Vladimir Badmeav7, John Copen; Mariwan Husni, Michael Woodbury: Liposomal-formulated curcumin [LipocurcTM ] targeting HDAC (Histone Deacetylase ), prevents apoptosis and improves motor deficits in Park 7 (DJ-1)- Knockout rat model of Parkinson’s disease: implications for Epigenetics-based Nanotechnology-driven Drug Platform.

30.	Zou P, Helson L, Maitra A, Stern St, McNeil SE Polymeric curcumin nanoparticle pharmacokinetics and metabolism in bile duct cannulated rats. Molecular Pharmaceutics 2013, 10(5),1977-1987

31.	Storka, Vcelar B, Helson L, “Safety and Pharamacokinetics of Liposomal Curcumin in Healthy Subjects: A Randomized PlaceboControlled Double Blind First-in-human Study Poster” AACR 2014

32.	Rajan AP, Mukerjee A, Helson L, Gupta R, Vishwanatha JK Efficacy of liposomal curcumin in a human pancreatic tumor xenograft model: inhibition of tumor growth and angiogenesis. Anticancer Res, 2013 Sep; 33(9):3603-3609.

33.	Chun YS, Bisht S, Chenna V, Pramanik D, Yoshida T, Hong SM, de Wilde RF, Zhang Z, Huso D, Zhao M, Rudek M, Stearns V, Maitra A, Sukumar S. Intraductal Administration of a Polymeric Nanoparticle Formulation of Curcumin (NanoCurc) Significantly Attenuates Incidence of Mammary Tumors in a Rodent Chemical Carcinogenesis Model Implications for breast cancer chemoprevention in at-risk populations. Carcinogenesis . 2012 Jul 25.

34.	Pramanik D, Campbell NR, Das S, Gupta S, Chenna V, Bisht S, Sysa-Shah P, Bedja D, Karikari C, Steenbergen C, Gabrielson KL, Maitra A, Maitra A. A composite polymer nanoparticle overcomes multidrug resistance and ameliorates doxorubicin-associated cardiomyopathy. Oncotarget . 2012 Jun;3(6):640-50.
35.	Bisht S, Maitra A. Systemic delivery of curcumin: 21st century solutions for an ancient conundrum. Curr Drug Discov Technol. 2009; 6:192-199.

36.	Anirban Maitra, Lawrence Helson Characterization of Nanocurcumin US Nanocharacterization Laboratory 2013 201304A.

37.	Storka A, Vcelar B, Klickovic U, Gouya G, Weisshaar S, Aschauer S, Helson L, Wolzt M. Effect of liposomal curcumin on red blood cells in vitro. Anticancer Res. 2013 Sep;33(9):3629-34.

38.	Amalendu P. Ranjan, Anindita Mukerjee, Jamboor K. Vishwanatha. University Of North Texas Health Science Center, Fort Worth, TX. targeted multifunctional lipid-plga hybrid nanosystems for metastatic breast cancer imaging and therapy. Submitted March 2015. For publication.

39.	Annie Bouchard, Marie-Claude Benoit,, Sabrina Baillargeon, Laurence Helson, George Shopp, any Salvail Increased risk of Torsades de Pointes in streptozotocin-induced diabetic rats. SBS November 2014 presentation and abstract.

40.	Yang Xu, Bo Hu, Robert Anders, Anirban Maitra, Jia Fan; Use of nanocurcumin to inhibit proliferation and metastases of hepatocellular carcinoma via NF-κB mediated matrix metalloproteinase-9 ownregulation. J Clin Oncol 31, 2013 (suppl; abstr e22103)

41.	Angela Storka, Brigitta Vcelar, Uros Klickovic, Ghazaleh Gouya, Stefan Weisshaar, Stefan Aschauer, Gordon Bolger, Lawrence Helson, and Michael Wolzt  Safety, tolerability and pharmacokinetics of liposomal curcumin (LipocurcTM) in healthy humans International Journal of Clinical Pharmacology and Therapeutics, Vol.2014 (1-12)

42.	Sordillo, P. Helson L.Curcumin Suppression of Cytokine Release and Cytokine Storm. A Potential Therapy for Patients with Ebola and Other Severe Viral Infections. In Vivo 2015, 29:1-4

43.	Aimin Tan; Yanxin Wu; Molly Wong; Albert Licollari; Gordon Bolger; John C. Fanaras; George Shopp; Lawrence Helson.Use of an Unconventional Approach to Boost Sensitivity and Improve Chromatography for Quantifying Curcumin and Tetrahydrocurcumin by LC-MS/MS 2015 Submitted for publication

ITEM 1 A. RISK FACTORS

An investment in the Company is speculative, involves a high degree of risk and should only be purchased by persons who can afford to lose their entire investment. Prospective investors should carefully consider, among other things, the following risk factors relating to the business of the Company.

Risks Related to Our Company

History of significant losses and risk of losing entire investment.

The Company’s financial statements reflect that it has incurred significant losses since inception, including net losses of $1,956,872 , and $12,~~310~~748,~~934~~190 for the years ended December 31, 2013 ~~and~~ ~~2012, respectively,~~ and ~~a loss from inception through December 31~~2014, ~~2013, of $10,668,408~~respectively. The Company expects to continue to have losses and negative cash flows for the foreseeable future, and it is possible that the Company may never reach profitability. Therefore, there is a significant risk that public investors may lose some or all of their investment.

Our financial statements have been prepared assuming that the Company will continue as a going concern.

Our audited financial statements for the fiscal year ended December 31, ~~2013~~2014 have been prepared assuming the Company will continue as a going concern. As discussed in Note 2 to the financial statements for the period ended December 31, ~~2013~~2014, the continuation of the Company as a going concern is dependent upon the continued financial support from its shareholders, the ability to raise equity or debt financing, and the attainment of profitable operations from the Company’s planned business. Our independent registered public accounting firm has included an explanatory paragraph expressing substantial doubt about our ability to continue as a going concern in their audit report for the fiscal year ended December 31, ~~2013~~2014. If we are unable to raise additional capital or borrow money we will not be able to complete and file INDs with the FDA in order to commence clinical trials. If that were to occur the Company would be forced to suspend or terminate operations and, in all likelihood cause investors to lose their entire investment. During Fiscal 2013, we ~~were~~raised ~~able to raise~~ $3,380,000 of gross proceeds, ~~from~~during ~~the~~Fiscal ~~sale~~2014, an additional $1,940,000 of ~~convertible~~gross ~~preferred~~proceeds ~~stock~~and $945,250 in 2015, all, excluding offering costs, which ~~will~~has ~~allow~~allowed us to continue operations.

We are a development stage company, making it difficult for you to evaluate our business and your investment.

We are in the development stage and our operations and the development of our proposed products are subject to all of the risks inherent in the establishment of a new business enterprise, including:

● the absence of an operating history; ● the lack of commercialized products; ● reliance on third parties for the development and commercialization of some of our proposed products; ● uncertain market acceptance of our proposed products; and ● reliance on our founder Dr. Lawrence Helson.

●

the lack of commercialized products;

●

reliance on third parties for the development and commercialization of some of our proposed products;

●

uncertain market acceptance of our proposed products; and

●

reliance on our founder Dr. Lawrence Helson.

Because we are subject to these risks, you may have a difficult time evaluating our business and your purchase of our securities.

No revenue for the foreseeable future, with substantial losses and no guarantee of profitability.

At this stage of its growth cycle, the Company has a limited operating history and no revenues, products ready for market (with the exception of an advertisement to sell liposomal curcumin for restricted animal research), customers or marketing resources.

As a development stage company, the Company has a limited relevant operating history upon which an evaluation of its prospects can be made. Such prospects must be considered in light of the risks, expenses and difficulties frequently encountered in establishing a new business in the evolving and heavily-regulated pharmaceuticals industry, which is characterized by an ever-increasing number of market entrants, intense competition and high failure rate. In addition, significant challenges are often encountered in shifting from developmental to commercial activities.

In addition, we are subject to many business risks, including but not limited to, unforeseen capital requirements, failure of market acceptance, failure to establish business relationships, and competitive disadvantages against larger and more established companies. In addition, there can be no assurance that the Company will ever be able to generate revenues or, if the Company generates revenues, that it will ever be profitable, or that the Company will be able to obtain sufficient additional funds to continue its planned activities. Therefore, prospective investors may lose all or a portion of their investment. The Company does not anticipate that it will have any revenues for the foreseeable future.

Concentration of ownership by a Founder and its affiliates raises a potential conflict of interest between the Company, a Founder and certain of their employees.

Bruce Meyers, a Founder of the Company and ~~President~~CEO of Meyers Associates, the ~~owns~~Company’s 2Placement Agent,~~657,500~~ ~~shares~~is ~~(20.6%)~~the ~~and~~General Partner of Meyers ~~Associates~~Investments Family Limited Partnership, which owns 25,~~305~~465,~~000~~283 shares ~~(17.9%)~~ of the 1225,~~877~~153,~~500~~930 outstanding shares (or an aggregate of 21.7% of the Company’s ~~common~~voting ~~stock~~securities. This concentration of ownership may not be in the best interests of the Company’s other stockholders and Meyers Associates ~~and~~ may be subject to potential conflicts of interest. As the Company’s largest shareholder, these conflicts of interest include Mr. Meyers being in a position to elect the Company’s Board of Director which may (i) vote to take the Company in a direction different from that of Management; (ii) approve extraordinary corporate transactions including the merger or consolidation of the Company or the sale of the Company’s assets to an entity including one related to Mr. Meyers; (iii) approve transactions with a short term return to Mr. Meyers, as opposed to waiting for transactions in the long-term best interests of the Company’ and (iv) approve transactions with a relation to Mr. Meyers, as opposed to negotiating with non-affiliated third parties. As a result of Meyers Associates’ ownership of the Company, it is likely that in the event the Company becomes a publicly-traded company, ~~Meyers~~the ~~Associates’~~Placement Agent would not be able to serve as a market maker in the Company’s common stock. ~~See~~To ~~Item~~date, 12Meyers Associates, “L.P. ~~Security~~has ~~Ownership~~not ofmade ~~Certain~~a ~~Beneficial~~market ~~Owners~~for ~~and~~the ~~Management~~Company’s ~~and~~securities ~~Related~~in ~~Stockholder~~the ~~Matters~~marketplace, nor has it submitted quotations on an interdealer quotation system for the Company’s common stock in the past or is currently doing so. See “Principal Stockholders”.

The Company does not have the financial resources necessary to successfully complete development and market any formulations of curcumin.

As of December 31, ~~2013~~2014, the Company had $1716,~~241,397cash~~193 cash on hand. ~~Since January 1, 2014, the Company has received gross proceeds of an additional $375,500 from the sale of convertible preferred stock.~~ These funds are expected to be sufficient to conduct clinical trials in Europe, ~~and~~ to file ana second IND toand commence clinical trials in the U.S. However, in order to complete product development and marketing, the Company will need to attract sufficient additional capital. IfEven if the Company does find such financing, it may be on terms that are unfavorable or dilutive, to owners of the Company’s equity securities.

Our drug development program will require substantial additional capital to successfully complete it, arising from costs to:

● complete research, preclinical testing and human studies; ● establish pilot scale and commercial scale manufacturing processes; and ● establish and develop quality control, regulatory, marketing, sales and administrative capabilities to support these programs.

●

establish pilot scale and commercial scale manufacturing processes; and

●

establish and develop quality control, regulatory, marketing, sales and administrative capabilities to support these programs.

Our future operating and capital needs will depend on many factors, including:

● the pace of scientific progress in our research and development programs and the magnitude of these programs; ● the scope and results of preclinical testing and human studies; ● the time and costs involved in obtaining regulatory approvals; ● the time and costs involved in preparing, filing, prosecuting, maintaining and enforcing patent claims; ● competing technological and market developments; ● our ability to establish additional collaborations; ● changes in our existing collaborations; ● the cost of manufacturing scale-up; and ● the effectiveness of our commercialization activities.

10● the scope and results of preclinical testing and human studies;

●

the time and costs involved in obtaining regulatory approvals;

●

the time and costs involved in preparing, filing, prosecuting, maintaining and enforcing patent claims;

●

competing technological and market developments;

●

our ability to establish additional collaborations;

●

changes in our existing collaborations;

●

the cost of manufacturing scale-up; and

●

the effectiveness of our commercialization activities.

We base our outlook regarding the need for funds on many uncertain variables. Such uncertainties include regulatory approvals, the timing of events outside our direct control such as negotiations with potential strategic partners and other factors. Any of these uncertain events can significantly change our cash requirements as they determine such one-time events as the receipt of major milestones and other payments.

We cannot be certain that additional funding will be available on acceptable terms, or at all. To the extent that we raise additional funds by issuing equity securities, our stockholders may experience significant dilution. Any debt financing, if available, may involve restrictive covenants that impact our ability to conduct our business. If we are unable to raise additional capital, when required, or on acceptable terms, we may have to significantly delay, scale back or discontinue the development and/or the commercialization of one or more of our product candidates. Accordingly, any failure to raise adequate capital in a timely manner would have a material adverse effect on our business, operating results, financial condition and future growth prospects.

Additional funds are required to support our operations but we may be unable to obtain them on favorable terms, we would be required to cease or reduce further development or commercialization of our potential products.

We will need to increase the size of our organization, and we may experience difficulties in managing growth.

We are a small company with one full-time employee, our CEO, as of the date of this report. To conduct our clinical trials and commercialize our product candidates, we will need to expand our employee base for managerial, operational, financial and other resources. Future growth will impose significant added responsibilities on members of management, including the need to identify, recruit, maintain and integrate additional employees. Our future financial performance and our ability to commercialize our product candidates and to compete effectively will depend, in part, on our ability to manage any future growth effectively.

The Company’s success is highly dependent on attracting and retaining key scientific and management personnel, but the Company may be unable to do so.

The Company’s future depends on the service of its scientific and management teams and other key personnel. The Company may be unable to attract highly qualified personnel, especially if it is unable to demonstrate to those individuals that it has sufficient funding to adequately compensate them either through current cash salary or with equity that could eventually have substantial value. If the Company is unable to attract highly qualified individuals, the Company may be unable to continue development or commercialization efforts of its proposed products which would have a material adverse effect on the Company’s operations.

Risks Related to Our Business

We have no experience in manufacturing, sales, marketing or distribution capabilities.

The Company has no experience in manufacturing, selling, marketing or distributing any formulations of curcumin or any other product. The Company has outsourced production of raw materials for production of liposomal curcumin and will outsource production of good manufacturing practice (“GMP”) grade of liposomal curcumin and nanocurcumin to commercial facilities. There can be no assurance that the Company will be able successfully to sell, market, commercialize or distribute any formulation of curcumin or any other products at any time in the future.

11If we lose the services of our Chief Executive Officer, our operations would be disrupted and our business could be harmed.

IfOur webusiness ~~lose~~plan relies significantly on the continued services of our ~~Chief~~CEO, ~~Executive~~Dr. ~~Officer~~Lawrence Helson, age 83. If we were to lose his services, our ~~operations~~ability ~~would~~to becontinue ~~disrupted~~to ~~and~~execute our business ~~could~~plan would be ~~harmed~~materially impaired. While we have entered into an employment agreement with Dr. Helson, the agreement would not prevent him from terminating his employment with us. Dr. Helson has not indicated he intends to leave the Company, and we are not currently aware of any facts or circumstances that suggest he might leave us. In the event that Dr. Helson is unable to fulfill his duties for any reason, the Company has adopted a contingency plan setting forth a recommended plan for the governance and operations of the Company. See Item 10. “Directors, Executive Officers and Corporate Governance.”

Our business plan relies significantly on the continued services of our CEO, Dr. Lawrence Helson, age 83. If we were to lose his services, our ability to continue to execute our business plan would be materially impaired. While we have entered into an employment agreement with Dr. Helson, the agreement would not prevent him from terminating his employment with us. Dr. Helson has not indicated he intends to leave the Company, and we are not currently aware of any facts or circumstances that suggest he might leave us.

We are devoting our efforts to a limited number of product candidates, and there is no assurance of product success.

The Company is an early stage biopharmaceutical company and, since its inception, has focused mainly on research and development. There can be no assurance that the Company will ever successfully develop liposomal curcumin, nanocurcucmin, slow release PLGA formulation, or any other formulation of curcumin or any product whatsoever, or obtain FDA approval.

Two of our three curcumin formulations will require extensive additional development, including preclinical testing and human studies, as well as regulatory approvals, before we can commercialize and market them. We cannot predict if or when any of the product candidates we are developing will be approved for marketing. There are many reasons that we may fail in our efforts to develop our potential products, including the possibility that:

● human studies may show that our potential products are ineffective or cause harmful side effects; ● the products may fail to receive necessary regulatory approvals from the FDA in a timely manner, or at all; ● the products, if approved, may not be produced in commercial quantities or at reasonable costs; ● the potential products, once approved, may not achieve commercial acceptance; ● regulatory or governmental authorities may apply restrictions to our potential products, which could adversely affect their commercial success; or ● the proprietary rights of other parties may prevent us from marketing our potential products (negligible because there is no other commercial arenteral curcumin developer, and we have approved patent protection).17

●

human studies may show that our potential products are ineffective or cause harmful side effects;

●

the products may fail to receive necessary regulatory approvals from the FDA in a timely manner, or at all;

●

the products, if approved, may not be produced in commercial quantities or at reasonable costs;

●

the potential products, once approved, may not achieve commercial acceptance;

●

regulatory or governmental authorities may apply restrictions to our potential products, which could adversely affect their commercial success; or

●

the proprietary rights of other parties may prevent us from marketing our potential products (negligible because there is no other commercial parenteral curcumin developer, and we have approved patent protection).

Given our limited focus on three product candidates, if these product candidates do not prove successful in clinical trials, and are not approved or are not commercialized because we have insufficient resources for continued development or for any other reason, we may be required to suspend or discontinue our operations and our business could be materially harmed.

SignPath partially depends on intellectual property licensed from third parties which it may not be able to maintain, however has submitted additional patent applications affording broad protection.

The Company’s business plan depends on developing products based on intellectual property licensed from The ~~Johns Hopkins~~ University ~~(“JHU”), The University~~ of Texas MD Anderson Cancer Center (“UTMDACC”), and the University of North Texas (“UNT”). See “Business - Intellectual Property.” The Company’s license agreements require the Company to make payments to the licensors in the future. The Company currently does not have sufficient resources to make all of such payments, and there can be no assurance that the Company will be able to make such payments in the future.

The Company’s exclusive license with UTMDACC is for the life of patent rights or, if no patent rights are issued, for up to 30 years; however, is terminable upon 30 days’ written notice if the Company fails to cure a breach of payment or funding requirement, or upon up to 90 days’ written notice for any other breach of contract by the Company.

The Company’s license agreement with JHU is for the life of the last patent to expire or 20 years if no patents issue. It is terminable for a breach of contract by SignPath not cured within 30 days after receipt of notice.

The Company’s license agreement with UNT terminates the later of the expiration of any patent rights or 15 years,. UNT ~~and~~has ifthe noright ~~patent~~to ~~is issued shall~~ terminate 15the ~~years~~license ~~after~~on ~~regulatory~~90 ~~approval~~days’ ofwritten ~~any~~notice ~~licensed~~if ~~product. The~~the Company ~~must~~has ~~evidence~~not ~~within~~provided ~~three~~written ~~years~~evidence that it is ~~advancing~~making ~~and~~diligent ~~effectively~~efforts ~~attempting~~ to ~~license~~actively acommercialize ~~commercialized~~licensed ~~product~~production.

Additional patents and pending patent applications filed by third parties, if issued, may cover aspects of products the Company intends to develop or may develop and test in the future. As a result, the Company may be required to obtain additional licenses from third-party patent holders in order to use, manufacture or sell the Company’s product candidates.

There can be no assurance that the Company’s current arrangements with JHU, UTMDACC, UNT or any future arrangements will lead to the development of any products with any commercial potential, that the Company will be able to obtain proprietary rights or licenses for proprietary rights with respect to any technology development in connection with these arrangements or that the Company will be able to ensure the confidentiality of any proprietary rights and information developed with JHU, UTMDACC, or UNT will prevent the public disclosure thereof. The Company is not aware of any litigation, threatened litigation, or challenge to intellectual property, however, once any patents are issued to the Company, we may be subject to future litigation.

There can be no assurance that the Company will be able to maintain its existing license agreements or obtain additional necessary licenses on reasonably acceptable terms or at all. The Company’s inability to maintain its existing licenses or obtain additional licenses on acceptable terms would have a material adverse effect on the Company’s business, financial condition and results of operations.

The US FDA regulatory process is costly, lengthy and requires specific expertise.

The Company will rely initially on consultants and service organizations with prior experience working with the FDA to guide the product through the regulatory process. The Company has contracts with Clinipace Inc. to analyze, prepare and present Investigational New Drug (“IND”) applications to the FDA and conduct clinical trials. The process of obtaining regulatory approvals can be extremely costly and time-consuming, and there is no guarantee of success. If the Company does not receive approval of any of its IND applications, it will not be able to proceed with Phase IIb-II clinical testing, in the United States, but has completed an IND, and an EMA approved Phase 1aIb trial in Austria. In addition, clinical testing is not predictable. Even if the FDA approves an IND application, the Company cannot guarantee that the FDA will approve Phase IIII clinical results. The Company’s failure to obtain required regulatory approvals would have a material adverse effect on the Company’s business, financial condition and results of operations and could require the Company to curtail or cease its operations.

Delays in clinical testing could result in increased cost to us and delay our ability to generate revenue.

We may experience delays in clinical testing of our product candidates. We do not know whether planned clinical trials will need to be redesigned or will be completed on schedule, if at all. Clinical trials can be delayed for a variety of reasons, including delays in obtaining regulatory approval to commence a trial, in reaching agreement on acceptable clinical trial terms with prospective sites, in obtaining institutional review board approval to conduct a trial at a prospective site, in recruiting patients to participate in a trial or in obtaining sufficient supplies of clinical trial materials. Many factors affect patient enrollments, including the size of the patient population, the proximity of patients to clinical sites, the eligibility criteria for the trial, competing clinical trials and new drugs approved for the conditions we are investigating. Prescribing physicians will also have to decide to use our product candidates over existing experimental drugs that have putative better safety and efficacy profiles. Any delays in completing our clinical trials will increase our cost, slow down our product development and approval process and delay our ability to generate revenue.

We may be required to suspend or discontinue clinical trials due to unexpected side effects or other safety risks that could preclude approval of our product candidates.

Our clinical trials may be suspended at any time for a number of reasons. For example, we may voluntarily suspend or terminate our clinical trials if at any time we believe that they present an unacceptable risk to the clinical trial patients. In addition, regulatory agencies may order the temporary or permanent discontinuation of our clinical trials at any time if they believe that the clinical trials are not being conducted in accordance with requirements or that they present an unacceptable safety risk to the clinical trial patients.

The Company has not encountered any adverse effects in mice or rats with liposomal curcumin or nanocurcumin. However, studies in humans have been initiated by the Company and an acceptable dose level has been identified, with less than grade I erythroid (RBC) toxicity. Administering any product candidates to humans may produce undesirable side effects. These side effects could interrupt, delay or halt clinical trials of our product candidates and could result in the FDA or other regulatory authorities denying further developments or approval of our product candidates for any or all targeted indications. Ultimately, some or all of our product candidates may prove to be unsafe for human use. Moreover, we could be subject to significant liability if any volunteer or patient suffers, or appears to suffer, adverse health effects as a result of participating in our clinical trials.

If testing of a particular product candidate does not yield successful results, then we will be unable to commercialize that product.

Our product candidates in clinical trials must meet rigorous testing standards. We must demonstrate the safety and efficacy of our potential products through extensive preclinical and clinical testing. Clinical trials are subject to continuing oversight by governmental regulatory authorities, such as the FDA, and the EMA and institutional review boards and must meet the requirements of these authorities in the United States and in Europe including those for informed consent and good clinical practices. We may not be able to comply with these requirements, which could disqualify completed or ongoing clinical trials. We may experience numerous unforeseen events during, or as a result of, the testing process that could delay or prevent commercialization of our product candidates, including the following:

● safety and efficacy results from human clinical trials may show the product candidate to be less effective or safe than desired, however, those results may not be replicated in later clinical trials; ● the results of preclinical studies may ~~be inconclusive or they may~~ not be indicative of results that will be obtained in human clinical trials; ● after reviewing relevant information, including preclinical testing or human clinical trial results, we may abandon or substantially restructure projects that we might previously have believed to be promising; ● we and/or the FDA or EMA may suspend or terminate clinical trials if the participating patients are being exposed to unacceptable health risks or for other reasons; and ● the effects of our product candidates may not be the desired effects or may include undesirable side effects or other characteristics that interrupt, delay or cause us or the FDA to halt clinical trials or cause the FDA or foreign regulatory authorities to deny approval of the product candidate for any or all target indications.

Data from our completed clinical trials, when and if completed, may not be sufficient to support approval by the FDA and the EMA. The clinical trials of our product candidates may not be completed as or when planned, and the FDA or EMA may not approve any of our product candidates for commercial sale. If we fail to demonstrate the safety or efficacy of a product candidate to the satisfaction of the FDA or EMA, this will delay or prevent regulatory approval of that product candidate. Therefore, any delay in obtaining, or inability to obtain, FDA or EMA approval of any of our product candidates could materially harm our business and cause our stock price to decline.

1419

Even if we receive regulatory approval for our product candidates, we will be subject to ongoing significant regulatory obligations and oversight.

If we receive regulatory approval to sell our product candidates, the FDA and foreign regulatory authorities may, nevertheless, impose significant restrictions on the indicated uses or marketing of such products, or impose ongoing requirements for post-approval studies. If we fail to comply with applicable regulatory requirements, we may be subject to fines, suspension or withdrawal of regulatory approvals, product recalls, seizure of products, operating restrictions and criminal prosecution. Any of these events could harm or prevent sales of the affected products or could substantially increase the costs and expenses of commercializing and marketing these products. In addition, if any of our product candidates receive marketing approval and we or others later identify undesirable side effects caused by the product, we could face one or more of the following:

	●	a change in the labeling statements or withdrawal of FDA or other regulatory approval of the product;

	●	a change in the way the product is administered; or

	●	the need to conduct additional clinical trials.

Discovery after approval of previously unknown problems with our products, manufacturers or manufacturing processes, or failure to comply with regulatory requirements, may result in actions such as:

● restrictions on such products’ manufacturers or manufacturing processes; ● restrictions on the marketing of a product; ● warning letters; ● withdrawal of the products from the market; ● refusal to approve pending applications or supplements to approved applications that we submit; ● recall of products; ● fines, restitution or disgorgement of profits or revenue; ● suspension or withdrawal of regulatory approvals; ● refusal to permit the import or export of our products; ● product seizure; ● injunctions; or ● imposition of civil or criminal penalties.

●

restrictions on the marketing of a product;

●

warning letters;

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withdrawal of the products from the market;

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refusal to approve pending applications or supplements to approved applications that we submit;

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recall of products;

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fines, restitution or disgorgement of profits or revenue;

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suspension or withdrawal of regulatory approvals;

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refusal to permit the import or export of our products;

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product seizure;

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injunctions; or

●

imposition of civil or criminal penalties.

Our potential products face significant regulatory hurdles prior to commercialization and marketing which could delay or prevent sales; No assurance of FDA approval.

The FDA and comparable agencies in foreign countries impose substantial requirements upon the introduction of therapeutic and diagnostic pharmaceutical and biological products through lengthy and detailed laboratory and clinical testing procedures, sampling activities and other costly and time-consuming procedures. Satisfaction of these requirements typically takes several years or more and varies substantially based upon the type, complexity and novelty of the product. The regulatory review may result in extensive delay in the regulatory approval process. Regulatory requirements ultimately imposed could adversely affect the Company’s ability to clinically test, manufacture or market potential products. Government regulation also applies to the manufacture of pharmaceutical and biological products.

1520

Before we obtain the approvals necessary to sell any of our potential products, we must show through preclinical studies and human testing that each potential product is safe and effective. Failure to show any potential product’s safety and effectiveness would delay or prevent regulatory approval of the product and could adversely affect our business. The clinical trials process is complex and uncertain. The results of preclinical studies and initial clinical trials may not necessarily predict the results from later large-scale clinical trials. In addition, clinical trials may not demonstrate a potential product’s safety and effectiveness to the satisfaction of the regulatory authorities. A number of companies have suffered significant setbacks in advanced clinical trials or in seeking regulatory approvals, despite promising results in earlier trials.

The rate at which we complete our clinical trials depends on many factors, including our ability to obtain adequate supplies of the potential products to be tested and patient enrollment. Patient enrollment is a function of many factors, including the size of the patient population, the proximity of patients to clinical sites and the eligibility criteria for the trial. Delays in patient enrollment may result in increased costs and longer development times. In addition, under our license agreements with UTMDACC, JHU, and UNT these universities have certain rights to control product development and clinical programs for products developed under the collaborations. As a result, the universities may conduct these programs more slowly or in a different manner than we had expected. Even if clinical trials are completed, we or the universities still may not apply for FDA approval in a timely manner or the FDA still may not grant approval.

Competition in the biotechnology and pharmaceutical industries is intense, and if SignPath fails to compete effectively its financial results will suffer.

SignPath’s business environment is characterized by extensive research efforts, rapid developments and intense competition. Its competitors may have or may develop superior technologies or approaches to the development of competing products, which may provide them with competitive advantages. The Company’s potential curcumin product candidates may not compete successfully. The Company believes that successful competition in its industry depends on product efficacy, safety, reliability, availability, timing, scope of regulatory approval, acceptance and price, among other things. Important factors to SignPath’s success also include speed in developing product candidates, completing clinical development and laboratory testing, obtaining regulatory approvals and manufacturing and selling commercial quantities of potential products to the market.

The Company expects competition to increase as technological advances are made and commercial applications broaden. In the event it develops its initial product candidates and any additional product candidates, the Company anticipates it may face substantial competition from pharmaceutical, biotechnology and other companies, universities and research institutions. The Company is aware of other companies and academic groups that focus on cellular signal transduction pathways and are developing specific pathway or related kinase inhibitors. These competitors include Exelixis Inc., Onyx Pharmaceuticals, and several major pharmaceutical companies, however, none of their compounds has the broad spectrum of activity of curcumin.

Many of the Company’s non-curcumin-competitors have substantially greater capital resources, research and development staffs, facilities and experience in conducting clinical trials and obtaining regulatory approvals, as well as in manufacturing and marketing pharmaceutical products. In addition, some of SignPath’s putative competitors may achieve product commercialization or patent protection earlier than SignPath achieves commercialization or patent protection, if at all.

If we or our collaborators receive regulatory approvals for our product candidates, some of our products will compete with well-established, FDA-approved therapies that have generated substantial sales over a number of years. However, we will focus on unmet needs, and indications where FDA-approved therapies have failed. In addition, we will face competition based on many different factors, including:

● the safety and effectiveness of our products; ● the timing and scope of regulatory approvals for these products; ● the availability and cost of manufacturing, marketing and sales capabilities; ● the effectiveness of our marketing and sales capabilities; ● the price of our products; ● the availability and amount of third-party reimbursement; and ● the strength of our patent position.

16● the timing and scope of regulatory approvals for these products;

●

the availability and cost of manufacturing, marketing and sales capabilities;

●

the effectiveness of our marketing and sales capabilities;

●

the price of our products;

●

the availability and amount of third-party reimbursement; and

●

the strength of our patent position.

We also anticipate that we will face increased competition in the future as new companies enter our target markets and scientific developments surrounding cancer therapies and drugs for treatment of inflammatory conditions continue to accelerate. Competitors may develop more effective or more affordable products, or may achieve patent protection or commercialize products before us or our collaborators. In addition, the health care industry is characterized by rapid technological change. New product introductions, technological advancements, or changes in the standard of care for our target diseases could make some or all of our products obsolete.

The Company may be unable to defend or protect its intellectual property.

The Company intends to protect its intellectual property through patents and trademarks. The patent positions of biotechnology companies generally are highly uncertain and involve complex legal and factual questions that will determine who has the right to develop a particular product or process. As a result, the Company cannot predict which of its patent applications will result in the granting of patents or the timing of the granting of the patents. Additionally, many of the Company’s competitors have significantly greater capital with which to pursue patent litigation. There can be no assurance that the Company would have the resources to defend its patents in the face of a lawsuit.

Further, the Company partially relies on trade secrets, know-how and other proprietary information. The Company seeks to protect this information, in part, through the use of confidentiality agreements with employees, consultants, advisors and others. Nonetheless, there can be no assurance that those agreements will provide adequate protection for the Company’s trade secrets, know-how or other proprietary information and prevent their unauthorized use or disclosure. While the Company is not aware of any challenges to its intellectual property, once any patents are issued to the Company litigation may ensue. There is also the risk that the Company’s employees, consultants, advisors or others will not maintain confidentiality of such trade secrets or proprietary information, or that this information may become known in some other way or be independently developed by the Company’s competitors.

SignPath is exposed to potential product liability risks.

The Company’s business exposes it to potential product liability risks that are inherent in the testing, including testing in human clinical trials, manufacturing, marketing and sale of biotechnology products. There can be no assurance that product liability claims will not be asserted against the Company.

We plan to have product liability insurance covering our clinical trials which we currently believe will be adequate to cover any product liability exposure we may have. Clinical trial and product liability insurance is becoming increasingly expensive. As a result, we may be unable to obtain sufficient insurance coverage at a reasonable cost to protect us against losses that could have a material adverse effect on our business. An individual may bring a product liability claim against us if one of our products or product candidates causes, or is claimed to have caused, an injury or is found to be unsuitable for consumer use. Any product liability claim brought against us, with or without merit, could result in:

● liabilities that substantially exceed our product liability insurance, which we would then be required to pay from other sources, if available; ● increase of our product liability insurance rates or the inability to maintain insurance coverage in the future on acceptable terms, or at all; ● withdrawal of clinical trial volunteers or patients; ● damage to our reputation and the reputation of our products, resulting in lower sales; ● regulatory investigations that could require costly recalls or product modifications; ● litigation costs; and ● the diversion of management’s attention from managing our business.

●

increase of our product liability insurance rates or the inability to maintain insurance coverage in the future on acceptable terms, or at all;

●

withdrawal of clinical trial volunteers or patients;

●

damage to our reputation and the reputation of our products, resulting in lower sales;

●

regulatory investigations that could require costly recalls or product modifications;

●

litigation costs; and

●

the diversion of management’s attention from managing our business.

A successful product liability claim or series of claims brought against the Company could have a material adverse effect on the Company’s business, financial condition and results of operation.

1722

The Company may be sued by third parties who claim that its products infringe on their intellectual property rights.

The Company may be exposed to future litigation by third parties based on claims that its patents, products or activities infringe on the intellectual property rights of others or that the Company has misappropriated the trade secrets of others. Any litigation or claims against the Company, whether or not valid, could result in substantial costs, could place a significant strain on the Company’s financial and managerial resources, and could harm the Company’s reputation. In addition, intellectual property litigation or claims could force the Company to do one or more of the following, any of which could have a material adverse effect on the Company or cause the Company to curtail or cease its operations:

● Cease testing, developing, using and/or commercializing liposomal curcumin, nanocurcumin, slow release PLGA formulation or other formulations of curcumin or other products that it may develop; or ~~● Obtain a license from the holder of the infringed intellectual property right, which could also be costly or may not be available on reasonable terms.~~

●

Obtain a license from the holder of the infringed intellectual property right, which could also be costly or may not be available on reasonable terms.

SignPath may be subject to damages resulting from claims that it or its employees have wrongfully used or disclosed alleged trade secrets of their former employers.

