SIGNAL PHARMACEUTICALS INC S-1

FORM S-1

EXHIBIT 3.1

EXHIBIT 3.2

EXHIBIT 3.3

EXHIBIT 3.4

EXHIBIT 3.5

EXHIBIT 3.6

EXHIBIT 10.1

EXHIBIT 10.2

EXHIBIT 10.3

EXHIBIT 10.4

EXHIBIT 10.5

EXHIBIT 10.6

EXHIBIT 10.7

EXHIBIT 10.8

EXHIBIT 10.9

EXHIBIT 10.10

EXHIBIT 10.11

EXHIBIT 10.12

EXHIBIT 10.13

EXHIBIT 10.14

EXHIBIT 10.15

EXHIBIT 10.16

EXHIBIT 10.17

EXHIBIT 10.18

EXHIBIT 10.19

EXHIBIT 10.20

EXHIBIT 10.21

EXHIBIT 10.22

EXHIBIT 10.23

EXHIBIT 10.24

EXHIBIT 10.25

EXHIBIT 10.26

EXHIBIT 10.27

EXHIBIT 10.28

EXHIBIT 10.29

EXHIBIT 10.30

EXHIBIT 10.31

EXHIBIT 10.32

EXHIBIT 10.33

EXHIBIT 10.34

EXHIBIT 10.35

EXHIBIT 10.36

EXHIBIT 10.37

EXHIBIT 10.38

EXHIBIT 10.39

EXHIBIT 10.40

EXHIBIT 10.41

EXHIBIT 10.42

EXHIBIT 10.43

EXHIBIT 10.44

EXHIBIT 10.45

EXHIBIT 10.46

EXHIBIT 10.47

EXHIBIT 10.48

EXHIBIT 10.49

EXHIBIT 10.50

EXHIBIT 10.51

EXHIBIT 10.52

EXHIBIT 23.1

EXHIBIT 27.1