UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 8-K

CURRENT REPORT
Pursuant to Section 13 or 15(d) of the
Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): ~~May~~July 2930, 2007

ISOTIS S.A.

(Exact Name of Registrant as Specified in its Charter)

Switzerland	000-50449
(State or Other Jurisdiction of Incorporation)	(Commission File Number)	(I.R.S. Employer Identification No.)
(State or Other Jurisdiction of	(Commission	(I.R.S. Employer
Incorporation)	File Number)	Identification No.)

2 Goodyear Irvine, California 92618 ~~(Address of Principal Executive Offices)(Zip Code)~~

(~~949) 595-8710 (Registrant’s~~Address ~~telephone~~of ~~number,~~Principal ~~including~~Executive ~~area~~Offices) ~~code~~(Zip Code)

~~Not Applicable~~ (~~Former Name or Former Address, if Changed Since Last Report~~949) 595-8710

(Registrant’s telephone number, including area code)

Not Applicable

(Former Name or Former Address, if Changed Since Last Report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

o Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) o Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) o Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) o Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

o Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

o Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

o Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

TABLE OF CONTENTS

	Item 2.03 Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant
	Item 8.01 Other Events
	Item 9.01 Financial Statements and Exhibits
SIGNATURES
EXHIBIT INDEX
EXHIBIT 10.1
EXHIBIT 99.1

Item 28.0301 Other ~~Creation of a Direct Financial Obligation or an Obligation under an Off-Balance~~Events ~~Sheet Arrangement of a Registrant~~

OnAs ~~May~~previously reported, on December 2914, ~~2007~~2006, IsoTis, Inc., a Delaware corporation (~~the~~ “~~Effective~~IsoTis ~~Date~~US”), ~~IsoTis,~~distributed ~~Inc.~~offer memorandums (the “Offer Memorandums”) commencing a public exchange offer (the “~~Company~~Exchange Offer”), for all of the ~~parent~~issued and outstanding registered shares of IsoTis S.A., ~~IsoTis~~a ~~OrthoBiologics, Inc.~~Swiss corporation (~~together~~the ~~with~~“Company”). As disclosed in the Offer Memorandums, IsoTis US intended to delist the securities of the Company from SWX Swiss Exchange, Euronext Amsterdam and the Toronto Stock Exchange (the “~~Borrowers~~Exchanges”),. ~~Merrill~~On ~~Lynch~~July 23, ~~Capital~~2007, the afinal ~~division~~step of ~~Merrill Lynch~~the ~~Business~~Exchange ~~Financial~~Offer ~~Services~~was ~~Inc.,~~consummated ~~individually~~by asmeans of a ~~Lender,~~squeeze-out merger between the Company and asIsoTis ~~Administrative~~International ~~Agent~~S.A., ~~Sole Lead~~a ~~Arranger~~wholly-owned ~~and~~subsidiary ~~Sole~~of ~~Bookrunner~~IsoTis ~~(“Merrill~~US. Following ~~Lynch”)~~the ~~and~~consummation ~~Silicon~~of ~~Valley~~the ~~Bank~~Exchange ~~(“SVB”)~~Offer, ~~entered~~the ~~into~~securities ~~a Credit~~of ~~and~~the ~~Security~~Company ~~Agreement~~were (officially delisted from the ~~“Credit~~Exchanges ~~Agreement”)~~before ~~that~~their ~~provides~~relevant ~~for~~markets anopened ~~aggregate~~on ~~$20.0~~July ~~million~~30, 2007. A copy of the ~~commitment~~press torelease regarding the ~~Borrowers~~delisting from the Exchanges is attached hereto as Exhibit 99.1.