The Company’s current employee and/or future employees have been previously employed by other biotechnology or pharmaceutical companies. Although no claims against the Company are currently pending or threatened, the Company may be subject to claims that these employees or the Company have inadvertently or otherwise used or disclosed trade secrets or other proprietary information of their former employers. Litigation may be necessary to defend against these claims. Even if SignPath is successful in defending against these claims, litigation could result in substantial costs and be a distraction to management. If the Company fails in defending such claims, in addition to paying money claims, it may lose valuable intellectual property rights or personnel. A loss of key research personnel or their work product could hamper or prevent its ability to commercialize certain product candidates, which could severely harm SignPath’s business.

Governmental and third-party payors may impose sales and pharmaceutical pricing restrictions or controls on SignPath’s potential products that could limit its future product revenues and adversely affect profitability.

The commercial success of the Company’s potential products is substantially dependent on whether third-party reimbursement is available for the ordering of its products by the medical profession for use by their patients. Medicare, Medicaid, health maintenance organizations and other third-party payors may not cover or provide adequate payment for SignPath’s potential products. They may not view the Company’s potential products as cost -effective and reimbursement may not be available to consumers or may not be sufficient to allow its potential products to be marketed on a competitive basis. Likewise, legislative or regulatory efforts to control or reduce health care costs or reform government health care programs could result in lower prices or rejection of its potential products. Changes in reimbursement policies or health care cost containment initiatives that limit or restrict reimbursement for the Company’s products may cause its revenue to decline.

Rapid technological change could make any products that SignPath eventually develops obsolete.

Biopharmaceutical technologies have undergone rapid and significant change and the Company expects that they will continue to do so. Any compounds, products or processes that SignPath develops may become obsolete or uneconomical before the Company recovers any expenses incurred in connection with their development.

We expect to rely heavily on third party relationships and termination of any of these programs could reduce the financial resources available to us, including research funding and milestone payments.

Our strategy for developing and commercializing many of our potential product candidates, including products aimed at larger markets, includes entering into collaborations with research partners, licensors, licensees and others. These collaborations will provide us with research and development resources for potential products. These agreements also will give our collaborative partners significant discretion when deciding whether or not to pursue any development program. Our collaborations may not be successful. Currently, we have collaborative relationships with JHU, UTMDACC, and UNT. See “Business – Intellectual Property”.

In addition, JHU, UTMDACC, or UNT may develop products, either alone or with others, ~~that~~which compete with the types of drugs they currently are developing with us. This would result in less support and increased competition for our programs. If any of our three licensors breach or terminate their agreements with us or otherwise fail to conduct their collaborative activities successfully, our product development under these agreements will be delayed or terminated.

We may have disputes in the future with JHU, UTMDACC, and UNT including disputes concerning who owns the rights to any technology developed. These and other possible disagreements between us and our licensors could delay our ability and the ability of the universities to achieve milestones or our receipt of other payments. In addition, any disagreements could delay, interrupt or terminate the collaborative research, development and commercialization of certain potential products, or could result in litigation or arbitration. The occurrence of any of these problems could be time-consuming and expensive and could adversely affect our business.

In general, collaborative agreements provide that they may be terminated under certain circumstances. There can be no assurance that the Company will be able to extend either of its agreements with the universities upon their termination or expiration, or that the Company will be able to enter into new collaborative agreements with existing or new partners in the future. To the extent the Company chooses not to or is unable to establish any additional third party arrangements, it would require substantially greater capital to undertake research, development and marketing of its proposed products at its own expense. In addition, the Company may encounter significant delays in introducing its proposed products into certain markets or find that the development, manufacture or sale of it proposed products in such markets is adversely affected by the absence of such third party agreements.

We will rely on third parties to supply and manufacture our product candidates, without any direct control over the timing for the supply, production and delivery of our product candidates, thereby possibly adversely affecting any future revenues23

~~Curcumin was initially obtained from SAFC and subsequently from Sabinsa in Bangalore, India.~~ We will rely ~~exclusively and be dependent~~ on ~~certain~~ third ~~party~~parties ~~source suppliers~~ to supply ~~pure~~and ~~synthetic~~manufacture ~~curcumin for~~ our product candidates~~. Liposomal curcumin is manufactured in Vienna~~, ~~Austria~~without byany ~~Polymun~~direct ~~Scientific~~control ~~Immunbiologische~~over ~~Forschung~~the ~~GmbH.~~timing Wefor ~~have~~the ~~obtained initial quantities of liposomal curcumin from Sabinsa/Sami Labs~~supply, ~~Bangalore,~~production ~~India. Nanocurcumin~~and ~~will~~delivery ~~be manufactured by Regis Pharmaceuticals. The polymer was manufactured by Surmodics. See Item 1 “Description~~ of ~~Business~~our –product ~~Potential~~candidates, ~~Commercialization~~thereby ofpossibly ~~Liposomal~~adversely ~~Curcumin~~affecting ~~and~~any ~~Nanocurcumin;~~future ~~and Raw Materials; Supplies~~revenues.”

Curcumin was initially obtained from SAFC and subsequently from Sabinsa in Bangalore, India. We will rely exclusively and be dependent on certain third party source suppliers to supply pure synthetic curcumin for our product candidates. Liposomal curcumin is manufactured in Vienna, Austria by Polymun Scientific Immunbiologische Forschung GmbH. We have obtained initial quantities of liposomal curcumin from Sabinsa/Sami Labs, Bangalore, India. Nanocurcumin will be manufactured by Regis Pharmaceuticals. The polymer was manufactured by Surmodics. See “Business – Potential Commercialization of Liposomal Curcumin and Nanocurcumin; and Raw Materials; Supplies.”

If any of these arrangements terminate, locating additional or replacement suppliers for these materials may take a substantial amount of time. In addition, we may have difficulty obtaining similar supplies from other suppliers that are acceptable to the FDA. If we have to switch to a replacement supplier, we may face additional regulatory delays and the manufacture and delivery of our product candidates could be interrupted for an extended period of time, which may delay completion of our clinical trials or commercialization of our product candidates. As a result, regulatory approval of our product candidates may not be received at all. All these delays could cause delays in commercialization of our product candidates, delays in our ability to generate revenue, and increase our costs.

Further, our contract manufacturers must comply with current Good Manufacturing Practices, or cGMPs, and other government regulations, which may limit the available sources of our needed supplies. The FDA periodically inspects manufacturing facilities, including third parties who manufacture products or active ingredients for us. The FDA may not believe that the chosen manufacturers have sufficient experience making the dosage forms that we have contracted with them to produce, and may subject those manufacturers to increased scrutiny. Pharmaceutical manufacturing facilities must comply with applicable cGMPs, and manufacturers usually must invest substantial funds, time and effort to ensure full compliance with these standards. We will not have control over our contract manufacturers’ compliance with these regulations and standards. Failure to comply with applicable regulatory requirements can result in sanctions, fines, delays or suspensions of approvals, seizures or recalls of products, operating restrictions, manufacturing interruptions, costly corrective actions, injunctions, adverse publicity against us and our products and possible criminal prosecutions.

We will rely on third parties to conduct our clinical trials. If these third parties do not successfully carry out their contractual duties or meet expected deadlines, we may not be able to seek or obtain regulatory approval for or commercialize our product candidates.

We will need to retain a third party clinical research organization, or CRO, to implement, provide monitors and manage data for our clinical programs. We and our CRO are required to comply with current Good Clinical Practices, or GCPs, regulations and guidelines enforced by the FDA for all of our products in clinical development. The FDA enforces GCPs through periodic inspections of trial sponsors, principal investigators and trial sites. In the future, if we or our CRO fails to comply with applicable GCPs, the clinical data generated in our clinical trials may be deemed unreliable and the FDA may require us to perform additional clinical trials before approving our marketing applications. We cannot assure you that, upon inspection, the FDA will determine that any of our clinical trials for products in clinical development comply with GCPs. In addition, our clinical trials must be conducted with products produced under cGMP regulations, and will require a large number of test subjects. Our failure to comply with these regulations may require us to repeat clinical trials, which would delay the regulatory approval process.

If CROs do not successfully carry out their contractual duties or obligations or meet expected deadlines, if they need to be replaced, or if the quality or accuracy of the clinical data they obtain is compromised due to the failure to adhere to our clinical protocols, regulatory requirements or for other reasons, our clinical trials may be extended, delayed or terminated, and we may not be able to obtain regulatory approval for or successfully commercialize our product candidates. As a result, our financial results and the commercial prospects for our product candidates would be harmed, our costs could increase, and our ability to generate revenue could be delayed.

The Orphan Drug Act may provide a competitor with up to seven years of market exclusivity.

The Orphan Drug Act was created to encourage companies to develop therapies for rare diseases by providing incentives for drug development and commercialization. One of the incentives provided by the act is seven years of market exclusivity for the first product in a class licensed for the treatment of a rare disease. We intend to target indications that would be covered by the Orphan Drug Act, and companies may obtain orphan drug status for therapies that are developed for this indication. In the event that any competitor of ours is first to obtain FDA licensure for a competitive product, we could be prevented from obtaining licensure and marketing our product candidates.

The commercial success of our product candidates will depend upon the degree of market acceptance of these products among physicians, patients, health care payors and the medical community.

Even if a product candidate is approved for sale by the appropriate regulatory authorities, physicians may not prescribe our product candidates, in which case we could not generate revenue or become profitable. Market acceptance by physicians, healthcare payors and patients will depend on a number of factors, including:

	●	acceptance by physicians and patients of each such product as a safe and effective treatment;
	●	cost effectiveness;
	●	adequate reimbursement by third parties;
	●	potential advantages over alternative treatments;
	●	relative convenience and ease of administration; and
	●	prevalence and severity of side effects.

We are subject to critical accounting policies, and we may interpret or implement required policies incorrectly.

We follow generally accepted accounting principles (GAAP) for the United States in preparing our financial statements. As part of this work, we must make many estimates and judgments about future events. These affect the value of the assets and liabilities, contingent assets and liabilities, and revenue and expenses that we report in our financial statements. We believe these estimates and judgments are reasonable, and we make them in accordance with our accounting policies based on information available at the time. However, actual results could differ from our estimates, and this could require us to record adjustments to expenses or revenues that could be material to our financial position and results of operations in future periods.

The obligations associated with being a public company require significant resources and management attention, which may divert from our business operations.

We are subject to the reporting requirements of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and the Sarbanes-Oxley Act of 2002, or the Sarbanes-Oxley Act. The Exchange Act requires that we file annual, quarterly and current reports with respect to our business and financial condition. The Sarbanes-Oxley Act requires, among other things, that we establish and maintain effective internal controls and procedures for financial reporting. As a result, we will incur significant legal, accounting and other expenses. Furthermore, the need to establish the corporate infrastructure demanded of a public company may divert management’s attention from implementing our growth strategy, which could prevent us from improving our business, results of operations and financial condition. We have made, and will continue to make, changes to our internal controls and procedures for financial reporting and accounting systems to meet our reporting obligations as a stand-alone public company. However, the measures we take may not be sufficient to satisfy our obligations as a public company. In addition, we cannot predict or estimate the amount of additional costs we may incur in order to comply with these requirements.

Section 404 of the Sarbanes-Oxley Act requires annual management assessments of the effectiveness of our internal control over financial reporting, starting with this, the second annual report that we are required to file with the Securities and Exchange Commission. In connection with the implementation of the necessary procedures and practices related to internal control over financial reporting, we may identify additional deficiencies. We may not be able to remediate any future deficiencies imposed by the Sarbanes-Oxley Act for compliance with the requirements of Section 404. In addition, failure to achieve and maintain an effective internal control environment could have a material adverse effect on our business and stock price.

Risks Related to Our Securities

Anti-Takeover, Limited Liability and Indemnification Provisions

Some provisions of our certificate of incorporation and by-laws may deter takeover attempts, which may limit the opportunity of our stockholders to sell their shares at a favorable price.

Certificate of Incorporation and By-laws. Under our certificate of incorporation, our Board of Directors may issue additional shares of common or preferred stock. Any additional issuance of common stock could have the effect of impeding or discouraging the acquisition of control of us by means of a merger, tender offer, proxy contest or otherwise, including a transaction in which our stockholders would receive a premium over the market price for their shares, and thereby protects the continuity of our management. Specifically, if in the due exercise of its fiduciary obligations, the Board of Directors were to determine that a takeover proposal was not in our best interest, shares could be issued by our Board of Directors without stockholder approval in one or more transactions that might prevent or render more difficult or costly the completion of the takeover by:

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● diluting the voting or other rights of the proposed acquirer or insurgent stockholder group; ● putting a substantial voting block in institutional or other hands that might undertake to support the incumbent Board of Directors; or ● effecting an acquisition that might complicate or preclude the takeover.,

●

putting a substantial voting block in institutional or other hands that might undertake to support the incumbent Board of Directors, or

●

effecting an acquisition that might complicate or preclude the takeover.

Our certificate of incorporation also allows our Board of Directors to fix the number of directors in the bylaws. Cumulative voting in the election of directors is specifically denied in our certificate of incorporation. The effect of these provisions may be to delay or prevent a tender offer or takeover attempt that a stockholder may determine to be in his or its best interest, including attempts that might result in a premium over the market price for the shares held by the stockholders.

Delaware Anti-Takeover Law. We are subject to the provisions of Section 203 of the Delaware General Corporation Law concerning corporate takeovers. This section prevents many Delaware corporations from engaging in a business combination with any interested stockholder, under specified circumstances. For these purposes, a business combination includes a merger or sale of more than 10% of our assets, and an interested stockholder includes a stockholder who owns 15% or more of our outstanding voting stock, as well as affiliates and associates of these persons. Under these provisions, this type of business combination is prohibited for three years following the date that the stockholder became an interested stockholder unless:

● the transaction in which the stockholder became an interested stockholder is approved by the Board of directors prior to the date the interested stockholder attained that status; ● on consummation of the transaction that resulted in the stockholder’s becoming an interested stockholder, the interested stockholder owned at least 85% of the voting stock of the corporation outstanding at the time the transaction was commenced, excluding those shares owned by persons who are directors and also officers; or ● on or subsequent to that date, the business combination is approved by the Board of Directors and authorized at an annual or special meeting of stockholders by the affirmative vote of at least two-thirds of the outstanding voting stock that is not owned by the interested stockholder.

	●	on consummation of the transaction that resulted in the stockholder’s becoming an interested stockholder, the interested stockholder owned at least 85% of the voting stock of the corporation outstanding at the time the transaction was commenced, excluding those shares owned by persons who are directors and also officers; or
	●	on or subsequent to that date, the business combination is approved by the Board of Directors and authorized at an annual or special meeting of stockholders by the affirmative vote of at least two-thirds of the outstanding voting stock that is not owned by the interested stockholder.

This statute could prohibit or delay mergers or other takeover or change in control attempts and, accordingly, may discourage attempts to acquire us.

Limited Liability and Indemnification. Our certificate of incorporation eliminates the personal liability of our directors for monetary damages arising from a breach of their fiduciary duty as directors to the fullest extent permitted by Delaware law. This limitation does not affect the availability of equitable remedies, such as injunctive relief or rescission. Our certificate of incorporation requires us to indemnify our directors and officers to the fullest extent permitted by Delaware law, including in circumstances in which indemnification is otherwise discretionary under Delaware law.

Under Delaware law, we may indemnify our directors or officers or other persons who were, are or are threatened to be made a named defendant or respondent in a proceeding because the person is or was our director, officer, employee or agent, if we determine that the person:

	●	conducted himself or herself in good faith, reasonably believed, in the case of conduct in his or her official capacity as our director or officer, that his or her conduct was in our best interests, and, in all other cases, that his or her conduct was at least not opposed to our best interests; and
	●	in the case of any criminal proceeding, had no reasonable cause to believe that his or her conduct was unlawful.

These persons may be indemnified against expenses, including ~~attorneys~~attorney’s fees, judgments, fines, including excise taxes, and amounts paid in settlement, actually and reasonably incurred, by the person in connection with the proceeding. If the person is found liable to the corporation, no indemnification will be made unless the court in which the action was brought determines that the person is fairly and reasonably entitled to indemnity in an amount that the court will establish. Insofar as indemnification for liabilities under the Securities Act may be permitted to directors, officers or persons controlling us under the above provisions, we have been informed that, in the opinion of the SEC, such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable.

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Absence of a public market for the securities offered hereby will lack liquidity.

There is currently no public market for any of the Company'’s securities and there can be no assurance that a public market will develop in the future. In the event there is no active trading market for the Company’s securities, an investor may be unable to liquidate an investment in the shares and, therefore, should be prepared to bear the economic risk of an investment in the shares for an indefinite period and to withstand a total loss of investment. Rule 144 promulgated under the Securities Act requires, among other conditions, a six month holding period prior to the resale of securities acquired in a non-public offering without having to satisfy the registration requirements of the Securities Act. In the event we do not have sufficient financial and human resources in the future, we may not be able to fulfill our reporting requirements under the Exchange Act or disseminate to the public any current financial or other information concerning the Company, as required by Rule 144 as one of the conditions of its availability. In such event we will not be absolved from liability for our failure to file these reports.

If our common stock is traded onin the ~~OTC~~over-the-counter ~~Bulletin Board~~market, which is not a national securities exchange, it may be detrimental to investors

We ~~have~~were ~~been~~previously approved for a listing of our shares of common stock on the OTC Bulletin Board maintained by FINRA, however have no present intention to have our securities publicly traded. Although there is currently no market for our securities, securities traded onin the ~~OTC~~over-the-counter ~~Bulletin Board~~market, as compared to the national securities exchanges, generally have limited trading volume and exhibit a wide spread between the bid/ask quotations. We cannot predict whether a more active market for our common stock will develop in the future. In the absence of an active trading market: investors may have difficulty buying and selling our common stock or obtaining market quotations; market visibility for our common stock may be limited; and a lack of visibility for our common stock may have a depressive effect on the mark price for our common stock.

Preferred Stock as an anti-takeover device

We are authorized to issue an aggregate of 5,000,000 shares of preferred stock, $0.10 par value. As of ~~date~~March of31, ~~this report~~2015, there were, 3,255.375 shares of Series A Preferred Stock issued and outstanding convertible into approximately 3,831,376 shares of common stock ~~and~~, 2,146 shares of Series B Preferred Stock convertible into approximately 2,525,842 Shares of Common Stock, and ~~3,755.~~5,001 shares of Series C Preferred stock convertible into 4,000,000 shares of Common Stock. The Company has also authorized 6,000 shares of Series D Preferred Stock convertible into 3,~~004~~000,~~400~~000 shares of Common ~~stock~~Stock, 1,265.25 of which shares of Series D Preferred Stock were issued and outstanding as of March 31, 2015, convertible into 632,625 shares of Common Stock. The preferred stock may be issued from time to time with such designation, voting and other rights, preferences and limitations as our Board of Directors may determine by resolution. Unless the nature of a particular transaction and applicable status require such approval, the Board of Directors has the authority to issue these shares without stockholder approval subject to approval of the holders of our preferred stock. The issuance of preferred stock may have the effect of delaying or preventing a change in control of the Company without any further action by our stockholders.

Our common stock will be subject to restrictions on sales by broker-dealers and penny stock rules, which may be detrimental to investors.

Our common stock will be subject to Rules 15g-1 through 15g-9 under the Exchange Act, which imposes certain sales practice requirements on broker-dealers who sell our common stock to persons other than established customers and “accredited investors” (as defined in Rule 501(a) of the Securities Act). For transactions covered by this rule, a broker-dealer must make a special suitability determination for the purchaser and have received the purchaser’s written consent to the transaction prior to the sale. This rule adversely affects the ability of broker-dealers to sell our common stock and purchasers of our common stock to sell their shares of our common stock.

Additionally, our common stock will be subject to SEC regulations applicable to “penny stocks.” Penny stocks include any non-exchange listed equity security that has a market price of less than $5.00 per share, subject to certain exceptions. The regulations require that prior to any non-exempt buy/sell transaction in a penny stock, a disclosure schedule proscribed by the SEC relating to the penny stock market must be delivered by a broker-dealer to the purchaser of such penny stock. This disclosure must include the amount of commissions payable to both the broker-dealer and the registered representative and current price quotations for our common stock. The regulations also require that monthly statements be sent to holders of a penny stock that disclose recent price information for the penny stock and information of the limited market for penny stocks. These requirements adversely affect the market liquidity of our common stock.

A significant number of our shares are eligible for sale, and their sale could depress the market price of our stock.

~~Sales~~The ofCompany arecently ~~significant~~registered ~~number~~23,387,488 of shares of common stock inon ~~the~~behalf ~~public~~of ~~market~~various ~~pursuant~~stockholders toof ~~a current prospectus could harm~~ the ~~market~~Company ~~price~~in ofa ~~our~~registration ~~common~~statement ~~stock.~~on ~~Pursuant to our most recent Registration Statement of~~ Form S-1 (File No. 333-~~169386~~198110), anwhich ~~aggregate~~was ofdeclared ~~6,161,448~~effective ~~shares~~by ofthe ~~common~~SEC ~~stock~~on ~~were~~February ~~registered~~6, in2015. Sales ~~October~~ of ~~2010~~a ~~all~~significant number of ~~which~~shares ~~would~~of becommon ~~free-trading~~stock ~~upon~~in ~~resale~~the public market pursuant to a current prospectus ~~filed~~could inharm athe market price of our common stock. All of the shares registered under the resale registration statement are free-trading upon resale by the stockholders. As additional shares of our common stock become available for resale in the public market, the supply of our common stock will increase, which could decrease its price. Some or all of the shares of our common stock may be offered from time to time in the open market pursuant to Rule 144, and these sales may have a depressive effect on the market for the shares of our common stock. In general, a non-affiliated person who has held restricted shares for a period of six months, under Rule 144, may sell into the market our common stock all of their shares, subject to the Company being current in its periodic reports filed with the SEC. An affiliate may sell an amount equal to the greater of 1% of the outstanding shares or, if listed on Nasdaq or another national securities exchange, the average weekly number of shares sold in the last four weeks prior to such sale. Such sales may be repeated once every three months, and any of the restricted shares may be sold by a non-affiliate without any restriction after they have been held the year.

Investors may experience substantial dilution of their ownership in the future.

Pursuant to the Company’s Stock Option Plan, employees, directors and independent contractors may acquire up to an aggregate of 1,~~047~~171,~~000~~630 shares (as amended on January 1, ~~2014~~2015) of the Company’s common stock through the exercise of stock options that may be granted in the future of which ~~570~~915,000 options are issued and outstanding. The Company’s stockholders will incur dilution upon exercise of such options. In addition, as of March 2131, ~~2014~~2015, there were currently outstanding Class A, Class B, ~~and~~ Class C and Class D warrants to purchase approximately 34,~~831~~037,~~576~~018, 2,525,842, 2,000,000 and 1158,~~502,200~~157 shares of common stock, respectively, and Series A, Series B, ~~and~~ Series C and Series D Convertible Preferred Stock convertible into approximately 3,831,576, 2,525,842, ~~and 3~~4,~~004~~000,~~400~~000 and 632,625 shares of Common Stock, respectively, plus placement agent warrants to purchase approximately 23,~~861~~265,~~512~~360.22 shares of common stock and vendor warrants to purchase ~~400~~800,000 shares of Common Stock. The mere existence of these derivative securities may have a depressive effect on any market for our common stock which may develop.

In addition, if the Company raises additional funds by issuing additional stock in one or more additional financings, further dilution to stockholders will result, and new investors may have rights superior to existing stockholders.

The Company’s officers, directors and principal stockholders may be able significantly to influence matters requiring stockholder approval because they own a large percentage of the Company’s outstanding shares.

The Company’s founder, Bruce Meyers, who is athe ~~principal~~CEO of Meyers Associates, a FINRA member firm, Dr. Lawrence Helson, CEO, ~~and~~of the Company, Dr. Arthur Bollon, Director, and Jack Levine beneficially own 45,~~962~~015,~~500~~865, 2,310,000, 800,000 and ~~800~~190,000 shares, respectively, an aggregate of 8,~~072~~315,~~500~~865 shares or approximately 3633.31% of the 2225,~~239~~153,~~318~~930 outstanding voting securities of the Company as of March 2015. These stockholders will be able to exercise control over substantially all matters requiring approval by the Company’s stockholders, including the election of directors and the approval of significant corporate transactions, which includes their ability to amend the Certificate of Incorporation, approve a merger or consolidation of the Company with another company or approve the sale of substantially all of the assets of the Company without the agreement of minority stockholders. This concentration of ownership may not be in the best interests of all of the Company’s stockholders. See ~~Item~~“Principal 12Stockholders. ”~~Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters.”~~

~~Limitations~~Meyers onAssociates, ~~ability~~L.P. and its principals are subject to ~~pay~~disciplinary ~~dividends~~proceedings from FINRA in connection with, among other things, previous offerings of the Company’s securities.

Meyers Associates, L.P. (“Meyers”), the Company’s placement agent, as well as Bruce Meyers (“B. Meyers”) and Imtiaz Khan (“Khan”), two of the principals of Meyers (collectively, the “Principals”), are subject to pending disciplinary proceeding from the Financial Industry Regulatory Authority, Inc. (“FINRA”). On October 6, 2014, FINRA filed a complaint (the “Complaint”) alleging, among other things, the violation of certain rules of FINRA and the National Association of Securities Dealers (“NASD”) and federal securities laws in connection with Meyers’ prior offerings of the Company’s securities as well as Meyers’ general operations. The Complaint has nine (9) separate causes of action, which include the following:

Unregistered public offerings in contravention of Section 5 of the Securities Act and FINRA Rule 2010, against Meyers and B. Meyers, in connection with the manner that Meyers allegedly solicited prospective investors in the Company’s Series A Offering in violation of the prohibition on general solicitation for private placements;

Advertising Violations in violation of NASD Conduct Rule 2210 and FINRA Rule 2010, against Meyers and B. Meyers, in connection with the alleged omission of material information in solicitation material and misleading statements to prospective investors;

	3.	Rule 5122 Violation (FINRA Rules 5122 and 2010) against Meyers, in connection with an alleged failure to comply with the rules of a “member private offering” under FINRA Rule 5122 during the Company’s Series B Offering, as Meyers was a control entity because Meyers, B. Meyers, and Khan collectively owned more than 50% of the Company’s outstanding voting securities, including the alleged failure to timely file a private placement memorandum and other solicitation documents with FINRA;
	4.	Inaccurate Books and Records in violation of Section 17(a) of the Securities and Exchange Act of 1934 (the “Exchange Act”) and Rules 17a-3, 17a-4, and 17a-5 thereunder, NASD Conduct Rule 3110, and FINRA Rules 4511 and 2010 against Meyers, B. Meyers, and Khan, for alleged failure of B. Meyers and Khan to identify personal expenses that were paid by Meyers and which were not recorded as compensation;
	5.	Failure to Observe High Standards of Commercial Honor and Just and Equitable Principles of Trade by Falsifying Tax Form W-2 in violation of FINRA Rule 2010 against Meyers, B. Meyers, and Khan, for B. Meyers and Khan allegedly causing Meyers to compensate them, in part, by paying personal expenses which were not properly reported on their Forms W-2;
	6.	Supervision of the Maintenance of Books and Records in violation of NASD Conduct Rule 3010 and FINRA Rule 2010 against Meyers and B. Meyers, for an alleged failure to establish and maintain a system to supervise the activities of employees and representatives in connection with the recording of payments for B. Meyers and Khan’s expenses;
	7.	Supervisory Review of Electronic Communications in violation of NASD Conduct Rules 3010 and 2110 and FINRA Rule 2010 against Meyers, for alleged failure to properly supervise and review Meyers’ electronic correspondence and Meyers not having adequate written supervisory procedures with respect to electronic communications;
	8.	Failure to Report Customer Complaints in violation of NASD Conduct Rules 3070 and 2110 and FINRA Rule 2010 against Meyers, in connection with Meyers’ alleged failure to report various customer complaints to FINRA;
	9.	Deficient Supervisory Control Procedures in violation of NASD Conduct Rule 3012 and FINRA Rule 2010 against Meyers, in connection with Meyers’ alleged failure to establish, maintain, and enforce reasonable written supervisory control policies and procedures regarding various aspects of the firm’s operations.

FINRA is seeking sanctions which may include a suspension and monetary sanctions under FINRA Rule 8310(a), an order that Meyers and the Principals bear the cost of proceedings under FINRA Rule 8330, as well as specific findings that Meyers willfully committed the alleged violations and violated Exchange Act Section 17, and Rule 17a-3, 17a-4, and 17a-5 thereunder. Meyers and the Principals have answered the Complaint which they maintain is without merit and that they will contest the enforcement action vigorously. However, if FINRA ultimately prevails in this action, of if Meyers or the Principals admit or concede any of FINRA’s allegations, it could have a material adverse effect on the Company, as the enforcement action could prevent Meyers from helping the Company raise additional funds from investors.

Limitations on ability to pay cash dividends.

The Company does not currently expect to pay cash dividends on any of its common stock for the foreseeable future. The ability of the Company to pay dividends on the Company’s common stock will depend upon, among other things, future earnings, if any, the success of the Company’s business activities, capital requirements, the general financial condition of the Company, and general business conditions. There can be no assurance that the Company will ever be in a financial position to declare and pay dividends on the Company’s common stock or that the Board of Directors would otherwise ever declare or pay such a dividend.

As of the date hereof, there are no material legal proceedings pending or threatened to be taken against the Company. SignPath has retained legal counsel to evaluate and advise on our intellectual property and patent strategy.

ITEM 2. DESCRIPTION OF PROPERTIES

The Company’s executive offices are located inat a3477 ~~building~~Corporate ~~owned~~Parkway, bySuite ~~Dr.~~100, ~~Lawrence~~Center ~~Helson~~Valley, ~~Chief~~PA ~~Executive Officer~~18034, ~~and~~telephone ~~are~~(215) ~~located~~538-9996. atThe ~~1375~~Company ~~California~~occupies ~~Road,~~this ~~Quakertown,~~space ~~Pennsylvania,~~on ~~18951. The~~a ~~Company~~month ~~does~~to ~~not~~month ~~pay~~basis at a rent atof ~~this~~$200 ~~location~~per month.

ITEM 3. LEGAL PROCEEDINGS

ITEM 4. MINE SAFETY DISCLOSURES

Not Applicable

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PART II

ITEM 5. PRICE RANGE OF COMMON STOCK, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES

(a) Market Information

Our common stock is not publicly traded. We ~~have~~were ~~been~~previously approved for trading of our common stock on the Over-The-Counter Bulletin Board (“OTCBB”), which is maintained by the Financial Industry Regulatory Authority, Inc. (“FINRA”), however, do not have a preset intention to commence trading at this point in time.

As of ~~As of~~ March 2131, ~~2014~~2015, there were outstanding: 1214,~~877~~163,~~500~~887 shares of common stock; ~~options to purchase 570,000 shares of common stock~~ 3,255.375, 2,146, 5,000, and 31,~~755~~265.525 shares of Series A, Series B, Series C, and Series CD Convertible Preferred Stock convertible into approximately 3,831,576, 2,525,842, 4,000,000, and 3632,~~004,400~~625 shares, respectively, of common stock; Class A, Class B, Class C, and Class CD common stock purchase warrants to purchase approximately 34,~~831~~037,~~576~~018, 2,525,842, 2,000,000, and 1158,~~502,200~~157 shares, respectively, of Common Stock, ~~and~~ placement agent warrants to purchase approximately 23,~~771~~265,~~392~~360 shares of Common Stock, vendor warrants to purchase 800,000 shares of Common Stock, options to purchase an aggregate of 915,000 shares of Common Stock, or an aggregate of approximately 1938,~~992~~855,~~562~~307 shares of Common Stock.

The 14,163,887 shares of common stock which are issued and outstanding and registered on Registration Statement No. 333-198110, as well as the 10,894,448 shares of common stock issuable upon conversion of preferred stock, 8,476,230 shares of common stock issuable upon exercise of warrants and 3,111,610 shares issuable upon exercise of placement agent warrants will be freely tradable without restriction under the Securities Act unless purchased by our “affiliates,” as that term is defined in Rule 144 under the Securities Act.

(b) Holders of Record

As of March 2131, ~~2014~~2015, there were approximately 4060 different holders of record of our common stock, 45 different holders of Series A Preferred Stock, 27 different holders of Series B Preferred Stock, 19 different holders of Series C Preferred Stock, and 22 holders of Series D Preferred Stock.

We have never declared or paid cash dividends on our shares of common stock. We currently intend to retain future earnings for use in our business and, therefore, do not anticipate paying any cash dividends on our shares of common stock in the foreseeable future. Any future determination as to the payment of cash dividends on our common stock will be at the discretion of our Board of Directors and will depend on our earnings, operating and financial condition, capital requirements and other factors deemed relevant by our Board of Directors including the General Corporation Law of the State of Delaware, which provides that cash dividends are only payable out of retained earnings or if certain minimum rations of assets to liabilities are satisfied. The declaration of cash dividends on our common stock also may be restricted by the provisions of credit agreements that we may enter into from time to time.

(d) Securities Authorized For Issuance Under Equity Compensation Plans

Equity Compensation Plan Information

The following table provides information regarding the status of our existing equity compensation plans at December 31, ~~2013~~2014.

Plan category	~~Number of shares of common stock to be issued on exercise of outstanding options, warrants and rights~~	Number of shares of common stock to be issued on exercise of outstanding options, warrants and rights	~~Weighted-average exercise price of outstanding options, warrants and rights~~		Weighted-average exercise price of outstanding options, warrants and rights	~~Number, of securities remaining available for future issuance under equity compensation plans (excluding securities reflected in the previous columns)~~		Number of securities remaining available for future issuance under equity compensation plans (excluding securities reflected in the previous columns)
Equity compensation plans approved by security holders (1)	~~450,000~~		$450,000	~~0.85~~	$	0.85			-0-
	120,000		$	1.25			477,000
			380,000		$	1.25			316,630
Equity compensation plans not approved by security holders	-0-		$	-0-			-0-
			25,000		$	2.00
Total	570,000		$	0.934			477,000
Equity compensation plans not approved by security holders			-0-			-0-			-0-
Total			855,000		$	1.06			316,630(2)

~~(1) Consists of our 2009 Employee Stock Incentive Plan, which authorized as of January 1, 2014, an aggregate of 1,047,000 options and/or shares of common stock.~~30

26 (1) Consists of our 2009 Employee Stock Incentive Plan, which authorized as of January 1, 2015, an aggregate of 1,171,630 options and/or shares of common stock.

(2) An aggregate of 60,000 options were issued to independent investors in March 2015.

OFF-BALANCE SHEET ARRANGEMENTS

We do not have any off-balance sheet arrangements that have or are reasonably likely to have a current or future effect on our financial condition, changes in financial condition, revenues or expenses, results of operations, liquidity, capital expenditures or capital resources that is material to investors.

ITEM 6. SELECTED FINANCIAL DATA

Not applicable to a smaller reporting company.

ITEM 7. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

The following discussion should be read in conjunction with the financial statements and notes thereto included in this report. Except for the historical information contained herein, the discussion in this report contains certain forward-looking statements that involve risk and uncertainties, such as statements of the Company’s plans, objectives, expectations and intentions as of the date of this filing. The cautionary statements made in this document should be read as being applicable to all related forward-looking statements wherever they appear in this document. The Company’s actual results could differ materially from those discussed here. Factors that could cause differences include those discussed in the “Risk Factors” section as well as discussed elsewhere herein.

Liquidity and Capital Resources

Liquidity and Capital Resources at December 31, ~~2013~~2014 Compared with December 31, ~~2012~~2013

As of December 31, ~~2013~~2014 and December 31, ~~2012~~2013, the Company had $1716,~~241,397~~193 and $311,~~922~~241,397, respectively, of cash on hand. The Company’s had ~~positive~~ working capital of $~~819~~268,~~765~~194 atas of December 31, ~~2013~~2014 compared to aworking ~~deficit~~capital of ($6819,~~549,671)~~765 asat of December 31, ~~2012~~2013, resulting from ~~decreases~~a net loss of ($2,748,190) offset, in ~~accounts~~part, ~~payables~~by ~~resulting~~options ~~from~~issued ~~net~~for ~~cash~~services ~~used~~of in$217,444 ~~operations~~and warrants issued for services of ($281,283. The Company received $1,~~620~~650,~~199)~~760 ~~and~~in proceeds from the ~~removal~~issuance of ~~the~~preferred ~~derivative~~stock ~~liability~~from financing activities. SignPath had aan ~~deficit~~ accumulated ~~during~~deficit ~~the development stage~~ of $1013,~~668~~416,~~408~~598 as of December 31, ~~2013~~2014.

