SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the ~~Securities Exchange Act of 1934~~

~~Date~~Securities ofExchange ~~Report~~Act ~~(Date~~ of ~~earliest event reported) November 4, 2003~~1934

Date of Report (Date of earliest event reported) August 3, 2004

EPOCH BIOSCIENCES, INC.

(Exact name of Registrant as specified in charter)


Delaware	0-22170	91-1311592

(State or other jurisdiction of incorporation)	(Commission File Number)	(I.R.S. Employer Identification No.)


21720 23rd Drive S.E., Suite 150, Bothell, Washington		98021

(Address of principal executive offices)	(Zip Code)

Registrant’s telephone number, including area code (425) 482-5555

(Former name or former address, if changed, since last report.)

TABLE OF CONTENTS

	Item 7. Exhibits
	Item 12. Results of Operations and Financial Condition.
SIGNATURES
EXHIBIT INDEX
EXHIBIT 99.1


Item 7. Exhibits
Item 12. Results of Operations and Financial Condition.
SIGNATURES
EXHIBIT INDEX
EXHIBIT 99.1

Item 7. Exhibits

(c)

Exhibits.

Exhibit
Number
99.1		~~Press~~Transcript ~~Release~~of ~~dated~~Conference ~~November~~Call 4held August 3, ~~2003~~2004

Item 12. Results of Operations and Financial Condition.

On ~~November~~August 43, ~~2003~~2004, Epoch Biosciences, Inc. ~~issued~~held a ~~press~~conference ~~release~~call towith ~~report~~analysts ~~its~~and ~~financial~~investors, ~~results for~~ the ~~quarter~~transcript ~~ended~~of ~~September 30,~~which ~~2003. The press release~~ is furnished as Exhibit 99.1 and is incorporated herein by reference.

The information in this Current Report on Form 8-K, including Exhibit 99.1, is furnished pursuant to Item 12 and shall not be deemed “filed” for the purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liability of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, except as shall be expressly set forth by specific reference in such a filing.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this Report to be signed on its behalf by the undersigned thereunto duly authorized.

	EPOCH BIOSCIENCES, INC.	~~EPOCH BIOSCIENCES, INC.~~
Date: November 4, 2003		By:	/s/ Bert W. Hogue
Date: August 12, 2004	By:	/s/ Bert W. Hogue
		Bert W. Hogue	~~Bert W. Hogue~~
			Vice President and
		Vice President and Chief Financial Officer
			Chief Financial Officer

EXHIBIT INDEX

The following exhibits are attached hereto and incorporated herein by reference:

Exhibit
Number
99.1		~~Press~~Transcript ~~Release~~of ~~dated~~Conference ~~November~~Call 4held August 3, ~~2003~~2004

Table of Contents

Table of Contents

Table of Contents

Table of Contents

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