UNITED STATES ~~STATESSECURITIES~~ SECURITIES AND EXCHANGE ~~COMMISSIONWashington,~~COMMISSION ~~D.C. 20549~~

Washington, D.C. 20549 ~~______________~~

FORM 8-~~KCURRENT~~K ~~REPORTPursuant to Section 13 or 15(d) ofThe Securities Exchange Act of 1934~~

CURRENT REPORT
Pursuant to Section 13 or 15(d) of
The Securities Exchange Act of 1934

Date of Report (Date of earliest event reported)

~~July 23~~January 13, ~~2008~~2009 (~~July 22~~January 9, ~~2008~~2009)

______________

Introgen Therapeutics, Inc.

(Exact name of registrant as specified in its charter)

Delaware	0-21291	74-2704230
(State or other jurisdiction of incorporation)	(Commission File Number)	(IRS Employer Identification No.)


Delaware (State or other jurisdiction of incorporation)		0-21291 (Commission File Number)		74-2704230 (IRS Employer Identification No.)

301 Congress Avenue, Suite ~~1850Austin~~ 1850 Austin, Texas 78701 (Address of principal executive offices, including zip code)~~(512) 708-9310~~

(512) 708-9310 (Registrant’s telephone number, including area code)

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

⃞ o Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) o Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) o Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) o Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

~~⃞ Soliciting material~~Item ~~pursuant~~5.02. toDeparture ~~Rule~~of ~~14a-12~~Directors ~~under~~or ~~the~~Certain ~~Exchange~~Officers; ~~Act~~Election ~~(17~~of ~~CFR 240~~Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.~~14a-12)~~

~~⃞ Pre-commencement communications~~ On ~~pursuant~~January 9, to2009, ~~Rule~~James ~~14d-2(b)~~E. ~~under~~Rothman, Ph.D. resigned from the ~~Exchange~~Board ~~Act~~of ~~(17~~Directors ~~CFR~~of Introgen ~~240~~Therapeutics, Inc.~~14d-2~~ (b“Introgen”) and its subsidiary, Introgen Technical Services, Inc. (“ITS”). In his letter of resignation, Dr. Rothman has stated that he had no disagreements with Introgen or ITS nor their respective boards of directors or management. A copy of the resignation letter is attached hereto as Exhibit 99.1.

~~⃞ Pre-commencement communications~~Item ~~pursuant~~9.01. toFinancial ~~Rule~~Statements ~~13e-4(c)~~and ~~under the Exchange Act (17 CFR 240~~Exhibits.~~13e-4(c))~~

~~Item 7.01 Regulation~~ (d) ~~FD Disclosure~~Exhibits.

~~On July 22, 2008, Introgen Therapeutics, Inc~~99.1 ~~(“Introgen”)~~Resignation ~~presented~~Letter ~~the results~~dated ofJanuary ~~additional statistical analyses of the data from the pivotal Phase 3 clinical trial of ADVEXIN in patients with recurrent~~9, ~~refractory head and neck cancer~~2009. Introgen presented these data at the American Association for Cancer Research (AACR) Centennial Conference on Translational Cancer Medicine 2008: Cancer Clinical Trials and Personalized Medicine. A copy of the press release announcing these results is attached hereto as Exhibit 99.1.

The information in this Current Report on Form 8-K, including Exhibit 99.1, is being furnished and shall not be deemed “filed” for the purposes of Section 18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that Section.

Item 9.01 Financial Statements and Exhibits.

	(d)	Exhibits.
	99.1	Press Release dated July 23, 2008.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

			INTROGEN THERAPEUTICS, INC.
		By:	/S/ RODNEY VARNER.
			Rodney Varner
			Secretary
Date:	July 22, 2008


	INTROGEN THERAPEUTICS, INC.
	By:	/s/ J. David Enloe, Jr.
		J. David Enloe, Jr., Chief Executive Officer and President

Date: January 13, 2009

EXHIBIT INDEX

Exhibit No.	~~Description~~	Description
99.1	~~Press Release dated July 23, 2008.~~	Resignation Letter dated January 9, 2009.

Filing Compare · INTROGEN THERAPEUTICS INC