During the 12year ~~months~~ ended December 31, ~~2013 (“Fiscal 2013”)~~2014, SignPath sold ~~3,380~~1940 Units consisting of its securities at a price of $1,000 per Unit. The Units sold in ~~2013~~2014 consisted of 1,620 Units of Series C Convertible Preferred Stock and 320 Units of Series D Convertible Preferred Stock. Each Series C Unit consists of (i) one share of 6.5% Series C Convertible Preferred Stock convertible into 800 shares of common stock (equivalent to $1.25 per share of common stock) following the effective date of its Registration Statement (the “Effective Date”) subject to adjustment, and (ii) Warrants to purchase 400 shares of common stock at $1.875 per share for a ~~five~~seven-year period following the Effective Date of a registration statement including the underlying securities. Each Series D Unit consists of: (i) one share of 6.5% Series D Convertible Preferred Stock convertible into 500 shares of common stock (equivalent to $2.00 per share of common stock) following the Effective Date, subject to adjustment, and (ii) Warrants to purchase 125 shares of common stock at $3.00 per share for a seven-year period following the Effective Date. The Company received gross proceeds of $31,~~380~~940,000 and incurred stock offering costs of $~~550~~289,~~326~~240 related to such offerings during ~~Fiscal~~the ~~2013~~year ended December 31, 2014.

~~The~~From ~~Company~~January ~~has no agreements~~1, ~~arrangements~~2015 orthrough ~~understandings~~February ~~with any officer~~27, ~~director or shareholder as to any future financing~~2015, ~~either equity or debt. The Company expects to continue to incur losses for~~ the ~~foreseeable future and it is possible the~~ Company ~~may~~sold ~~never~~an ~~reach profitability. Therefore, the Company will require~~ additional ~~capital resources and financing to implement its business plan and continue its operations~~795. ~~The~~25 ~~Company’s~~Units ~~current~~of ~~burn~~Series ~~rate~~D ~~for~~Preferred ~~salaries,~~Stock ~~research~~at ~~programs and professional fees averages about~~ $601,000 per ~~month. Thus~~Unit, itto is16 ~~expected~~different ~~that~~investors ~~the~~for ~~Company~~aggregate ~~currently~~proceeds ~~does~~of ~~not have sufficient cash on hand to operate through the next 12 months~~$795,250. ~~Management~~Meyers ~~believes~~Associates ~~it has enough funds to complete its pre-clinical trials~~L. ~~Management~~P. ~~believes~~received ~~that~~sales itcommissions ~~has~~of ~~enough~~10% ~~funds~~($79,525) toof ~~complete~~the ~~its~~gross ~~pre-clinical~~proceeds ~~trials. If~~of the ~~Company~~sale ~~receives~~of ~~favorable results~~Units, ~~Management~~as ~~believes~~well itas ~~will~~a ~~have~~non-accountable ~~the~~expense ~~ability~~allowance toequal ~~raise additional funds~~ to ~~complete~~3% ~~INDs. In view~~ of ~~general~~the ~~economic~~gross ~~conditions,~~proceeds ~~there~~of ~~can~~the beOffering noand ~~assurance~~received ~~that~~a ~~any~~Unit ~~additional~~Purchase ~~financing~~Option ~~will~~(subsequently betransferred ~~available~~ to ~~us,~~Meyers ~~that~~Investments ~~any~~Family ~~affiliate~~Limited ~~will~~Partnership) ~~provide~~to ~~additional~~purchase ~~investments~~20% inof the ~~Company~~shares orsold ~~that~~in ~~adequate~~the ~~funds for our operations will otherwise be available when needed or on terms acceptable to us~~Offering.

27The Company has no agreements, arrangements or understandings with any officer, director or shareholder as to any future financing, either equity or debt. The Company expects to continue to incur losses for the foreseeable future and it is possible the Company may never reach profitability. Therefore, the Company will require additional capital resources and financing to implement its business plan and continue its operations. The Company’s current burn rate for salaries, research programs and professional fees averages about $204,000 per month. Thus, it is expected that the Company may have sufficient cash on hand to operate through the next 12 months. Management believes it has enough funds to complete its pre-clinical trials. Management believes that it has enough funds to complete its pre-clinical trials. If the Company receives favorable results, Management believes it will have the ability to raise additional funds to complete INDs. In view of general economic conditions, there can be no assurance that any additional financing will be available to us, that any affiliate will provide additional investments in the Company or that adequate funds for our operations will otherwise be available when needed or on terms acceptable to us.

Cash used in operating activities during Fiscal 2013 was ($1,620,199) compared to cash used of ($883,328) during Fiscal 2012. This resulted from a net loss of $1,956,872 in Fiscal 2013, offset by Common Stock and options issued for services of $701,449, a change in derivative liabilities of $3,926, and a decrease in accounts payable and accrued expenses of $368,846. This compared to a loss of $1,310,934 during Fiscal 2012, offset by common Stock and options issued for services of $23,147, a change in derivative liabilities of $8,154, and an increase in accounts payable and accrued expenses of $395,040.31

~~The~~Cash ~~Series~~used Bin ~~Preferred~~operating ~~Stock~~activities ~~sold~~during inFiscal ~~2012~~2014 iswas ~~substantially~~($2,175,964) ~~the~~compared ~~same~~to ascash ~~the~~used ~~Series~~of C($1,620,199) ~~Preferred~~during ~~Stock~~Fiscal ~~with~~2013. ~~regard~~This toresulted ~~dividends however~~from isa ~~convertible~~net ~~into~~loss ~~common~~of ~~shars~~$2,748,190 in Fiscal 2014, offset by non-cash Common Stock and options expense of $251,444, warrants modification valued at $~~0.85~~13,132, ~~per~~warrants ~~share.~~issued ~~Both~~for ~~the~~services ~~Series~~of C$281,283, and Ba ~~Prefered~~decrease ~~Stock~~in ~~are~~accounts ~~junior~~payable toand ~~the~~accrued ~~Series~~expenses Aof ~~Preferred~~26,367 ~~Stock~~This oncompared ~~liquidation~~to ~~and~~a donet ~~not~~loss ~~have~~of ~~anti-dilution~~$1,956,872 ~~price~~in ~~protection~~Fiscal 2013, ~~nor~~offset doby ~~the~~non-cash ~~Class~~Common CStock and Boptions ~~Warrants~~expense ~~issued~~of as$701,449, ~~part~~a change in derivative liabilities of ~~the~~$3,926, ~~Units~~and ~~have~~a ~~anti-dilution~~decrease ~~price~~in ~~protection~~accounts payable and accrued expenses of $368,846.

The Company had net cash provided by financing activities of $21,~~829~~650,~~674~~760 induring the Fiscal ~~2013~~year 2014 as a result of the $31,~~380~~940,000 received in ~~the 2013~~ Private ~~Placement described above~~Placements, reduced by $~~550~~289,~~326~~240 of offering costs. During the Fiscal ~~2012~~year 2013, the Company had ~~$894,826 of~~ net cash provided by financing activities of $2,829,674 as a result of the $13,~~116~~380,~~001~~000 received ~~from~~in the ~~2012~~2013 Private Placement, ofreduced ~~Preferred~~by ~~Stock~~$550,326 ~~less~~of ~~the stock~~ offering costs ~~of $221,175~~.

As a result of the foregoing, the Company’s cash ~~increased~~decreased by $1525,~~209,475~~204 during Fiscal ~~2013~~2014 from $311,~~922~~241,397 to $1716,~~241,397~~193.

The financial statements included in this report have been prepared in conformity with generally accepted accounting principles that contemplate our continuance as a going concern. The Company has had no revenues and has generated losses from operation. As set forth in Note 2 to the audited Financial Statements, the continuation of the Company as a going concern is dependent upon the Company obtaining adequate capital to fund operating losses until it becomes profitable, if ever. The financial statements do not include any adjustments to the recoverability and classification of recorded asset amounts and classification of liabilities that might be necessary should the Company be unable to continue as a going concern.

Results of Operations

Material Changes in Results of Operations

Year ended December 31, ~~2012~~2014, as compared with year ended December 31, ~~2012~~2013

The Company does not expect to receive any revenues prior to late 2015. Total operating expenses during Fiscal ~~2013~~2014 increased to $12,~~953~~742,~~731~~125 as compared with $1,~~312~~953,~~405~~731 during Fiscal ~~2012~~2013 primarily as a result of $~~841~~1,~~502~~927,851 of research and development expenses ~~decreasing~~increasing from $~~939~~841,~~296~~502, offset by professional fees decreased to $413,953 in Fiscal ~~2012~~2014 from $808,865 in Fiscal 2013, related to the continued manufacture and preclinical development of its lead curcumin formulations. General and administrative expenses increased to $5373,~~957~~005 in the ~~2013~~2014 period from $4553,~~596~~957 in Fiscal ~~2012~~2013, primarily as a result of an increase in travel and other office related expenses. Professional fees ~~increased~~decreased to $~~808~~413,~~865~~953 in the ~~2013~~2014 period from $~~121~~808,~~586~~865 in Fiscal ~~2012~~2013, primarily as a result of a ~~increase~~decrease primarily due to an ~~increase~~decrease in amortization of stock options as compared to ~~2012~~2013. Salaries and wages increased to $327,316 in the 2014 period from $249,407 in 2013.

Research and Development fees in Fiscal ~~2013 included $59~~2014,~~739~~ ~~paid to University of Texas, MD Anderson Cancer Center (“UTMDACC”) for non-clinical and mouse pre-clinical non-GLP studies of lipsomal curcumin. Other major research and development expenses~~ included payments to ~~Polymnun~~Dalton Pharma, ~~Nucro Technology~~Gemeinn, ~~University~~Northern ~~of North Texas~~Lipids, DrInc. ~~Robert Heinz~~, ~~John’s~~ClinicPace ~~Hopkin’s University~~Worldwide, ~~Medizinche University~~ and ~~Regis~~Polymun ~~Pharmaceuticals~~ for, $~~260~~69,~~087~~165, $~~149~~8,~~036~~853, $94300,~~289~~661, $40219,~~000~~116, ~~$198,336,~~ and $401,~~015~~138,178, respectively, for lab fees and other costs related to the Company’s research and development efforts. The Company incurred $191,878, in legal fees classified as research and development.

Research and Development fees in Fiscal ~~2012~~2013 included $3459,739 paid to University of Texas, MD Anderson Cancer Center (“UTMDACC”) for non-clinical and mouse pre-clinical non-GLP studies of lipsomal curcumin. Other major research and development expenses included payments to Polymnun, Nucro Technology, University of North Texas, Dr. Robert Heinz,/Johns ~~John’s~~Hopkins ~~Hopkin’s~~ University, Medizinche University and Regis Pharmaceuticals for, $~~221~~260,~~773~~087, $~~174~~149,~~297~~036, $~~115~~94,~~781~~289, $6140,~~273~~000, $40198,~~866~~336, and $~~240~~40,~~567~~015, respectively, for lab fees and other costs related to the Company’s research and development efforts.

~~The~~As ~~amount~~a ~~paid~~result ~~for~~of ~~research~~the ~~and~~foregoing, ~~development~~the inCompany ~~the~~had ~~2013~~a ~~Period~~net ~~consisted~~loss of ~~payments~~2,748,190 ~~for~~in ~~overhead~~Fiscal ~~and~~2014 ~~patent~~as ~~fees~~compared ~~for~~to ~~non-clinical~~a ~~studies~~net ~~and~~loss ~~pre-clinical~~of ~~studies~~$1,956,872 in ~~the~~Fiscal ~~nanocurcumin~~2013. ~~compound~~The ~~and~~Company torecorded ~~produce~~a ~~polymer~~deemed ~~under~~dividend ~~the~~on ~~JHU~~Warrants ~~Agreement~~in ~~for~~Fiscal ~~animal~~2013 ~~studies~~ of ~~nanocurcumin~~$2,445,621. ~~During~~ ~~Fiscal~~The ~~2011,~~amount ~~the~~of ~~Company~~loss ~~paid~~attributable ~~UTMDACC~~to ~~for~~common ~~non-clinical~~shareholders ~~and~~for ~~mouse~~the ~~pre-clinical~~calendar ~~pre-GLP~~year ~~studies~~2014 ofis ~~lipomal curcumin~~$3,388,863. It ~~also~~This ~~includes~~translates ~~expenses relating~~ to ~~development of depotcurcumin,~~ a ~~slow~~loss ~~release~~per ~~formulation. Depotcurcumin~~share ~~was~~of ~~originally made at UNT under non-GLP conditions from curcumin extract~~ (~~and~~$0.25) ~~PLGA,~~in aFiscal ~~chemical~~2014 ~~surrounding~~compared ~~the~~to ~~curcumin~~($0.38) ~~originally~~in ~~purchased~~Fiscal ~~from a U~~2013.~~S. chemical supplier, Sigma Aldrich Fine Chemicals (“SAFC”).~~

As a result of the foregoing, the Company had a net loss of $1,956,872 in Fiscal 2013 as compared to a net loss of $1,310,934 in Fiscal 2012. The Company recorded a deemed dividend, due to the extension of several warrant, in the amount of $2,445,621. The amount of loss attributable to common shareholders for the calendar year 2013 is $4,402,493. This translates to a loss per share of ($0.34) in Fiscal 2013 compared to ($0.10) in Fiscal 2012.

Critical Accounting Policies

We have identified the policies outlined below as critical to our business operations and an understanding of our results of operations. The list is not intended to be a comprehensive list of all of our accounting policies. In many cases, the accounting treatment of a particular transaction is specifically dictated by accounting principles generally accepted in the United States, with no need for management’s judgment in their application. The impact and any associated risks related to these policies on our business operations is discussed throughout Management’s Discussion and Analysis of Financial Condition and Results of Operations where such policies affect our reported and expected financial results. Note that our preparation of the financial statements requires us to make estimates and assumptions that affect the reported amount of assets and liabilities, disclosure of contingent assets and liabilities at the date of our financial statements, and the reported amounts of revenue and expenses during the reporting period. There can be no assurance that actual results will not differ from those estimates.

Basis of Presentation

These financial statements and related notes are presented in accordance with accounting principles generally accepted in the United States, and are expressed in U.S. dollars. The Company’s fiscal year-end is December 31.

Use of Estimates

The preparation of these financial statements in conformity with generally accepted accounting principles in the United States requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the consolidated financial statements and the reported amounts of revenues and expenses during the reporting period. The Company regularly evaluates estimates and assumptions related to valuation and amortization policies on property and equipment and valuation allowances on deferred income tax losses. The Company bases its estimates and assumptions on current facts, historical experience and various other factors that it believes to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities and the accrual of costs and expenses that are not readily apparent from other sources. The actual results experienced by the Company may differ materially and adversely from the Company’s estimates. To the extent there are material differences between the estimates and the actual results, future results of operations will be affected.

Derivative Financial Instruments

The Company generally does not use derivative financial instruments to hedge exposures to cash-flow risks or market-risks that may affect the fair values of its financial instruments. The Company utilizes various types of financing to fund our business needs, including preferred stock with warrants attached and other instruments not indexed to our stock. The Company is required to record its derivative instruments at their fair value. Changes in the fair value of derivatives are recognized in earnings in accordance with ASC 815.

Revenue Recognition

As of the date of this disclosure, the Company has yet to recognize revenues. As the Company continues to develop and implement its business plan, revenue from the performance of services or sale of products will be recognized in accordance with FASB codification standards. Revenue will be recognized only when the price is fixed or determinable, persuasive evidence of an arrangement exists, the service is provided, and collectability is assured.

Basic and Diluted Net Income (Loss) Per Share

The Company computes net income (loss) per share in accordance with FASB codification standards. The standard requires presentation of both basic and diluted earnings per share (EPS) on the face of the income statement. Basic EPS is computed by dividing net income (loss) available to common shareholders (numerator) by the weighted average number of shares outstanding (denominator) during the period. Diluted EPS gives effect to all dilutive potential common shares outstanding during the period using the treasury stock method and convertible preferred stock using ~~the~~their if converted method. In computing Diluted EPS, the average stock price for the period is used in determining the number of shares assumed to be purchased from the exercise of stock options or warrants. Diluted EPS excludes all dilutive potential shares if their effect is anti-dilutive.

Income Taxes

Potential benefits of income tax losses are not recognized in the accounts until realization is more likely than not. The Company has adopted FASB codification regarding the required tax asset benefit computations for net operating losses carry forward. The potential benefits of net operating losses have not been recognized in these ~~consolidated~~ financial statements because the Company cannot be assured it is more likely than not it will utilize the net operating losses carried forward in future years.

Stock-Based Compensation

The Company records stock-based compensation in accordance with FASB codification standards, using the fair value method. All transactions in which goods or services are the consideration received for the issuance of equity instruments are accounted for based on the fair value of the consideration received or the fair value of the equity instrument issued, whichever is more reliably measurable. Equity instruments issued to employees and the cost of the services received as consideration are measured and recognized based on the fair value of the equity instruments issued.”

In accordance with FASB codification standard, the Company estimates the grant-date fair value of its stock options using the Black-Scholes option-pricing model, which takes into account assumptions regarding an expected dividend yield, a risk-free interest rate, an expected volatility factor for the market price of the Company’s common stock and an expected term of the stock options. The fair value of stock options granted is amortized on a straight-line basis over the vesting period. For the years ended December 31, 2014 and 2013, stock-based compensation expense associated with stock options totaled $217,444 and $667,449, respectively.

Plan of Operations

~~The~~Manufacturing ~~Company’s~~of ~~current~~GMP ~~focus~~grade synthesized curcumin is oncontinuing at Sami labs, in India. Over 4.3 kilograms of the ~~manufacture~~active principle was sent to Dalton Pharma Services in Canada for analytical and ~~preclinical~~continuing ~~development~~stability oftesting. ~~its~~Aliquots ~~lead~~of curcumin ~~formulations~~are ~~(intravenous~~sent to Polymun Scientific in Austria to manufacture the formulated GMP grade liposomal curcumin, ~~and~~product. aThe ~~slow~~product ~~release~~is ~~PLGA~~further ~~formulation)~~analyzed ~~with~~for aendotoxins ~~view~~in ~~toward~~Gibraltar ~~filing~~Labs ~~two~~in ~~IND~~New ~~applications~~Jersey, ~~with~~and ~~the~~for ~~FDA~~release kinetics at Northern Lipids in Canada. The ~~Company’s~~final product ~~candidates~~has ~~are~~been ~~still~~used in ~~the~~45 ~~preclinical~~human ~~development~~normal ~~phase~~subjects in a Phase Ia ascending dose trial in Austria. Based upon these data, a Phase Ib clinical trial is ongoing in Austria: accruing as of this date 12 cancer patients who progressed on standard of care therapy.

~~The~~In ~~Company believes that a novel pharmaceutical preparation with enhanced absorption of~~ the ~~active~~US, ~~compound~~following ~~could~~discussions ~~potentially~~and ~~have~~suggestions ~~greater~~by ~~clinical efficacy than~~ the ~~oral~~FDA, ~~versions.~~an ~~The~~IND ~~laboratory~~for ~~and~~liposomal ~~oral~~curcumin ~~administration~~in ~~studies~~a byPhase ~~other~~Ib ~~researchers~~trial towas ~~date~~approved ~~suggest~~in ~~that~~the ~~curcumin~~second ~~has~~quarter ~~high potency~~2014. The ~~Company~~first ~~believes~~indication ~~that~~will anbe ~~alternate route~~ for ~~administering~~non-small ~~this~~cell ~~compound,~~lung ~~such~~cancer ~~as the Company’s parenteral~~ (~~taken into the body other than through the digestive canal~~NSCLC) ~~formulation,~~patients ~~could~~who behave ~~more~~progressed ~~effective~~on atstandard ~~lower dosages. SignPath intends to develop a parenteral liposomal formulation, to overcome the limitations~~ of ~~the~~care ~~oral form~~therapy.

~~SignPath~~Following ~~believes~~allowance ~~that~~of the ~~development~~protocol ~~and~~by ~~comparison~~the ~~of liposomal curcumin~~FDA, ~~and~~a ~~the~~second ~~PLGA formulation could expose potential differences in biological effects and distribution to different tissues. The Company intends to manufacture good manufacturing practice (GMP) grade of~~ liposomal curcumin indication, ~~and~~for ~~the~~progressive ~~PLGA~~Parkinson’s ~~formulation.~~disease ~~These formulations~~ will ~~require~~be ~~outsourcing~~submitted ~~production~~ to ~~one or more commercial facilities. Our initial goals are to obtain sufficient material for in vitro and animal analysis and to develop these formulations in order to submit INDs to~~ the FDA. ~~Determination of safety, dosage, and efficacy of these formulations in a quantifiable manner will permit us to pursue clinical registration trials~~ for a ~~variety of malignant diseases. Following submission of the INDs, the Company plans to initially run~~ Phase III ~~studies~~trial ~~with~~at ~~both~~Thomas ofJefferson ~~the parenteral formulations in patients with treatment refractory malignant disease~~University. ~~Subsequently, if the Phase I trials are successful, the Company plans to seek FDA authorization to run Phase II trials in selected malignancies.~~

~~Liposomal~~A ~~curcumin:~~veterinary ~~The~~application ~~Company has agreements with contract manufacturers for the manufacture, chemistry, and controls for supplies~~ of ~~the drugs to be tested. Liposomal curcumin is manufactured by our contract manufacturer, Polymun, Inc. Initial quantities of GMP grade~~ liposomal curcumin toin ~~conduct~~dogs ~~preclinical~~with ~~studies~~progressive tocancer ~~corroborate previously published data from other researchers were obtained from Sigma Aldrich Fine Chemicals (“SAFC”) or from Sabinsa. Final production of liposmal curcumin GMP~~ was ~~completed~~initiated ~~at Polymun in Vienna, Austria~~ during ~~2009. Using Iipocurc, anti-cancer activity without toxicity in human colon and pancreatic cancer xenograft models were published. Following~~ the ~~determination~~1st ofquarter ~~safety and the optimum dosage and schedule in the most sensitive~~ of 2014 ~~the~~at ~~three species, we will be able to estimate starting dosages for Phase I trials in humans~~U.C. WeDavis ~~plan to outsource corroborative studies of Iiposomal absorption, distribution, metabolism,~~ and ~~excretion~~is ~~(ADME),~~continuing: ~~and~~6 ~~pharmacokinetics in rats with the aim of estimating optimum dosage schedules, as well as dosage and safety in mice, rats and~~ dogs toare ~~satisfy~~under ~~IND regulations to GLP laboratories in M~~study.~~D. Anderson Cancer Center in Houston, Texas.~~

~~Nanocurcumin:~~Preclinical ~~The~~Non-GLP ~~Company~~formulated ~~intends~~product tounderwent ~~obtain~~repeat ~~commercial~~efficacy ~~volumes~~trials ~~of purified curcumin from third party manufacturer, Sabinsa,~~ in ~~quantities~~mice ~~suitable~~with toxeno-transplanted ~~satisfy~~human ~~preclinical~~NSCLC ~~and~~tumors ~~clinical~~with ~~demands.~~a ~~The~~52% ~~Company~~reduction ~~believes~~in ~~that~~growth ~~the manufacture~~ of ~~Iiposomal~~tumor ~~curcumin~~observed ~~can~~after ~~also~~six beweeks ~~scaled~~Non-clinical scale-up asmanufacturing ~~necessary~~of ~~since~~GMP ~~these~~grade ~~substances~~Liposomal-PLGA-curcumin ~~are readily available from commercial sources utilizing established production technologies. We have completed non~~(Curcumin-~~clinical~~ER): and ~~preclinical~~extended ~~analyses~~release offormulation ~~nanocurcumin~~ at ~~the~~Sami ~~NCI~~labs ~~Nanocharacterization Laboratory. A parenteral formulation of nanocurcumin~~ in ~~human~~India ~~pancreatic~~and ~~cancer~~research ~~xenografts~~is inplanned ~~nude~~for ~~mice has demonstrated anti-cancer effects. We will measure inhibiting effects of curcumin on disease progression in Parkinson’s Disease patients at~~ the ~~Thomas~~2nd quarter ~~Jefferson University~~of 2015.

30The liposome composed of DMPC and DMPG was initially discovered to prevent curcumin induced cardiac arrhythmias in in vitro, in ex vivo studies in rabbit models, and in vivo in rabbit models challenged with clinically approved QTc prolonging anticancer drugs, Crizotinib and Nilotinib. Additional studies of anticancer QTc prolonging drugs and liposome mitigation are current in the 4th quarter, 2014. Additional exploration of the molecular mechanism of action of the liposome, its component lipids, and metabolites in the cardiac potassium channel began in the 4th quarter of 2014 in a collaborative study with Avanti Polar Inc., IPS Therapeutique, Canada. The optimum compound of oral formulations with a eutectic mixture and DMPC,DMPG, LysoPC ,LysoPG and EGPG are being studied at IPS therapeutic to decide upon a lead compound to take into the clinic. Animal toxicology at Nucro Technics Inc. in 1st quarter of 2015 will follow.

The effects of liposomal curcumin on mercury poisoning in mice are being explored at Thomas Jefferson University, Philadelphia commenced in the 4th quarter of 2014.

ITEM 7A. Quantitative and Qualitative Disclosures About Market Risk

Not required.

ITEM 8. FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA

The Report of the Independent Registered Public Accounting Firm appears on ~~page~~pages 4446-47 and the Financial Statements and Notes to Financial Statements appear on in Part IV of this Report.

ITEM 9. CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIAL DISCLOSURES.

None.

ITEM 9A. CONTROLS AND PROCEDURES

The chief executive officer and the chief financial officer, after evaluating the effectiveness of the Company’s “disclosure controls and procedures” (as defined in the Securities Exchange Act of 1934 Rules 13a-15(e) and 15d-15(e); collectively, “Disclosure Controls”) as of the end of the period covered by this annual report (the “Evaluation Date”) have concluded that as of the Evaluation Date, our Disclosure Controls were not effective to provide reasonable assurance that information required to be disclosed in our reports filed or submitted under the Securities Exchange Act of 1934 is recorded, processed, summarized and reported within the time periods specified by the SEC, and that material information relating to our company and any consolidated subsidiaries is made known to management, including the chief executive officer and chief financial officer, particularly during the period when our periodic reports are being prepared to allow timely decisions regarding required disclosure.

Management assessed the effectiveness of our internal control over financial reporting as of the Evaluation Date based on criteria for effective internal control over financial reporting described in Internal Control—Integrated Framework issued by the Committee of Sponsoring Organizations of the Treadway Commission. Based on this evaluation, management has determined that as of the Evaluation Date, there were material weaknesses in our internal control over financial reporting. The material weaknesses identified during management’s assessment were (i) a lack of sufficient internal accounting resources; and (ii) a lack of segregation of duties to ensure adequate review of financial statement preparation. In light of these material weaknesses, management has concluded that we did not maintain effective internal control over financial reporting at the Evaluation Date.

Management is responsible for establishing and maintaining adequate internal control over financial reporting for the Company. As defined by the Public Company Accounting Oversight Board Auditing Standard No. 5, a material weakness is a deficiency or a combination of deficiencies, such that there is a reasonable possibility that a material misstatement of the annual or interim financial statements will not be prevented or detected. A clear and concise segregation of duties is important to maximize checks and balances so that no single individual has control over two or more phases of a transaction or operation. A strong segregation of duty also is critical to reduce effectively the risk of mistakes and inappropriate actions preventing fraud and discourages collusion. It can be difficult for small businesses to always have a clear separation of duties because there simply are not enough personnel to cover each and every process and procedure. Ultimately, checks and balances need to be in place as a supportive measure to the business operations, but also as a fraud prevention measure as well. Because we have limited financial personnel, and limited resources, compliance with segregation of duties and proper oversight of control requirements is extremely difficult In connection with the evaluation referred to in the foregoing paragraph, we have identified no change in our internal control of financial reporting that occurred during the ~~quarter~~year ended December 31, ~~2013~~2014, that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

We are a non-accelerated filer and are required to comply with the internal control reporting and disclosure requirements of Section 404 of the Sarbanes-Oxley Act for fiscal years ending December 31, ~~2013~~2014. Although we are working to comply with these requirements, we have limited financial personnel, making compliance with Section 404 – especially with segregation of duty control requirements – very difficult and cost ineffective, if not impossible. This annual report does not include an attestation report of the Company’s registered public accounting firm regarding internal control over financial reporting. Management’s report was not subject to attestation by the Company’s registered public accounting firm pursuant to rules of the Securities and Exchange Commission that permit the company to provide only management’s report in this annual report.

ITEM 9B. OTHER INFORMATION

NONE

PART III

ITEM 10. DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE

Set forth below is also a brief description of the relevant business and/or scientific experience and background of each person named below.

Officers, Directors and Other Key Staff

Our current officers, directors, and other key advisors to the Company consist of:

Name	Age		Position	~~Position~~
Lawrence Helson, BSci, BMed, M.Sci, MD	83	83	Chief Executive Officer, Chief Financial Officer, Director, and President	~~Chief Executive Officer, Director, and President~~
Arthur P. Bollon, Ph.D.	72	71	Director	~~Director~~
Jack Levine, CPA	64	63	Director	~~Director~~

Lawrence Helson, BSci, BMed, M.Sci, MD

Dr. Helson has served as Chief Executive Officer, Director and President of the Company since May 28, 2008. From 1967 to 1986, Dr. Helson was employed at Memorial Sloan Kettering Cancer Center NYC, the last 12 years as attending physician. From 1982 to 1986, he was an associate attending pediatrician at Cornell University Medical School, New York City. From 1986-1987 he was director of Phase III clinical trials of Zoladex ICI in Delaware. From 1987 to 1997 he was Professor of Pediatric and Adult Oncology at New York Medical College, Valhalla, NY. From 1997 to 2007 he was a founder-scientist at Onconova Inc, a biotechnology company in Princeton, New Jersey, and since 1993 has also been part-time Vice President of Bio-Research at NaproBiotherapeutics, Boulder, Colorado. He has held oncology consulting positions from 1985 to 1997 at Bambino Jesu Hospital, Vatican City, Metaxa Hospital; Pireaus, Greece; and for the Brazilian Consulate in New York City. From 2003 until present, he has provided unpaid informal consulting services to HemoBiotech Inc, in Dallas, Texas. He ran various research laboratories at Sloan Kettering Institute from 1973-1985, from 1987 to 1997 at New York Medical College, and from 2002 to 2005 for NaproBiotherapeutics (now Tapestry Pharmaceuticals) in Allentown, Pennsylvania. Dr. Helson has over 200 peer reviewed publications and 4 Issued Patents. He initiated the bone marrow transplant program at Memorial Sloan Kettering Hospital in 1973, and published the first peer reviewed paper in the journal Nature on Tumor Necrosis Factor in 1975. His laboratory research also developed six human neural tumor cell lines which are in the ATCC and English repositories and are distributed worldwide. He also edits the journal Anticancer Research, published in Athens, Greece and was an editor for Nude Mouse Heterotransplantation Research, published by Karger and Co.

Arthur P. Bollon, Ph.D.

Dr. Arthur P. Bollon has served as a director of the Company since May 28, 2008. Dr. Bollon has more than 25 years of experience in biotechnology as a scientist, executive and entrepreneur. Since 2011, Dr. Bollon has been Chairman and CEO of Vitruvian BioMedical, Inc., which is developing an Alzheimer Disease Vaccine and diagnostic technologies. From October 2003, until August 2010, he was the Chairman, President and Chief Executive Officer ~~and since August 2010, he is a consultant~~ to HemoBioTech, Inc. which is developing HemoTech, a potential substitute for human blood. He is a founder and had served as Chairman and Chief Executive Officer of Wadley Biosciences Inc./LPL, a joint venture between Wadley Cancer Center and Phillips Petroleum which focused on cancer and immune disease therapeutics from 1987 to 1991. From 1992 to 2000, he was a founder, Chairman and Chief Executive Officer of Cytoclonal Pharmaceutics Inc. which focused on cancer and infectious disease therapeutics. While at Cytoclonal, he completed an initial public offering. In addition, he has completed research contracts with multiple universities including UCLA, Montana State University, University of California at San Diego, Texas Tech University and University of British Columbia and licensing agreements with Brisol Meyers-Squibb, Phillips Petroleum, Merck & Co. and Nuron Biotech.

From 1979 through 1987, Dr. Bollon served as Chairman of the Department of Molecular Genetics and Director of Genetic Engineering at the Wadley Cancer Center focusing on the cloning of human cytokine genes for treatment of cancer. Prior to Wadley, he was a faculty member at the University of Texas Southwestern Medical School and Adjunct Professor in the Department of Molecular and Cell Biology at the University of Texas at Dallas. He is the author of multiple scientific communications including Editor of “Recombinant DNA Products: Insulin, Interferon and Growth Hormone,” by CRC Press. Dr. Bollon received his Ph.D. in molecular genetics from the Waxman Institute of Microbiology at Rutgers University and was a Post-Doctoral Fellow at Yale University.

Jack Levine, CPA

Jack Levine was appointed to the Board of Directors of the Company on July 12, 2010. Mr. Levine, a Certified Public Accountant, has been advising private companies for over 30 years. As of November 2011, he was elected Chairman of the Audit Committee ~~and Chairman~~ of ~~the Nominating and Corporate Governance Committee of~~ Provista Diagnostics, Inc., a cancer detection and diagnostics company focused on women’s cancer. The company has established partnerships that allow access to some of the most innovative biomarkers in the molecular oncology market. He has been a director of Biscayne Pharmaceuticals, Inc. since January 2013. Biscayne is a biopharmaceutical company discovering and developing novel therapies based on growth hormone-releasing hormone(GHRH) analogs. The company’s technology stems from the discoveries of Dr. Andrew V. Schally, a Nobel laureate and pioneering endocrine drug developer. From 1999 to 2007 he served as an Independent Board Member to Pharmanet, Inc. ~~(Nasdaq)~~ where from 2006-2007, he served as Chairman of the Board; in 2005, was a member of the Nominating Committee, Lead Director in 2004; a member of the Compensation Committee in 2003, a Chairman of the Audit Committee in 1999. Pharmanet is a global drug development services company providing a comprehensive range of services to pharmaceutical biotechnology, generic drug and medical device companies that was traded on Nasdaq and has since been acquired. From 2004-2008, Mr. Levine served as Chairman of the Audit Committee of Grant Life Sciences (OTCBB), an R&D company focused on early detection of cervical cancer and also providing medical diagnostic kits. From 2000-2006, Mr. Levine was Chairman either of the Audit Committee, Executive Committee or ALCO Committee of Beach Bank, Miami Beach, Florida. He also served as Chairman of the Audit Committees of Prairie Fund (2000-2006) and Bankers Savings Bank (1996-1998). From 2004-2006, Mr. Levine was a member of the Audit Committee of Miami Dade County School Board, the nation’s third largest school system with an annual budget exceeding $5 Billion. Mr. Levine currently sits on the Board of Biscayne Pharmaceuticals, Inc. Biscayne is a biopharmaceutical company discovering and developing novel therapies based on growth hormone-releasing hormone (GHRH) analogs. Mr. Levine has been a Board Member since January 2013.

Mr. Levine has been a licensed CPA in Florida since 1983 and in New York since 2009. He has been a Committee member of the State of Florida – Florida Bar since 1993 and a Board Member of the Southeast Region of the American Friends of Bar-Ilan University since 2002.

