3 1 form_3.txt INITIAL STATEMENT OF BENEFICIAL OWNERSHIP U.S. SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 FORM 3 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(f) of the Investment Company Act of 1940 ________________________________________________________________________________ 1. Name and Address of Reporting Person* Johnson & Johnson -------------------------------------------------------------------------------- (Last) (First) (Middle) One Johnson & Johnson Plaza -------------------------------------------------------------------------------- (Street) New Brunswick NY 08933 -------------------------------------------------------------------------------- (City) (State) (Zip) ________________________________________________________________________________ 2. Date of Event Requiring Statement (Month/Day/Year) 11/12/02 ________________________________________________________________________________ 3. IRS or Social Security Number of Reporting Person (Voluntary) 22-1024240 ________________________________________________________________________________ 4. Issuer Name and Ticker or Trading Symbol OraPharma, Inc. (NASDAQ: OPHM) ________________________________________________________________________________ 5. Relationship of Reporting Person to Issuer (Check all applicable) [ ] Director [X] 10% Owner [ ] Officer (give title below) [ ] Other (specify below) ________________________________________________________________________________ 6. If Amendment, Date of Original (Month/Day/Year) ________________________________________________________________________________ 7. Individual or Joint/Group Filing (Check applicable line) [X] Form Filed by One Reporting Person [ ] Form Filed by More than One Reporting Person ================================================================================ Table I -- Non-Derivative Securities Beneficially Owned ================================================================================

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. * If the Form is filed by more than one Reporting Person, see Instruction 5(b)(v). Page 1 of 2 FORM 3/A (continued) Table II -- Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities) ================================================================================

(1) Johnson & Johnson, a New Jersey Corporation, is party to a Stockholder Agreement dated as of November 12, 2002 with certain stockholders of OraPharma, Inc. (the "Stockholder Agreement"). Pursuant to the Stockholder Agreement, Johnson & Johnson has shared voting power with respect to, as well as a certain pecuniary interest in, the 3,540,697 shares of common stock, par value $0.001 per share, of OraPharma, Inc. that are subject to the Stockholder Agreement (the "Shares"). As a result, Johnson & Johnson may be deemed to beneficially own the Shares. ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a). Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure. Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number. JOHNSON & JOHNSON by /s/ Michael H. Ullmann November 21, 2002 -------------------------------- ----------------- Name: Michael H. Ullmann Date Title: Secretary **Signature of Reporting Person Page 2 of 2

ORAPHARMA INC 3