The loan consists of two facilities, a Revolving Note and a Term Note each in the amount of $10.0 million (each a “Loan”, collectively, the “Loans”). The Revolving Note bears interest at the rate of LIBOR plus 3.00% per annum and the Term Note bears interest at the rate of LIBOR plus 4.50% per annum. The amount available to be drawn under the Revolving Note is limited to 85% of the net collectible value of eligible accounts receivable of the Borrowers. The Loans must be paid in full on the Termination Date, which is the earlier to occur of (i) June 1, 2010 or (ii) acceleration pursuant to the occurrence of an Event of Default. Following interest-only payments on the Term Loan for a six-month period, the Term Note is payable in 30 equal payments of principal and interest beginning on January 1, 2008. Principal on account of the Revolving Note is payable immediately upon receipt by Borrowers of any payments on or proceeds from any of the Borrowers’ accounts and interest on the Revolving Note is payable in arrears on the first day of each month.

The Loans are secured by a pledge of substantially all currently existing and after-acquired property of the Borrowers, including all proceeds and products therefrom. The Credit Agreement excludes from the collateral (i) any intellectual property rights, including copyrights, patents, trademarks and inbound licenses relating to any of the copyrights, patents or trademarks, (ii) any claims for damages relating to infringement of the intellectual property and (iii) voting capital stock in any foreign subsidiary in excess of sixty-five percent (65%) of such voting capital stock. While these items are excluded from collateral, the Lenders have a lien on all proceeds arising out of or related the intellectual property and other excluded collateral.

The Credit Agreement contains customary covenants, which, among other things, prohibit the Borrowers from assuming further debt obligations and any liens, unless otherwise permitted under the Credit Agreement. The entire principal amount of the Loans and any accrued but unpaid interest may be declared immediately due and payable in the event of the occurrence of an event of default as defined in the Credit Agreement, which includes the failure to make payments when due, breaches of representations, warranties or covenants, the occurrence of certain insolvency events, the occurrence of an event or change which could have a material adverse effect on the Borrowers and failure by the Borrowers to obtain 510(k) clearance prior to December 31, 2007 for all of their Accell Products marketed as of the closing date.

Additionally, the Credit Agreement requires the Company to deposit $7.5 million of the borrowed funds in a collateral account that will not be accessible by the Company unless and until the Company shall have raised a specified amount of additional capital prior to August 31, 2007. If the Company fails to raise the additional capital prior to that time, the Company will be required to prepay the $7.5 million to the Lenders, which will be applied toward the balance of the Terms Loans.

A copy of the Credit Agreement is attached as Exhibit 10.1 and the foregoing summary is qualified by reference to the full agreement.

Item 9.01 Financial Statements and Exhibits

(d) Exhibits

10.1 Credit and Security Agreement dated as of May 29, 2007 by and among IsoTis, Inc., IsoTis OrthoBiologics, Inc., Merrill Lynch Capital and Silicon Valley Bank.


Exhibit No.		Document

99.1		Press Release, dated July 25, 2007.

SIGNATURES

WePursuant ~~have~~to ~~authorized~~the requirements of the ~~person~~Securities ~~whose~~Exchange ~~signature~~Act ~~appears~~of ~~below~~1934, tothe ~~sign~~registrant has duly caused this report to be signed on ~~our~~its behalf~~, in~~ ~~accordance~~by ~~with~~ the ~~Securities~~undersigned ~~Exchange~~hereunto ~~Act~~duly ~~of 1934~~authorized.

Date: June 4, 2007	ISOTIS, S.A. (registrant)
Date: July 30, 2007	ISOTIS S.A.
	By:	/s/ Robert J. Morocco
		Robert J.Morocco
		Robert J. Morocco
		Chief Financial Officer, Senior Vice President, Secretary & Treasurer

EXHIBIT INDEX

Exhibits:		Description of Document
Exhibit No.		Document
10.1		Credit and Security Agreement dated as of May 29, 2007 by and among IsoTis, Inc., IsoTis OrthoBiologics, Inc., Merrill Lynch Capital and Silicon Valley Bank.
99.1		Press Release, dated July 25, 2007.

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