Audit Committee

The Company’s audit committee presently consists of one member, Jack Levine. Mr. Levine is an Audit Committee Financial Expert as defined in Item 407(d)(5)(i) of Regulation S-K. The audit committee’s duties are to recommend to our board of directors the engagement of independent auditors to audit our financial statements and to review our accounting and auditing principles. The audit committee reviews the scope, timing and fees for the annual audit and the results of audit examinations performed by independent public accountants, including their recommendations to improve the system of accounting and internal controls. The audit committee oversees the independent auditors, including their independence and objectivity. However, the committee members are not acting as professional accountants or auditors, and their functions are not intended to duplicate or substitute for the activities of management and the independent auditors. The audit committee is empowered to retain independent legal counsel and other advisors as it deems necessary or appropriate to assist the audit committee in fulfilling its responsibilities, and to approve the fees and other retention terms of the advisors. Our audit committee member possesses an understanding of financial statements and generally accepted accounting principles.

Director Independence

The Company presently does not have any other committees of the Board of Directors, including compensation, nominating and corporate governance, and the Board acts together on all matters. We are not required to comply with the director independence requirement of any securities exchange. In determining whether our directors are independent, however, we intend to comply with the independent rules of Nasdaq provided by Rule 4200(a)(15). As of the date of this report, Dr. Arthur Bollon and Jack Levine, two of our three directors, are non-officer independent members of the Board of Directors.

Scientific Advisory Board

SignPath has established a Scientific Advisory Board (“SAB”) to review the research projects of SignPath and of partnerships in which SignPath is a partner and analyze the progress and direction of the research projects; to consider and advise SignPath with respect to any proposed or future research projects; and to consider and suggest general areas of research to be pursued or significant products that should be developed.

Members of the SAB, acting as independent contractors, shall provide consulting services to the Company from time to time as requested. Members are expected to be available for telephonic conversations and for review of proposed products from time to time. The consulting agreements are renewable on an annual basis and are subject to termination on 30 days prior written notice by either party. The Company will pay its SAB members a reasonable royalty, to be negotiated on a case by case basis, from revenues derived by the Company as a result of any inventions, improvements or projects submitted by the advisors. The current members of the SAB and their biographical information are as follows:

Lawrence Helson, MD, See “Management” above.

Arthur Bollon, PhD, See “Management” above.

33Anirban Maitra, MBBS, is the recipient of the Sponsored Research Agreement Johns Hopkins Hospital Preclinical nanocurcumin development. Dr. Maitra holds a Medical degree from All India Institute of Medical Sciences at New Delhi, India in 1996. He then had a residency in Anatomic Pathology from University of Texas Southwestern Medical Center Dallas followed by a Fellowship in Pediatric Pathology Dallas Children’s Medical Center and Gastrointestinal/liver Pathology clinical research fellowship at Johns Hopkins in 2001, with a faculty appointment in 2002. Currently, he is Associate Professor of Pathology and Oncology, and on the faculty of McKusick-Nathans Institute of Genetic Medicine. He is associate editor of Current Molecular Medicine and has five major awards for his research contributions. His research activities include mechanism-based cancer-specific therapies for pancreatic cancer exploring small molecule inhibitors of developmental signaling pathways, high-throughput approaches for identification of abnormal pancreatic cancer genes, and using targeted nanoparticles as novel drug delivery systems to enhance therapeutic efficacy while restricting side effects. This latter research is supported by a Sponsored Research Agreement with SignPath Pharma Inc.

Anirban Maitra, MBBS, is its recipient of the Sponsored Research Agreement Johns Hopkins Hospital Preclinical nanocurcumin development. Dr. Maitra holds a Medical degree from All India Institute of Medical Sciences at New Delhi, India in 1996. He then had a residency in Anatomic Pathology from University of Texas Southwestern Medical Center Dallas followed by a Fellowship in Pediatric Pathology Dallas Childrens Medical Center and Gastrointestinal/liver Pathology clinical research fellowship at Johns Hopkins in 2001, with a faculty appointment in 2002. Currently, he is Associate Professor of Pathology and Oncology, and on the faculty of McKusick-Nathans Institute of Genetic Medicine. He is associate editor of Current Molecular Medicine and has five major awards for his research contributions. His research activities include mechanism-based cancer-specific therapies for pancreatic cancer exploring small molecule inhibitors of developmental signaling pathways, high-throughput approaches for identification of abnormal pancreatic cancer genes, and using targeted nanoparticles as novel drug delivery systems to enhance therapeutic efficacy while restricting side effects. This latter research is supported by a Sponsored Research Agreement with SignPath Pharma Inc.

Tauseef Ahmed, MD, is the medical director of the Zalman A. Arlin Cancer Institute at Westchester County Medical Center. He also serves as Chief to the division of oncology at New York Medical College as well as Professor of Medicine. He stands on 11 cancer-related committees including serving as Chair of the Cancer Committee and the Oncology Steering Committee at Westchester Medical Center. Dr. Ahmed is widely published with over 130 peer reviewed articles appearing in various medical journals.

Judith A. Smith, Pharm.D. FCCP, BCOP, is Asst. Professor Dept. Gynecology, Division of Surgery, MD Anderson Director, Translational Research Fellowship Division of Pharmacy and Head, Curcumin Group UT MD Anderson Cancer Center. Dr. Smith received a Bachelor of Science in Pharmacy from Union University Albany College of Pharmacy in 1996 and completed a Doctor of Pharmacy degree in 1997. She completed a residency in Oncology Pharmacy Practice with a Pharmacy Practice equivalent at the National Institutes of Health. After residency, Dr. Smith completed a two-year fellowship in Clinical Pharmacology at the University of Texas M.D. Anderson Cancer Center (MDACC), then joined the Faculty at UT MD Anderson Cancer Center. Currently, Dr. Smith is Director of Pharmacology Research and an Associate Professor in the Department of Gynecologic Oncology, Division of Surgery at MDACC. In addition, she has a joint-faculty appointment as an Assistant Professor in the Department of Obstetrics and Gynecology at the University of Texas Health Science Center (UTHSC) at Houston Medical School and also in the Department of Clinical Sciences and Administration at the University of Houston College of Pharmacy where Dr. Smith is the course coordinator for two graduate elective courses. She is an active clinical pharmacist in the Gynecology Oncology Center at MDACC as well as the Core Pharmacology Laboratory Director at UTHSC Medical School at Houston. Her research focus is on drug development for gynecologic cancers and conditions with a specific focus on drug interactions/drug resistance with a focus on integration of herbal and nutritional supplements for treatment of cancer.

Muhammad Majeed, PhD., is the Founder, President, and Chief Executive Officer, Sabinsa Corporation, a manufacturer of fine chemicals for nutritional, pharmaceutical and food industries. Dr. Majeed received a B. Pharm. from Trivandrum Medical College, India; MS in Pharmacy and PhD in Industrial Pharmacy in New York in 1975. He worked in Pfizer, Carter Wallace and other major companies on drug formulations prior to establishing Sabinsa Corp. whose goal was to integrate modern pharmaceutical technology with Ayurvedic medicine. He developed methods to extract and synthesize medicinal products such as Boswellin, curcuminoids, gugulipids, bioperine, citrine, petro Selenic acid, and 50 other standardized products which are marketed globally with the US and Japan as the major markets. Currently Sabinsa manufactures synthetic intermediates used in pharmaceutical herb powders. Manufacturing, Research and Development is in India. His company has 32 U.S. and international patents.37

~~George~~Muhammad ~~M. Shopp~~Majeed, ~~PhD~~Ph.D., ~~DABT~~ is ~~a private consultant assisting clients in~~ the ~~nonclinical~~Founder, ~~discovery~~President, and ~~development~~Chief ofExecutive ~~small~~Officer, ~~molecule~~Sabinsa ~~and~~Corporation, ~~biological~~a ~~therapeutics.~~manufacturer Heof ~~has~~fine 33chemicals ~~years~~for ~~experience in the fields of toxicology~~nutritional, ~~pharmacology,~~pharmaceutical ~~pharmacokinetics~~ and ~~drug~~food ~~development~~industries. ~~This~~Dr. ~~includes~~Majeed ~~two~~received ~~years~~a atB. ~~toxicology~~Pharm. ~~contract~~from ~~research~~Trivandrum ~~organizations~~Medical ~~(CRGs)~~College, 12India; ~~years~~MS in ~~grant~~Pharmacy and ~~contract~~PhD ~~supported~~in ~~basic~~Industrial ~~and~~Pharmacy ~~applied~~in ~~research~~New ~~(Medical~~York ~~College~~in ~~of Virginia and Lovelace Medical Foundation)~~1975. ~~Fourteen~~He ~~years~~worked in ~~industrial drug development including: 3 years at Synergen responsible for all regulatory and research investigational toxicology; 2 years at Genentech directing the research toxicology group~~Pfizer, ~~and~~Carter ~~responsible~~Wallace ~~for nonclinical development of growth factors~~ and ~~monoclonal~~other ~~antibodies;~~major ~~and~~companies ~~Elan~~on ~~Pharmaceuticals~~drug ~~for~~formulations 9prior ~~years~~to ~~responsible~~establishing ~~for~~Sabinsa ~~global~~Corp. ~~nonclinical~~whose ~~development~~goal ~~and~~was ~~research~~to ~~toxicology~~integrate ofmodern ~~small~~pharmaceutical ~~molecule~~technology ~~drugs~~with ~~and~~Ayurvedic ~~biopharmaceutics~~medicine. ~~Therapeutic~~He ~~areas~~developed ~~include:~~methods ~~Alzheimer’s~~to ~~disease,~~extract ~~Parkinson’s~~and ~~disease,~~synthesize ~~pain,~~medicinal ~~migraine,~~products ~~oncology,~~such ~~diabetes,~~as ~~epilepsy~~Boswellin, ~~stroke~~curcuminoids, ~~rheumatoid arthritis~~gugulipids, ~~inflammatory bowel disease~~bioperine, ~~and sepsis. Drug classes include: enzyme inhibitors~~citrine, ~~ion~~petro ~~channel~~Selenic ~~blockers~~acid, ~~anti-angiogenesis factors, growth factors, monoclonal antibodies, human proteins,~~ and ~~polyethylene~~50 ~~glycol~~other ~~conjugated~~standardized ~~molecules.~~products ~~Areas~~which ofare ~~expertise~~marketed ~~include:~~globally ~~building~~with ~~and managing skilled and efficient nonclinical safety groups in~~ the ~~pharmaceutical~~US ~~industry, global nonclinical development of small molecule~~ and ~~protein drugs, regulatory toxicology (FDA, ED and~~ Japan), ~~performing~~as ~~due~~the ~~diligence~~major onmarkets. ~~potential~~Currently inSabinsa ~~licensed~~manufactures ~~programs,~~synthetic ~~conducting~~intermediates ~~inhouse~~used ~~and contract GLP pharmacology/toxicology/ADME/PK studies,~~ in ~~vitro~~pharmaceutical ~~toxicity~~herb ~~testing~~powders. ~~and screening~~Manufacturing, inResearch ~~vivo disease models, research~~ and ~~investigational~~Development ~~toxicology,~~is ~~assessment~~in ofIndia. ~~immunotoxicologic/host~~His ~~resistance/hematopoietic~~company ~~effects~~has of32 ~~drugs and chemicals, flow cytometry, and pulmonary toxicology/immunology~~U. DrS. Shopp was President of the Board of Directors for the American Board of Toxicology in 2003. He has a PhD in Pharocolgy Toxicology from the Medical College of Virginia, post doctoral work in pulmmary immunology/ toxicology and ainternational ~~BS in Biology and Chemistry from Bucknell University~~patents.

34George M. Shopp, PhD. DABT is a private consultant assisting clients in the nonclinical discovery and development of small molecule and biological therapeutics. He has 33 years of experience in the fields of toxicology, pharmacology, pharmacokinetics and drug development. This includes two years at toxicology contract research organizations (CRGs), 12 years in grant and contract supported basic and applied research (Medical College of Virginia and Lovelace Medical Foundation). Fourteen years in industrial drug development including: 3 years at Synergen responsible for all regulatory and research investigational toxicology; 2 years at Genentech directing the research toxicology group, and responsible for nonclinical development of growth factors and monoclonal antibodies; and Elan Pharmaceuticals for 9 years responsible for global nonclinical development and research toxicology of small molecule drugs and biopharmaceutics. Therapeutic areas include: Alzheimer’s disease, Parkinson’s disease, pain, migraine, oncology, diabetes, epilepsy, stroke, rheumatoid arthritis, inflammatory bowel disease, and sepsis. Drug classes include: enzyme inhibitors, ion channel blockers, anti-angiogenesis factors, growth factors, monoclonal antibodies, human proteins, and polyethylene glycol conjugated molecules. Areas of expertise include: building and managing skilled and efficient nonclinical safety groups in the pharmaceutical industry, global nonclinical development of small molecule and protein drugs, regulatory toxicology (FDA, ED and Japan), performing due diligence on potential in licensed programs, conducting in-house and contract GLP pharmacology/toxicology/ADME/PK studies, in vitro toxicity testing and screening, in vivo disease models, research and investigational toxicology, assessment of immunotoxicologic/host resistance/hematopoietic effects of drugs and chemicals, flow cytometry, and pulmonary toxicology/immunology. Dr. Shopp was President of the Board of Directors for the American Board of Toxicology in 2003. He has a PhD in Pharocolgy Toxicology from the Medical College of Virginia, post-doctoral work in pulmonary immunology/toxicology and a BS in Biology and Chemistry from Bucknell University.

Robert H. Horne, MDM.D. has been an orthopedic and hand surgeon since 1966. Since 2009 he has been on the staff of Mee Memorial Hospital, King City, Oklahoma and prior thereto Claxton-Hepburn Hospital, Ogdensberg, New York from 1968 to 2008 he was in private practice in Salt Lake City, Utah. Prior thereto, he was Chief of Surgical Services at McClellan U.S. Air Force Base from 1963 to 1965. From 2007 to 2008, Dr. Horne was Honorary President, Utah Medical Association. Dr. Horne received his Doctor of Medicine from Cornell University Medical College in 1960.

Peter Sordillo MDM.D. PhD ~~has~~was ~~been~~ on the attending staff of Hematology and Medical Oncology at Lenox Hill Hospital, New York, New York ~~since~~from 1987 until his retirement in 2014. He is also a consultant to Institute for Ultrafast Spectroscopy and Lasers, Physics Department of City University of New York. From 1981 to 1989, he was an oncologist on the attending staff of Solid Tumor Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center. Dr. Sordillo received his Diplomate of American Board of Medical Oncology in 1981 and his Diplomate of American Board of Internal Medicine in 1977. Dr. Sordillo received his Doctor of Medicine from New York Medical College in 1974, his Ph.D. in Physics from Columbia University in 1990 and his M.S. in Physics from New York University in 2001.

Business Advisory Board

Adam ~~Scheer~~Sheer was elected a member of the Company’s Business Advisory Board in January 2012. He is a consultant to the equities business. From January, 2010 until January 2011 he was a consultant to Magnetar Capital in Chicago. From September 2007 until January 2010, he was a managing principal and Chief Investment Officer to Aldebaran Investors, a SPAC (Special Purpose Acquisition Company). From January, 2005 until September 2007, Mr. Scheer was portfolio manager for SPACs at Fir Tree Partners. He started his career at Goldman ~~Sacks~~Sachs/SpeerLeeds and ~~Kellog~~Kellogg as a trader trainee in 2002. Mr. Sheen holds a B.A. in International Economics & Commerce from Lafayette College.

Contingency Plan

In the event that Dr. Helson, our current CEO, is unable to fulfill his duties due to a short-term, long-term, or permanent absence, the Company ~~expects~~has ~~that~~adopted a contingency plan setting forth a recommended plan for the governance of the Company. Under the terms of the contingency plan, Dr.~~Tauseef~~ ~~Ahmed~~George ~~will~~Shopp, ~~serve~~a asmember ~~acting~~of ~~CEO~~our ~~until~~Scientific Advisory Board, is expected to supervise our general and preclinical science, and Dr. Peter Sordillo, a ~~permanent~~member ~~replacement~~of our Scientific Advisory Board, is ~~found~~expected to supervise our clinical issues, trials and related matters. Drs. Shopp and Sordillo are expected to enter into employment agreements with the Company under their current positions, and Dr. Shopp would become interim CEO if Dr. Helson is unable to perform his duties.

ITEM 11. EXECUTIVE COMPENSATION

~~The~~On February 20, 2013, the Company has entered into a three-year employment agreement with Dr. Lawrence Helson to secure his services as Chairman, President and Chief Executive Officer. The contract ends February 20, 2016. Pursuant to this Agreement, Dr. Helson will receive a base salary of $204,000 per annum. On ~~February~~May 201, ~~2013~~2014, heDr. ~~agreed~~Helson ~~to waive $104,000 of his accrued $204,000 salary for 2012 and~~ received options to purchase 200,000 shares of Common Stock exercisable at $01.8525 per share~~. As~~ offor ~~December~~services ~~31,~~rendered ~~2012,~~during ~~the~~2013. On ~~Company~~February ~~booked~~20, an2013, ~~accrual~~he ~~for~~agreed ~~the~~to ~~waived~~waive ~~compensations totaling~~ $104,000~~. On~~ ~~December~~of ~~28,~~his ~~2010~~accrued ~~and December 22~~$200,000 ~~2011,~~salary ~~the~~for ~~Board~~2012 ofand ~~Directors~~received ~~awarded~~options ~~Dr.~~to ~~Helson~~purchase ~~(and/or his assignees) 300~~200,000 ~~restricted~~ shares of Common Stock onexercisable ~~each~~at ~~date~~$0.85 inper ~~lieu of all accrued and unpaid salary and any bonus~~share.

Dr. Helson will be eligible to receive stock options to purchase up to 250,000 shares of Common Stock exercisable at $0.85 per share for 10 years from the date of grant upon initiation of Phase ~~1(b)~~Ib trials and approvals from either the U.S. FDA to initiate Phase 2II trials on one or more cancer indications. Dr. Helson would also then be entitled to a 20% increase in salary. Upon successful completion of one or more clinical Phase 2II trials and approvals from (either or both the FDA and EMA to initiate Phase 3III trials on at least one cancer indication, Dr. Helson shall be granted stock options to purchase 250,000 shares of the Company’s common stock exercisable at $1.25 per share and an increase in salary to $325,000 per annum. If the Company is acquired or a Change of Control takes place at a price not less than $500 million before the completion of either of these milestones and/or other milestones authorized on December 12, ~~both~~2014 described below, all bonuses shall be payable upon closing of such transaction.

Dr. Helson may terminate the agreement upon 30 days’ prior written notice. If the Company terminates without Cause (as defined) or Dr. Helson terminates for Good Reason (as defined) or a Disability, the Company shall pay Dr. Helson in addition to all accrued compensation, a severance payment equal to two times Dr. Helson’s then current base salary. The Company shall also pay the severance payment in the event it fails to notify Dr. Helson of its intentions to continue employment past the expiration date no less than 90 days prior to the expiration date, or if they fail to reach an agreement on a new employment agreement prior to the expiration date. The severance payment shall be paid 25% upon termination and the balance in five equal monthly installments commencing one month after termination. Dr. Helson’s employment agreement provides for a non-compete for one year following termination of employment with any business primarily involved in the development, marketing and licensing that are in competition with the Company’s products or the Company was in the process of developing at termination.

35On December 12, 2014, the Board of Directors authorized an amendment to Dr. Helson’s employment agreement to provide that: (A) upon successful completion of Phase I trials for anti-Ebola testing in Africa paid for by the United States Army Medical Research Institute of Infectious Diseases (“USAMRIID”), exclusive of the cost of drug products and shipping, Dr. Helson would receive options to purchase 300,000 shares of Common Stock exercisable at then current fair market value and a cash bonus of $75,000, and (B) upon successful completion of Phase I trials in Vienna, Austria for the lead anti-QT prolongation drugs (Moxifloxacin) for liposomes Dr. Helson would receive additional options to purchase 300,000 shares of Common Stock exercisable at then current fair market value and a cash bonus of $25,000.

~~Members of the~~ Scientific Advisory Board (SAB) are reimbursed for reasonable expenses incurred in connection with travel to attend SAB meetings. We expect a maximum of one SAB meeting will be held per year. Advisors will be paid $2,000 for attending each meeting called by SignPath. Options to purchase common shares of SignPath may be made available to the Advisor under the 2009 Option Plan.

~~The~~Members ~~following~~of ~~table~~the ~~sets~~Scientific ~~forth,~~Advisory Board (SAB) are reimbursed for reasonable expenses incurred in connection with ~~respect~~travel to ~~the~~attend ~~Company’s~~SAB ~~fiscal~~meetings. We ~~years~~expect ~~ended~~a ~~December~~maximum ~~31,~~of ~~2013~~one ~~and~~SAB ~~2012,~~meeting ~~all~~will ~~compensation~~be ~~earned~~held byper year. Advisors will be paid $2,000 for attending each ~~person~~meeting ~~who~~called isby ~~required~~SignPath. Options to purchase common shares of SignPath may be ~~listed~~made ~~pursuant~~available to ~~Item~~the ~~402(m)(2)~~advisors under the 2009 Option Plan. On December 10, 2014, the Compensation Committee of ~~Regulation~~the ~~S-K~~Board awarded Dr. Peter Sordillo options to purchase 25,000 shares of Common Stock at $2.00 per share under the plan.

Name and Principal Position	Year	Salary ($)		Bonus($)	Stock Awards ($)(1)(2) (3)	Option Awards ($)		Non-Equity Incentive Plan Compensation ($)(4)	All Other Compensation ($)(5)	Total ($)
Lawrence Helson	2013	$
President and Chief	2012		96,000	0	0		104,000	0	0	$	200,000
Executive Officer	2011			150,000			150,000

The following table sets forth, with respect to the Company’s fiscal years ended December 31, 2014 and 2013, all compensation earned by each person who is required to be listed pursuant to Item 402(m)(2) of Regulation S-K.

(1) Under Dr. Helson’s prior employment contract he received a base salary of $200,000 per annum. He received $96,000, in cash during each of 2013 and 2012. In 2012, Dr. Helson earned $104,000 of his salary and received options to purchase 200,000 shares of common stock exercisable at $0.85 per share in February 2013. In 2011, Dr. Helson was awarded 150,000 shares of common stock to settle the remaining $104,000 of his unpaid base salary and an additional 150,000 shares as a stock bonus.

Name and Principal Position	Year	Salary ($)		Bonus($)			Stock Awards ($)		Option Awards ($)			Non-Equity Incentive Plan Compensation ($)			All Other Compensation($)(5)			Total ($)

Lawrence Helson	2014	$	200,000(1)	$	30,000	(2)	$	-	$	162,580	(3)		$	-	$	20,300	(4)	$	412,880
President and Chief Executive Officer	2013	$	96,000	$	-		$	-	$	104,000	(5)		$	-	$	-		$	304,000

_________________________

(1) Under Dr. Helson’s employment contract he received a base salary of $204,000 per annum, of which he received $200,000 in 2013 and 2014.

(2) A discretionary cash bonus of $30,000 was authorized by the Board on December 12, 2014, in consideration of additional services rendered by Dr. Helson during 2014.

(3) On May 1, 2014, the Company issued 200,000 options to Dr. Helson under the 2009 plan. The options have an exercise price of $0.85 per share and have a life of five years. The options vest immediately on grant date. The Company valued these options using the Black-Scholes option pricing model totaling $162,580 under the following assumptions: $0.85 stock price, $1.25 exercise price, 5 years to maturity, 415.87% volatility, 1.66% risk free rate.

(4) Pursuant to the terms of Dr. Helson’s employment agreement, the Compensation Committee of the Board of Directors authorized the reimbursement of an aggregate of approximately $20,300 for Medicare payments deducted from Dr. Helson’s salary from the beginning of his employment by the Company.

(5) On February 20, 2013, Dr. Helson agreed to waive $104,000 of his accrued $200,000 salary for 2012. In exchange for waiving this accrued salary, the Company issued Dr. Helson options to purchase 200,000 shares of Common Stock exercisable at $0.85 per share. The Company valued these options using the Black-Scholes option pricing model totaling $104,000 under the following assumptions: $0.85 stock price, $0.85 exercise price, 5 years to maturity, 626% volatility, .35% risk free rate.

Director’s Compensation

Members of the Board of Directors are reimbursed for reasonable expenses incurred in connection with travel to attend board meetings. Options to purchase 60,000 shares of Common Stock of SignPath were granted to each of Jack Levine and Arthur Bollon, independent directors, under the 2009 Option Plan for 2012 exercisable for five (5) years at $0.85 per share. An additional 60,000 options were granted to each of Jack Levine and Arthur Bollon, which vested in quarterly increments during ~~2013~~2015 and are exercisable for five (5) years at $1.25 per share. An additional 30,000 options were granted to each of Jack Levine and Arthur Bollon on May 1, 2014 which vest in quarterly increments during 2014 and are exercisable for five (5) years at $1.25 per share. An additional 30,000 options were granted to each of Jack Levine and Arthur Bollon on March 20, 2015 which vest in quarterly increments during 2015 and are exercisable for five (5) years at $2.00 per share. No cash compensation has been paid to directors. See “2009 Employee Stock Incentive Plan” below.

Pursuant to the terms of a Letter Agreement dated July 12, 2010, Jack Levine was granted options to purchase 100,000 shares of common stock at $0.85 per share upon his joining the Board of Directors. The option ~~vests~~vested in three equal installments on each of the first three anniversary dates of the date of grant and is exercisable for ten (10) years from the date of grant. He also received 30,000, 40,000, 40,000, 40,000 and 40,000 restricted shares of Common Stock on December 28, 2010, December 22, 2011, February 20, 2013, May ~~and~~1, ~~March~~2014 and 28January 1, ~~2014~~2015, in consideration of consulting and accounting services as chairman of the Company’s Audit Committee. He will be reimbursed for reasonable expenses incurred, however will not receive any other cash compensation.

2009 Employee Stock Incentive Plan

The Company’s 2009 Employee Stock Incentive Plan (the “2009 Option Plan”) was adapted by the Company’s Board of Directors on February 9, 2009 in order to motivate participants by means of stock options and restricted stock to achieve the Company’s long-term performance goals and enable our employees, officers, directors and consultants to participate in our long term growth and financial success. The 2009 Plan, which is administered by our Board of Directors, authorizes the issuance of a maximum of 1,~~047~~171,~~000~~630 ~~(as~~shares of ~~January~~our 1,common ~~2014)~~stock ~~shares~~(as of ~~our~~January ~~common~~1, ~~stock~~2015), which may be authorized and unissued shares or treasury shares. Employee options shall be deemed Incentive Stock Options (as defined in the 2009 Option Plan) to the maximum extent permitted by Section 422 of the Internal Revenue Code including a five-year limit on exercise for 10% or greater stockholders with any excess grant to the above individuals over the limits set by Section 422 being Non-Qualified Stock Options as defined in the 2009 Option Plan. Both the Incentive Stock Options or any Non-Qualified Stock Options must be granted at an exercise price of not less than the fair market value of shares of common stock at the time the option is granted and Incentive Stock Options granted to 10% or greater stockholders must be granted at an exercise price of not less than 110% of the fair market value of the shares on the date of grant. If any award under the 2009 Plan terminates, expires unexercised, or is cancelled, the shares of common stock that would otherwise have been issuable pursuant thereto will be available for issuance pursuant to the grant of new awards. The 2009 Plan will terminate on February 9, 2019. An aggregate of ~~340~~460,000 options have been granted under the 2009 Plan to independent directors of the Company, ~~200~~400,000 options to the Company'’s CEO, ~~and~~ 30,000 options to the Company’s outside law firm, and 25,000 options to a member of the Scientific Advisory Board. See “Director’s Compensation” above.

3640

ITEM 12. SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS

The following table sets forth certain information regarding the beneficial ownership of the Company’s common stock and convertible preferred stock as(“Voting ofStock”) ~~date~~as of ~~this~~March ~~report~~31, 2015 by (i) each person which is known by the Company to beneficially own more than 5% of the Company’s common stock, (ii) by each of the Company’s directors, (iii) by each executive officer of the Company, and (iv) by all executive officers and directors as a group.

The address of each of the persons listed below, unless otherwise noted, is c/o SignPath Pharma Inc., ~~1375~~3477 ~~California~~Corporate ~~Road~~Parkway, ~~Quakertown~~Suite 100, Center Valley, PA ~~18951~~18034.

Name of Beneficial Owner	Number of Shares of Common Stock Beneficially Owned (1)	~~Number of Shares of Common Stock Beneficially Owned (1)~~		Percentage of Common Stock and Preferred Stock Beneficially Owned (2)			~~Percentage of Common Stock and Preferred Stock Beneficially Owned (2)~~
Dr. Lawrence Helson	2,710,000	(3	~~2,510,000~~)		(310.7	)%		~~11.3~~	%
Dr. Arthur Bollon	980,000	(4	~~915,000~~)		(43.9	)%		~~4.1~~	%
Jack Levine	470,000	(4) (5	~~370,000~~)		(41.8	~~)(5)~~%		~~1.6~~	%
Meyers Associates, L.P. (6)			2,305,000		(7	)		10.5	%
Bruce Meyers (6)	5,914,503	(7	)		23.2	%
Bruce Meyers (6)			4,962,500		(8	)		22.6	%
Imtiaz Khan (6)(8)	2,450,000				9.8	%
Imtiaz Khan (6)(9)			2,450,000					11.2	%
All Executive Officers and Directors as a Group (3 persons)	4,160,000				15.9	%
All Executive Officers and Directors as a Group (3 persons)			3,645,000					16.2	%

(1) Except as otherwise noted in the footnotes to this table, the named person owns directly and exercises sole voting and investment power over the shares listed as beneficially owned by such person. Includes any securities that such person has the right to acquire within sixty days pursuant to options, warrants, conversion privileges or other rights. As of ~~March~~the ~~21,~~date ~~2014~~of this report, there were 1214,~~877~~163,~~500~~887 shares of our common stock issued and outstanding. As of that date,: (i) 1,~~047~~171,~~000~~630 shares of common stock were authorized for issuance under our 2009 Option Plan of which ~~570~~855,000 options had been granted; (ii) approximately 3,831,576 shares of our common stock were reserved for issuance pursuant to conversion of Series A Preferred Stock; (iii) approximately 34,~~831~~037,~~576~~018 shares were reserved for issuance pursuant to exercise of Class A Warrants to purchase common stock; (iv) 368,894 shares of our common stock were reserved for issuance pursuant to the issuance of ~~Dividend~~shares ~~Shares~~in payment of liquidated damages concerning registration rights; (v) 2,525,842 shares of Common Stock were reserved for issuance pursuant to conversion of Series B Preferred Stock; (vi) 2,525,842 shares of Common Stock were reserved for issuance pursuant to exercise of Class B Warrants; (vii) 34,~~004~~000,~~400~~000 shares of Common Stock were reserved for issuance pursuant to conversion of Series C Preferred Stock; (viii) 12,~~502~~000,~~200~~000 shares of Common Stock were reserved for issuance pursuant to exercise of Class C Warrants; (ix) there were Placement Agent Warrants to purchase approximately 2,771,392 shares of common stock pursuant to the Units sold in the 2008 - 2013 Private Placements; and (x) 600,000 shares issuable upon exercise of vendor warrants granted in 2013632.625 ~~(2) As of March 21, 2014, based on an aggregate of 22,239,318 voting~~ shares, ~~consisting~~ of ~~12,877,500 shares of~~ Common Stock, ~~3,831,576~~were ~~shares~~reserved offor ~~Common~~issuance ~~Stock~~pursuant ~~issuable~~to ~~upon~~ conversion of ~~Series~~outstanding ~~A Preferred Stock, and 2,525,842~~ shares of ~~Common Stock issuable upon conversion of~~ Series BD Preferred Stock,; ~~and 3,004,400 shares of Common Stock issuable upon conversion of Series C Preferred Stock.~~ (3x) ~~Dr. Helson disclaims beneficial ownership of an aggregate of 90~~158,~~000~~157 shares of Common Stock ~~gifted~~were ~~for~~reserved ~~estate planning purposes. Includes option to purchase 200,000 shares of Common Stock granted on February 20, 2013, in lieu of $104,000 of accrued compensation~~ for ~~2012.~~issuance ~~(4)~~pursuant ~~Includes options~~ to ~~purchase:~~exercise ~~(A) 60,000 shares~~ of ~~Common~~Class ~~Stock~~D ~~issuable~~Warrants; ~~at $0.85 per share for 2012 compensation as an independent director,~~ (Bxi) ~~60,000~~there ~~shares~~were ofPlacement ~~Common~~Agent ~~Stock,~~Warrants ~~issuable~~to atpurchase ~~$1.25~~approximately ~~per share for 2013 compensation granted on February 20~~3, ~~2013 and (c) 100~~265,~~000 shares issuable at $0~~360.8522 ~~per share upon his joining the board of directors in July 2010. (5) Includes options to purchase an aggregate of 220,000~~ shares of common stock, ~~all~~pursuant ofto ~~which~~the ~~are~~Units ~~current~~sold ~~exercisable.~~in ~~(6)~~the ~~The~~2008 ~~address~~- of2015 ~~each~~Private ofPlacements; ~~these~~and ~~persons is 45 Broadway, 2nd Fl., New York, NY 10006.~~ (7xii) ~~Does not include 2~~800,~~771,392~~000 shares ~~of common stock~~ issuable upon exercise of ~~Meyers~~vendor ~~Associates’~~warrants ~~Placement~~granted ~~Agent~~in ~~Warrants~~2013 and ~~additional shares of common stock beneficially owned by Bruce Meyers, the President of Meyers Associates~~2014. Bruce Meyers has the power to vote and dispose of the Shares owned by Meyers Associates. (8) Mr. Meyers is Principal and Chief Executive Officer of Meyers Associates. This amount includes shares owned by Meyers Associates set forth in note (7) above. (9) Mr. Kahn is Vice President of Meyers Associates.

37(2) As of the date of this report, based on an aggregate of 25,153,930 voting shares, consisting of 14,163,887 shares of Common Stock, 3,831,576 shares of Common Stock issuable upon conversion of Series A Preferred Stock, 2,525,842 shares of Common Stock issuable upon conversion of Series B Preferred Stock, 4,000,000 shares of common stock issuable upon conversion of Series C Preferred Stock, and 632.625 shares of Common Stock issuable upon conversion of Series D Preferred Stock.

(3) Dr. Helson disclaims beneficial ownership of an aggregate of 90,000 shares of Common Stock gifted for estate planning purposes. Includes options to purchase 200,000 shares of Common Stock granted on February 20, 2013, in lieu of $104,000 of accrued compensation for 2012 and options to purchase 200,000 shares of Common Stock granted on May 1, 2014.

(4) Includes options to purchase: (a) 60,000 shares of Common Stock issuable at $0.85 per share for 2012 compensation as an independent director, (b) 60,000 shares of Common Stock, issuable at $1.25 per share for 2013 compensation granted on February 20, 2013, (c) 30,000 shares of Common Stock issuable at $1.25 per share for 2014 compensation granted on May 1, 2014, and (d) 30,000 shares of Common Stock issuable at $2.00 per share for 2015 compensation granted on March 20, 2015.

(5) Includes options to purchase 100,000 shares of common stock issuable at $0.85 per share upon his joining the board of directors in July 2010 are currently exercisable.

(6) The address of each of these persons is 45 Broadway, 2nd Fl., New York, NY 10006.

(7) Bruce Meyers is the General Partner of Meyers Investments Family Limited Partnership and has the power to vote and dispose of the shares, consisting of: 5,015,865 shares of common stock, 449,418 shares issuable upon conversion of 381,665 shares of Series A Preferred Stock and 449,220 shares issuable upon exercise of Class A Warrants. Does not include 2,715,008 shares of common stock issuable upon exercise of Placement Agent Warrants held by Meyers Investments Family Limited Partnership and Meyers Associates under blocking amendments pursuant to which the holder must give at least 61 days prior notice to the Company prior to any exercise if the holder would beneficially own in excess of either 4.99% or 9.99% of the outstanding common stock of the Company.

(8) Mr. Khan is Vice President of Meyers Associates L.P. and owns 1% of Meyers Securities Corp., the parent of Meyers Associates L.P., the Company’s placement agent. Consists of shares of common stock held by Mr. Khan personally.

Unless otherwise indicated in the foregoing table (or the footnotes thereto), the persons named in the table have sole voting and dispositive power with respect to the shares of the Company’s common stock and/or options owned by such person, subject to community property laws where applicable.

ITEM 13. CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

As described elsewhere in this ~~report~~Annual Report on Form 10-K, the Company, Meyers Securities Corp. and Meyers Associates LP, the placement agent for its preferred stock offerings, have several ~~numerous~~ relationships and related transactions. Mr. Bruce Meyers, the Principal and Chief Executive Officer of Meyers Securities Corp. and Meyers Associates LP, is a founder of the Company. Mr. Meyers, as General Partner of Meyers Investments Family Limited Partnership, a principal stockholder of the Company~~’s common stock~~, has influence in the affairs and operations of the Company which may present a conflict of interest between the Company and the Placement Agent. A potential conflict of interest may arise if Mr. Meyers recommends and/or implements a transaction with the placement agent on less favorable terms than those available through a third party. All activities and influence of Mr. Meyers regarding Company affairs have consisted of corporate finance and capital formation as the Company’s investment banker, including, but not limited to, advice on various potential financing transactions, besides those with the Company’s placement agent, joint-ventures and other transaction with industry partners. (See “Risk Factors”).

~~Each~~During ~~Unit~~fiscal ~~consists~~2013, ofthe ~~one~~Company ~~share~~sold of3,380 aUnits ~~6.5%~~of Series BC ~~Convertible~~ Preferred Stock ~~convertible~~at ~~into~~ $1,~~177~~000 ~~shares~~per ofUnit, ~~common~~to ~~stock~~nine ondifferent ~~the~~investors ~~same~~for ~~terms~~aggregate ~~described~~proceeds ~~above~~of ~~plus~~$3,380,000. Each ~~one~~Unit ~~warrant~~consists toof ~~purchase~~one ~~1,177~~share ~~shares~~ of ~~common~~a ~~stock at $1~~6.275% ~~per share. The~~ Series BC ~~Units~~Convertible ~~were~~Preferred ~~sold to 13 different investors~~Stock. ~~During Fiscal 2011~~ Meyers Associates L.P., received ~~aggregate~~ sales commissions of 10% ($~~144~~338,~~850~~000) of the gross proceeds of ~~$1,448,500 from~~ the sale of Units, as well as a non-~~accountable~~refundable expense allowance equal to 3% of the gross proceeds of the offering, and a Unit Purchase Option (subsequently transferred to Meyers Investments Family Limited Partnership) to purchase 1520% of the ~~Units~~shares sold in the offering.

During ~~fiscal~~the ~~2012~~period from January 1, 2014 through June 18, 2014, the Company sold an aggregate of 1,~~116~~620 Units of Series BC Preferred Stock at $1,000 per Unit, to 17eight (8) different investors for aggregate proceeds of $1,~~116~~620,000. Each Unit consists of one share of a 6.5% Series B Convertible Preferred Stock convertible into 1,177 shares of common stock plus one warrant to purchase 1,177 shares of common stock at $1.27 per share. Meyers Associates, L.P. received sales ~~commission~~commissions of 10% ($~~111~~162,~~600~~000) of the gross proceeds ~~from~~of the sale of Units, as well as a non-~~accountable~~refundable expense allowance equal to 3% of the gross proceeds of the offering and a Unit Purchase Option (subsequently transferred to Meyers Investments Family Limited Partnership) to purchase 1520% of the ~~Units~~shares sold in the offering.

During ~~fiscal~~the ~~2013~~period from October 31, 2014 to November 26, 2014, the Company sold ~~3,380~~an aggregate of 320 Units of Series CD Preferred Stock at $1,000 per Unit, to ~~nine~~four (4) different investors for aggregate proceeds of $3320,~~380,~~000. ~~Each Unit consists of one share of a 6.5% Series C Convertible Preferred Stock.~~ Meyers Associates L.P. received aggregate sales commissions of 10% ($~~338~~32,000) of the gross proceeds of the sale of Units, as well as a non-~~refundable~~accountable expense allowance equal to 3% of the gross proceeds of the ~~Offering~~offering and a Unit Purchase Option (subsequently transferred to Meyers Investments Family Limited Partnership) to purchase 20% of the ~~Units~~shares sold in the ~~Offering~~offering.

OnFrom January 1, 2015 through February 2027, ~~2013~~2015, the ~~Board~~Company sold an additional 795.25 Units of ~~Directors~~Series ~~authorized:~~D ~~(A)~~Preferred aStock ~~new~~at ~~three-year~~$1,000 ~~employment~~per ~~agreement~~Unit, to 16 different investors for Draggregate proceeds of $795,250. Meyers ~~Helson~~Associates ~~described~~L.P. ~~above~~received ~~under~~sales ~~“Executive~~commissions ~~Compensation”,~~of ~~and~~10% (B$79,525) ~~options~~of tothe ~~purchase~~gross ~~60,000~~proceeds ~~shares~~of the sale of ~~Common~~Units, ~~Stock~~as towell ~~each~~as ofa ~~Jack~~non-accountable ~~Levine~~expense ~~and~~allowance ~~Arthur~~equal ~~Bollon,~~to ~~independent~~3% ~~directors,~~of ~~for~~the ~~2012~~gross ~~compensation~~proceeds ~~exercisable~~of atthe ~~$0.85~~Offering ~~per~~and ~~share~~received ~~for~~a ~~five~~Unit ~~years~~Purchase ~~and~~Option ~~60,000~~(subsequently ~~shares~~transferred ofto ~~Common~~Meyers ~~Stock~~Investments ~~for~~Family ~~2013~~Limited ~~compensation~~Partnership) ~~exercisable~~to atpurchase ~~$1.25~~20% ~~per~~of ~~share~~the ~~for~~shares ~~five~~sold ~~years~~in the Offering.

On May 28, 2014, the Company voided 1,537,840 placement warrants which were replaced by 1,484,851 placement agent warrants with an exercise price of $1.25 which will expire on the seventh anniversary of the modification. The Company valued these warrants using the Black-Scholes option pricing model under the following assumptions: $0.85 stock price, $1.25 exercise price, 7 years to maturity, 117.07% volatility, 2.01% risk free rate. As a result of the modification the value of the replacement placement warrants was less than the valuation of the original warrants, therefore the Company did not recognize a gain on equity modification.

On July 22, 2014, the Company voided and replaced 2,092,051 placement agent warrants with an exercise price of $0.85 to $1.25 which will expire on the seventh anniversary of the modification. The Company valued these warrants using the Black-Scholes option pricing model under the following assumptions: $0.85 stock price, $0.85 exercise price, 5 to 7 years to maturity, 99.66% volatility, 1.91% to 2.13% risk free rate. As a result of the modification, the Company recognized a loss on equity modification of $13,132.

On January 14, 2015, the Company voided and were replaced by 2,621,851.22 placement agent warrants with an exercise price of $1.25 which will expire on the seventh anniversary of the modification. The Company valued these warrants using the Black-Scholes option pricing model under the following assumptions: $0.85 stock price, $1.25 exercise price, 7 years to maturity, 144.70% volatility, 1.62% risk free rate. As a result of the modification, the Company recognized a loss on equity modification of $24,868 in 2015.

On December 22, 2011, the Board of Directors awarded (i) 150,000 restricted shares of Common Stock to Dr. Helson in exchange for his forfeiture of approximately $104,000 in accrued and unpaid salary, and an additional 150,000 shares of Common Stock in exchange for his forfeiture of bonus compensation through December 31, 2012; (ii) 200,000 restricted shares of Common Stock to Meyers Securities Corp. for administrative functions performed for the Company which is without staff; (iii) 30,000 restricted shares of Common Stock to Jack Levine, who performed various tasks without compensation as Chairman of the Audit Committee. He also received 40,000 restricted shares of Common Stock on December 22, 2011 and February 20, 2013 in consideration of consulting and accounting services as Chairman of the Audit Committee.

On February 20, 2013, as amended on December 10, 2014, the Board of Directors authorized: (a) a new three-year employment agreement for Dr. Helson described above under “Executive Compensation”, and (b) options to purchase 60,000 shares of Common Stock to each of Jack Levine and Arthur Bollon, independent directors, for 2012 compensation exercisable at $0.85 per share for five years and 60,000 shares of Common Stock for 2013 compensation exercisable at $1.25 per share for five years. See “Executive Compensation” for the terms of the Amendment to the Company’s Employment Agreement with Dr. Lawrence Helson, its Chief Executive Officer.

On May 1, 2014, the Board of Directors authorized: (a) options to purchase 200,000 shares of Common Stock to Lawrence Helson, CEO, exercisable at $1.25 per share for ten years, and (b) options to purchase 30,000 shares of Common Stock to each of Jack Levine and Arthur Bollon, independent directors, for 2014 compensation exercisable at $1.25 per share for five (5) years.

On March 20, 2015, the Board of Directors authorized options to purchase 30,000 shares of Common Stock to each of Jack Levine and Arthur Bollon, independent directors, for 2015 compensation exercisable at $2.00 per share for five (5) years.

Meyers Associates, Bruce Meyers, and Imtiaz Khan, principals of Meyers Associates, L.P. (collectively, the “Principals”), are subject to pending disciplinary proceeding from the Financial Industry Regulatory Authority, Inc. (“FINRA”). On October 6, 2014, FINRA filed a complaint (the “Complaint”) alleging, among other things, the violation of certain rules of FINRA and the National Association of Securities Dealers and federal securities laws in connection with Meyers’ prior offerings of the Company’s securities. Meyers and the Principals have answered the Complaint which they maintain is without merit and that they will contest the enforcement action vigorously. For more information regarding the Complaint, see the Risk Factor titled “Meyers Associates, L.P. and its principals are subject to disciplinary proceedings from FINRA in connection with, among other things, previous offerings of the Company’s securities.”

Otherwise, none of our directors or officers, nor any person who beneficially owns, directly or indirectly, shares carrying more than 5% of the voting rights attached to all of our outstanding shares, nor any promoter, nor any relative or spouse of any of the foregoing persons has any material interest, direct or indirect, in any presently proposed transaction which, in either case, has or will materially affect us.

Our management is involved in other business activities and may, in the future, become involved in other business opportunities. If a specific business opportunity becomes available, such persons may face a conflict in selecting between our business and their other business interests. In the event that a conflict of interest arises at a meeting of our directors, a director who has such a conflict will disclose his interest in a proposed transaction and will abstain from voting for or against the approval of such transaction.

Director Independence

Because our common stock is not currently listed on a national securities exchange, we have used the definition of “independence” of The NASDAQ Stock Market to make this determination. NASDAQ Listing Rule 5605(a)(2) provides that an “independent director” is a person other than an officer or employee of the Company or any other individual having a relationship which, in the opinion of the Company’s board of directors, would interfere with the exercise of independent judgment in carrying out the responsibilities of a director. The NASDAQ listing rules provide that a director cannot be considered independent if:

	·	the director is, or at any time during the past three years was, an employee of the company;
	·	the director or a family member of the director accepted any compensation from the company in excess of $120,000 during any period of 12 consecutive months within the three years preceding the independence determination (subject to certain exclusions, including, among other things, compensation for board or board committee service);
	·	a family member of the director is, or at any time during the past three years was, an executive officer of the company;
	·	the director or a family member of the director is a partner in, controlling stockholder of, or an executive officer of an entity to which the company made, or from which the company received, payments in the current or any of the past three fiscal years that exceed 5% of the recipient’s consolidated gross revenue for that year or $200,000, whichever is greater (subject to certain exclusions);
	·	the director or a family member of the director is employed as an executive officer of an entity where, at any time during the past three years, any of the executive officers of the company served on the compensation committee of such other entity; or the director or a family member of the director is a current partner of the company’s outside auditor, or at any time during the past three years was a partner or employee of the company’s outside auditor, and who worked on the company’s audit.

WeAs of the date of this report, we have determined that ~~Arthur P~~Dr. Arthur Bollon and Jack Levine, two of our three directors, are non-officer independent members of the Board of Directors.

ITEM 14. PRINCIPAL ACCOUNTANT FEES AND SERVICES

During Fiscal ~~2013~~2014 and ~~2012~~2013, M&K CPAS, PLLC (“M&K”) served as our independent auditors. ~~The~~However, ~~following~~the ~~table~~Company ~~presents~~terminated ~~fees~~the ~~for professional audit~~ services ~~rendered~~of by M&K ~~for~~on ~~the~~January ~~audit~~29, of2015 ~~our~~and ~~annual~~engaged ~~financial~~Friedman ~~statements~~LLP ~~for~~(“Friedman”) as the ~~years~~Company’s ~~ended~~independent ~~December~~auditors 31on February 11, ~~2013~~2015. Friedman ~~and~~performed ~~2012,~~the ~~and~~audit ~~fees~~of the Company’s consolidated financial statements for ~~other~~Fiscal ~~services~~2014 ~~rendered~~and byissued ~~such~~the ~~firm~~audit ~~during~~report ~~those~~in ~~periods~~this Annual Report.

	2013		2012
Audit Fees	$	26,500	$	23,500
Audit Related Fees		-0-		-0-
Tax Fees		-0-		-0-
All Other Fees		-0-		-0-
Total	$	26,500	$	$23,500

The following table presents: (1) fees for professional audit services rendered by M&K for the audit of our annual financial statements and for other services for the year ended December 31, 2013; (2) fees for professional services rendered by M&K for the year ended December 31, 2014; and (3) fees for professional audit services rendered by Friedman for the audit of our annual financial statements and for other services for the year ended December 31, 2014.

	2014 (Friedman)		2014 (M&K)		2013 (M&K)
Audit Fees	$	20,000	$	28,500	$	26,500
Audit Related Fees		-0-		-0-		-0-
Tax Fees		-0-		-0-		-0-
All Other Fees		-0-		-0-		-0-
Total	$	20,000	$	28,500	$	26,500

Audit Fees. Annual audit fees relate to services rendered in connection with the audit of our annual financial statements and the quarterly reviews of financial statements included in our Forms 10-Q.

Audit Related Fees. Audit related services include fees for SEC registration statement services, benefit plan audits, consultation on accounting standards or transactions, statutory audits, business acquisitions, and assessment of risk management controls in connection with the implementation of Section 404 of the Sarbanes-Oxley Act of 2002.

Tax Fees. Tax services include fees for tax compliance, tax advice and tax planning.

All Other Fees: The aggregate fees, including expenses, billed for all other services, not described above, rendered to the Company by M&K and Friedman during Fiscal year ~~2013~~2014 and ~~2012~~2013 were zero.

We have been advised by both M&K and Friedman that neither the ~~firm~~firms, nor any member of the ~~firm~~firms, ~~has~~have any financial interest, direct or indirect, in any capacity in the Company or its subsidiaries.

3944

Policy on Audit Committee Pre-Approval of Audit and Non-Audit Services of Independent Auditor

The ~~entire~~Company’s ~~Board~~audit committee presently consists of ~~Directors~~one ~~(the~~member, ~~“Board”)~~Jack Levine. The audit committee is responsible ~~for~~recommend ~~appointing,~~to ~~setting~~the ~~compensation~~Company’s Board the engagement of independent auditors to audit the Company’s financial statements and to review the Company’s accounting and auditing principles, and for overseeing the work of the independent auditor, including their independence and objectivity. The Board is responsible for approving the compensation of the auditor. The Board has established a policy regarding pre-approval of all audit and non-audit services provided by the independent auditor, as follows: on an ongoing basis, management communicates specific projects and categories of service for which the advance approval of the Board is requested, and the Board reviews these requests and advises management if the Board approves the engagement of the independent auditor. On a periodic basis, management reports to the Board regarding the actual spending for such projects and services compared to the approved amounts. All audit-related fees, tax fees and all other fees were approved by the entire Board. The projects and categories of service are as follows:

Audit—Annual audit fees relate to services rendered in connection with the audit of our financial statements and the quarterly reviews of financial statements included in our Forms 10-Q.

Audit Related Services—Audit related services include fees for SEC registration statement services, benefit plan audits, consultation on accounting standards or transactions, statutory audits, and business acquisitions.

Tax—Tax services include fees for tax compliance, tax advice and tax planning.

All Other – fees for all other services provided by ~~M&K~~the auditor.

4045

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

To the Board of Directors and Stockholders of

SignPath Pharma, Inc.

(AWe ~~Development~~have ~~Stage~~audited the accompanying balance sheet of SignPath Pharma, Inc. (the “Company”) as of December 31, 2014, and the related statements of operations, stockholders’ equity (deficit), and cash flows for the year then ended. The Company’s management is responsible for these financial statements. Our responsibility is to express an opinion on these financial statements based on our audit.

We ~~have~~conducted ~~audited~~our ~~the~~audit ~~accompanying~~in ~~balance~~accordance ~~sheets~~with the standards of ~~SignPath~~the ~~Pharma,~~Public ~~Inc.~~Company (AAccounting ~~Development~~Oversight ~~Stage~~Board ~~Company~~(United States). Those asstandards ofrequire ~~December~~that ~~31,~~we ~~2013~~plan and ~~2012,~~perform ~~and~~the audit to obtain reasonable assurance about whether the ~~related~~financial statements are free of ~~operations,~~material ~~stockholders’~~misstatement. The ~~equity~~Company ~~(deficit)~~is not required to have, ~~and~~nor ~~cash~~were ~~flows~~we ~~for~~engaged ~~the~~to ~~years~~perform, ~~then~~an ~~ended.~~audit ~~The~~of its internal control over financial ~~statements~~reporting. Our ~~for~~audit ~~the~~included ~~period~~consideration ~~from~~of ~~inception~~internal ~~(May~~control ~~15,~~over ~~2006)~~financial toreporting ~~December~~as ~~31,~~a ~~2007~~basis ~~were~~for ~~audited~~designing byaudit ~~other~~procedures ~~auditors~~that ~~whose~~are ~~report~~appropriate ~~expressed~~in anthe ~~unqualified~~circumstances, ~~opinion~~but onnot ~~those~~for ~~statements.~~the ~~These~~purpose ~~financial~~of ~~statements~~expressing ~~are~~an opinion on the ~~responsibility~~effectiveness of the Company'’s ~~management.~~internal ~~Our~~control ~~responsibility~~over isfinancial toreporting. Accordingly, we express anno such opinion. An audit also includes examining, on ~~these~~a test basis, evidence supporting the amounts and disclosures in the financial statements, ~~based~~assessing onthe accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our ~~audits~~audit provides a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly, in all material respects, the financial position of SignPath Pharma, Inc. as of December 31, 2014, and the results of its operations and its cash flows for the year ended in conformity with accounting principles generally accepted in the United States of America.

The accompanying financial statements have been prepared assuming that the Company will continue as a going concern. As discussed in Note 2 to the financial statements, the Company’s accumulated deficit and operating losses raise substantial doubt about its ability to continue as a going concern. Management’s plans in regard to these matters are also described in Note 2. The financial statements do not include any adjustments that might result from the outcome of these uncertainties.

/s/ Friedman LLP

Marlton, New Jersey

April 9, 2015

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

To the Board of Directors and Stockholders of

SignPath Pharma, Inc.

We have audited the accompanying balance sheet of SignPath Pharma, Inc. as of December 31, 2013, and the related statement of operations, stockholders’ equity (deficit), and cash flow for the year then ended. The financial statements for the period from inception (May 15, 2006) to December 31, 2007 were audited by other auditors whose report expressed an unqualified opinion on those statements. These financial statements are the responsibility of the Company's management. Our responsibility is to express an opinion on these financial statements based on our audits.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. The Company is not required to have, nor were we engaged to perform, an audit of its internal control over financial reporting. An audit includes consideration of internal control over financial reporting as a basis for designing audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the effectiveness of internal control over financial reporting. Accordingly, we express no such opinion. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.

In our opinion, the financial ~~statements~~statement referred to above present fairly, in all material respects, the financial position of the SignPath Pharma, Inc. as of December 31, 2013 ~~and 2012~~, and the results of its operations and its cash ~~flows~~flow for the ~~years~~year then ended, in conformity with accounting principles generally accepted in the United States.

The accompanying financial statements have been prepared assuming that the Company will continue as a going concern. As discussed in Note 2 to the financial statements, the Company has an accumulated deficit of $10,960,243, which raises substantial doubt about its ability to continue as a going concern. Management’s plans concerning these matters are also described in Note 2. The financial statements do not include any adjustments that might result from the outcome of this uncertainty.

/s/ M&K CPAS, PLLC

www.mkacpas.com

Houston, Texas

~~March~~April 319, ~~2014~~2015

4147

SIGNPATH PHARMA, INC.
(A Development Stage Company)
Balance Sheets
Balance Sheets
ASSETS
ASSETS
	December 31,				December 31,
			December 31,				December 31,
	2014				2013
				2013				2012
CURRENT ASSETS
CURRENT ASSETS
Cash		$	716,193			$	1,241,397
Cash			$	1,241,397			$	31,922
Total Current Assets			716,193				1,241,397
	Total Current Assets			1,241,397				31,922
TOTAL ASSETS		$	716,193			$	1,241,397
EQUIPMENT, net				-				144
LIABILITIES AND STOCKHOLDERS' EQUITY
	TOTAL ASSETS		$	1,241,397			$	32,066
CURRENT LIABILITIES
LIABILITIES AND STOCKHOLDERS' EQUITY (DEFICIT)
Accounts payable and accrued expenses		$	447,999			$	421,632
CURRENT LIABILITIES
Total Current Liabilities			447,999				421,632
Accounts payable and accrued expenses			$	421,632			$	894,475
STOCKHOLDERS' EQUITY
Derivative liability				-				5,687,262
Convertible Preferred Stock, 5,000,000 shares authorized, $0.10 par value
	Total Current Liabilities			421,632				6,581,737
Series A; 5,000 shares authorized 3,256 shares issued and outstanding, respectively			326				326
STOCKHOLDERS' EQUITY (DEFICIT)
Series B; 3,000 shares authorized 2,146 shares issued andoutstanding, respectively			215				215
Preferred stock; $0.10 par value, 5,000,000 shares authorized 8,532 and 4,286 shares issued andoutstanding, respectively				879				541
Series C; 6,000 shares authorized 5,001 and 3,380 shares issued andoutstanding, respectively			500				338
Common stock; $0.001 par value, 45,000,000 shares authorized; 12,877,500 and 12,837,500 shares issued and outstanding, respectively				12,879				12,839
Series D; 6,000 shares authorized 320 and 0 shares issued and outstanding, respectively			32				-
Accrued dividends				1,353,961				861,872
Common stock; $0.001 par value, 50,000,000 shares authorized; 14,123,887 and 12,877,500 shares issued and outstanding, respectively			14,124				12,879
Additional paid-in capital				10,120,454				1,286,613
Accrued dividends			969,230				1,353,961
Deficit accumulated during the development stage				(10,668,408)				(8,711,536)
Additional paid-in capital			12,700,365				10,120,454
	Total Stockholders' Equity (Deficit)			819,765				(6,549,671)
Accumulated deficit			(13,416,598	)			(10,668,408	)
	TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY (DEFICIT)		$	1,241,397			$	32,066
Total Stockholders' Equity			268,194				819,765
TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY		$	716,193			$	1,241,397

The accompanying notes are an integral part of these financial statements.

4248

SIGNPATH PHARMA, INC.
(A Development Stage Company)
Statements of Operations
Statements of Operations
	For the Years Ended
(unaudited)
	December, 31
							From Inception
	2014			2013
							on May 15, 2006
REVENUES	$	-		$	-
	For the Years Ended						Through
OPERATING EXPENSES
	December 31,						December 31,
General and administrative		73,005			53,957
	2013			2012			2013
Professional fees		413,953			808,865
REVENUES	$	-		$	-		$	-
Research and development		1,927,851			841,502
OPERATING EXPENSES
Salaries and wages		327,316			249,407
General and administrative		53,957			45,596			1,303,596
Total Operating Expenses		2,742,125			1,953,731
Professional fees		808,865			121,586			1,784,218
OPERATING LOSS		(2,742,125	)		(1,953,731	)
Financing expense		-			-			1,063,401
OTHER INCOME (EXPENSE)
Research and development		841,502			939,296			4,297,433
Gain (loss) on derivative liability		-			(3,926	)
Salaries and wages		249,407			205,927			1,249,329
Transaction loss		(6,671	)		-
Total Operating Expenses		1,953,731			1,312,405			9,697,977
Interest income		606			785
OPERATING LOSS		(1,953,731	)		(1,312,405	)		(9,697,977	)
Total Other Income (Expense)		(6,065	)		(3,141	)
OTHER INCOME (EXPENSE)
NET LOSS BEFORE INCOME TAXES		(2,748,190	)		(1,956,872	)
Gain (loss) on derivative liability		(3,926	)		(8,154	)		(998,403	)
Provision for income taxes		-			-
Gain on shares issued for services		-			9,625			9,625
NET LOSS	$	(2,748,190	)	$	(1,956,872	)
Grant income		-			-			81,556
DEEMED DIVIDEND ON WARRANTS		-			(2,445,621	)
Interest income		785			-			785
PREFERRED STOCK DIVIDEND		(640,673	)		(492,089	)
Interest expense		-			-			(63,995	)
NET LOSS ATTRIBUTABLE TO COMMON STOCKHOLDERS	$	(3,388,863	)	$	(4,894,582	)
Total Other Income (Expense)		(3,141	)		1,471			(970,432	)
BASIC AND DILUTED LOSS PER SHARE	$	(0.25	)	$	(0.38	)
NET LOSS BEFORE INCOME TAXES		(1,956,872	)		(1,310,934	)		(10,668,408	)
WEIGHTED AVERAGE NUMBER OF SHARES OUTSTANDING		13,505,925			12,877,500
Provision for income taxes		-			-			-
NET LOSS	$	(1,956,872	)	$	(1,310,934	)	$	(10,668,408	)
DEEMED DIVIDEND ON WARRANTS		(2,445,621	)		-			(2,445,621	)
NET LOSS ATTRIBUTABLE TO
COMMON STOCKHOLDERS	$	(4,402,493	)	$	(1,310,934	)	$	(13,114,029	)
BASIC AND DILUTED LOSS PER SHARE	$	(0.34	)	$	(0.10	)
WEIGHTED AVERAGE NUMBER OF SHARES OUTSTANDING		12,877,500			12,833,258

The accompanying notes are an integral part of these financial statements.

4349

SIGNPATH PHARMA, INC.

SIGNPATH PHARMA, INC.
Statements of Stockholders' Equity (Deficit)

												Additional							Total
	Preferred Stock				Common Stock				Accrued			Paid-In				Deficit			Stockholders'
	Shares		Amount		Shares		Amount		Dividends			Capital				Accumulated			Equity (Deficit)

Balance, December 31, 2012		5,402	$	541		12,837,500	$	12,839	$	861,872			$	1,286,613		$	(8,711,536	)	$	(6,549,671	)

Preferred stock issued for cash		3,380		338		-		-		-				3,379,662			-			3,380,000

Stock offering costs		-		-		-		-		-				(550,326	)		-			(550,326	)

Common stock issued for services		-		-		40,000		40		-				33,960			-			34,000

Executive forfeited salary		-		-		-		-		-				104,000			-			104,000

Amortization of options issued for services		-		-		-		-		-				667,449			-			667,449

Preferred dividend accrued		-		-		-		-		492,089				(492,089	)		-			-

Adjustment for derivative liability		-		-		-		-		-				5,691,185			-			5,691,185

Net loss for the year ended December 31, 2013		-		-		-		-		-				-			(1,956,872	)		(1,956,872	)

Balance, December 31, 2013		8,782	$	879		12,877,500	$	12,879	$	1,353,961			$	10,120,454		$	(10,668,408	)	$	819,765

Preferred stock and warrants issued for cash, net of $289,240 offering costs		1,941		194		-		-		-				1,650,567			-			1,650,760

Amortization of options issued for services		-		-		-		-		-				217,444			-			217,444

Modification of warrants		-		-		-		-		-				13,132			-			13,132

Warrants issued for services		-		-		-		-		-				281,283			-			281,283

Common Stock issued for services		-		-		40,000		40		-				33,960			-			34,000

Common Stock issued payment of preferred stock dividends		-		-		1,206,387		1,206		(1,025,404	)			1,024,198			-			-

Preferred dividend accrued		-		-		-		-		640,673				(640,673	)		-			-

Net loss for the year ended December 31, 2014		-		-		-		-		-				-			(2,748,190	)		(2,748,190	)

Balance, December 31, 2014		10,723	$	1,073		14,123,887	$	14,124	$	969,230			$	12,700,365		$	(13,416,598	)	$	268,194

(A Development Stage Company)

Statements of Stockholders' Equity (Deficit)

											Deficit
											Accumulated
									Additional		During the		Total
	Preferred Stock			Common Stock			Accrued		Paid-in		Development		Stockholders'
	Shares	Amount		Shares	Amount		Dividends		Capital		Stage		Equity (Deficit)
Balance, May 15, 2006	-	$	-	-	$	-	$	-	$	-	$	-	$	-
Common stock issued to founders for cash at $0.001 per share	-		-	10,000,000		10,000		-		-		-		10,000
Net loss for the year ended December 31, 2006	-		-	-		-		-		-		-		-
Balance, December 31, 2006	-		-	10,000,000		10,000		-		-		-		10,000
Common stock issued for bridge debt at $0.85 per share	-		-	257,500		258		-		218,617		-		218,875
Net loss for the year ended December 31, 2007	-		-	-		-		-		-		(526,833)		(526,833)
Balance, December 31, 2007	-		-	10,257,500		10,258		-		218,617		(526,833)		(297,958)
Preferred stock issued for bridge debtat $1,000 per share	890		89	-		-		-		889,786		-		889,875
Preferred stock issued for cash at $1,000 per share	562		56	-		-		-		561,944		-		562,000
Common stock issued for bridge debt at $0.85 per share	-		-	1,082,500		1,083		-		919,043		-		920,126
Stock offering costs	-		-	-		-		-		(270,948)		-		(270,948)
Preferred dividend accrued	-		-	-		-		9,308		(9,308)		-		-
Net loss for the year ended December 31, 2008	-		-	-		-		-		-		(1,695,766)		(1,695,766)
Balance, December 31, 2008 (restated)	1,452		145	11,340,000		11,341		9,308		2,309,134		(2,222,599)		107,329

Cumulative effect of adoption of ASC 815	-	-	-	-	-	(1,632,825)	(43,808)	(1,676,633)
Preferred stock issued for cash at $1,000 per share	810	81	-	-	-	(178,632)	-	(178,551)
Stock offering costs	-	-	-	-	-	(166,154)	-	(166,154)
Preferred dividend accrued	-	-	-	-	124,576	(124,576)	-	-
Net loss for the year endedDecember 31, 2009	-	-	-	-	-	-	(730,743)	(730,743)
Balance, December 31, 2009 (restated)	2,262	226	11,340,000	11,341	133,884	206,947	(2,997,150)	(2,644,752)
Preferred stock issued for cash at $1,000 per share	575	58	-	-	-	574,942	-	575,000
Stock offering costs	-	-	-	-	-	(121,709)	-	(121,709)
Common stock issued for services	-	-	850,000	850	-	721,650	-	722,500
Amortization of options issued for services	-	-	-	-	-	39,210	-	39,210
Adjustment for derivative liability	-	-	-	-	-	(852,346)	-	(852,346)
Preferred dividend accrued	-	-	-	-	157,609	(157,609)	-	-
Net loss for the year ended December 31, 2010	-	-	-	-	-	-	(2,119,059)	(2,119,059)
Balance, December 31, 2010 (restated)	2,837	284	12,190,000	12,191	291,493	411,085	(5,116,209)	(4,401,156)

Preferred stock issued for cash at $1,000 per share	1,449	145	-	-	-	1,448,355	-	1,448,500
Stock offering costs	-	-	-	-	-	(267,966)	-	(267,966)
Common stock issued for services	-	-	640,000	640	-	543,360	-	544,000
Amortization of options issued for services	-	-	-	-	-	23,368	-	23,368
Adjustment for derivative liability	-	-	-	-	-	(917,263)	-	(917,263)
Preferred dividend accrued	-	-	-	-	219,082	(219,082)	-	-
Net loss for the year ended December 31, 2011	-	-	-	-	-	-	(2,284,393)	(2,284,393)
Balance, December 31, 2011 (restated)	4,286	429	12,830,000	12,831	510,575	1,021,857	(7,400,602)	(5,854,910)
Preferred stock issued for cash	1,116	112	-	-	-	1,115,889	-	1,116,001
Stock offering costs	-	-	-	-	-	(221,175)	-	(221,175)
Common stock issued for services	-	-	7,500	8	-	6,367	-	6,375
Amortization of options issued for services	-	-	-	-	-	16,772	-	16,772
Adjustment for derivative liability	-	-	-	-	-	(301,800)	-	(301,800)
Preferred dividend accrued	-	-	-	-	351,297	(351,297)	-	-
Net loss for the year ended December 31, 2012	-	-	-	-	-	-	(1,310,934)	(1,310,934)
Balance, December 31, 2012	5,402	541	12,837,500	12,839	861,872	1,286,613	(8,711,536)	(6,549,671)

Preferred stock issued for cash	3,380		338	-		-		-		3,379,662		-		3,380,000
Stock offering costs	-		-	-		-		-		(550,326)		-		(550,326)
Common stock issued for services	-		-	40,000		40		-		33,960		-		34,000
Executive forfeited salary	-		-	-		-		-		104,000		-		104,000
Amortization of options issued for services	-		-	-		-		-		667,449		-		667,449
Preferred dividend accrued	-		-	-		-		492,089		(492,089)		-		-
Adjustment for derivative liability	-		-	-		-		-		5,691,185		-		5,691,185
Net loss for the year ended December 31, 2013												(1,956,872)		(1,956,872)
Balance, December 31, 2013	8,782	$	879	12,877,500	$	12,879	$	1,353,961	$	10,120,454	$	(10,668,408)	$	819,765

The accompanying notes are an integral part of these financial statements.

4750

SIGNPATH PHARMA, INC.
(A Development Stage Company)
Statements of Cash Flows
Statements of Cash Flows
	For the Years Ended
				From Inception
	December, 31
				on May 15, 2006
	2014			2013
	For the Years Ended			Through
OPERATING ACTIVITIES
	December 31,			December 31,
Net loss	$	(2,748,190	)	$	(1,956,872	)
	2013			2012			2013
Adjustments to reconcile net loss to net cash used in operating activities:
OPERATING ACTIVITIES
Common stock issued for services		34,000			34,000
Net loss	$	(1,956,872	)	$	(1,310,934	)	$	(10,668,408	)
Stock options compensation		217,444			667,449
Adjustments to reconcile net loss to net cash used in operating activities:
Modification of warrants		13,132			-
Common stock issued for services		34,000			6,375			1,306,875
Warrants issued for services		281,283			-
Options issued for services		667,449			16,772			746,799
Depreciation expense		-			144
Common stock issued with bridge financing		-			-			1,139,001
Change in derivative liability, net of bifurcation		-			3,926
Depreciation expense		144			1,265			5,390
Changes in operating assets and liabilities
Change in derivative liability, net of bifurcation		3,926			8,154			998,403
Accounts payable and accrued expenses		26,367			(368,846	)
Changes in operating assets and liabilities
Net Cash Used in Operating Activities		(2,175,964	)		(1,620,199	)
Accounts payable and accrued expenses		(368,846	)		395,040			525,629
FINANCING ACTIVITIES
Net Cash Used in Operating Activities		(1,620,199	)		(883,328	)		(5,946,311	)
Preferred stock issued for cash, net of stock offering costs		1,650,760			2,829,674
INVESTING ACTIVITIES
Proceeds from related party notes payable		-			30,000
Purchase of equipment		-			-			(5,390	)
Repayment of related party notes payable		-			(30,000	)
Net Cash Used in Investing Activities		-			-			(5,390	)
Net Cash Provided by Financing Activities		1,650,760			2,829,674
FINANCING ACTIVITIES
NET INCREASE (DECREASE) IN CASH		(525,204	)		1,209,475
Preferred stock issued for cash		3,380,000			1,116,001			7,891,501
CASH AT BEGINNING OF PERIOD		1,241,397			31,922
Stock offering costs paid		(550,326	)		(221,175	)		(1,598,278	)
CASH AT END OF PERIOD	$	716,193		$	1,241,397
Common stock issued for cash		-			-			10,000
SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION:
Proceeds from related party notes payable		30,000						30,000
CASH PAID FOR:
Proceeds from notes payable		-			55,075			944,950
Interest	$	-		$	-
Repayment of related party notes payable		(30,000	)		-			(30,000	)
Income taxes	$	-		$	-
Repayment of notes payable		-			(55,075	)		(55,075	)
NON CASH FINANCING ACTIVITIES:
Net Cash Provided by Financing Activities		2,829,674			894,826			7,193,098
Executive salary forfeited	$	-		$	104,000
NET INCREASE IN CASH		1,209,475			11,498			1,241,397
Common stock issued for dividends	$	1,025,404		$	-
CASH AT BEGINNING OF PERIOD		31,922			20,424			-
Settlement of derivative liability	$	-		$	5,691,185
CASH AT END OF PERIOD	$	1,241,397		$	31,922		$	1,241,397
Preferred dividend accrual	$	640,673		$	492,089
SUPPLEMENTAL DISCLOSURES OF
CASH FLOW INFORMATION:
CASH PAID FOR:
Interest	$	-		$	-		$	-
Income taxes	$	-		$	-		$	-
NON CASH FINANCING ACTIVITIES:
Preferred stock issued for bridge financing	$	-		$	-		$	889,875
Derivative liability	$	-		$	301,800		$	4,692,786
Executive forfeited salary	$	104,000		$	-		$	104,000
Settlement of derivative liability	$	5,691,185		$	-		$	5,691,185
Preferred dividend accrual	$	492,089		$	351,298		$	1,353,961

The accompanying notes are an integral part of these financial statements.

4851

SIGNPATH PHARMA, INC.

(A Development Stage Company)

Notes to the Financial Statements

December 31, ~~2013~~2014 and ~~2012~~2013

NOTE 1 – NATURE OF OPERATIONS

SignPath Pharma, Inc., (the “Company”) was incorporated under the laws of the State of Delaware on May 15, 2006. The Company was organized to develop proprietary formulations of curcumin (diferuloylmethane), a naturally occurring compound found in the root of the Curcuma longa (turmeric) plant, for applications in malignant diseases. The Company’s product candidates are currently in ~~the~~Phase ~~pre-~~I clinical ~~testing~~trials ~~phase~~in Austria and an Investigational New Drug (“IND”) application was approved by the U.S. Food and Drug Administration (“FDA”) in 2014.

NOTE 2 - GOING CONCERN

The Company's financial statements are prepared using generally accepted accounting principles in the United States of America applicable to a going concern which contemplates the realization of assets and liquidation of liabilities in the normal course of business. The Company has not yet established an ongoing source of revenues sufficient to cover its operating costs and allow it to continue as a going concern. During the year ended December 31, ~~2013~~2014, the Company recognized sales revenue of $-0- and incurred a net loss of $12,~~956~~748,~~872~~190. As of December 31, ~~2013~~2014, the Company had an accumulated deficit of $1013,~~668~~416,~~408~~598. The continuation of the Company as a going concern is dependent upon the continued financial support from its shareholders, the ability to raise equity or debt financing, and the attainment of profitable operations from the Company's planned business. If the Company is unable to obtain adequate capital, it could be forced to cease operations. These consolidated financial statements do not include any adjustments to the recoverability and classification of recorded asset amounts and classification of liabilities that might be necessary should the Company be unable to continue as a going concern.

In order to continue as a going concern, the Company will need, among other things, additional capital resources. Management's plan is to obtain such resources for the Company by obtaining capital from significant shareholders sufficient to meet its ~~minimal~~ operating expenses and seeking equity and/or debt financing from third parties. However management cannot provide any assurances that the Company will be successful in accomplishing any of its plans.

The ability of the Company to continue as a going concern is dependent upon its ability to successfully accomplish the plans described in the preceding paragraph and eventually secure other sources of financing and attain profitable operations. The accompanying financial statements do not include any adjustments that might be necessary if the Company is unable to continue as a going concern.

NOTE 3 – SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Use of Estimates

The preparation of financial statements in conformity with accounting principles generally accepted in the United States of America requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities at the date of the financial statements and the reported amounts of revenue and expenses during the reporting period. Actual results could differ from those estimates.

Accounting Basis

The Company’s financial statements are prepared using the accrual basis of accounting in accordance with accounting principles generally accepted in the United States. The Company has elected a December 31 fiscal year end.

Cash and Cash Equivalents

The Company considers all highly liquid instruments with maturity of three months or less at the time of issuance to be cash equivalents. There were no cash equivalents as of December 31, ~~2013~~2014 or ~~2012~~2013.

Concentration of Credit Risk

Financial instruments, which potentially subject us to concentrations of credit risk, consist principally of cash. Our cash balances are maintained in accounts held by major banks and financial institutions located in the United States. The Company occasionally maintains amounts on deposit with a financial institution that are in excess of the federally insured limit of $250,000. The risk is managed by maintaining all deposits in high quality financial institutions. The Company had $991,397 and $0 of cash balances in excess of federally insured limits at December 31, 2013 and 2012, respectively.

49The Company occasionally maintains amounts on deposit with a financial institution that are in excess of the federally insured limit of $250,000. The risk is managed by maintaining all deposits in high quality financial institutions. The Company had $437,081 and $991,397 of cash balances in excess of federally insured limits at December 31, 2014 and 2013, respectively.

SIGNPATH PHARMA, INC.

(A Development Stage Company)

Notes to the Financial Statements

December 31, 2013 and 2012

Property and Equipment

Property and equipment is recorded at cost less accumulated depreciation. Depreciation and amortization is calculated using the straight-line method over the expected useful life of the asset, after the asset is placed in service. The Company generally uses the following depreciable lives for its major classifications of property and equipment:

Description	Useful Lives
Computers	3 years
Equipment	5 years

Fair Value of Financial Instruments

In accordance with ASC 820, the carrying value of cash and cash equivalents, accounts receivable and accounts payable approximates fair value due to the short-term maturity of these instruments. ASC 820 clarifies the definition of fair value, prescribes methods for measuring fair value, and establishes a fair value hierarchy to classify the inputs used in measuring fair value as follows:

Level 1-Inputs are unadjusted quoted prices in active markets for identical assets or liabilities available at the measurement date.

Level 2-Inputs are unadjusted quoted prices for similar assets and liabilities in active markets, quoted prices for identical or similar assets and liabilities in markets that are not active, inputs other than quoted prices that are observable, and inputs derived from or corroborated by observable market data.

Level 3-Inputs are unobservable inputs which reflect the reporting entity’s own assumptions on what assumptions the market participants would use in pricing the asset or liability based on the best available information.

The carrying amounts reported in the balance sheets for cash, accounts payable and accrued expenses approximate their fair market value based on the short-term maturity of these instruments. ~~The following table presents assets and liabilities that are measured and recognized at fair value as of December 31, 2013, on a recurring basis:~~

Description

Level 1

Level 2

Level 3

Total

Derivative Liability

Total

The following table presents assets and liabilities that are measured and recognized at fair value as of December 31, 2012, on a recurring basis:

Description	Level 1		Level 2		Level 3			Total
Derivative Liability	$	-	$	-	$	(5,687,262	)	$	(5,687,262	)
Total	$	-	$	-	$	(5,687,262	)	$	(5,687,262	)

A financial instrument's categorization within the valuation hierarchy is based upon the lowest level of input that is significant to the fair value measurement. The following is a description of the valuation methodology used to measure fair value, as well as the general classification of such instruments pursuant to the valuation hierarchy.

Derivative Liability: Market prices are not available for the Company's warrants nor are market prices of similar warrants available. The Company assessed that the fair value of this liability approximates its carrying value since carrying value has been adjusted to fair value.

SIGNPATH PHARMA, INC.

(A Development Stage Company)

Notes to the Financial Statements

December 31, 2013 and 2012

The method described above may produce a current fair value calculation that may not be indicative of net realizable value or reflective of future fair values. If a readily determined market value became available or if actual performance were to vary appreciably from assumptions used, assumptions may need to be adjusted, which could result in material differences from the recorded carrying amounts. The Company believes its method of determining fair value is appropriate and consistent with other market participants. However, the use of different methodologies or different assumptions to value certain financial instruments could result in a different estimate of fair value.

The following tables present the fair value of financial instruments as of December 31, 2013, by caption on the condensed balance sheet and by ASC 820 valuation hierarchy described above.

	Stock Warrant
Level 3 Reconciliation:	Derivative
Level 3 assets and liabilities at December 31, 2012		$	(5,687,262	)
Purchases, sales, issuances and settlements (net)			5,687,262
Total level 3 assets and liabilities at December 31, 2013		$	-

Derivative Financial Instruments

Research and Development Costs

The Company expenses the costs of the development of its pharmaceutical products during the period incurred. The Company incurred research and development expenses of $~~841~~1,~~502~~927,851 and $~~939~~841,~~296~~502 during the years ended December 31, ~~2013~~2014 and ~~2012~~2013, respectively.

Stock-Based Compensation

The Company follows the provisions of ASC 718 which requires all share-based payments to employees, including grants of employee stock options, to be recognized in the income statement based on their fair values. The Company uses the Black-Scholes pricing model for determining the fair value of stock based compensation.

Equity instruments issued to non-employees for goods or services are accounted for at fair value and are marked to market until service is complete or a performance commitment date is reached, whichever is earlier.

Income Taxes

The Company accounts for income taxes under the asset and liability method. Deferred tax assets and liabilities are determined based on differences between the financial reporting and tax bases of assets and are measured using the enacted tax rates and laws that will be in effect when the differences are expected to reverse.

In July, 2006, the FASB issued ASC 740, Accounting for Uncertainty in Income Taxes, which clarifies the accounting for uncertainty in tax positions taken or expected to be taken in a return. ASC 740 provides guidance on the measurement, recognition, classification and disclosure of tax positions, along with accounting for the related interest and penalties. ASC 740 became effective as of January 1, 2007 and had no impact on the Company’s financial statements.

The charge for taxation is based on the results for the year as adjusted for items, which are non-assessable or disallowed. It is calculated using tax rates that have been enacted or substantively enacted by the balance sheet date.

Basic and Diluted Net income (Loss) per Share

The Company computes net income (loss) per share in accordance with ASC 260 which requires presentation of both basic and diluted earnings per share (EPS) on the face of the income statement. Basic EPS is computed by dividing net income (loss) available to common shareholders (numerator) by the weighted average number of shares outstanding (denominator) during the period. Diluted EPS gives effect to all dilutive potential common shares outstanding during the period using the treasury stock method and convertible preferred stock using the if-converted method. In computing Diluted EPS, the average stock price for the period is used in determining the number of shares assumed to be purchased from the exercise of stock options or warrants. Diluted EPS excludes all dilutive potential shares if their effect is anti-dilutive.

51For the years ended December 31, 2014 and 2013, all of the Company’s potentially dilutive securities (warrants, options, convertible preferred stock) were excluded from the computation of diluted earnings per share as they were anti-dilutive. The total number of potentially dilutive Common Shares that were excluded were 23,922,480 and 22,424,146 at December 31, 2014 and 2013, respectively.

SIGNPATH PHARMA, INC.

(A Development Stage Company)

Notes to the Financial Statements

December 31, 2013 and 2012

For the years ended December 31, 2013 and 2012, all of the Company’s potentially dilutive securities (warrants, options, and convertible preferred stock) were excluded from the computation of diluted earnings per share as they were anti-dilutive. The total number of potentially dilutive shares that were excluded was 18,162,608 and 12,814,874 at December 31, 2013 and 2012, respectively.

Deemed Dividend on Warrant Amendment

During the year ended December 31, 2013, the Company amended the terms of its Class A, B, C and PAW Warrants with certain investors who held warrants to purchase 11,364,453 shares of our common stock to extend the terms of the Warrants such that none of the Warrants expire before the 5th anniversary of the date on which the Common Stock begins public trading on a national securities exchange. The modification of the expiration date of the warrant resulted in a deemed dividend to warrant holders of approximately, $2,445,621 which was calculated as the difference between fair value of the warrants immediately before and after the modification using the Black-Scholes option pricing model. The deemed dividends have been included in the calculation of the net loss attributable to common stockholders of approximately $4,402,493 or $0.34 per share, the the year ended December 31, 2013. The deemed dividends are exluded form our net loss (from operating activities) of approximately $4,402,493, or $0.34 per share, for the year ended December 31, 2013.

Recent Accounting Pronouncements

In ~~July~~June ~~2013~~2014, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update ~~(ASU)~~ No. ~~2013~~2014-~~11: Presentation~~10, Development Stage Entities (Topic 915) - Elimination of Certain Financial Reporting Requirements, Including an ~~Unrecognized~~Amendment ~~Tax~~to ~~Benefit~~Variable ~~When~~Interest aEntities ~~Net~~Guidance ~~Operating~~in ~~Loss~~Topic ~~Carryforward~~810, aConsolidation ~~Similar~~(“ASU ~~Tax~~2014-10”). ~~Loss,~~ASU or2014-10 eliminates the concept of a ~~Tax~~development ~~Credit~~stage ~~Carryforward~~entity ~~Exists~~in its entirety from current accounting guidance. The new guidance ~~requires~~eliminates ~~that~~the ~~unrecognized~~requirements ~~tax~~for ~~benefits~~development bestage ~~presented~~entities onto (i) present inception-to-date information in the statement of operations, stockholders’ equity and cash flows, (ii) label the financial statements as those of a ~~net~~development ~~basis~~state ~~with~~entity, (iii) disclose a description of the ~~deferred~~development ~~tax~~stage ~~assets~~activities ~~for~~in ~~such~~which ~~carryforwards.~~the ~~This~~entity ~~new~~is ~~guidance~~engaged, and (iv) disclose in the first year in which the entity is ~~effective~~no ~~for~~longer ~~fiscal~~a development stage entity that in prior years it and ~~interim~~been ~~periods~~in ~~within~~the ~~those~~development ~~years~~stage. ASU 2014-10 is effective prospectively for public entities for annual reporting periods beginning after December 15, ~~2013.~~2015, Weand dointerim ~~not~~periods ~~expect~~within ~~the~~those annual periods; however, early adoption ofis ~~the~~permitted. ~~new~~The ~~provisions~~Company elected to ~~have~~adopt aASU ~~material~~2014-10 ~~impact~~as onpermitted, ~~our~~for the financial ~~condition~~statements orended ~~results~~September of30, ~~operations~~2014 and, accordingly, has not included the inception-to-date disclosures and other previously required disclosures for development stage entities.

In February 2013, FASB issued ASU No. 2013-02, Comprehensive Income (Topic 220): Reporting of Amounts Reclassified Out of Accumulated Other Comprehensive Income , to improve the transparency of reporting these reclassifications. Other comprehensive income includes gains and losses that are initially excluded from net income for an accounting period. Those gains and losses are later reclassified out of accumulated other comprehensive income into net income. The amendments in the ASU do not change the current requirements for reporting net income or other comprehensive income in financial statements. All of the information that this ASU requires already is required to be disclosed elsewhere in the financial statements under U.S. GAAP. The new amendments will require an organization to:

- Present (either on the face of the statement where net income is presented or in the notes) the effects on the line items of net income of significant amounts reclassified out of accumulated other comprehensive income - but only if the item reclassified is required under U.S. GAAP to be reclassified to net income in its entirety in the same reporting period; and - Cross-reference to other disclosures currently required under U.S. GAAP for other reclassification items (that are not required under U.S. GAAP) to be reclassified directly to net income in their entirety in the same reporting period. This would be the case when a portion of the amount reclassified out of accumulated other comprehensive income is initially transferred to a balance sheet account (e.g., inventory for pension-related amounts) instead of directly to income or expense.

The amendments apply to all public and private companies that report items of other comprehensive income. Public companies are required to comply with these amendments for all reporting periods (interim and annual). The amendments are effective for reporting periods beginning after December 15, 2012, for public companies. Early adoption is permitted. The adoption of ASU No. 2013-02 is not expected to have a material impact on our financial position or results of operations.

In January 2013, the FASB issued ASU No. 2013-01, Balance Sheet (Topic 210): Clarifying the Scope of Disclosures about Offsetting Assets and Liabilities , which clarifies which instruments and transactions are subject to the offsetting disclosure requirements originally established by ASU 2011-11. The new ASU addresses preparer concerns that the scope of the disclosure requirements under ASU 2011-11 was overly broad and imposed unintended costs that were not commensurate with estimated benefits to financial statement users. In choosing to narrow the scope of the offsetting disclosures, the Board determined that it could make them more operable and cost effective for preparers while still giving financial statement users sufficient information to analyze the most significant presentation differences between financial statements prepared in accordance with U.S. GAAP and those prepared under IFRSs. Like ASU 2011-11, the amendments in this update will be effective for fiscal periods beginning on, or after January 1, 2013. The adoption of ASU 2013-01 is not expected to have a material impact on our financial position or results of operations.

In October 2012, the Financial Accounting Standards Board (FASB) issued Accounting Standards Update (ASU) 2012-04, "Technical Corrections and Improvements" in Accounting Standards Update No. 2012-04. The amendments in this update cover a wide range of Topics in the Accounting Standards Codification. These amendments include technical corrections and improvements to the Accounting Standards Codification and conforming amendments related to fair value measurements. The amendments in this update will be effective for fiscal periods beginning after December 15, 2012. The adoption of ASU 2012-04 is not expected to have a material impact on our financial position or results of operations.

SIGNPATH PHARMA, INC.

(A Development Stage Company)

Notes to the Financial Statements

December 31, 2013 and 2012

In August 2012, the FASB issued ASU 2012-03, "Technical Amendments and Corrections to SEC Sections: Amendments to SEC Paragraphs Pursuant to SEC Staff Accounting Bulletin (SAB) No. 114, Technical Amendments Pursuant to SEC Release No. 33-9250, and Corrections Related to FASB Accounting Standards Update 2010-22 (SEC Update)" in Accounting standards Update No. 2012-03. This update amends various SEC paragraphs pursuant to the issuance of SAB No. 114. The adoption of ASU 2012-03 is not expected to have a material impact on our financial position or results of operations.

In July 2012, the FASB issued ASU 2012-02, "Intangibles – Goodwill and Other (Topic 350): Testing Indefinite-Lived Intangible Assets for Impairment" in Accounting Standards Update No. 2012-02. This update amends ASU 2011-08, Intangibles – Goodwill and Other (Topic 350): Testing Indefinite-Lived Intangible Assets for Impairment and permits an entity first to assess qualitative factors to determine whether it is more likely than not that an indefinite-lived intangible asset is impaired as a basis for determining whether it is necessary to perform the quantitative impairment test in accordance with Subtopic 350-30, Intangibles - Goodwill and Other - General Intangibles Other than Goodwill. The amendments are effective for annual and interim impairment tests performed for fiscal years beginning after September 15, 2012. Early adoption is permitted, including for annual and interim impairment tests performed as of a date before July 27, 2012, if a public entity’s financial statements for the most recent annual or interim period have not yet been issued or, for nonpublic entities, have not yet been made available for issuance. The adoption of ASU 2012-02 is not expected to have a material impact on our financial position or results of operations.

The Company has implemented all new accounting pronouncements that are in effect. These pronouncements did not have any material impact on the financial statements unless otherwise disclosed, and the Company does not believe that there are any other new accounting pronouncements that have been issued that might have a material impact on its financial position or results of operation

NOTE 4 – EQUIPMENT

Property and equipment consists of the following as of December 31, 2013 and 2012. Depreciation expense was $144 and $1,265 for the years ended December 31, 2013 and 2012, respectively.

	2013			2012
Computer equipment	$	5,390		$	5,390
Accumulated Depreciation		(5,390	)		(5,246	)
Net Book Value	$	-		$	144

NOTE 5 – ACCRUED LIABILITIES

Pursuant to the applicable Codification literature, the Company has concluded it is probable that it will pay $85,738 in liquidated damages pursuant to the registration rights clause in certain of the securities sold in fiscal years 2008 and 2009, the Company was required to file a registration statement by January 27, 2009. The Company failed to do so until April 7, 2009, resulting in liquidated damages of 2% per month of the gross proceeds, which approximated $1.8 million as of that date. During the year ended December 31, 2009, the Company’s registration statement covering the securities was declared effective by the SEC. Each holder is entitled to $47.32 per share owned. The Company has resolved to pay the liquidated damages in shares of Common Stock valued at $1.00 per share, pursuant to the terms and provisions of the Certificate of Designation, Preferences and Rights of Series A Convertible Preferred Stock.

NOTE 6 – NOTE PAYABLE

In January 2012, the Company received cash pursuant to a short-term promissory note with a related party. The note was repaid in full in February 2012. The note did not bear interest.

On September 27, 2012, the Company received $55,075 in cash pursuant to a short-term promissory note with a related party. The note did not bear interest and was due on demand. In December 2012, the balance on the note was repaid in full.

In January 2013, the Company received $25,000 in cash pursuant to a short-term promissory note with a related party. In March 2013 the Company received $5,000 in cash pursuant to a short-term promissory note with the same related party. The note did not bear interest. The Company assessed the imputed interest and found the balance to be immaterial. In April 2013, the balance on the note was repaid in full.

~~SIGNPATH~~NOTE ~~PHARMA,~~4 ~~INC.~~– ACCRUED LIABILITIES

(APursuant ~~Development~~to ~~Stage~~the applicable Codification literature, the Company) has concluded it is probable that it will pay $85,738 in liquidated damages pursuant to the registration rights clause in certain of the securities sold in fiscal years 2008 and 2009, the Company was required to file a registration statement by January 27, 2009. The Company failed to do so until April 7, 2009, resulting in liquidated damages of 2% per month of the gross proceeds, which approximated $1.8 million as of that date. During the year ended December 31, 2009, the Company’s registration statement covering the securities was declared effective by the SEC. Each holder is entitled to $47.32 per share owned. The Company has resolved to pay the liquidated damages in shares of Common Stock valued at $1.00 per share, pursuant to the terms and provisions of the Certificate of Designation, Preferences and Rights of Series A Convertible Preferred Stock.

~~Notes~~NOTE to5 ~~the~~– ~~Financial~~NOTE ~~Statements~~PAYABLE

~~December~~In 31January 2013, the Company received $25,000 in cash pursuant to a short-term promissory note with a related party. In March 2013 the Company received $5,000 in cash pursuant to a short-term promissory note with the same related party. The notes did not bear interest. The Company assessed the imputed interest and ~~2012~~found the balance to be immaterial. In April 2013, the balance on the notes was repaid in full.

NOTE 76 – DERIVATIVE LIABILITY AND FAIR VALUE MEASUREMENTS

The Company’s only asset or liability measured at fair value on a recurring basis is its derivative liability associated with its Series A Preferred Stock and associated warrants to purchase common stock. On ~~May~~July 717, 2013, the Company amended its Certificate of Incorporation to eliminate anti-dilution price protection from its Series A Preferred Stock and associated derivative liability. On ~~January~~The 1,change 2009, the Company adopted ASC Topic No. 815-40 which defines determining whether an instrument (or embedded feature) is solely indexed to an entity’s own stock. As of January 1, 2009, the Company had issued 3,572,714 warrants which have exercise prices that are subject to “reset” provisions in ~~the~~fair ~~event~~value ~~the~~during ~~Company~~years ~~subsequently~~ended ~~issues~~December ~~common stock~~31, ~~stock~~2014 ~~warrants,~~and ~~stock~~2013 ~~options~~of ~~or convertible debt with a stock price, exercise price or conversion price lower than~~ $0~~.85~~ and ($~~1.27~~3,926), respectively~~. If these provisions are triggered~~, ~~the~~is ~~exercise~~recorded ~~price~~as ~~of all of those warrants will be reduced. As~~ a ~~result,~~derivative ~~the~~loss ~~warrants~~in ~~are not considered to be solely indexed to~~ the ~~Company’s~~accompanying ~~own~~Statements ~~stock~~of ~~and are not afforded equity treatment~~Operations.

AsNOTE a result, on January 1, 2009, 3,572,714 of the Company’s outstanding warrants containing exercise price reset provisions, originally classified as permanent equity, were reclassified to derivative liability. These warrants had exercise prices ranging from $0.85 - $1.27 and expire starting in December 2013. As of January 1, 2009, the fair value of these warrants of $1,676,633 was recognized and resulted in a cumulative effect adjustment to retained earnings of $43,808. On May 7, ~~2013,~~– ~~the~~PREFERRED Company effectively removed the derivative provision from the warrants and convertible debt and valued the derivatives market to market as of that date. The derivative liability was then converted to additional paid-in-capital. The change in fair value during years ended December 31, 2013 and 2012 of ($3,926) and ($8,154), respectively, is recorded as a derivative loss in the accompanying Statements of Operations.STOCK

~~During~~The ~~the~~Company ~~year~~has ~~ended~~authorized ~~December~~5,000,000 31shares of Preferred Stock, ~~2012~~$.10 par value, ~~the~~of ~~Company~~which, ~~issued~~as 1of December 31,~~313~~ 2014,~~533~~ ~~warrants~~an ~~which~~aggregate of 10,722.375 shares were ~~attached~~issued toand 1outstanding consisting of (i) 5,~~116~~000 shares of ~~convertible~~Series ~~preferred~~A ~~stock.~~Convertible ~~The~~Preferred ~~Company~~Stock authorized and 3,255.375 shares issued anand ~~additional~~outstanding, ~~757~~(ii) 3,~~223~~000 ~~warrants~~shares asof ~~stock~~Series ~~offering~~B ~~costs~~Convertible toPreferred ~~the~~Stock ~~Company’s~~authorized ~~placement~~and ~~agent.~~2,146 ~~The~~shares ~~combined~~were ~~fair~~issued ~~market~~and ~~value~~outstanding, (iii) 6,000 shares of ~~the~~Series ~~derivative~~C ~~liability~~Convertible ~~associated~~Preferred ~~with~~Stock ~~these~~authorized ~~issuances~~and at5,001 ~~the~~shares ~~date~~were issued and outstanding, and (iv) 6,000 shares of ~~issuance~~Series ~~was~~D ~~$301~~Convertible Preferred Stock are authorized,~~800~~ 320 of which were issued and outstanding.

~~During~~Series ~~the~~A ~~year~~Convertible ~~ended~~Preferred December 31, 2011, the Company issued 1,704,884 warrants which were attached to 1,449 shares of convertible preferred stock. The Company issued an additional 1,022,931 warrants as stock offering costs to the Company’s placement agent. The combined fair market value of the derivative liability associated with these issuances at the date of issuance was $2,184,753.Stock

~~During~~The ~~the~~Series ~~year~~A ~~ended~~Convertible ~~December~~Preferred ~~31,~~Stock ~~2010,~~(“Series A Preferred Stock”) was authorized by resolutions adopted by the Company’s ~~issued~~Board ~~676,775~~of ~~warrants~~Directors ~~which~~and ~~were~~set ~~attached~~forth toin ~~575~~a ~~shares~~Certificate of ~~convertible~~Designation, ~~preferred~~Preferences ~~stock. The~~and ~~Company~~Rights ~~issued~~(“Certificate anof ~~additional~~Designation”), ~~391~~filed with the Secretary of State of Delaware on November 26,~~353~~ ~~warrants~~2008, as ~~stock~~amended ~~offering~~and ~~costs~~restated toon July 17, 2013, which contains the ~~Company’s~~designations, ~~placement~~rights, ~~agent. The~~powers, ~~Combined~~preferences, ~~fair~~qualifications ~~market~~and ~~value~~limitations of the ~~derivative~~Series ~~liability~~A ~~associated~~Preferred ~~with~~Stock. The ~~these~~shares ~~issuances~~of ~~for~~Series ~~the~~A ~~year~~Preferred ~~ended~~Stock ~~December~~are ~~31,~~fully ~~2010~~paid ~~was~~and ~~$852,346~~non-assessable.

~~During~~Between ~~the~~November ~~year~~25, ~~ended~~2008 ~~December~~and 31July 26, ~~2009~~2011, the Company completed the private placement of an aggregate of 3,255.375 Units of the Company’s securities, representing $3,255,375 principal amount of 6.5% Series A Preferred Stock at $1,000 per Unit. This was the first series of preferred Stock issued ~~953~~by the Company. Each Unit consisted of: $1,~~370~~000 ~~warrants~~face ~~which~~value ~~were~~of ~~attached~~one toshare ~~810~~of Preferred Stock, convertible at $.85 per share into 1,177 shares of ~~convertible~~common ~~preferred~~stock, with each share of Preferred Stock accruing an annual dividend of 6.5% or $65 per share payable annually in cash or shares of common stock at the option of the Company, unless earlier converted or redeemed. ~~The~~Warrants ~~Company~~included ~~issued~~in the Units, as amended, are exercisable for five years from the date when the Common Stock is publicly traded at an ~~additional~~exercise ~~286~~price of $1.27,~~011~~ ~~warrants~~payable asin ~~stock~~cash, ~~offering~~unless ~~costs~~the Company fails to keep the ~~Company’s~~registration ~~placement~~statement ~~agent~~effective to purchase 1,177 shares of common stock. ~~The~~A ~~Combined~~total ~~fair~~of ~~market~~3,255.375 ~~value~~shares of Preferred Stock were purchased in the ~~derivative~~offering, ~~liability~~which ~~associated~~are ~~with~~convertible ~~these~~into ~~issuances~~an aggregate of approximately 3,831,576 shares of common stock. Of this amount, an aggregate of 3,382,357 shares have been registered for ~~the~~resale ~~year~~by ~~ended~~33 ~~December~~retail 31investors, ~~2009~~which ~~was~~amount ~~$988~~excludes 449,~~552~~220 shares of common Stock issuable upon conversion of Preferred Stock sold to the Placement Agent’s affiliates.

The Company classifies the fair value of these warrants under level three of the fair value hierarchy of financial instruments. The fair value of the derivative liability was calculated using a lattice model that values the compound embedded derivatives based on a probability weighted discounted cash flow model. This model is based on future projections of the various potential outcomes. The embedded derivatives that were analyzed and incorporated into the model included the conversion feature with the full ratchet reset, and the redemption options.

~~SIGNPATH~~Rank. The ~~PHARMA~~Preferred Stock ranks (i) senior to the common stock and any other class or series of the Company’s capital stock either specifically ranking by its terms junior to the Preferred Stock or not specifically ranking by its terms senior to or on parity with the Preferred Stock, ~~INC~~(ii) on parity with any class or series of the Company’s capital stock specifically ranking by its terms on parity with the Preferred Stock, and (iii) junior to any class or series of capital stock specifically ranking by its terms senior to the Preferred Stock, in each case, as to payment of dividends or as to distributions of assets upon liquidation, dissolution or winding-up of the Company, whether voluntary or involuntary. The approval of the holders of a majority of the Preferred Stock is required in order for the Company to issue any capital stock with rights on parity with or senior to the Preferred Stock.

(ADividends. The ~~Development~~holders ~~Stage~~of the Preferred Stock are entitled to receive annual cumulative per share dividends of 6.5% of the liquidation preference of the Preferred Stock, out of funds legally available, prior to any payment of dividends on the Company’s common stock or any other class of stock ranking junior to the Preferred Stock. Such dividends are payable in cash or shares of common stock, at the option of the Company, semiannually on the last business day of February and August of each year (each a “Dividend Payment Date”), commencing in February 2009 with respect to the period from issuance through such date. The holders of the Preferred Stock are entitled to share ratably with the holders of the common stock in any dividend declared on the common stock.

~~Notes~~Dividends on the Preferred Stock will accrue whether or not the Company has earnings, whether or not there are funds legally available for the payment of such dividends and whether or not such dividends are declared. Dividends accumulate to the ~~Financial~~extent ~~Statements~~they are not paid on the Dividend Payment Date to which they relate. Accumulated unpaid dividends will not bear interest. According to Delaware law, the Company may declare and pay dividends or make other distributions on its capital stock only out of legally-available funds. In addition, no dividends or distributions may be declared, paid or made if the Company is or would be rendered insolvent by virtue of such dividend or distribution.

~~December~~The 31Company may not (i) pay any dividends in respect of any shares of capital stock ranking junior to the Preferred Stock (including the common stock), ~~2013~~other than dividends payable in the form of additional shares of the same junior stock as that on which such dividend is declared, or (ii) redeem any shares of capital stock ranking junior to the Preferred Stock (including the common stock), unless and ~~2012~~until all accumulated and unpaid dividends on the Preferred Stock have been, or contemporaneously are, declared and paid in full.

Conversion. At the election of the holder thereof, each share of Preferred Stock will be convertible into common stock, at any time after issuance, at the Conversion Rate, as it may be adjusted from time to time in accordance with the Certificate of Designation. The ~~Series~~Preferred AStock will not convert automatically into Common Stock upon completion of this offering and only the underlying Common Stock issuable upon conversion is registered for the resale under this prospectus. The Conversion Rate initially will be 1,177 shares of common stock ($.85 per share) for each Share of Preferred ~~Derivatives~~Stock. Conversion ~~were~~Price ~~valued~~is ~~using~~also subject to adjustment from time to time in the ~~following~~event ~~assumptions:~~of (i) the issuance of common stock as a dividend or distribution on any class of the Company’s capital stock; or (ii) the combination, subdivision or reclassification of the common stock. No fractional shares will be issued upon conversion. Payment of accumulated and unpaid dividends will be made upon conversion to the extent of legally-available funds.

·	The Company was 3 months from being publicly traded and the Company/Holder would convert the Preferred Stock based on 200% of the adjusted conversion price;
·	The Preferred maturity date used was 7 years following the Company being publicly traded (rolling 6 years from the Valuation Date);

The shares of Preferred Stock may also be converted into common stock at the Conversion Rate at the Company’s option following the effectiveness of a Registration Statement, if the Company’s common stock trades above 200% of the Conversion Rate per share for a period of 20 consecutive trading days.

·	The stock price of $0.85 was used as the fair value of the common stock based on the previous common stock transaction;
·	The projected volatility curve was based on the average of 15 comparable biotech companies historical volatility:

Voting Rights. The affirmative vote of the holders of at least two-thirds of the outstanding shares of Preferred Stock, voting as a class, shall be required to authorize, effect or validate (i) any change in the rights, privileges or preferences of the Preferred Stock that would adversely affect the Preferred Stock, or (ii) the authorization, creation, issuance or increase in the authorized or issued amount of any class or series of stock ranking on parity with or superior to the Preferred Stock with respect to the declaration and payment of dividends or distribution of assets upon liquidation, dissolution or winding-up of our Company. In addition, the holders of Preferred Stock shall have the right to vote, together with holders of common stock as single class, on all matters upon which the holders of common stock are entitled to vote pursuant to applicable Delaware law or the Company’s Certificate of Incorporation. The Preferred Stock shall vote on an “as converted basis” with each holder of Preferred Stock having one vote for each Conversion Share underlying such holder’s shares of Preferred Stock.

·	The Holder would automatically convert at a stock price of $1.70 if the Company was not in default;
·	The Holder would convert on a quarterly basis in equal amounts to maturity if in the money; and

Liquidation. In the event of any voluntary or involuntary liquidation, dissolution or winding-up of the Company, before any payment or distribution of the assets of the Company (whether capital or surplus), or the proceeds thereof, may be made or set apart for the holders common stock or any stock ranking junior to Preferred Stock, the holders of Preferred Stock will be entitled to receive, out of the assets of the Company available for distribution to stockholders, a liquidating distribution of $1,000 per share, plus any accrued and unpaid dividends, subject to adjustment upon the occurrence of certain events. If, upon any voluntary or involuntary liquidation, dissolution or winding up of the Company, the assets of the Company are insufficient to make the full payment of $1,000 per share, plus all accrued and unpaid dividends on the Preferred Stock and similar payments on any other class of stock ranking on a parity with the Preferred Stock upon liquidation, then the holders of Preferred Stock and such other shares will share ratably in any such distribution of the Company’s assets in proportion to the full respective distributable amounts to which they are entitled. Certain events, including a consolidation or merger of the Company with or into another corporation or sale or conveyance of all or substantially all the property and assets of the Company will be deemed to be a liquidation, dissolution or winding-up of the Company for purposes of the foregoing.

· Capital raising events would occur annually, generating reset events based on pricing not greater than 100% of market.

The warrants were valued at issuance and marked to market quarterly for the period 2009 through December 2011. The five-year warrants are options to purchase shares of common stock at an exercise price of $0.85 per share and $1.27, subject to adjustments. The following assumptions were used for the valuation of the derivative:

·	The stock price of $0.85 was used as the fair value of the common stock based on the previous common stock transaction;
·	The projected volatility curve was based on the average of comparable companies as provided in the Preferred assumptions above;

·		The Holder would exercise the warrant at maturity if the stock price was above the exercise price;
·	The Holder would exercise the warrant at target prices starting at $1.58 for the Investor Warrants and $1.40 for the Placement Agent Warrants, and lowering such target as the warrants approached maturity.

·	The Holder would automatically convert all of the shares at a stock price of $1.58 for the Investor Warrants and $1.40 for the Placement Agent Warrants;
·	The Holder would convert on a quarterly basis in amounts not to exceed the average quarters trading volume based on historical performance, assuming the volume would increase by 5% each quarter; and

· Capital raising events would occur annually, generating reset events based on pricing not greater than 100% of market for the Placement Agent Warrants and for the Investor Warrants the reset would be 150% of the Preferred.

The Company determined the fair value of the preferred stock to be $0 and $3,182,380 and the fair value of the warrants to be $0 and $2,504,879 at December, 2013 and December 31, 2012, respectively.

The following shows the changes in the level three liability measured on a recurring basis from December 31, 2012 through December 31, 2013:

Balance, December 31, 2012	$	5,687,262
Derivative loss		3,923
Derivative liability for warrants removed during the period		(5,691,185	)
Balance, December 31, 2013	$	-

NOTE 8 – CAPITAL STOCK

The Series A Convertible Preferred Stock (“Preferred Stock”) has been authorized by resolutions adopted by the Company’s Board of Directors and set forth in a Certificate of Designation, Preferences and Rights (“Certificate of Designation”), filed with the Secretary of State of Delaware on November 26, 2008, and as last amended on July 17, 2013, which contains the designations, rights, powers, preferences, qualifications and limitations of the Series A Preferred Stock. The shares of Preferred Stock are fully paid and non-assessable. As of December 31, 2013, the Company has issued 3,255 shares of Series A Preferred Stock.

~~SIGNPATH~~Miscellaneous. The ~~PHARMA~~Company is not subject to any mandatory redemption or sinking fund provision with respect to the Preferred Stock. The holders of the Preferred Stock are not entitled to preemptive rights to subscribe for or to purchase any shares or securities of any class which may at any time be issued, ~~INC~~sold or offered for sale by the Company. Shares of Preferred Stock redeemed or otherwise reacquired by the Company shall be retired and shall be unavailable for subsequent issuance as any class of the Company’s preferred stock.

(A Development Stage Company)

Notes to the Financial Statements

December 31, 2013 and 2012

Rank

The Preferred Stock ranks(i) senior to the common stock and any other class or series of the Company’s capital stock either specifically ranking by its terms junior to the Preferred Stock or not specifically ranking by its terms senior to or on parity with the Preferred Stock, (ii) on parity with any class or series of the Company’s capital stock specifically ranking by its terms on parity with the Preferred Stock, and (iii) junior to any class or series of capital stock specifically ranking by its terms senior to the Preferred Stock, in each case, as to payment of dividends or as to distributions of assets upon liquidation, dissolution or winding-up of the Company, whether voluntary or involuntary. The approval of the holders of a majority of the Preferred Stock is required in order for the Company to issue any capital stock with rights on parity with or senior to the Preferred Stock.

Dividends

The holders of the Preferred Stock are entitled to receive annual cumulative per share dividends of 6.5% of the liquidation preference of the Preferred Stock, out of funds legally available, prior to any payment of dividends on the Company’s common stock or any other class of stock ranking junior to the Preferred Stock. Such dividends are payable in shares of common stock, semiannually on the last business day of February and August of each year (each a “Dividend Payment Date”), commencing in February 2009 with respect to the period from issuance through such date. The holders of the Preferred Stock are entitled to share ratably with the holders of the common stock in any dividend declared on the common stock.

Dividends on the Preferred Stock will accrue whether or not the Company has earnings, whether or not there are funds legally available for the payment of such dividends and whether or not such dividends are declared. Dividends accumulate to the extent they are not paid on the Dividend Payment Date to which they relate. The Company may not (i) pay any dividends in respect of any shares of capital stock ranking junior to the Preferred Stock (including the common stock), other than dividends payable in the form of additional shares of the same junior stock as that on which such dividend is declared, or (ii) redeem any shares of capital stock ranking junior to the Preferred Stock (including the common stock), unless and until all accumulated and unpaid dividends on the Preferred Stock have been, or contemporaneously are, declared and paid in full.

Conversion

At the election of the holder thereof, each share of Preferred Stock will be convertible into common stock, at any time after issuance, at the Conversion Rate, as it may be adjusted from time to time in accordance with the Certificate of Designation. The Conversion Rate initially will be 1,177 shares of common stock ($.85 per share) for each share of Preferred Stock.

The Conversion Price is subject to adjustment from time to time in the event of (i) the issuance of common stock as a dividend or distribution on any class of the Company’s capital stock; or (ii) the combination, subdivision or reclassification of the common stock. No fractional shares will be issued upon conversion. Payment of accumulated and unpaid dividends will be made upon conversion to the extent of legally-available funds. The shares of Preferred Stock may also be converted into common stock at the Conversion Rate at the Company’s option following the effectiveness of a Registration Statement, if the Company’s common stock trades above 300% of the Conversion Rate per share for a period of 20 consecutive trading days.

Voting Rights

The affirmative vote of the holders of at least two-thirds of the outstanding shares of Preferred Stock, voting as a class, shall be required to authorize, effect or validate (i) any change in the rights, privileges or preferences of the Preferred Stock that would adversely affect the Preferred Stock, or (ii) the authorization, creation, issuance or increase in the authorized or issued amount of any class or series of stock ranking on parity with or superior to the Preferred Stock with respect to the declaration and payment of dividends or distribution of assets upon liquidation, dissolution or winding-up of our Company. In addition, the holders of Preferred Stock shall have the right to vote, together with holders of common stock as single class, on all matters upon which the holders of common stock are entitled to vote pursuant to applicable Delaware law or the Company’s Certificate of Incorporation. The Preferred Stock shall vote on an “as converted basis” with each holder of Preferred Stock having one vote for each Conversion Share underlying such holder’s shares of Preferred Stock.

SIGNPATH PHARMA, INC.

(A Development Stage Company)

Notes to the Financial Statements

December 31, 2013 and 2012

Liquidation

In the event of any voluntary or involuntary liquidation, dissolution or winding-up of the Company, before any payment or distribution of the assets of the Company (whether capital or surplus), or the proceeds thereof, may be made or set apart for the holders common stock or any stock ranking junior to Preferred Stock, the holders of Preferred Stock will be entitled to receive, out of the assets of the Company available for distribution to stockholders, a liquidating distribution of $1,000 per share, plus any accrued and unpaid dividends, subject to adjustment upon the occurrence of certain events. If, upon any voluntary or involuntary liquidation, dissolution or winding up of the Company, the assets of the Company are insufficient to make the full payment of $1,000 per share, plus all accrued and unpaid dividends on the Preferred Stock and similar payments on any other class of stock ranking on a parity with the Preferred Stock upon liquidation, then the holders of Preferred Stock and such other shares will share ratably in any such distribution of the Company’s assets in proportion to the full respective distributable amounts to which they are entitled. Certain events, including a consolidation or merger of the Company with or into another corporation or sale or conveyance of all or substantially all the property and assets of the Company will be deemed to be a liquidation, dissolution or winding-up of the Company for purposes of the foregoing.

Series B Convertible Preferred Stock

The Series B Convertible Preferred Stock (“Series B Preferred Stock”) has been authorized by resolutions adopted by the Company’s Board of Directors and set forth in a Certificate of Designation, ~~Preferences and Rights (“Certificate of Designation”),~~ filed with the Secretary of State of Delaware on September 2, 2011, which contains the designations, rights, powers, preferences, qualifications and limitations of the Series B Preferred Stock. The shares of Series B Preferred Stock are fully paid and non-assessable. ~~As of December 31, 2013, the Company had issued 2,146 shares of Series B Preferred Stock.~~

~~Rank~~The Conversion Rate and dividend rates are the same for Series A and Series B Preferred Stock; however, the Series A Preferred Stock is senior to the Series B Preferred Stock on sale or liquidation of the Company. Each share of Series B Preferred Stock is convertible at $.85 per share into an aggregate of 1,177 shares of common stock, with each share of Series B Preferred Stock accruing an annual dividend of 6.5% or $65 per share payable annually in cash or shares of common stock at the option of the Company, unless earlier converted or redeemed on the same terms as the Series A Preferred Stock. The Series B Preferred Stock votes on an as converted basis with the Common Stock and Series A Preferred Stock having one vote for each share issuable upon conversion of the Series B Preferred Stock.

The Series B Preferred Stock ranks(i) senior to the common stock and any other class or series of the Company’s capital stock either specifically ranking by its terms junior to the Series B Preferred Stock or not specifically ranking by its terms senior to or on parity with the Series B Preferred Stock, (ii) on parity with any class or series of the Company’s capital stock specifically ranking by its terms on parity with the Series B Preferred Stock, and (iii) junior to Series A Preferred Stock, in each case, as to distributions of assets upon liquidation, dissolution or winding-up of the Company, whether voluntary or involuntary.

Dividends

The holders of the Series B Preferred Stock are entitled to receive annual cumulative per share dividends of 6.5% of the liquidation preference of the Series B Preferred Stock, out of funds legally available, prior to any payment of dividends on the Company’s common stock or any other class of stock ranking junior to the Series B Preferred Stock. Such dividends are payable in cash or shares of common stock, at the option of the Company. The holders of the Series B Preferred Stock are entitled to share ratably with the holders of the common stock in any dividend declared on the common stock.

Dividends on the Series B Preferred Stock will accrue whether or not the Company has earnings, whether or not there are funds legally available for the payment of such dividends and whether or not such dividends are declared. Dividends accumulate to the extent they are not paid on the Dividend Payment Date to which they relate. According to Delaware law, the Company may declare and pay dividends or make other distributions on its capital stock only out of legally-available funds. In addition, no dividends or distributions may be declared, paid or made if the Company is or would be rendered insolvent by virtue of such dividend or distribution. The Company may not (i) pay any dividends in respect of any shares of capital stock ranking junior to the Series B Preferred Stock (including the common stock), other than dividends payable in the form of additional shares of the same junior stock as that on which such dividend is declared, or (ii) redeem any shares of capital stock ranking junior to the Series B Preferred Stock (including the common stock), unless and until all accumulated and unpaid dividends on the Series B Preferred Stock have been, or contemporaneously are, declared and paid in full.

SIGNPATH PHARMA, INC.

(A Development Stage Company)

Notes to the Financial Statements

December 31, 2013 and 2012

Conversion

At the election of the holder thereof, each share of Series B Preferred Stock will be convertible into common stock, at any time after issuance, at the Conversion Rate, as it may be adjusted from time to time in accordance with the Certificate of Designation. The Conversion Rate initially will be 1,177 shares of common stock ($.85 per share) for each Share of Series B Preferred Stock.

The Conversion Price is subject to adjustment from time to time in the event of (i) the issuance of common stock as a dividend or distribution on any class of the Company’s capital stock; or (ii) the combination, subdivision or reclassification of the common stock but does not contain the same price protection ratchets as the Series A Preferred Stock. No fractional shares will be issued upon conversion. Payment of accumulated and unpaid dividends will be made upon conversion to the extent of legally-available funds. The shares of Preferred Stock may also be converted into common stock at the Conversion Rate at the Company’s option following the effectiveness of a Registration Statement, if the Company’s common stock trades above 200% of the Conversion Rate per share for a period of 20 consecutive trading days.

Voting Rights

The affirmative vote of the holders of at least a majority of the outstanding shares of Preferred Stock, voting as a class, shall be required to authorize, effect or validate (i) any change in the rights, privileges or preferences of the Series B Preferred Stock that would adversely affect the Series B Preferred Stock, or (ii) the authorization, creation, issuance or increase in the authorized or issued amount of any class or series of stock ranking on parity with or superior to the Series B Preferred Stock with respect to the declaration and payment of dividends or distribution of assets upon liquidation, dissolution or winding-up of our Company. In addition, the holders of Preferred Stock shall have the right to vote, together with holders of common stock as single class, on all matters upon which the holders of common stock are entitled to vote pursuant to applicable Delaware law or the Company’s Certificate of Incorporation. The Series B Preferred Stock shall vote on an “as converted basis” with each holder of Preferred Stock having one vote for each Conversion Share underlying such holder’s shares of Preferred Stock.

Liquidation

In the event of any voluntary or involuntary liquidation, dissolution or winding-up of the Company, before any payment or distribution of the assets of the Company (whether capital or surplus), or the proceeds thereof, may be made or set apart for the holders common stock or any stock ranking junior to Preferred Stock, after payment to the holders of Series A Preferred Stock the holders of Preferred Stock will be entitled to receive, out of the assets of the Company available for distribution to stockholders, a liquidating distribution of $1,000 per share, plus any accrued and unpaid dividends, subject to adjustment upon the occurrence of certain events. If, upon any voluntary or involuntary liquidation, dissolution or winding up of the Company, the assets of the Company are insufficient to make the full payment of $1,000 per share, plus all accrued and unpaid dividends on the Preferred Stock and similar payments on any other class of stock ranking on a parity with the Preferred Stock upon liquidation, then the holders of Preferred Stock and such other shares will share ratably in any such distribution of the Company’s assets in proportion to the full respective distributable amounts to which they are entitled. Certain events, including a consolidation or merger of the Company with or into another corporation or sale or conveyance of all or substantially all the property and assets of the Company will be deemed to be a liquidation, dissolution or winding-up of the Company for purposes of the foregoing.

SIGNPATH PHARMA, INC.

(A Development Stage Company)

Notes to the Financial Statements

December 31, 2013 and 2012

Series C Convertible Preferred Stock

The Series C Convertible Preferred Stock (“Series C Preferred Stock”) has been authorized by resolutions adopted by the Company’s Board of Directors and set forth in a Certificate of Designation, Preferences and Rights (“Certificate of Designation”), filed with the Secretary of State of Delaware on March 12, 2013, which contains the designations, rights, powers, preferences, qualifications and limitations of the Series C Preferred Stock. The shares of Series C Preferred Stock are fully paid and non-assessable. ~~As of December 31, 2013, the Company had issued 3,380 shares of Series C Preferred Stock.~~

~~Rank~~The dividend rate of 6.5% per annum and the terms of the dividends are the same as Series A and B Preferred Stock. The Conversion Rate is 800 shares of Common Stock (at $1.25 per share) for each $1,000 stated value of Series C Preferred Stock and may be converted into Common Stock by the Company following the effectiveness of a registration statement if the Company’s Common Stock trades above 300% of the Conversion Rate for 10 consecutive trading days. The Series C Preferred Stock ranks on parity with the Series B Preferred Stock and junior to the Series A Preferred Stock on sale or liquidation of the Company. The Series C Preferred Stock votes on an as converted basis with the Common Stock and Series A and B Preferred Stock having one vote for each share issuable upon conversion of the Series C Preferred Stock

~~The~~ Series CD ~~Preferred~~Convertible ~~Stock ranks(i) senior to the common stock and any other class or series of the Company’s capital stock either specifically ranking by its terms junior to the Series C~~ Preferred Stock or not specifically ranking by its terms senior to or on parity with the Series C Preferred Stock, (ii) on parity with the Series B Preferred Stock and any class or series of the Company’s capital stock specifically ranking by its terms on parity with the Series C Preferred Stock, and (iii) junior to Series A Preferred Stock, in each case, as to distributions of assets upon liquidation, dissolution or winding-up of the Company, whether voluntary or involuntary.

~~Dividends~~The Series D Convertible Preferred Stock (“Series D Preferred Stock”) has been authorized by resolutions adopted by the Company’s Board of Directors and set forth in a Certificate of Designation, Preferences and Rights, filed with the Secretary of State of Delaware on September 22, 2014, which contains the designations, rights, powers, preferences, qualifications and limitations of the Series C Preferred Stock. The shares of Series D Preferred Stock are fully paid and non-assessable.

The ~~holders~~dividend rate of 6.5% per annum and the terms of the dividends are the same as Series A, B and C Preferred Stock. The ~~are~~Conversion ~~entitled~~Rate tois ~~receive~~500 ~~annual~~shares ~~cumulative~~of ~~per~~Common ~~share~~Stock ~~dividends~~(at ~~of 6~~$2.5%00 ofper ~~the~~share) ~~liquidation~~for ~~preference~~each of$1,000 ~~the~~stated value of Series CD Preferred Stock, ~~out~~and ofmaybe ~~funds~~converted ~~legally~~into ~~available,~~Common ~~prior~~Stock tofollowing ~~any~~the ~~payment~~effectiveness of ~~dividends~~a onregistration statement if the Company’s ~~common~~Common ~~stock~~Stock ortrades ~~any~~above ~~other~~200% ~~class~~ of ~~stock~~the ~~ranking~~Conversion ~~junior~~Rate tofor ~~the~~10 consecutive trading days. The Series CD Preferred Stock. ~~Such~~ranks ~~dividends~~on ~~are~~parity ~~payable~~with inthe ~~cash~~Series orB ~~shares~~and ofC ~~common~~Preferred ~~stock,~~Stock atand junior to the ~~option~~Series ofA ~~the~~Preferred ~~Company.~~Stock ~~The~~on ~~holders~~sale or liquidation of the Company. The Series CD Preferred Stock ~~are~~votes ~~entitled~~on toan ~~share~~as ~~ratably~~converted basis with the ~~holders~~Common ofStock ~~the~~and ~~common~~Series ~~stock~~A, inB ~~any~~and ~~dividend~~C ~~declared~~Preferred onStock having one vote for each share issuable upon conversion of the ~~common~~Preferred ~~stock~~Stock.

~~Dividends~~NOTE 8 on– ~~the~~COMMON Series C Preferred Stock will accrue whether or not the Company has earnings, whether or not there are funds legally available for the payment of such dividends and whether or not such dividends are declared. Dividends accumulate to the extent they are not paid on the Dividend Payment Date to which they relate. According to Delaware law, the Company may declare and pay dividends or make other distributions on its capital stock only out of legally-available funds. In addition, no dividends or distributions may be declared, paid or made if the Company is or would be rendered insolvent by virtue of such dividend or distribution. The Company may not (i) pay any dividends in respect of any shares of capital stock ranking junior to the Series C Preferred Stock (including the common stock), other than dividends payable in the form of additional shares of the same junior stock as that on which such dividend is declared, or (ii) redeem any shares of capital stock ranking junior to the Series C Preferred Stock (including the common stock), unless and until all accumulated and unpaid dividends on the Series C Preferred Stock have been, or contemporaneously are, declared and paid in full.STOCK

~~Conversion~~During year ended December 31, 2014, the Company issued 40,000 shares of common stock to the Chairman of the Audit Committee for services which were valued at $34,000 based on $0.85 per share fair value of common stock.. The Company also settled $1,024,198 of accrued dividends payable by issuing 1,206,387 shares of common stock to Series A Preferred shareholders valued at $.85 per share.

AtDuring ~~the~~year ~~election~~ended ofDecember 31, 2013, the ~~holder~~Company ~~thereof~~issued 40,000 ~~each~~shares ~~share~~ of ~~Series~~common Cstock, ~~Preferred~~for ~~Stock~~services ~~will~~performed beat ~~convertible~~$0.85 ~~into~~per ~~common~~share. ~~stock~~The 40,000 atissued ~~any~~in ~~time~~the ~~after~~quarter ~~issuance~~ended March 31, at2013 ~~the~~were ~~Conversion~~not ~~Rate,~~issued asuntil itthe ~~may~~current beyear ~~adjusted~~and ~~from~~were ~~time~~booked toinitially ~~time~~as ina ~~accordance~~stock ~~with~~payable in the ~~Certificate~~amount of ~~Designation.~~$34,000 ~~The~~valued ~~Conversion~~at ~~Rate~~the ~~initially~~stock ~~will~~price beon ~~800~~February ~~shares~~20, 2013 of ~~common stock (~~$10.2585. ~~per~~As ~~share)~~of ~~for~~December ~~each~~31, ~~Share~~2013, ofstock ~~Series~~payable Cwas ~~Preferred Stock~~$-0-.

SIGNPATH PHARMA, INC.

(A Development Stage Company)

Notes to the Financial Statements

December 31, 2013 and 2012

Voting Rights

The affirmative vote of the holders of at least a majority of the outstanding shares of Preferred Stock, voting as a class, shall be required to authorize, effect or validate (i) any change in the rights, privileges or preferences of the Series C Preferred Stock that would adversely affect the Series C Preferred Stock, or (ii) the authorization, creation, issuance or increase in the authorized or issued amount of any class or series of stock ranking on parity with or superior to the Series C Preferred Stock with respect to the declaration and payment of dividends or distribution of assets upon liquidation, dissolution or winding-up of our Company. In addition, the holders of Preferred Stock shall have the right to vote, together with holders of common stock as single class, on all matters upon which the holders of common stock are entitled to vote pursuant to applicable Delaware law or the Company’s Certificate of Incorporation. The Series C Preferred Stock shall vote on an “as converted basis” with each holder of Preferred Stock having one vote for each Conversion Share underlying such holder’s shares of Preferred Stock.

Liquidation

In the event of any voluntary or involuntary liquidation, dissolution or winding-up of the Company, before any payment or distribution of the assets of the Company (whether capital or surplus), or the proceeds thereof, may be made or set apart for the holders common stock or any stock ranking junior to Preferred Stock, after payment to the holders of Series A Preferred Stock the holders of Preferred Stock will be entitled to receive, out of the assets of the Company available for distribution to stockholders, a liquidating distribution of $1,000 per share, plus any accrued and unpaid dividends, subject to adjustment upon the occurrence of certain events. If, upon any voluntary or involuntary liquidation, dissolution or winding up of the Company, the assets of the Company are insufficient to make the full payment of $1,000 per share, plus all accrued and unpaid dividends on the Preferred Stock and similar payments on any other class of stock ranking on a parity with the Preferred Stock upon liquidation, then the holders of Preferred Stock and such other shares will share ratably in any such distribution of the Company’s assets in proportion to the full respective distributable amounts to which they are entitled. Certain events, including a consolidation or merger of the Company with or into another corporation or sale or conveyance of all or substantially all the property and assets of the Company will be deemed to be a liquidation, dissolution or winding-up of the Company for purposes of the foregoing.

During the year ended December, 2013, the Company issued 3,380 shares of its par value $0.10 Series C Convertible Preferred Stock for cash at $1,000 per share.

During the year ended December 31, 2012, the Company issued 1,116 shares of its par value $0.10 convertible Series B preferred stock for cash at $1,000 per share.

During the year ended December 31, 2011, the Company issued 419 shares of its par value $0.10 Series A Convertible Preferred Stock and 1,030 shares of its par value $0.10 Series B Convertible Preferred Stock, for a total of 1,449 shares of Preferred Stock, for cash at $1,000 per share.

During the year ended December 31, 2010, the Company issued 575 shares of its par value $0.10 Series A Convertible Preferred Stock for cash at $1,000 per share.

During the year ended December 31, 2009, the Company issued 810 shares of its par value $0.10 Series A Convertible Preferred Stock at $1,000 per share.

On November 25, 2008, the Company issued 562 shares of its par value $0.10 Series A Convertible Preferred Stock for cash at $1,000 per share.

On November 25, 2008, the Company issued 890 shares of its par value $0.10 Series A Convertible Preferred Stock to extinguish bridge debt financing totaling $889,875.

Between January 24 and April 15, 2008, the Company issued 1,082,500 common shares of the Company at $0.85 per common share in accordance with the Bridge Note agreements.

As of December 31, 2013 and 2012, the Company has accrued $1,353,961 and $861,872 and has not paid any dividends, respectively.

SIGNPATH PHARMA, INC.

(A Development Stage Company)

Notes to the Financial Statements

December 31, 2013 and 2012

Common Stock

During year ended December 31, 2013, the Company issued 40,000 shares of common stock, for services performed at $0.85 per share. The Chairman of the Audit Committee also received 30,000, 40,000 and 40,000 restricted shares of Common Stock on December 28, 2010, December 22, 2011 and February 20, 2013, in consideration of consulting and accounting services as chairman of the Company’s Audit Committee. The 40,000 issued in the quarter ended March 31, 2013 were not issued until the current quarter and were booked initially as a stock payable in the amount of $34,000 valued at the stock price on February 20, 2013 of $0.85. As of December 31, 2013, stock payable was $-0-. He will be reimbursed for reasonable expenses incurred, however will not receive any other cash compensation.

During the year ended December 31, 2012, the Company issued 7,500 shares of common stock to a consultant of the Company in exchange for services valuing $16,000. The shares were valued based on the last sale price of $0.85 per share. The difference of $9,625 was recognized as a gain.

During the year ended December 31, 2011, the Company issued 640,000 shares of common stock to officers and consultants in exchange for services provided. The shares were valued based on the price of $0.85 per share and the Company recognized $151,000 in salaries and wages, $289,000 in consulting expense, and extinguished $104,000 in accrued officer salary.

On September 16, 2010 the Company issued 400,000 shares of common stock to officers and consultants of the Company in exchange for services provided. The shares were valued based on the price of $0.85 per share and the Company recognized $340,000 in consulting expense.

On December 28, 2010 the Company issued 450,000 shares of common stock to officers and consultants of the Company in exchange for services provided. The shares were valued based on the price of $0.85 per share and the Company recognized $382,500 in consulting expense.

NOTE 9 – WARRANTS

A summary of the status of the Company's warrants as of December 31, ~~2013~~2014 and ~~changes~~2013 ~~from inception through December 31, 2012~~ are presented below:

Date of	Warrant			Exercise			Value if
	Number of Warrants			Weighted Average Exercise Price			Weighted Average Grant Date Fair Value		Expiration Date (yrs)		Value if Exercised
Issuance	Shares			Price			Exercised
Outstanding as of December 31, 2012		8,674,372		$	1.03		$	0.85		2.90	$	8,957,486
11/25/08		1,259,639			1.27		$	1,599,742
Granted		4,344,392			1.15			0.85		3.70		5,008,864
11/25/08		530,314			0.85			450,767
Cancelled/Expired		-			-			-		-		-
11/26/08		449,220			1.27			570,509
Outstanding as of December 31, 2013		13,018,764			1.07			0.85		4.88		13,966,350
Outstanding at 12/31/2008		2,239,173			1.17			2,621,018
Granted		2,071,011			1.40			0.85		4.88		2,893,701
03/05/09		347,215			1.27			440,963
Cancelled/Expired		(2,539,713	)		(1.27	)		-		-		(1,160,957	)
03/05/09		104,165			0.85			88,540
Outstanding as of December 31, 2014		12,550,062		$	1.25		$	0.85		4.60	$	15,699,094
04/01/09		17,655			1.27			22,422
04/01/09		5,296			0.85			4,502
06/17/09		235,400			1.27			298,958
06/17/09		70,620			0.85			60,027

61As of December 1, 2013, the Company’s Board of Directors extended the terms of all outstanding warrants, some of which were set to expire in 2014 or 2015, such that none of the warrants expire before the fifth anniversary of the date on which the Company’s common stock begins trading on a national securities exchange, the OTC Bulletin Board or OTC Pink. The Company valued these warrants using the Black-Scholes option pricing model under the following assumptions: $0.85 and $1.27 stock price, $0.85 and $1.27 exercise price, expected term of 5 years, 107.73% volatility, .10% to 143% risk free rate. The Company recorded a deemed dividend of $2,445,621 related to the extensions.

~~SIGNPATH~~During ~~PHARMA~~the year ended December 31, ~~INC~~2013, the Company extended the exercise period of 3,226,032 Class A warrants with an exercise price of $0.85 to expire on the fifth anniversary of the next registration statement to be filed. The Company valued these warrants using the Black-Scholes option pricing model under the following assumptions: $0.85 stock price, $0.85 exercise price, 5 to 7 years to maturity, 107% to 112% volatility, .96% to 2.26% risk free rate. As a result of the modification the value of the replacement placement warrants was less than the valuation of the original warrants, therefore the Company did not recognize a gain on equity modification.

(A Development Stage Company)

Notes to the Financial Statements

December 31, 2013 and 2012

Date of	Warrant		Exercise		Value if
Issuance	Shares		Price		Exercised
07/23/09		58,850		1.27		74,740
07/23/09		35,310		0.85		30,014
08/20/09		58,850		1.27		74,740
09/09/09		235,400		1.27		298,958
09/09/09		70,620		0.85		60,027
Outstanding at 12/31/2009		3,478,554		1.17		4,074,909
02/11/10		29,425		1.27		37,370
02/11/10		17,655		0.85		15,007
05/21/10		29,425		1.27		37,370
05/21/10		17,655		0.85		15,007
08/10/10		88,275		1.27		112,109
08/10/10		52,965		0.85		45,020
09/15/10		264,825		1.27		336,328
09/15/10		52,965		0.85		45,020
09/24/10		105,930		0.85		90,041
10/27/10		147,125		1.27		186,849
10/27/10		73,563		0.85		62,529
11/19/10		117,700		1.27		149,479
11/24/10		70,620		0.85		60,027
Outstanding at 12/31/2010		4,546,682		1.16		5,267,063
01/26/11		117,700		1.27		149,479
01/26/11		60,027		1.27		76,234
01/26/11		106,636		0.85		90,641
03/15/11		58,850		1.27		74,740
03/15/11		35,310		0.85		30,014
04/06/11		70,620		0.85		60,027

SIGNPATH PHARMA, INC.

(A Development Stage Company)

Notes to the Financial Statements

December 31, 2013 and 2012

Date of	Warrant		Exercise		Value if
Issuance	Shares		Price		Exercised
04/06/11		117,700		1.27		149,479
06/08/11		51,200		0.85		43,520
06/08/11		85,333		1.27		108,373
06/20/11		17,655		0.85		15,007
06/20/11		29,425		1.27		37,370
07/26/11		23,540		1.27		29,896
07/26/11		14,124		0.85		12,005
08/22/11		29,424		1.27		37,368
08/22/11		17,655		0.85		15,007
08/30/11		105,930		0.85		90,041
09/02/11		176,550		1.27		224,219
09/09/11		58,850		1.27		74,740
09/09/11		35,310		0.85		30,014
09/22/11		441,375		1.27		560,546
09/22/11		264,825		0.85		225,101
11/02/11		141,240		0.85		120,054
11/02/11		235,400		1.27		298,958
11/23/11		35,310		0.85		30,014
11/23/11		58,850		1.27		74,740
12/27/11		127,116		0.85		108,049
12/27/11		211,860		1.27		269,062
Outstanding at 12/31/11		7,274,497		1.14		8,301,757
01/31/12		117,700		1.27		149,479
01/31/12		70,620		0.85		60,027
02/02/12		76,505		1.27		97,161
02/02/12		45,903		0.85		39,018

SIGNPATH PHARMA, INC.

(A Development Stage Company)

Notes to the Financial Statements

December 31, 2013 and 2012

Date of	Warrant			Exercise		Value if
Issuance	Shares			Price		Exercised
02/10/12		58,850			1.27		74,740
02/10/12		35,310			0.85		30,014
04/10/12		41,666			0.85		35,416
04/10/12		69,443			1.27		88,193
05/11/12		35,310			0.85		30,014
05/11/12		58,850			1.27		74,740
06/04/12		35,310			0.85		30,014
06/04/12		58,850			1.27		74,740
06/19/12		35,310			0.85		30,014
06/19/12		58,850			1.27		74,740
07/24/12		44,138			1.27		56,055
07/24/12		58,850			1.27		74,740
07/24/12		30,896			0.85		26,262
07/30/12		235,400			1.27		298,958
07/30/12		141,240			0.85		120,054
08/28/12		258,352			1.27		328,107
08/28/12		155,011			0.85		131,759
10/18/12		158,895			1.27		201,797
10/18/12		95,337			0.85		81,036
11/26/12		58,850			1.27		74,740
11/27/12		35,310			0.85		30,014
Outstanding at 12/31/12		9,345,253			1.14		10,613,584
02/28/13		400,000			0.85		340,000
03/01/13		(1,625,192	)		0.85		(1,381,413	)
03/01/13		1,625,192			0.85		1,381,413

SIGNPATH PHARMA, INC.

(A Development Stage Company)

Notes to the Financial Statements

December 31, 2013 and 2012

Date of	Warrant			Exercise		Value if
Issuance	Shares			Price		Exercised
03/13/13		800,000			1.88		1,500,000
03/13/13		480,000			0.85		408,000
06/19/13		127,200			0.85		108,120
06/19/13		212,000			1.88		397,500
07/24/13		60,000			1.88		112,500
07/24/13		100,000			1.88		187,500
07/24/13		96,000			1.25		120,000
08/29/13		80,000			1.88		150,000
08/29/13		48,000			1.25		60,000
08/29/13		(48,000	)		1.25		(60,000	)
10/24/13		61,764			0.85		52,499
10/24/13		10,588			0.85		9,000
10/24/13		1,552,840			0.85		1,319,914
10/24/13		(1,552,840	)		0.85		(1,319,914	)
10/24/13		10,000			1.25		12,500
10/24/13		38,000			1.25		47,500
11/08/13		100,000			1.88		187,500
11/08/13		60,000			1.25		75,000
12/18/13		78,000			1.25		97,500
12/18/13		78,000			1.25		97,500
12/18/13		15,000			0.85		12,750
12/18/13		1,537,840			0.85		1,307,164
Outstanding at 12/31/2013		13,689,648			1.13		15,849,164

SIGNPATH PHARMA, INC.

(A Development Stage Company)

Notes to the Financial Statements

December 31, 2013 and 2012

The warrants were issued in connection with the Preferred Stock Offering and were valued using the Lattice model and accounted for as described in Note 7.

As of December 1, 2013, the Company’s Board of Directors extended the terms of all outstanding warrants, some of which were set to expire in 2014 or 2015, such that none of the warrants expire before the fifth anniversary of the date on which the Company’s common stock begins trading on a national securities exchange, the OTC Bulletin Board or OTC Pink. The Company valued these warrants using the Black-Scholes option pricing model under the following assumptions: $0.85 and $1.27stock price, $0.85 and $$1.27 exercise price, the Warrants expire before the 5th anniversary of the date on which the Common Stock begins public trading on a national securities exchange, 107.73% volatility, .10% to 1.43% risk free rate.

During the period ended December 31, 2013, the Company extended the exercise period of 3,226,032 Class A warrants with an exercise prices of $0.85 to expire on the fifth anniversary of the next registration statement to be filed. The Company valued these warrants using the Black-Scholes option pricing model under the following assumptions: $0.85 stock price, $0.85 exercise price, 5 to 7 years to maturity, 107% to 112% volatility, .96% to 2.26%risk free rate. As a result of the modification the Company recognized a loss on equity modification of $156,477.

On February 20, 2013, the Company issued 400,000 warrants to its vendor for curcumin. The warrants have an exercise price of $0.85 per share and have a life of five years from the effective date of a registration statement. The Company valued these warrants using the Black-Scholes option pricing model under the following assumptions: $0.85 stock price, $0.85 exercise price, 5 years to maturity, 885% volatility, .85% risk free rate. The Company recorded expense of $339,997 related to these warrants for the year ended December 31, 2013.

During the ~~period~~year ended December 31, 2013, the Company issued 1,087,552 warrants as stock offering costs to the Company’s placement agent. The warrants were not deemed to be derivative instruments because they do not have a reset feature, and therefore no liability was booked related to the warrants.

The Company will issue cash or warrants as stock offering costs. The Company recognizes the cost upon completion of the share purchase. Warrants are valued and recorded using the ~~lattice~~Black-Scholes option pricing model. Total stock issuance costs for December 31, ~~2013~~2014 and ~~2012~~2013 were $~~550~~289,~~326~~240 and $~~221~~550,~~175~~326, respectively.

The ~~holders~~Company ofalso ~~the~~issued ~~Series~~200,000 ~~C Preferred~~warrants ~~Stock are entitled~~ to ~~receive~~its ~~annual~~vendor ~~cumulative~~for ~~per~~curcumin ~~share~~on ~~dividends~~January of24, 62014.5% ~~and~~The ~~a liquidation~~warrants ~~preference~~have ,an ~~out~~exercise price of ~~funds~~$1.875 ~~legally~~per ~~available,~~share ~~prior~~and tohave ~~any~~a ~~payment~~life of ~~dividends~~five onyears from the ~~Company’s~~effective ~~common~~date ~~stock~~of ora ~~any~~registration ~~other~~statement. ~~class~~The ofCompany ~~stock~~valued ~~ranking~~these ~~junior~~warrants tousing the ~~Series~~Black-Scholes Coption ~~Preferred~~pricing ~~Stock~~model ~~but~~under ~~junior to~~ the ~~Series~~following Aassumptions: ~~Preferred Stock~~$0.85 ~~Such~~stock ~~dividends~~price, ~~are~~$2.00 ~~payable~~exercise inprice, ~~cash~~5 oryears ~~shares~~to ofmaturity, ~~common~~123.35% ~~stock~~volatility, at1.75% ~~the~~risk ~~option~~free ~~of the Company~~rate. ~~The~~As ~~holders~~a result of the ~~Series~~Company Crecognized ~~Preferred~~a ~~Stock~~research ~~are~~and ~~entitled~~development toexpense ~~share ratably with the holders~~ of ~~the common stock in any dividend declared on the common stock~~$130,249.

~~Dividends~~The ~~on the Series C Preferred Stock will accrue whether or not the~~ Company ~~has~~also ~~earnings~~issued 200,000 ~~whether~~warrants orto ~~not~~its ~~there~~vendor ~~are funds legally available~~ for ~~the~~curcumin ~~payment~~on ofDecember ~~such~~12, ~~dividends and whether or not such dividends are declared~~2014. ~~Dividends~~The ~~accumulate~~warrants tohave ~~the~~an ~~extent~~exercise ~~they~~price ~~are~~of ~~not paid on the Dividend Payment Date to which they relate~~$2.00 ~~According~~per toshare ~~Delaware law, the Company may declare~~ and ~~pay~~have ~~dividends~~a orlife ~~make other distributions on its capital stock only out~~ of ~~legally-available~~seven ~~funds.~~years Infrom ~~addition, no dividends or distributions may be declared, paid or made if~~ the ~~Company~~effective isdate ~~or would be rendered insolvent by virtue~~ of ~~such~~a ~~dividend~~registration ~~or distribution~~statement. The Company ~~may~~valued ~~not~~these ~~(i)~~warrants ~~pay~~using ~~any dividends in respect of any shares of capital stock ranking junior to~~ the ~~Series~~Black-Scholes Coption ~~Preferred~~pricing ~~Stock~~model ~~(including~~under the ~~common~~following ~~stock),~~assumptions: ~~other~~$0.85 ~~than dividends payable in the form of additional shares of the same junior~~ stock asprice, ~~that~~$2.00 onexercise ~~which such dividend is declared~~price, or7 ~~(ii)~~years ~~redeem any shares of capital stock ranking junior~~ to ~~the~~maturity, ~~Series~~132.88% ~~B Preferred Stock (including the common stock)~~volatility, ~~unless~~1.75% ~~and~~risk ~~until~~free ~~all~~rate. ~~accumulated~~As ~~and~~a ~~unpaid~~result ~~dividends~~of on the ~~Series~~Company Crecognized ~~Preferred~~a ~~Stock~~research ~~have~~and ~~been,~~development orexpense ~~contemporaneously~~of ~~are~~$151, ~~declared and paid in full~~034.

~~The~~During ~~Company’s~~the ~~balance~~year ended December 31, ~~for~~2014, ~~dividends~~the ~~payable~~Company issued 443,800 warrants as ofstock ~~December~~offering ~~31,~~costs ~~2013~~to ~~and~~the ~~2012~~Company’s ~~is,~~placement $1agent. The warrants were not deemed to be derivative instruments because they do not have a reset feature,~~353,960~~ and ~~$861,872,~~therefore ~~respectively~~no liability was booked related to the warrants.

On May 28, 2014, the Company voided 1,537,840 placement warrants which were replaced by 1,484,851 placement agent warrants with an exercise price of $1.25 which will expire on the seventh anniversary of the modification. The Company modified the terms of the warrants from $0.85 exercise price to $1.25.The Company valued these warrants using the Black-Scholes option pricing model under the following assumptions: $0.85 stock price, $1.25 exercise price, 7 5 years to maturity, 117.07% volatility, 2.01% risk free rate. As a result of the modification the value of the replacement placement warrants was less than the valuation of the original warrants, therefore the Company did not recognize a gain on equity modification.

On July 22, 2014, the Company voided and replaced 2,092,051 placement agent warrants with an exercise price of $0.85 to $1.25 which will expire on the seventh anniversary of the modification. The Company modified the terms so all warrants had an exercise price of $1.25. The Company valued these warrants using the Black-Scholes option pricing model under the following assumptions: $0.85 stock price, $0.85 exercise price, 5 to 7 years to maturity, 99.66% volatility, 1.91% to 2.13% risk free rate. As a result of the modification, the Company recognized a loss on equity modification of $13,132.

NOTE 10 – STOCK OPTIONS

The Company’s 2009 Employee Stock Incentive Plan (the “2009 Plan”) was adapted by the Company’s Board of Directors on February 9, 2009 in order to motivate participants by means of stock options and restricted stock to achieve the Company’s long-term performance goals and enable our employees, officers, directors and consultants to participate in our long term growth and financial success. The 2009 Plan, ~~as amended on February 13, 2013,~~ which is administered by our Board of Directors, currently authorizes the issuance of a maximum of 1,~~000~~171,~~000~~630 (as of January 1, 2015) shares of our common stock, ~~plus~~which onmay abe ~~yearly~~authorized ~~basis~~and anunissued ~~additional~~shares ~~amount~~or ~~equal~~treasury toshares. ~~10%~~On ofFebruary 13, 2013, the ~~amount~~Board of ~~shares~~Directors ~~issued~~authorized ~~during~~an amendment to the ~~prior~~2009 ~~year. Thus,~~Plan asto ofincrease ~~January~~the 1,number ~~2014,~~of aauthorized ~~maximum~~options ofand shares to 1,~~047~~000,000 ~~shares~~plus ~~were~~on ~~authorized~~a ~~for~~yearly ~~issuance~~basis ~~under~~by 10% of the ~~2009~~amount ~~Plan~~of shares issued during the prior year. Employee options shall be deemed Incentive Stock Options (as defined in the 2009 Option Plan) to the maximum extent permitted by Section 422 of the Internal Revenue Code including a five-year limit on exercise for 10% or greater stockholders with any excess grant to the above individuals over the limits set by Section 422 being Non-Qualified Stock Options as defined in the 2009 Option Plan. Both the Incentive Stock Options or any Non-Qualified Stock Options must be granted at an exercise price of not less than the fair market value of shares of common stock at the time the option is granted and Incentive Stock Options granted to 10% or greater stockholders must be granted at an exercise price of not less than 110% of the fair market value of the shares on the date of grant.

If any award under the 2009 Plan terminates, expires unexercised, or is cancelled, the shares of common stock that would otherwise have been issuable pursuant thereto will be available for issuance pursuant to the grant of new awards. The 2009 Plan will terminate on February 9, 2019. As of December 31, ~~2013~~2014, ~~the~~an ~~following~~aggregate of 855,000 options had been granted under the plan, as follows:

	Number of Options		Weighted Average Exercise Price		Weighted Average Grant Date Fair Value		Expiration Date (yrs)		Value if Exercised

Outstanding as of December 31, 2012		100,000	$	0.85	$	0.85		7.50	$	85,000
Granted		470,000		0.95		0.85		5.00		447,500
Cancelled/Expired		-		-		-		-		-
Outstanding as of December 31, 2013		570,000		0.93		0.85		4.56		532,500
Granted		285,000		1.32		0.85		5.06		375,000
Cancelled/Expired		-		-		-		-		-
Outstanding as of December 31, 2014		855,000	$	1.06	$	0.85		3.84	$	907,500

~~SIGNPATH~~During ~~PHARMA~~the year ended December 31, ~~INC~~2013, the Company issued an aggregate of 240,000 options to two members of its board of directors, 82,400 non-qualified stock options to its CEO and a member of its board of directors, and 117,600 incentive options to its CEO and a member of its board of directors under the 2009 plan. for compensation during 2013. The options have exercise prices of $.85 and $1.25 per share and have a life of five years. The options vest as follows: one fourth on the date of grant, one fourth on every quarter from grant date. The Company valued these options using the Black-Scholes option pricing model totaling $51,000 under the following assumptions: $0.85 stock price, $.85 and $1.25 exercise prices, 5 years to maturity, 649% volatility, .35% risk free rate. As of December 31, 2013, these options were fully vested and expensed.

(AIn ~~Development~~2013, ~~Stage~~the Company) also issued 30,000 options to its law firm under the 2009 Plan. The options have an exercise price of $0.85 per share and have a life of five years. The options vest as follows: one fourth on the date of grant, one fourth on every quarter from grant date. The Company valued these options using the Black-Scholes option pricing model totaling $25,500 under the following assumptions: $0.85 stock price, $0.85 exercise price, 5 years to maturity, 885% volatility 88% risk free rate.

~~Notes to the Financial Statements~~58

During the year ended December 31, ~~2013~~2014, the Company issued an aggregate 60,000 options to two members of its board of directors and ~~2012~~under the 2009 plan for compensation during 2014. The options have an exercise price of $1.25 per share and have a life of five years. The options vest as follows: one fourth on the date of grant, one fourth on every quarter from grant date. The Company valued these options using the Black-Scholes option pricing model totaling $43,226 under the following assumptions: $0.85 stock price, $1.25 exercise price, 2.69 years to maturity, 305% volatility, .64% risk free rate.

OnThe ~~July 12, 2010 the~~ Company issued ~~100~~225,000 options to its CEO and a member of its board of directors under the 2009 plan. The options have an exercise price of $01.8525 to $2.00 per share and have a life of ~~ten~~five years. The options vest asimmediately ~~follows: one third~~ on ~~the date of~~ grant, ~~one third on each of the second and third anniversary dates from the~~ date ~~of grant~~. The Company valued these options using the Black-Scholes option pricing model totaling $84179,~~300~~232 under the following assumptions: $0.85 stock price, $01.8525 ~~stock~~to $2.00 exercise price, 105 years to maturity, ~~400~~286.96% ~~volatility,~~to 2415.0287% ~~risk~~volatility, ~~free rate~~1.66% ~~The Ccompany recorded amortization expense of $4,952 and 16,772 related~~ to ~~these~~1.92% ~~options~~risk ~~for~~free ~~the years ended December 31, 2013 and 2011~~rate.

~~On February 20, 2013 the Company issued 60,000 options to a member of its board of directors under the 2009 plan for services to be rendered during 2013.~~ The ~~options have an exercise price of $1.25 per share and have a life of five years. The options vest as follows: one fourth on the date of grant, one fourth on every quarter from grant date. The~~ Company ~~valued~~has these options using the Black-Scholes option pricing model totaling $51,000 under the following assumptions: $0.85 stock price, $1.25 exercise price, 5 years to maturity, 649% volatility, .35% risk free rate. The Company recorded amortization expense of $50217,~~928~~444 and $667,449 related to these options for the ~~year~~years ended December 31, 2014 and 2013.

On February 20, 2013 the Company issued 60,000 options to a member of its board of directors under the 2009 plan for services rendered during 2012. The options have an exercise price of $0.85 per share and have a life of five years. The options vest as follows: one fourth on the date of grant, one fourth on every quarter from grant date. The Company valued these options using the Black-Scholes option pricing model totaling $51,000 under the following assumptions: $0.85 stock price, $0.85 exercise price, 5 years to maturity, 649% volatility, .35% risk free rate. The Company recorded amortization expense of $50,941 related to these options for the year ended December 31, 2013.

On February 20, 2013 the Company issued 60,000 options to a member of its board of directors under the 2009 plan for services to be rendered during 2013. The options have an exercise price of $1.25 per share and have a life of five years. The options vest as follows: one fourth on the date of grant, one fourth on every quarter from grant date. The Company valued these options using the Black-Scholes option pricing model totaling $51,000 under the following assumptions: $0.85 stock price, $1.25 exercise price, 5 years to maturity, 649% volatility, .35% risk free rate. The Company recorded amortization expense of $50,928 related to these options for the year ended December 31, 2013.

On February 20, 2013 the Company issued 60,000 options to a member of its board of directors under the 2009 plan for services rendered during 2012. The options have an exercise price of $0.85 per share and have a life of five years. The options vest as follows: one fourth on the date of grant, one fourth on every quarter from grant date. The Company valued these options using the Black-Scholes option pricing model totaling $51,000 under the following assumptions: $0.85 stock price, $0.85 exercise price, 5 years to maturity, 649% volatility, .35% risk free rate. The Company recorded amortization expense of $50,928 related to these options for the year ended December 31, 2013.

On February 20, 2013 the Company issued 82,400 incentive stock options to its CEO and a member of its board of directors under the 2009 plan. The options have an exercise price of $0.85 per share and have a life of five years. The options vest as follows: one fourth on the date of grant, one fourth on every quarter from grant date. The Company valued these options using the Black-Scholes option pricing model totaling $70,040 under the following assumptions: $0.85 stock price, $0.85 exercise price, 5 years to maturity, 626% volatility, .35% risk free rate. The Company recorded amortization expense of $69,918 related to these options for the year ended December 31, 2013.

On February 20, 2013 the Company issued 117,600 options to its CEO and a member of its board of directors under the 2009 plan. The options have an exercise price of $0.85 per share and have a life of five years. The options vest as follows: one fourth on the date of grant, one fourth on every quarter from grant date. The Company valued these options using the Black-Scholes option pricing model totaling $99,960 under the following assumptions: $0.85 stock price, $0.85 exercise price, 5 years to maturity, 626% volatility, .35% risk free rate. The Company recorded amortization expense of $99,786 related to these options for the year ended December 31, 2013.

On February 20, 2013 the Company issued 30,000 options to its law firm under the 2009 Plan. The options have an exercise price of $0.85 per share and have a life of five years. The options vest as follows: one fourth on the date of grant, one fourth on every quarter from grant date. The Company valued these options using the Black-Scholes option pricing model totaling $25,500 under the following assumptions: $0.85 stock price, $0.85 exercise price, 5 years to maturity, 885% volatility, .88% risk free rate The Company recorded amortization expense of $25,471 related to these options for the year ended December 31, 2013.The Company has recorded amortization expense of $667,449 and $16,772 related to these options for the year ended December 31, 2013 and 2012.

NOTE 11 – INCOME TAXES

The Company’s provision for income taxes was $0 for the years ended December 31, ~~2013~~2014 and ~~2012~~2013 respectively since the Company incurred net operating losses which have a full valuation allowance through December 31, ~~2012~~2014.

ASC 740 requires the reduction of deferred tax assets by a valuation allowance if, based on the weight of available evidence, it is more likely than not that some or all of the deferred tax assets will not be realized. In the Company’s opinion, it is uncertain whether they will generate sufficient taxable income in the future to fully utilize the net deferred tax asset. Accordingly, a full valuation allowance equal to the deferred tax asset has been recorded. The total deferred tax asset is calculated by multiplying a 39% marginal tax rate by the cumulative Net Operating Loss (“NOL”) of $710,~~436~~171,~~707~~765. The total valuation allowance is equal to the total deferred tax asset. The valuation allowance increased by $~~488~~1,~~084~~066,672 from $2,~~412~~900,~~232~~316 to $23,~~903~~966,~~316~~988 for the year ended December 31, ~~2013~~2014.

67The tax effects of significant items comprising the Company's net deferred taxes as of December 31, 2014 and 2013 were as follows:

SIGNPATH PHARMA, INC.

	2014			2013
Cumulative NOL	$	10,171,765		$	7,436,707
Deferred Tax assets:
Net operating loss carry forwards		3,966,988			2,900,316
Valuation allowance		(3,966,988	)		(2,900,316	)
	$	-		$	-

(AThe ~~Development~~income ~~Stage~~tax ~~Company)~~provision differs from the amount of income tax determined by applying the U.S. federal and state income tax rates of 39% to pretax income from continuing operations for the years ended December 31, 2014 and 2013 due to the following:

Notes to the Financial Statements

	2014			2013
Income tax benefit at U. S. federal statutory rates:	$	(1,071,794	)	$	(763,180	)
Stock-based compensation		-			273,565
Derivative liability		-			1,531
Modification of warrants		5,121			-
Change in valuation allowance		1,066,673			488,084
	$	-		$	-

~~December 31, 2013 and 2012~~59

The ~~tax~~Company ~~effects~~adopted the provisions of ~~significant~~ASC ~~items~~740 ~~comprising~~at the beginning of fiscal year 2008. As a result of this adoption, the Company's ~~net~~has not made any adjustments to deferred ~~taxes~~tax asassets ofor liabilities. The Company did not identify any material uncertain tax positions on returns that have been filed or that will be filed. The Company did not recognize any interest or penalties for unrecognized tax benefits during the years ended December 31, ~~2013~~2014 and ~~2012~~2013, nor were any interest or penalties accrued as ~~follows:~~ of December 31, 2014.

	2013			2012
Cumulative NOL	$	7,436,707		$	6,185,210
Deferred Tax assets:
Net operating loss carry forwards		2,900,316			2,412,232
Valuation allowance		(2,900,316	)		(2,412,232	)
	$	-		$	-

The Company has filed income tax returns in the United States and Pennsylvania. All tax years prior to 2010 are closed by expiration of the statute of limitations. The years ended December 31, 2014, 2013, 2012, and 2011 are open for examination.

The ~~income~~Company’s ~~tax~~net ~~provision~~state ~~differs~~and ~~from the amount of income tax determined by applying the U.S.~~ federal ~~and~~operating ~~state~~loss ~~income~~carry ~~tax~~forwards ~~rates~~ of ~~39%~~approximately to$9,605,038 ~~pretax~~expire ~~income~~in ~~from~~various ~~continuing operations for the~~ years ~~ended~~beginning ~~December~~in ~~31,~~2028 ~~2013~~ and ~~2012~~carrying ~~due~~forward tothrough ~~the following:~~2034.

	2013			2012
Income tax benefit at U. S. federal statutory rates:	$	(763,180	)	$	(511,264	)
Stock-based compensation		273,565			9,027
Derivative liability		1,531			3,180
Change in valuation allowance		488,084			499,057
	$	-		$	-

The Company adopted the provisions of ASC 740 at the beginning of fiscal year 2008. As a result of this adoption, the Company has not made any adjustments to deferred tax assets or liabilities. The Company did not identify any material uncertain tax positions on returns that have been filed or that will be filed. The Company did not recognize any interest or penalties for unrecognized tax benefits during the years ended December 31, 2013 and 2012, nor were any interest or penalties accrued as of December 31, 2013.

The Company has filed income tax returns in the United States and Florida. All tax years prior to 2009 are closed by expiration of the statute of limitations. The years ended December 31, 2013, 2012, and 2011 is open for examination.

The Company’s net state and federal operating loss carry forwards of approximately $7,436,707 expire in various years beginning in 2027 and carrying forward through 2033.

The Company has had numerous transactions in its common stock. Such transactions may have resulted in a change in the Company's ownership, as defined in the Internal Revenue Code Section 382. Such change may result in an annual limitation on the amount of the Company's taxable income that may be offset with its net operating loss carry forwards. The Company has not evaluated the impact of Section 382, if any, on its ability to utilize its net operating loss carry forwards in future years.

NOTE 12 – RELATED PARTY TRANSACTIONS

On January 31, 2013, the Company signed a demand promissory note with a related party. The principal sum of the note was $25,000, bearing no interest.

On March 4, 2013, the Company signed a demand promissory note with a related party. The principal sum of the note was $5,000, bearing no interest.

On March 1, 2013, the Company paid the principal sum of $30,000 on the demand promissory notes described above.

NOTE 13 – ~~SUBSEQUENT~~COMMITMENT ~~EVENTS~~AND CONTINGENCIES

InSignPath ~~accordance~~is ~~with~~obligated ~~ASC~~to ~~855-10~~pay ~~Company~~running ~~management~~royalties ~~reviewed~~of ~~all~~2.5% ~~material~~on ~~events~~net ~~through~~sales of less than $250 million for products covered by an issued patent licensed under the ~~date~~UTMDACC License Agreement. This royalty rate increases to 3% for sales equal to, or greater than, $250 million. A royalty of ~~this~~1.5% ~~report~~of ~~and~~net ~~had~~sales nois ~~material~~payable ~~subsequent~~by ~~events~~SignPath for products covered under the license which are not protected by an issued patent. After sales to ~~report~~the public begin, SignPath must pay a minimum annual royalty $75,000 which can be deducted from the royalties on net sales due under the agreement. In addition, SignPath is obligated to pay 20% to 25% of all non-royalty consideration received under sublicensing agreements.

68SignPath was obligated under the JHU License Agreement to pay $50,000 in license fees which have been paid, plus minimum annual royalties increasing from $10,000 in the first two years to $25,000 in the third and fourth years and $30,000 in the fifth year. An aggregate of approximately $160,000 has been paid under this license agreement. The JHU License Agreement also provides that we will be obligated to pay JHU running royalty rates of two percent (2%) of net sales less than $250 million for licensed products covered by one or more claims in an issued patent, and three percent (3%) of net sales equal to or greater than $250 million for licensed products covered by one or more claims in an issued patent, or one and one half percent (1.5%) of net sales of licensed products not covered by an issued patent. The running royalties payable under the agreement are subject to a minimum annual rate. SignPath is also subject to other substantial payments, including all reasonable costs of patent reimbursement. The Company is obligated to make the following payments upon development milestones to JHU regardless of whether the milestone is achieved by the Company, a sublicensee or an affiliate: (1) $25,000 upon dosing the first patient with a licensed product in a Phase I clinical trial at a site other than JHU; (2) $50,000 upon dosing the first patient with a licensed patent in a Phase II clinical trial at a site other than JHU; (3) $25,000 upon dosing the first patient with the licensed patent in a Phase III clinical trial at a site other than JHU; (4) $250,000 upon first regulatory approval of the licensed patent, or $100,000 if no patent has issued; (5) $10,000 upon issuance of a patent sublicense fees (if applicable), and reimbursement of costs reasonably incurred by JHU in connection with the patent.

On December 12, 2014, the Board of Directors authorized an amendment to Dr. Helson’s employment agreement to provide that: (A) upon successful completion of Phase I trials for anti-Ebola testing in Africa paid for by the United States Army Medical Research Institute of Infectious Diseases (“USAMRIID”), exclusive of the cost of drug products and shipping, Dr. Helson would receive options to purchase 300,000 shares of Common Stock exercisable at then current fair market value and a cash bonus of $75,000, and (B) upon successful completion of Phase I trials in Vienna, Austria for the lead anti-QT prolongation drugs (Moxifloxacin) for liposomes Dr. Helson would receive additional options to purchase 300,000 shares of Common Stock exercisable at then current fair market value and a cash bonus of $75,000.

NOTE 14 – SUBSEQUENT EVENTS

In accordance with ASC 855-10 Company management reviewed all material events through the date of this report and had the following material subsequent events to report. Pursuant to the terms of a Letter Agreement dated July 12, 2010, Jack Levine received 40,000 restricted shares of Common Stock on January 1, 2015, in consideration of 2014 consulting and accounting services as chairman of the Company’s Audit Committee.

From January 1, 2015 through March 31, 2015, the Company sold an additional 945.25 Units of Series D Preferred Stock at $1,000 per Unit, to 18 different investors for aggregate proceeds of $945,250. Meyers Associates L.P. received sales commissions of 10% ($94,525) of the gross proceeds of the sale of Units, as well as a non-accountable expense allowance equal to 3% of the gross proceeds of the Offering and received a Unit Purchase warrant (a portion of which was subsequently transferred to Meyers Investments Family Limited Partnership) to purchase 20% of the shares sold in the Offering. The Company issued 118,157 Series D warrants as part of the subsequent Series D Preferred Stock sold. Warrants are valued and recorded using the Black-Scholes option pricing model valued at $88,144.

The Company issued 118,157 placement warrants as stock offering costs during 2015. The Company recognizes the cost upon completion of the share purchase. Warrants are valued and recorded using the Black-Scholes option pricing model. Total stock issuance costs subsequent to December 31, 2014 totalled $90,187.

On January 14, 2015, the Company voided and were replaced by 2,621,851.22 placement agent warrants with an exercise price of $1.25 which will expire on the seventh anniversary of the modification. The replacement warrants have the same terms as the original warrants that were consolidated. The Company valued these warrants using the Black-Scholes option pricing model under the following assumptions: $0.85 stock price, $1.25 exercise price, 7 years to maturity, 144.70% volatility, 1.62% risk free rate. As a result of the modification, the Company recognized a loss on equity modification of $24,868.

PART IV

ITEM 15. EXHIBITS AND FINANCIAL STATEMENT SCHEDULES

3	.1	Certificate of Incorporation of the registrant (1)	~~Certificate of Incorporation of the registrant (1)~~
3	.2	Amended and Restated Certificate of Incorporation of the registrant dated August 2, 2006 (1)	~~Amended and Restated Certificate of Incorporation of the registrant dated August 2, 2006 (1)~~
3	.3	Certificate of Amendment to the Certificate of Incorporation dated May 27, 2008 (1)	~~Certificate of Amendment to the Certificate of Incorporation dated May 27, 2008 (1)~~
3	.4	Certificate of Designation, Preferences and Rights of Series A Convertible Preferred Stock (1)	~~Certificate of Designation, Preferences and Rights of Series A Convertible Preferred Stock (1)~~
3	.5	Certificate of Amendment to Certificate of Incorporation (3)	~~Certificate of Amendment to Certificate of Incorporation (3)~~
3	.6	Certificate of Designation, Preferences and Rights of Series B Convertible Preferred Stock (4)	~~Certificate of Designation, Preferences and Rights of Series B Convertible Preferred Stock (4)~~
3	.7	Certificate of Designation, Preferences and Rights of Series C Convertible Preferred Stock (5)	~~Certificate of Designation, Preferences and Rights of Series C Convertible Preferred Stock (5)~~
3	.8	Amended and Restated Certificate of Designations, Preferences and Rights of Series A Convertible Preferred Stock (6)	~~Amended and Restated Certificate of Designations, Preferences and Rights of Series A Convertible Preferred Stock (6)~~
3	.9	By-Laws of the registrant (1)	~~By-Laws of the registrant (1)~~
4	.1		Form of Common Stock Certificate (1)
4	.2		Form of Class C Common Stock Purchase Warrant (5)
4	.3		Form of Bridge Note (1)
4	.4		Form of Registration Rights Agreement (1)
4	.5		Form of Subscription Agreement (1)
4	.6		Form of Series B Subscription Agreement (3)
4	.7		Form of Series C Subscription Agreement (5)
4	.8		Form of Registration Rights Agreement (5)

6962

*10	.1		Employment Agreement dated as of February 20, 2013 between the registrant and Dr. Lawrence Helson
3	.10	Certificate of Designation, Preferences and Rights of Series D Convertible Preferred Stock (8)
10	.2		2009 Employee Stock Incentive Plan (1)
4	.1	Form of Common Stock Certificate (1)
10	.3		License Agreement from University of Texas MD Anderson Career Center (1)
4	.2	Form of Class C Common Stock Purchase Warrant (5)
10	.4		License Agreement from The Johns Hopkins University (1)
4	.3	Form of Bridge Note (1)
10	.5		September 6, 2007 Liposomal Formulation Manufacturing Agreement with Polymun Scientific Immunbiologische Forschung (GmbH) (1)
4	.4	Form of Registration Rights Agreement (1)
10	.6		January 30, 2008 Service Agreement with Brookwood Pharmaceuticals (1)
4	.5	Form of Subscription Agreement (1)
10	.7		Sponsored Research Agreement dated as of September 18, 2007, by and between The Johns Hopkins University, employer of Dr. Anirban Maitra and the registrant. (1)
4	.6	Form of Series B Subscription Agreement (3)
10	.8		Form of Consulting Agreement for Scientific Advisory Board Members filed with this Report (1)
4	.7	Form of Series C Subscription Agreement (5)
4	.8	Form of Registration Rights Agreement (5)
*4	.9	Form of Class D Common Stock Purchase Warrant
*4	.10	Form of Series D Subscription Agreement
10	.1	Employment Agreement dated as of February 20, 2013 between the registrant and Dr. Lawrence Helson (7)
10	.2	2009 Employee Stock Incentive Plan (1)
10	.3	License Agreement dated February 21, 2007, with University of Texas MD Anderson Career Center (1)
10	.4	License Agreement dated October 2, 2007, with The Johns Hopkins University (1)
10	.5	September 6, 2007 Liposomal Formulation Manufacturing Agreement with Polymun Scientific Immunbiologische Forschung (GmbH) (1)
*10	.6	Amendment dated April 12, 2012 to the Lipsomal Foundation Manufacturing Agreement with Polymun Scientific Immunbiologische Forchung GmbH.
*10	.7	Amendment, dated August 23, 2012, to the Liposomal Formulation Manufacturing Agreement with Polymun Scientific Immunbiologische Forschung GmbH.
10	.8	Form of Consulting Agreement for Scientific Advisory Board Members (1)
*10	.9	Exclusive License Agreement, dated June 5, 2013, with Johns Hopkins University.
10	.10	Sponsored Research Agreement by and between the registrant and University of North Texas Health Science Center at Fort Worth. (1)
*10	.11	Patent and Technology License Agreement dated November 25, 2015, between the registrant and the University of North Texas Health Science Center.
*10	.12	Placement Agency Agreement dated as of September 17, 2014 by and between SignPath Pharma Inc. and Meyers Associates L.P.
10	.13	Amendment No. 1 to Sponsored Laboratory Research Agreement dated as of August 26, 2009 by and between the registrant and The University of Texas M.D. Anderson Cancer Center.

10	.9	Patent and Technology License Agreement dated August 18, 2008 between the registrant and the University of North Texas Health Science Center. (1)
10	.10	Sponsored Research Agreement by and between the registrant and University of North Texas Health Science Center at Fort Worth. (1)
10	.11	Agreement dated June 30, 2007 by and between the Registrant and SAFC. (1)
*10	.12	Placement Agency Agreement dated as of March 5, 2013 by and between SignPath Pharma Inc. and Meyers Associates L.P.
10	.13	Amendment No. 1 to Sponsored Laboratory Research Agreement dated as of August 26, 2009 by and between the registrant and The University of Texas M.D. Anderson Cancer Center.

10	.14	Sponsored Research Agreement by and between the registrant and University of North Texas Health Science Center at Fort Worth dated December 2010. (2).

*10	.15	Sponsored Research Agreement by and between the registrant and University of North Texas Health Science Center at Fort Worth dated August 1, 2013.

*10	.16	Amendment No. 1, dated July 18, 2014, to the Sponsored Research Agreement by and between the registrant and University of North Texas Health Science Center at Fort Worth dated August 1, 2013.

*10	.17	Amendment No. 1, dated December 12, 2014, to the Employment Agreement by and between the registrant and Dr. Lawrence Helson.

*31	.1	Certification of the Chief Executive Officer and Chief Financial Officer pursuant to Rule 13a-14(a) or Rule 15d-14(a), as adopted pursuant to Section 302 of The Sarbanes-Oxley Act of 2002.

*32	.1	Certificate of the Chief Executive Officer and Chief Financial Officer pursuant to 18 U.S.C. 1350, as adopted pursuant to Section 906 of The Sarbanes-Oxley Act of 2002.

*101	.ins	XBRL Instance

*101	.xsd	XBRL Schema

*101	.cal	XBRL Calculation

*101	.def	XBRL Definition

*101	.lab	XBRL Label

*101	.pre	XBRL Presentation

10	.14	Agreement dated June 30, 2009 by and between the registrant and Topaz Technology, Inc.
10	.15	Sponsored Research Agreement by and between the registrant and University of North Texas Health Science Center at Fort Worth dated December 2010. (2)
*31	.1	Certification of the Chief Executive Officer and Chief Financial Officer pursuant to Rule 13a-14(a) or Rule 15d-14(a), as adopted pursuant to Section 302 of The Sarbanes-Oxley Act of 2002.
*32	.1	Certificate of the Chief Executive Officer and Chief Financial Officer pursuant to 18 U.S.C. 1350, as adopted pursuant to Section 906 of The Sarbanes-Oxley Act of 2002.
*101	.ins	XBRL Instance
*101	.xsd	XBRL Schema
*101	.cal	XBRL Calculation
*101	.def	XBRL Definition
*101	.lab	XBRL Label
*101	.pre	XBRL Presentation

_______________________

* As filed with this Report

	(1)	Incorporated by reference to the Company’s Registration Statement on Form S-1 (Registration No. 333-158474), declared effective on August 10, 2009.
	(2)	Incorporated by reference to the Company’s Annual Report on Form 10-K for the year ended December 31, 2010.
	(3)	Incorporated by reference to the Company’s Current Report on Form 8-K filed on October 21, 2011.
	(4)	Incorporated by reference to the Company’s Quarterly Report on Form 10-Q filed on November 21, 2011.
	(5)	Incorporated by reference to the Company’s Quarterly Report on Form 10-Q filed on May 15, 2013.
	(6)	Incorporated by reference to the Company’s Quarterly Report on Form 10-Q filed on November 14, 2013.
	(7)	Incorporated by reference to the Company’s Annual Report on Form 10-K filed on March 31, 2014.
	(8)	Incorporated by reference to the Company’s Registration Statement on Form S-1 (Registration Number 333-198110), filed on December 12, 2014.

7164

SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

		SIGNPATH PHARMA INC.
Dated: March 31, 2014	By:	/s/ Lawrence Helson, M.D.
Dated: April 9, 2015	By:	/s/ Lawrence Helson, M.D.
		Lawrence Helson, M.D.
		Chief Executive Officer
		Chief Financial Officer
		(Principal Executive Officer, Principal Financial Officer and Principal Accounting Officer)

In accordance with the Exchange Act, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.

Signatures	Title	Date
/s/ Lawrence Helson, M.D	Chief Executive Officer, Chief Financial Officer, and Director (Principal Executive Officer, Principal Financial Officer, and Principal Accounting Officer)	~~March~~April 319, ~~2014~~2015
Lawrence Helson, M.D
/s/ Arthur P. Bollon, Ph.D.	Director	~~March~~April 319, ~~2014~~2015
Arthur P. Bollon, Ph.D.
/s/ Jack Levine	Director	~~March~~April 319, ~~2014~~2015
Jack Levine

7265

Filing Compare · SignPath Pharma, Inc.